• Korean Journal of Crystallography
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• v.10 no.2
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• pp.125-129
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• 1999

X-선 회절법을 이용하여 1-(3 Carbamoyl-3,3-diphenylpropyl)-1-methylhexahydro-1H-azepinium iodide[이하: DIP]의 분자 및 결정구조를 규명하였다. 이 결정의 분자식은 C23H31N2O·I, 결정계는 Monoclinic이며 공간군은 P21이다. 단위포 상수는 a =8.937(1) Å, b=19.522(2) Å, c=6.485(2) Å이며, β= 105.18(2)°, V=1091.9(6) Å3, T=293(2)K, Z=2, Dc=1.45 Mgm-3이다. 회절반점들의 세기는 Enarf-Nonius CAD-4 diffractometer로 얻었으며 Mo Katjs(λ=0.71073 Å)을 사용하였다. 분자구조는 직접법으로 개략적인 분자모델을 설정하고, Fo>4σ(Fo)인 4112개의 독립 회절 데이터에 대하여 최소자승법으로 정밀화하여 최종 신뢰도 값 R=5.23%인 최종적인 분자모형을 구하였다.

• Journal of computational fluids engineering
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• v.19 no.3
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• pp.24-28
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• 2014

With ever rising concerns about saving of fossil fuel resource, there have been an increasing demand for use of energy more efficiently. The electric motor driven inverters can be a great help to improve energy efficiency. They are also used to control the motor speed to the actual need. Therefore the use of them can lead to reduce energy consumption. In particular, the medium voltage(MV) drive systems used for pumps, fans, steel rolling mills and tractions have widespread applications in the industry. They cover power ratings from 0.4MW to 40MW at the MV level of 2.3kV to 13.8kV. The majority of the installed MV drive systems however, are in the 1MW to 4MW range with voltage rating from 3.3kV to 6.6kV. But they are required to reduce size and weight like other power electronic equipments. In this paper, we studied on the 3.3kV(105A) compact rack type inverter system for improving the cooling efficiency. At first, we confirmed the tendency of temperature with computational simulation using ANSYS ICEPAK and actual experimental tests. And then we researched thermal performance improvement designs in order to reduce temperature of the transformer for the safe operation. It can reduce temperature of transformer that using pipe type flow guide in the system. As a result, we found out more efficient solution by thermal-fluid analysis.

• Bulletin of the Korean Chemical Society
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• v.20 no.11
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• pp.1295-1298
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• 1999

Novel platinum(IV) complexes with asymmetric chiral diamine ligands cis,cis,trans-A2PtCl2(X)2 (X = OH, OCOCH3, OCOC2H5, A2 =NH2CH(CH3)CH2NH(c-C6H11)(apcha), NH2CH(CH3)CH2NH(c-C5H9)(apcpa)) have been prepared. One of the platinum(IV) complexes, (apcpa)PtCl2(OCOC2H5)2(6), was subjected to X-ray crystallographic analysis. The crystal structure of (apcpa)PtCl2(OCOC2H5)2 (monoclinic, P21 (No. 4), a = 9.1391(1), b = 22.2517(1), c = 10.0687(1)Å, β= 109.105(1)。 , V = 1934.80(3)Å3 , Z = 4, R1 = 0.0532) exhibits that the platinum atom achieves a typical octahedral arrangement with two nitrogen atoms in cis positions and two carboxylato group in trans positions. The spectroscopic data disclose that these platinum(IV) complexes are stable and their molecular structures are retained in aqueous solution. The title complexes are highly cytotoxic in vitro but do not exhibit oral anticancer activity in vivo.

• Membrane and Water Treatment
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• v.9 no.2
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• pp.105-113
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• 2018

Maillard reaction products like melanoidins present in industrial fermentation wastewaters are complex compounds with various functional properties. In this work, novel ultrafiltration (UF) mixed matrix membrane (MMM) composed of polysulfone (PSF) and nanocomposites was prepared through a phase inversion process for the recovery of melanoidins. Nanocomposites were prepared with acid functionalized multiwalled carbon nanotubes (MWCNTs) as the reinforcing filler for chitosan-thermoplastic starch blend. Higher nanocomposites content in the PSF matrix reduced the membrane permeability and melanoidins retention indicating tighter membrane with surface defects. The membrane surface defects could be sealed with dilute polyvinyl alcohol (PVA) solution. The best performing membrane (1% nanocomposites in 18% PSF membrane sealed with 0.25% PVA coating) resulted in uniform melanoidins retention of 98% and permeability of 3.6 L/m2 h bar over a period of 8h. This demonstrates a low fouling PSF membrane for high melanoidins recovery.

• International Journal of Oral Biology
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• v.39 no.2
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• pp.97-105
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• 2014

The aim of this study was to determine the beneficial effect of propofol on human keratinocytes that have undergone hypoxia reoxygenation (H/R) injury and to investigate whether autophagy is associated with the protective mechanism. Thus, we evaluated how propofol influences the intracellular autophagy and apoptosis during the H/R process in the HaCaT cells. The cultured human keratinocyte cells were exposed to 24 h of hypoxia (5% $CO_2$, 1% $O_2$, 94% $N_2$) followed by 12 h of reoxygenation (5% $CO_2$, 21% $O_2$, 74% $N_2$). The experiment was divided into 4 groups: (1) Control=Normoxia ; (2) H/R=Hypoxia Reoxygenation ; (3) PPC+H/R=Propofol Preconditioning+Hypoxia Reoxygenation; (4) 3-MA+PPC+ H/R=3-MA-Methyladenine+Propofol Preconditioning+ Hypoxia Reoxygenation. In addition, Western blot analysis was performed to identify the expression of apoptotic pathway parameters, including Bcl-2, Bax, and caspase 3 involved in mitochondrial-dependent pathway. Autophagy was determined by fluorescence microscopy, MDC staining, AO staining, and western blot. The H/R produced dramatic injuries in keratinocyte cells. In our study, the viability of Propofol in H/R induced HaCaT cells was first studied by MTT assay. The treatment with 25, 50, and $100{\mu}M$ Propofol in H/R induced HaCaT cells enhanced cell viability in a dose-dependent manner and $100{\mu}M$ was the most effective dose. The Atg5, Becline-1, LC3-II, and p62 were elevated in PPC group cells, but H/R-induced group showed significant reduction in HaCaT cells. The Atg5 were increased when autophagy was induced by Propofol, and they were decreased when autophagy was suppressed by 3-MA. These data provided evidence that propofol preconditioning induced autophagy and reduced apoptotic cell death in an H/R model of HaCaT cells, which was in agreement with autophagy playing a very important role in cell protection.

• Publications of The Korean Astronomical Society
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• v.32 no.1
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• pp.105-107
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• 2017

We present results of AKARI/IRC near-infrared (NIR) slit-spectroscopy ($2.5-5.0{\mu}m$, R ~ 100) of Galactic sources, focusing on ice absorption features. We investigate the abundance of $H_2O$ and $CO_2$ ices and other ice species (CO and XCN ices) along lines of sight towards Galactic H $\small{II}$ regions, massive YSOs, and infrared diffuse sources. Even among those different kinds of astronomical objects, the abundance ratio of $CO_2$ to $H_2O$ ices does not vary significantly, suggesting that the pathway to $CO_2$ ice formation driven by UV irradiation is not effective at least among the present targets.

• Korean Journal of Crystallography
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• v.2 no.2
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• pp.7-12
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• 1991

C13H1SN203, Mr=250.29, is monoclinic, space group P21/a with a=8.765(4), b=17.679(3), c= 9.238(4) A, b=105.6(3)A, Z=4, V=1378.53 A3, A (Mo Ka)=0.71069 A, F(000)=536, T=299, R=0.080 for 1783 unique observed reflections with I > 1.0 σ(I). The structure was solved by direct methods and relined by cascade diagona! least-squares refinement. The C-H bond lengths and methyl groups were fixed and refined as their ideal geometry. One of two ethoxy groups is more twisted by 1 was compared with another. There is one hydrogen bond in the crystal lattice, N H‥‥0= 2.789A, forming a molecular pair packing along the b-axis.

• Asian-Australasian Journal of Animal Sciences
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• v.22 no.8
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• pp.1078-1084
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• 2009

The Jindo dog is a Korean natural monument and is recognized by the Fédération Cynologique Internationale. A prominent feature is the diverse coat color within the breed. To analyze the genetic basis of variation in the Jindo coat color, we sequenced the protein-coding regions of the melanocortin 1 receptor gene (MC1R). The MC1R coding sequence was determined from 154 dogs in five breeds (Jindo, Labrador Retriever, English Springer Spaniel, Belgian Malinois, and German Shepherd). To confirm the genetic structure of sampled populations, we tested for Hardy-Weinberg equilibrium (HWE) and computed $F_{st}$ The sample populations did not significantly deviate from HWE. $F_{st}$ was 0.02 between white and fawn Jindo dogs; this was lower than $F_{st}$ between breeds. Six single nucleotide polymorphisms (SNPs) were detected in the MC1R coding region. Among the six SNPs, five were non-synonymous (S90G, T105A, Q159P, M264V, and R306ter) and one was synonymous SNP (Y298Y). From the SNPs, we predicted four haplotypes (H1, H2, H3, and H4) for Jindo MC1R. Jindo dogs had different haplotypes corresponding to different coat colors. H1 was frequently observed in white Jindo dogs with an odds ratio of 5.03 (95% CI: 2.27-11.18, p<0.0001), whereas H2 and H4 were observed only in fawn Jindo dogs. Our findings indicate that SNP haplotype can influence coat color. Knowledge of MC1R haplotypes can help discriminate white and fawn coats in Jindo dogs. We hope this report will trigger more research into the genetics of this traditional Korean dog and will be a reference for dogs of Asian origin. Also, our results will provide a useful genetic marker for Jindo dog breeders who have selected for specific colors.

• The Korean Journal of Ecology
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• v.24 no.1
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• pp.51-59
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• 2001

Estimation of the annual net production, nitrogen (N) and base cation (BC＝K, Mg, Ca) uptake by stocked forests in South Korea has been done with national statistical data of forestry from 1995 to 1999. The annual net production of stems and branches was about 1.8 ton DM ha/sup -1/ yr/sup -1/. The net productivity of deciduous forests was higher than that of coniferous forests. Total net production of the stocked forests from the whole stocked area of South Korea of 6.246×10/sup 6/ ha, was about 1.13×10/sup 7 ton DM/yr, and the total harvested biomass obtained from timber production data in 1999, was estimated about 6.1×105 ton DM/yr that was equivalent to 98 kg DM ha/sup -1/ yr/sup -1/f. Net growth uptake of N and BC were 350 mol ha/sup -1/ yr/sup -1/ and 296 mol ha/sup -1/ yr/sup -1/ respectively, and the content of N and BC contained in the harvested biomass were 20 mol ha/sup -1/ yr/sup -1/ and 16 mol ha/sup -1/ yr/sup -1/ respectively. Net uptake of N was higher than that of BC. Total net uptake of N and BC from growth and harvest by stocked forests in South Korea were 2.309×10/sup 9/ mol/yr and 1.953×10/sup 9 mol/yr respectively.

• Bulletin of the Korean Chemical Society
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• v.33 no.6
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• pp.1839-1844
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• 2012

We have investigated binding between wild-type and mutant Heat Shock Factor (HSF) DNA binding domains (DBDs) with 17-bp HSE containing a central 5'-NGAAN-3' element by equilibrium analytical ultracentrifugation using multi-wavelength technique. Our results indicate that R102 plays critical role in HSE recognition and the interactions are characterized by substantial negative changes of enthalpy (${\Delta}H^0_{\theta}=-9.90{\pm}1.13kcal\;mol^{-1}$) and entropy (${\Delta}S^0_{\theta}=-12.46{\pm}3.77cal\;mol^{-1}K^{-1}$) with free energy change, ${\Delta}G^0_{\theta}$ of $-6.15{\pm}0.03kcal\;mol^{-1}$. N105 plays minor role in the HSE interactions with ${\Delta}H^0_{\theta}$ of $-2.54{\pm}1.65kcal\;mol^{-1}$, ${\Delta}S^0_{\theta}$ of $19.28{\pm}5.50cal\;mol^{-1}K^{-1}$ and ${\Delta}G^0_{\theta}$ of $-8.35{\pm}0.05kcal\;mol^{-1}$, which are similar to those observed for wild-type DBD:HSE interactions (${\Delta}H^0_{\theta}=-3.31{\pm}1.86kcal\;mol^{-1}$, ${\Delta}S^0_{\theta}=17.38{\pm}6.20cal\;mol^{-1}K^{-1}$ and ${\Delta}G^0_{\theta}=-8.55{\pm}0.06kcal\;mol^{-1}$) indicating higher entropy contribution for both wild-type and N105A DBD bindings to the HSE.