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Reduction of Local Body Fat Thickness and Stimulation of Fat Cell Lipolysis by Slim813 (Slim813의 지방산 분해 촉진을 통한 슬리밍 효능 연구)

  • Park, Mi-Young;Jung, Kyoung-Mi;Joo, Kyoung-Mi;Kim, Yeon-Joon;Park, Young-Ho;Lim, Kyung-Min
    • Journal of the Society of Cosmetic Scientists of Korea
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    • v.38 no.2
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    • pp.189-195
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    • 2012
  • Slim813 is a 2-cyclopentene-1-one oxime derivative with potent anti-inflammatory and anti-photoaging effects. Slim813 inhibited LPS-induced TNF-${\alpha}$ production and attenuated UVB-induced MMP1 expression. Here in an attempt to find an unrevealed efficacy of Slim813, we found that Slim813 stimulates lipolysis in a dose-dependent manner by increasing intracellular cAMP level through the elevation of HSL activity in fully differentiated adipocytes. Moreover, topical application of Slim813 for two weeks in human reduced the thickness of subcutaneous fat in arm and thigh regions, implying it could be effectively used in the reduction of unwanted local fat accumulation.

GMTI Two Channel Raw Data Processing and Analysis (GMTI 2채널 원시데이터 처리 및 분석)

  • Kim, So-Yeon;Yoon, Sang-Ho;Shin, Hyun-Ik;Youn, Jae-Hyuk;Kim, Jin-Woo;You, Eung-Noh
    • Korean Journal of Remote Sensing
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    • v.34 no.6_1
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    • pp.847-855
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    • 2018
  • GMTI (Ground Moving Target Indicator) is a kind of airborne radar function that is used widely in military applications to detect the moving targets on the ground. In this paper, GMTI signal processing technique was presented and its performance was verified using sum and difference channels raw data obtained by the captive flight test.

Synthesis and Structure-Activity Relationships of Novel Compounds for the Inhibition of TNF-$\alpha$ Production

  • Park, Joon-Seok;Baik, Kyong-Up;Son, Ho-Jung;Lee, Jae-Ho;Lee, Se-Jong;Choi, Jae-Youl;Park, Ji-Soo;Yoo, Eun-Sook;Byun, Young-Seok;Park, Myung-Hwan
    • Archives of Pharmacal Research
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    • v.23 no.4
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    • pp.332-337
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    • 2000
  • This study describes the synthesis, in vitro evaluation and molecular modeling study of novel compounds for the inhibition of TNF-$\alpha$production, Among these compounds, 2-[3-(cyclopentyloxy)-4-methoxyphenyl]-1-isoindolinone (9) was selected as a lead compound and its pyridine derivative 10 was more potent in activity and safer than rolipram.

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The Contribution of R&D Outsourcing to Productivity Growth

  • Seo, Hwan Joo;Kim, Han Sung;Lee, Young Soo
    • STI Policy Review
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    • v.3 no.1
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    • pp.80-95
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    • 2012
  • Few studies have focused on the impact of R&D outsourcing on technological innovation and productivity despite the increased importance of R&D outsourcing. This study analyzes the productivity effects of investment in R&D outsourcing with a sample of Korean manufacturing industries from 2001 to 2009. The estimation results show a nonlinear U-shaped relationship between productivity and the share of R&D outsourcing capital for total R&D capital. This implies that the cost of R&D outsourcing outweighs its benefits in the early stages of R&D outsourcing. The U-shaped relationship is particularly pronounced in high-technology industries.

Micronucleus test of SS cream and CJ-4001 using Acridine orange staining method

  • Park, Jie-Eun;Lee, Sung-Hak;Choi, Jae-Mook;Kim, Il-Hwan;Kim, Taek-Rho;Kim, Deog-Yeor;Noh, Hyun-Jung;Kang, Hee-Chol;Cho, Hi-Jae;Kim, Young-Hoon
    • Proceedings of the PSK Conference
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    • 2003.10b
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    • pp.118.1-118.1
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    • 2003
  • SS cream and its revised formula, CJ-4001 is topical Chinese herbal drugs for premature ejaculation. To evaluate the genotoxic potentials of these drugs, micronucleus test using Acridine orange (AO) staining method was performed. Acridine orange (AO) staining is adopted in OECD guideline 474 and widely used in micronucleus test. In dose range finding study, no mouse was dead at 2000 mg/kg using single treatment subcutaneously. Therefore, 3 dose levels were chosen at 500, 1000, 2000 mg/kg. (omitted)

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NMR Chemical Shift for 4d$^n$System (Ⅳ). Calculation of NMR Chemical Shift for 4d$^2$ System in a Strong Crystal Field Environment of Octahedral Symmetry

  • Ahn, Sang-Woon;Oh, Se-Woong;Yang, Jae-Hyun
    • Bulletin of the Korean Chemical Society
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    • v.6 no.5
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    • pp.255-259
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    • 1985
  • The NMR chemical shift arising from 4d electron orbital angular momentum and 4d electron spin dipolar-nuclear Spin angular momentum interactions for a $4d^2$ system in a strong crystal field environment of octahedral symmetry has been investigated when the four fold axis is taken as the quantization axis. The NMR results are comparted with the multipolar shift at various R-values and we find that the exact results are in agreement with the multipolar shift when $R{\geqslant}0.20 nm.$ We also separate the NMR shift into the contribution of the $1/R^5$ and $1/R^7$ terms. It is found that the contribution of the $1/R^5$term to the NMR shift is dominant than the contribution of the $1/R^7$ term. Temperature dependence analysis shows that the $1/T^2$ term is the dominant contribution to the NMR shift for a $4d^2$ system but the contribution of the 1/T term may not negligible. The similar results are obtained for a $4d^1$ system from the temperature dependence analysis.