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A Longitudinal Study on the Prevalence of Major Adult Chronic Disease in Korean Employees between 2001 and 2010

  • Lee, Gyu-Jang;Kim, Soon-Ki;Kim, Hye-Young;Lee, Chang-Kyou;Lee, Seung-Gwan;Cho, Kyung-Jin
    • Korean Journal of Clinical Laboratory Science
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    • v.44 no.1
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    • pp.7-16
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    • 2012
  • The Korean GDP per capita doubled during the last 10 years. As the GDP increases, Korean health behaviors such as, eating, drinking, smoking, and exercise habits changed as well. Compared to the remarkably advanced diagnostic technologies and therapeutics during the last decade, the leading causes of death in Korea scarcely changed. Among the leading causes of death, cerebrovascular disease, heart disease, diabetes, liver disease and hypertension are closely related to health behaviors. Using the database of medical check-up between 2001 and 2010, the authors performed a longitudinal study for the prevalence rates and the trends of major chronic adult diseases among the 2,721 workers along with their health behavior. Among the diagnostic test items, fasting blood sugar, cholesterol and BMI levels showed steady increase and these three test items all showed linear trends (p<0.001). The average blood sugar and cholesterol levels were near worrying levels. Moreover, the average BMI of males was found to be at the overweight level, intimating the possibility reaching thee Obese Class I level soon if there are no aggressive counter measures. Fasting blood sugar and cholesterol levels were higher in a drinking group as compared to a non-drinking group, and the BMI levels were also higher in the drinking group and the smoking group as compared to the non-drinking and the non-smoking group (p<0.001). Finally, the authors believe that the fasting blood sugar, cholesterol and BMI levels should be designated as target monitoring test items in the medical check-up for Korean employees.

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Ex12 helper phage improves the quality of a phage-displayed antibody library by ameliorating the adverse effect of clonal variations

  • Choi, Hyo-Jung;Song, Suk-Yoon;Yoon, Jae-Bong;Liu, Li-Kun;Cho, Jae-Youl;Cha, Sang-Hoon
    • BMB Reports
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    • v.44 no.4
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    • pp.244-249
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    • 2011
  • The quality of a phage-displayed antibody library deteriorates with clonal variations, which are caused by differentially expressed Escherichia coli antibody genes. Using the human Fab SP114 against the pyruvate dehydrogenase complex-E2 (PDCE2), we created four E. coli TOP10F' clones with a pCMTG phagemid encoding Fab-pIII (pCMTG-Fab), Fd ($V_H+C_{H1}$)-pIII (pCMTG-Fd), or light chain (L) (pCMTG-L), or the vector only (pCMTG-${\Delta}Fab$) to investigate the effect of clonal variations in a defined manner. Compared to the others, the E. coli clone with pCMTG-Fab was growth retarded in liquid culture, but efficiently produced phage progenies by Ex12 helper phage superinfection. Our results suggest that an antibody library must be cultured for a short duration before helper phage superinfection, and that the Ex12 helper phage helped to alleviate the detrimental effect of clonal variation, at least in part, by preferentially increasing functional phage antibodies during phage amplification.

Posterior Microscopic Lesionectomy for Lumbar Disc Herniation with Tubular Retraction Using $METRx^{TM}$ System

  • Choi, Yu-Yeol;Yoon, Seung-Hwan;Ha, Yoon;Kim, Eun-Young;Park, Hyung-Chun;Park, Chong-Oon
    • Journal of Korean Neurosurgical Society
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    • v.40 no.6
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    • pp.406-411
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    • 2006
  • Objective : The authors have developed a procedure, termed posterior microscopic lesionectomy, that creates a minimal laminotomy site according to the location of the shifted disc using the $METRx^{TM}$ system in the lumbar spine. This study compared the usefulness and surgical outcomes of this procedure with those of traditional standard lumbar discectomy. Methods : From June 2003 to June 2004, Twenty-two patients with one-level radiculopathy due to lumbar disc herniation underwent posterior microscopic lesionectomy with the assistance of an operating microscope and the $METRx^{TM}$ tubular retractor. Surgical results of the new procedure were compared to those of 39 patients who underwent traditional lumbar discectomy from April 2003 to September 2004. All patients were evaluated for pain score, clinical assessment according to the VAS, and Roland-Morris scores pre-operatively and at 1, 3, 6, and 12 months post-operatively. Results : Mean blood loss, operation time, and admission date showed significant improvements for microscopic lesionectomy compared to traditional lumbar discectomy [P < 0.001]. Also, both measures of short-term functional improvement, the Visual Analogue Scale[VAS] and Roland-Morris[RM] scores, were statistically better for microscopic lesionectomy than for traditional discectomy [P < 0.001]. Conclusion : Posterior microscopic lesionectomy can be performed more safely and provide greater benefit than traditional discectomy. The procedure is associated with less post-operative pain, shorter hospital stays, and quicker rehabilitation.

Effect of Taping on a Home Program of Hip Abductor Exercise on Pain and Quadriceps Muscle Strength in Elderly Women with Knee Osteoarthritis (무릎 골관절염이 있는 여성 노인들에게 테이핑을 적용한 엉덩관절 벌리기 운동 홈 프로그램이 통증과 대퇴사두근 근력에 미치는 영향)

  • Choi, Jin-Ho
    • Journal of the Korean Society of Physical Medicine
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    • v.13 no.3
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    • pp.61-66
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    • 2018
  • PURPOSE: This study was conducted to determine the effects of taping on a home program of hip abductor exercise on pain and quadriceps muscle strength during knee joint osteoarthritis. METHODS: The subjects were 24 elderly women aged over 65 years with knee joint osteoarthritis. Twenty-four subjects were divided into two groups of 12. The intervention was conducted three times a week for six weeks. The control group underwent a home program of hip abductor exercise, while the experimental group underwent taping applied to a home program of hip abductor exercise. The measurement factors were knee joint pain and quadriceps muscle strength. Knee joint pain was measured using the VAS, while quadriceps muscle strength was measured using the 1RM method. RESULTS: Changes in pain following intervention were significantly reduced from $4.83{\pm}.72$ to $3.92{\pm}.67$ in the control group. In the experimental group, changes in pain following intervention were reduced significantly from $4.67{\pm}.78$ to $3.25{\pm}.45$. In the experimental group, the pain decreased significantly, while muscle strength increased significantly as in the control group. However, there were significant differences in pain and muscle strength between groups post intervention (p<.05). CONCLUSION: In the elderly women with knee osteoarthritis, the home program of hip abductor exercise will be a good intervention, and taping will be applied as an intervention program for better osteoarthritis.

A Modified EGEAS Model with Avoided Cost and the Optimization of Generation Expansion Plan (회피비용을 고려한 EGEAS 모형 개발과 전원개발계획의 최적화)

  • 이재관;홍성의
    • Korean Management Science Review
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    • v.17 no.1
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    • pp.117-134
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    • 2000
  • Pubilc utility industries including the electric utility industry are facing a new stream of privatization com-petition with the private sector and deregulation. The necewssity to solve now and in the future power supply and demand problems has been increasing through the sophisticated generation expansion plan(GEP) approach con-sidering not only KEPCo's supply-side resources but also outside resources such as non-utility generation(NUG) demand-side management (DSM). Under the environmental situation in the current electric utility industry a new approach is needed to acquire multiple resources competitively. This study presents the development of a modified electric generation expansion analysis system(EGEAS) model with avoided cost based on the existing EGEAS model which is a dynamic program to develope an optimal generation expansion plan for the electric utility. We are trying to find optimal GEP in Korea's case using our modified model and observe the difference for the level of reliabilities such as the reserve margin(RM) loss of load probability(LOLP) and expected unserved energy percent(EUEP) between the existing EGEAS model and our model. In addition we are trying to calculate avoided cost for NUG resources which is a criterion to evaluate herem and test possibility of connection calculation of avoided cost with GEP implementation using our modified model. The results of our case study are as follows. First we were able to find that the generation expansion plan and reliability measures were largely influenced by capacity size and loading status of NUG resources, Second we were able to find that avoided cost which are criteria to evaluate NUG resources could be calculated by using our modified EGEAS model with avoided cost. We also note that avoided costs were calculated by our model in connection with generation expansion plans.

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EFFECTS OF THE HERBICIDE, BUTACHLOR, ON NITROGEN FIXATION IN PHOTOTROPHIC NONSULFUR BACTERIA

  • Lee, Kyung-Mi;Kim, Jai-Soo;Lee, Hyun-Soon
    • Environmental Engineering Research
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    • v.12 no.4
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    • pp.136-147
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    • 2007
  • In an effort to identify possible microbes for seeking bioagents for remediation of herbicide-contaminated soils, seven species of phototrophic nonsulfur bacteria (Rhodobacter capsulatus and sphaeroides, Rhodospirillum rubrum, Rhodopseudomonas acidophila, blastica and viridis, Rhodomicrobium vannielii) were grown in the presence of the herbicide, butachlor, and bacterial growth rates and nitrogen fixation were measured with different carbon sources. Under general conditions, all species showed 17-53% reductions in growth rate following butachlor treatment. Under nitrogen-fixing conditions, Rb. capsulatus and Rs. rubrum showed 1-4% increases in the growth rates and 2-10% increases in nitrogen-fixing abilities, while the other 5 species showed decreases of 17-47% and 17-85%, respectively. The finding that Rp. acidophila, Rp. blastica, Rp. viridis and Rm. vannielii showed stronger inhibitions of nitrogenase activity seems to indicate that species in genera Rhodobacter and Rhodospirillum are less influenced by butachlor than those in Rhodopseudomonas and Rhodomicrobium in terms of nitrogen-fixing ability. Overall, nitrogenase activity was closely correlated with both growth rate and glutamine synthetase activity (representing nitrogen metabolism). When the carbon sources were compared, pyruvate (three carbons) was best for all species in terms of growth rate and nitrogen fixation, with malate (four carbons) showing intermediate values and ribose(five carbons) showing the lowest; these trends did not change in response to butachlor treatment. We verified that each of the 7 species had a plasmid ($12.2{\sim}23.5\;Kb$). We found that all 7 species could use butachlor as a sole carbon source and 3 species were controlled by plasmid-born genes, but it is doubtful whether plasmid-born genes were responsible to nitrogen fixation.

A Study on the Characteristics of the Parameters for the Statistical Analysis of Vibration Signal by Using Bearing Wear Test (베어링 마모시험을 이용한 진동신호의 통계적 파라미터 특성연구)

  • Jun, Oh-Sung;Hwang, Cheol-Ho;Yoon, Byung-Ok;Eun, Hee-Joon
    • The Journal of the Acoustical Society of Korea
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    • v.8 no.1
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    • pp.5-12
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    • 1989
  • This paper is concerned with the characteristics on the statistical parameters of vibration signal from bearing with changing its operating conditions as well as the spreading of faults. The rms, Kurtosis, crest factor, probability of exceedance and probability density function have been chose as the statistical parameters. To characterize of each, vibration signals have been recorded from four ball tester at different loads, operation speeds and time. The values of the statistical parameters for each frequency band have been calculated after A/D conversion and digital filtering of the recorded signals. It has been found that unlike rms values the statistical parameters such as Kurtosis etc. are almost unchanging with the change of the operating conditions such as load and speed. This suggests that the statistical parameters may be used for determining the development of faults independent of the operating conditions. In fact, the statistical parameters deviate considerably from their respective normal values when the faults developed under load conditions in the samples, conforming the suggestion.

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A study on the Muscle Activity and Fatigue between Quadriceps Femoris Muscle during the Mode Shift of Contraction (수축모드 변화에 따른 대퇴사두근의 근 활성도와 근 피로도에 관한 연구)

  • Chon, Ki-Hwan;Yang, Dong-Il;Lee, Gwi-Yeol
    • Journal of Advanced Navigation Technology
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    • v.15 no.6
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    • pp.1152-1162
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    • 2011
  • This study was function experiment or inspection of diagnosis x-ray unit at the hospital. It's how many changes tube voltage, tube current, DOSE value through the experiment depending on temperature increasing. The study want to know whether which parameter shown out of range or not how about image quality and so on. Increasing tube current and DOSE were not only too many radiation to the patient and radiation workers and make bad images but also the tube should be damaged by heat. This study was recommended proper exposure at intervals of seconds because passed inspection, reduced radiations for patient and the tube used long term. This results in the hospital's finances will be very helpful.

A Study on the Analysis of Broadband Direction finding Antenna on Aircraft (항공기 탑재된 광대역 방향 탐지용 안테나 분석 연구)

  • Baek, Jong-Gyun;Ji, Sung-Hwan;Mun, Byeonggwi;Lee, Kyung-Won;Kim, Dong-Gyu;Lee, Wang-Yong
    • The Journal of the Institute of Internet, Broadcasting and Communication
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    • v.18 no.5
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    • pp.89-95
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    • 2018
  • In this paper, we analyze the antenna performance changes caused by the aircraft structure, diffraction and reflection, when the direction finding antenna used in the aircraft is mounted on the aircraft. Direction finding antenna is an antenna that receives radar threat signal in the direction finding device of aircraft electronic warfare system. Recently, because various antenna are mounted on an aircraft, various analyzes such as antenna performance and interference analysis are required. Therefore, the electromagnetic analysis was carried out by installing a broadband direction finding antenna with 50% bandwidth on simulated aircraft, and the direction finding performance was analyzed by comparing the single antenna performance with the performance mounted on the aircraft. The analyzed direction finding accuracy was $6.47^{\circ}$ RMS and predicted to be suitable as an antenna for aircraft direction finding antenna.

Production Condition, Purification and Properties of Anticaries Microbial Agent by Bacilluse alkalo-philshaggy JY-827 (Bacillus alkalophilshaggy JY-827가 생산하는 항우식균물질의 생산조건과 분리, 정제 및 특성)

  • 전주연;류일환;이상욱;이갑상
    • Microbiology and Biotechnology Letters
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    • v.28 no.5
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    • pp.270-278
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    • 2000
  • The study was performed to investgate the excellent microbial anticaries substance which is more effective that the chlorhexidine in the dental caries treatment. A typi-cal strain which produced the most excellent antimicrobial subatance was selected. and identified novel alkalophillic Bacillus alkalophilshaggy JY-827. For the maximal production of themicrobial antibiotic against Streptococcus mutans from B. alkalophilshaggy JY-827, the optimal culture condition was in the medium containing glucose 15g/ L, pepton 10g/L and $K_2$$HPO_4$ 2g/L the highest production of antibiotic against S.mutans was obtained at $25^{\circ}C$ and pH 11.0 for 5 days. The antibiotic from B. alkalophilshaggy JY-827 was purified by organic solvent extraction, silica gel and sephadex LH-20 column chromatograpies, and then crystallized with methanol. The crystallin compoma-tion of this antibiotic was as a curcular shape. The melting point and rm[$\alpha$]$D^{20}$ were 152-154$^{\circ}C$ and +55。, respec-tively. Based on Instumental analyses such as FT-IR, $^{1}$H-NMR $^{13}$ C-NMR and GC-mass, the antibiotic was identified as aminoglycoside. It was obtained as amorphous white power, and soluble in water power, and soluble in water, methanol but insoluble in ether, chroloform. This antibiotic inhibited the growth of S.mutans to about 3 day at the concentration of $2.5$\times$10^{-7}$ /M. It was stable at the alkalli condition but unstable within the acid condition. It was also stable up to $70^{\circ}C$.

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