• Title/Summary/Keyword: 2,3-DPG

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Effect of 1,3-Diphenyl-guanidine (DPG) Mixing Step on the Properties of SSBR-silica Compounds

  • Lim, Seok-Hwan;Lee, Sangdae;Lee, Noori;Ahn, Byeong Kyu;Park, Nam;Kim, Wonho
    • Elastomers and Composites
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    • v.51 no.2
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    • pp.81-92
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    • 2016
  • 1,3-Diphenylguanidine (DPG) is commonly used as a secondary accelerator which not only acts as booster of cure but also activating silanization reaction. The aim of this study is to increase the interaction between silica and rubber by using DPG. In this study, mixing was proceeded in two steps. The T-1 compound is mixed DPG with silica and silane coupling agent in the kneader at high temperature which is named as $1^{st}$ mixing step. T-3 compound is mixed DPG with curatives in the two-roll mill at low temperature which is named as $2^{nd}$ mixing step. The T-2 compound is mixed a half of DPG in $1^{st}$ mixing step and the remainder is mixed in $2^{nd}$ mixing step. Total DPG content was equal for all compounds. When DPG is mixed with silica, silane coupling agent during the $1^{st}$ mixing step, a decrease in cure rate and an increase in scorch time can be seen. This indicates that DPG is adsorbed on the surface of silica. during rubber processing. However, bound rubber content is increased and dynamic properties are improved. These results are due to the highly accelerated silanization reaction. However, there are no significant difference in 100%, 300% modulus.

FURTHER PURIFIED GINSENG EXTRACT FRACTION (D-O-ANA) FOR INSULIN RELEASE AND ITS MODE OF ACTION COMPARED WITH THE ISOLATED RESIDUAL COMPONENTS (인삼성분 D-O-ANa이 인슐린 분비에 미치는 영향 및 작용기전에 관한연구)

  • KIMURA Masayasu;SUZUKI Jun;WAKI Isami;KIMURA Ikuko;TANAKA Osamu;MATSU-URA Hiromichi
    • Proceedings of the Ginseng society Conference
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    • 1984.09a
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    • pp.191-197
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    • 1984
  • A further purified fraction (D-O-ANa) was obtained from DPG 3-2 fraction of Ginseng Radix by complete removal of saponins, nucleosides, nucleic acid bases, amino acids, and sugars. D-O-ANa - induced insulin release was investigated to compare with that of DPG 3-2 and other isolated components. Among the sub fractions of DPG 3-2, D-O-ANa exhibited the most potent release of insulin with or without high concentrations of glucose, and it particularly enhanced the second phase of glucose-induced insulin release. DGP 3-2 potentiated significantly the glucose-induced insulin release from the isolated islets of diabetic mice at increasing concentrations of extracellular calcium ions (0.16 - 2.5 mM). A definite relationship was found between calcium $(^{45}Ca)$ uptake and insulin release. Ginsenoside $(G)-Rb_1\;and\;G-Rg_1$ did not enhance the glucose-induced insulin release. The effect of ginseng saponins was blocked by glucose (16.7 mM), being distinctly different from the glucose-potentiated effect of DPG 3-2. The insulin release effect of $G-Rg_1$ was unaffected by the presence or absence of extracellular $Ca^{2+}$ and theophylline. Adenosine also increased insulin release from isolated islets, but had no effect on perfused rat pancreas. Arginine stimulated insulin release less evidently than D-O-ANa, though arginineand adenosine-induced glucagon releases were more remarkable. In conclusion, D-O-ANa appears to be a major fraction in insulin release activity of ginseng and its mode of action may be related to $Ca^{2+}$ ion uptake. This physiological mechanism was distinct from that of the abnormal release induced by ginseng saponins.

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Effect of Hypobaric Hypoxia on Levels of Reduced Glutathione and 2,3-Diphosphoglycerate in Rabbit Red Blood Cells (저기압(低氣壓)이 가토적혈구(家兎赤血球) GSH 및 2, 3-DPG에 미치는 영향에 대하여)

  • Yu, Chang-Jun;Agar, N.S.;Webster, M.E.D.;Stacy, R.
    • Korean Journal of Veterinary Research
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    • v.22 no.1
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    • pp.9-13
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    • 1982
  • 저기압(低氣壓)이 가토(家兎)의 적혈구(赤血球)용적, 혈색소(血色素)농도, 적혈구수(赤血球數), 적혈구(赤血球) GSH 및 DPG에 끼치는 영향에 대(對)하여 연구 하였다. 적혈구(赤血球) DPG만 제외하고 모든 관찰수치는 증가(增加)되었다.

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Studies on Synthesis of Liquid Polyester Polyol by using DMT(Dimethylterephthalate) and NDC(Dimethyl-2,6-Naphthalene Dicarboxylate) (DMT(Dimethylterephthalate), NDC(Dimethy1-2,6-Naphthalene Dicarboxylate)를 이용한 액상 폴리에스터 폴리올의 합성에 관한 연구)

  • Kim, Sang-Hern
    • Journal of the Korean Applied Science and Technology
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    • v.26 no.3
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    • pp.317-327
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    • 2009
  • In this study DMT(Dimethylterephthalate), NDC(Dimethyl-2, 6-Naphthalene Dicarboxylate) were used to synthesize polyester polyol which shows enhanced storage stability, improved flame retardancy, and good compressive strength. If DMT and NDC react respectively with DEG(Diethylene Glycol) which is kind of linear diol, the obtained polyester polyols tend to crystallize easily after the reaction. In case of DMT, PA(Phthalic Anhydride) which has asymmetric structure was introduced to retard the crystallization. In case of NDC, DPG(Dipropylene Glycol) which has an methyl side chain was introduced to prevent the crystallization. It was found that to introduce DPG was much more effective method to prevent the crystallization than PA. NDC and DMT were reacted together with DPG for various compositions of NDC:DMT(8:2, 6:4, 4:6 mol ratio). The obtained NDC-DMT-DPG based polyester polyol showed improved flame retardancy, and good compressive strength with increasing the content of NDC.

A 6.5 - 8.5 GHz CMOS UWB Transmitter Using Switched LC VCO

  • Eo, Yun Seong;Park, Myung Cheol;Ha, Min-Cheol
    • JSTS:Journal of Semiconductor Technology and Science
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    • v.15 no.3
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    • pp.417-422
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    • 2015
  • A 6.5 - 8.5 GHz CMOS UWB transmitter is implemented using $0.18{\mu}m$ CMOS technology. The transmitter is mainly composed of switched LC VCO and digital pulse generator (DPG). Using RF switch and DPG, the uniform power and sidelobe rejection are achieved irrespective of the carrier frequency. The measured UWB carrier frequency range is 7 ~ 8 GHz and the pulse width is tunable from 1 to 2 ns. The measured energy efficiency per pulse is 2.1 % and the power consumption is 0.6 mW at 10 Mbps without the buffer amplifier. The chip core size is $0.72mm^2$.

A Study on the Load Balancing Algorithm using Unit Sub-block for Distributed Volume Rendering (분산 볼륨 렌더링에서 단위 서브-블록을 이용한 로드 밸런싱 알고리즘에 대한 연구)

  • Kim, Dae-Hyun;Kim, Tai-Yun
    • Journal of the Korea Computer Graphics Society
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    • v.1 no.2
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    • pp.213-225
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    • 1995
  • 3 차원 볼륨 데이터를 시각화(visualization)하기 위해서는 많은 계산 량과 메모리 량을 필요로 한다. 단일컴퓨터에서 순차 알고리즘을 이용하여 데이터를 시각화하고 분석하는 것은 실시간 응용 프로그램에는 부적합하다. 기존의 병렬 볼륨 렌더링에서의 데이터 분할 방법은 대부분 정적 로드 밸런싱(static load balancing)에 기반하고 있다. 동적 로드 밸런싱에 기반한 기존의 방법들은 불륨 데이터의 정규성(regularity)을 이용할 수 없다는 단점이 있다. 본 연구에서는 3 차원 볼륨 데이터에 대하여 로컬 태스크 큐(local task queue) 기법에 기반한 새로운 로드밸런싱 알고리즘을 제안한다. 제안한 방법은 계산에 참여할 노드(node)들을 PVM(parallel virtual machine)의 동적 프로세스 그룹(dynamic process group: DPG)을 이용하여 정적으로 그룹화(grouping)한다. 각각의 DPG들은 로컬 태스크 큐를 기반으로 단위 서브-블록에 대하여 동적 로드 밸런싱을 수행한다. 최적화된 레이 캐스팅 알고리즘들을 분산 환경에 새롭게 적용함으로써 로드 밸런싱으로 생길 수 있는 오버 헤드를 최소화하였다.

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Cure Characteristics and Mechanical Properties of Ternary Accelerator System in NR/BR Compounds (NR/BR Compounds의 가황촉진제 병용에 의한 가황 특성 및 기계적 물성 연구)

  • Kim, Il-Jin;Kim, Wook-Soo;Lee, Dong-Hyun;Bae, Jong-Woo;Byon, Young-Hoo;Kim, Wonho
    • Korean Chemical Engineering Research
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    • v.47 no.4
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    • pp.403-409
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    • 2009
  • In the 1840s, Goodyear found out sulfur cure system, but cure time was too slow. So producing of rubber product takes a long time. In 1904, Oenslager et al. found that aniline is accelerated sulfur cure system. Recently, many rubber industries needed high yield and good quality. So, many researchers have studied a rubber system with fast vulcanization time and good mechanical properties. In this study, cure characteristics and mechanical properties of NR/BR compounds by accelerator with MBTS(2,2' Dithiobisbenzothiazole), TMTM(Tetramethylthiuram Monosulfide), ZDMC (Zinc dimethyldithiocarbamate), CBS(N-Cyclohexyl benzothiazolyl-2-sulfenamide), DPG(Diphenylguanidine) were evaluated. The results of the study indicate that cure charateristics($t_{90}$: 235 sec, $T_{max}$: 5.77 Nm) and mechanical properties (100, 300% modulus : 2,180, 5.656 Mpa and tear strength: 59.58 kgf/cm) of NR/BR compounds shows efficient acceleration with MBTS 1.5 phr, TMTM 0.5 phr, DPG 0.15phr. This is due to the synergistic activity of ternary accelerator system in rubber vulcanization.

Low-dose Radiation Induces Antitumor Effects and Erythrocyte System Hormesis

  • Yu, Hong-Sheng;Liu, Zi-Min;Yu, Xiao-Yun;Song, Ai-Qin;Liu, Ning;Wang, Hao
    • Asian Pacific Journal of Cancer Prevention
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    • v.14 no.7
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    • pp.4121-4126
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    • 2013
  • Objective: Low dose radiation may stimulate the growth and development of animals, increase life span, enhance fertility, and downgrade the incidence of tumor occurrence.The aim of this study was to investigate the antitumor effect and hormesis in an erythrocyte system induced by low-dose radiation. Methods: Kunming strain male mice were subcutaneously implanted with S180 sarcoma cells in the right inguen as an experimental in situ animal model. Six hours before implantation, the mice were given 75mGy whole body X-ray radiation. Tumor growth was observed 5 days later, and the tumor volume was calculated every other day. Fifteen days later, all mice were killed to measure the tumor weight, and to observe necrotic areas and tumor-infiltration-lymphoreticular cells (TILs). At the same time, erythrocyte immune function and the level of 2,3-diphosphoglyceric acid (2,3-DPG) were determined. Immunohistochemical staining was used to detect the expression of EPO and VEGFR of tumor tissues. Results: The mice pre-exposed to low dose radiation had a lower tumor formation rate than those without low dose radiation (P < 0.05). The tumor growth slowed down significantly in mice pre-exposed to low dose radiation; the average tumor weight in mice pre-exposed to low dose radiation was lighter too (P < 0.05). The tumor necrosis areas were larger and TILs were more in the radiation group than those of the group without radiation. The erythrocyte immune function, the level of 2,3-DPG in the low dose radiation group were higher than those of the group without radiation (P < 0.05). After irradiation the expression of EPO of tumor tissues in LDR group decreased with time. LDR-24h, LDR-48h and LDR-72h groups were all statistically significantly different from sham-irradiation group. The expression of VEGFR also decreased, and LDR-24h group was the lowest (P < 0.05). Conclusion: Low dose radiation could markedly increase the anti-tumor ability of the organism and improve the erythrocyte immune function and the ability of carrying $O_2$. Low-dose total body irradiation, within a certain period of time, can decrease the expression of hypoxia factor EPO and VEGFR, which may improve the situation of tumor hypoxia and radiosensitivity of tumor itself.

The Effect of Woohwangcheongsim-won on Circulatory Disturbance in Diabetes (우황청심원이 당뇨병 Rat의 혈액순환장애에 미치는 영향)

  • 황성록;정승현;신길조;이원철
    • The Journal of Korean Medicine
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    • v.23 no.2
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    • pp.164-179
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    • 2002
  • Object: Death rate due to hypertension, atherosclerosis, ischemic heart disease and cerebral infarction induced by Westernized diet and increased average life span is on the rise. Decrease in blood circulation, activation of thrombus generation and intravascular lipid accumulation, cited as the principal causes of the above mentioned diseases in recent studies, result in circulatory disturbance and blood vessel obstruction leading to ischemic cell death of heart, brain and peripheral vessels. Method: We investigated the biochemical changes in microvascular permeability, aggregation of platelet and the intravascular lipid accumulation in induced-diabetic rat using Streptozotocin. We also studied the effects of Woohwangcheongsirn-won after oral administration on blood circulation, platelet function and lipid metabolism. The results are as follows: I. Woohwangcheongsim-won increased blood circulation in microvessels. 2. Woohwangcheongsim-won increased the reduced erythrocyte deformability in diabetes. 3. Woohwangcheongsim-won induced the reduction of contents of 2, 3-DPG, but failed to affect the reduced contents of ATP in erythrocyte in diabetes. 4. Woohwangcheongsim-won reduced the activity of Ca/sup 2+/-ATPase in the membrane of erythrocyte. 5. Woohwangcheongsim-won reduced the platelet aggregation evoked by platelet agglutinin factor. 6. Woohwangcheongsim-won reduced the production of platelet-derived granules. 7. Woohwangcheongsim-won reduced the production of metabolites of arachidonic acid in diabetes, and also reduced the production of increased thromboxane B2. 8. Woohwangcheongsim-won reduced the synthesis of oxidized LDL-cholesterol. In conclusion, Woohwangcheongsim-won enhanced blood circulation in microvesseles, erythrocyte deformability and inhibited the increased platelet aggregation and the synthesis of oxidized LDL-cholesterol in diabetes. Therefore Woohwangcheongsim-won is believed to positively affect blood circulation (J Korean Oriental Med 2002;23(2):164-179)

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Red Blood Cell Metabolism in Goats after Blood Transfusion (산양에서 수혈후의 적혈구 대사에 관하여)

  • Yu Chang Jun
    • Journal of the korean veterinary medical association
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    • v.15 no.1112
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    • pp.559-562
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    • 1979
  • 산양에서 수혈후 적혈구과다증을 지속시킬 수 있는지 또 해당중간생산물들이 변하는 가에 관하여 연구한바 아래의 결론을 얻었다. 1. 산양의 상동적혈구는 순환혈액에서 곧 사라졌다. 이와 같은 현상은 수혈적혈구가 지속적으로 적혈구과다증을 일으킬 수 없다는 것을 시사한다. 2. 적혈구용적과 혈색소농도는 수혈후 유의성 있게 증가되었으나 해당중간생산물인 GSH 2,3-DPG 및 ATP는 유의성 있게 변하지 아니하였다.

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