• Journal of Microbiology and Biotechnology
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• v.29 no.6
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• pp.989-998
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• 2019

Autophagy is crucial for immune defense against Mycobacterium tuberculosis (Mtb) infection. Mtb can evade host immune attack and survival within macrophages by manipulating the autophagic process. MicroRNAs (miRNAs) are small, non-coding RNAs that are involved in regulating vital genes during Mtb infection. The precise role of miRNAs in autophagy with the exits of Mtb remains largely unknown. In this study, we found miR-1958, a new miRNA that could regulate autophagy by interacting with 3'UTR of autophagy-related gene 5 (Atg5). In addition, Mtb infection triggered miR-1958 expression in RAW264.7 cells. What's more, miR-1958 overexpression blocked autophagic flux by impairing the fusion of autophagosomes and lysosomes. Overexpression of miR-1958 reduced Atg5 expression and LC3 puncta while inhibition of miR-1958 brought an increase of Atg5 and LC3 puncta; the opposite results were observed in detection of p62. The survival of Mtb in RAW264.7 cells transfected with mimic of miR-1958 was enhanced. Taken together, our research demonstrated that a novel miR-1958 could inhibit autophagy by interacting with Atg5 and favored intracellular Mtb survival in RAW264.7 cells.

• Journal of Chest Surgery
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• v.16 no.3
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• pp.356-361
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• 1983

Pulmonary tuberculosis is still one of unsolved problems in Korea due to increased number of far-advanced and drug-resistant patients, who have poor pulmonary function. We have analyzed 1332 operated Gases during the period of 1958-1981. Annual incidence of the disease decreased from 110 [1960] to 21 [1980]. The ratio between male and female was 7:3 and the age of peak incidence was in the 3rd and 4th decades. Recently, patients below the age of 20 years were slightly decreased, but above 50 years were slightly increased. The patients consisted of far-advanced case in 60% and moderately-advanced in 39% in 1980, as compared with 40% and 59% correspondingly in 1965. Preoperative sputum positively decreased from 91% [1958-1963] to 43.8% [ 1974-1981 ]. Medically treated patients for more than 3 years increased from 16% [1958-1963] to 51% [1974-1981]. From the view of surgical indication, totally destroyed hung increased from 27% [1958-1963] to 4396 [1974-1981 ]. Therefore, pneumonectomy occupied 53.8% of total surgical management recently. Mode of surgical treatment showed that thoracoplasty [33%], resection [57%] in 1958-1963 and thoracoplasty [2%], resection [98%] in 1974-1981. As Semb`s thoracoplasty was the first choice of treatment until 1960, thereafter resection became the choice. Postoperative mortality increased from 1.6-2.096 to 396 recently as well as morbidity. It was mainly due to increased number of poor pulmonary function and postoperative spread of disease. On the basis of our experience, far-advanced and drug-resistant patients increased in number recently, whose pulmonary function was poor. So postoperative mortality and morbidity increased. Proper surgical intervention should be considered before the appearance of resistance for all chemotherapeutic drugs.

• Korean Architects
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• s.640
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• pp.116-119
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• 2022

• Iberoamérica
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• v.23 no.2
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• pp.1-54
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• 2021

On December 29, 1996, the Guatemala government and guerrilla group "Unidad Revolucionaria Nacional Guatemala: URNG" signed the "Guatemalan Peace Agreement," ending the civil war that lasted in Guatemala for 36 years (1960-1996). During the 36-year civil war, 200,000 people were killed or missing, and 400,000 Guatemalans fled Guatemala as a result of the civil war. In June 1954, with the help of the United States, Carlos Castillo Armas (1954-1957) coup d'état in Guatemala overthrew the then government of Jacobo Arbenz Guzmán (1950-1954). Armas later became president of Guatemala. Armas was assassinated in 1957, and a 36-year civil war began in 1958 when Miguel Ydígoras Fuentes (1958-1963), a conservative, was elected president. Armas later became president of Guatemala. Armas was assassinated in 1957, and a 36-year civil war began in 1958 when Miguel Ydígoras Fuentes (1958-1963), a conservative, was elected president. Idygoras was rated as America's puppet president for the benefit of American corporations. Although Guatemala's 36-year civil war began with the government of Idigoras, more fundamentally, the 1954 coup d'état was the cause of the 36-year civil war. The purpose of this study is to examine the background and characteristics of the 1954 coup in Guatemala.

• Korean journal of applied entomology
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• v.47 no.2
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• pp.117-126
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• 2008

Nine species of Curculionidae, Pimelocerus elongates (Roelofs, 1873), Phylaitis maculiventris Voss, 1958, Egiona picta (Roelofs, 1875), Cryptorhynchus electus (Roelofs, 1875), Rhadinopus confinis Voss, 1958, R. sulcatostriatus (Roelofs, 1875), 1962, Deiradocranus setosus (Morimoto, 1962), Rhadinomerus annulipes (Roelofs, 1875), and R. maebarai Chujo et Voss, 1960 are recorded for the first time in Korea. And the distribution of the species of Shirahoshizo hiurai Morimoto to Korea which its distribution was unclear is confirmed with this report. Habitus photos and descriptions of the species are given.

• Journal of Agricultural Extension & Community Development
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• v.18 no.4
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• pp.1011-1049
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• 2011

This study is mainly to investigate the influences of both Western's utopian socialism and cooperatives ideas on the process of China's rural cooperation from 1919(the occurrence of 5.4 movement) to 1958(the completion of People's commune). To accomplish this, first, we will discuss that how these two ideas emerged as an alternative to Western capitalism in the before/early 20th century were introduced into China and how these ideas effected on the process of the China's Communist Revolution. Then, we will review the process of China's rural cooperation during the 1950s' new socialist nation-building period since the foundation of New China(1949), the sharp debates about rural cooperation in the process of its realization, and the reasons of radically promoting rural cooperation in the late 1950s. Finally, through these debates and experiences regarding rural cooperation in rural China during 1919-1958, any implications in solving rural cooperation problems of contemporary China facing difficulties will be provided.

• Korean journal of applied entomology
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• v.47 no.3
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• pp.209-216
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• 2008

In order to find phenological change of butterflies due to global warming, we analyzed weekly monitoring data of butterfly at Gwangneung forest in 1958 and 2004. It was tested whether the timing of first flight and mean flight of butterflies in 2004 became earlier due to global warming compared with those in 1958 and whether the duration of flight period became longer. No significant difference was found in timing of first flight and in duration of flight period between 1958 and 2004. Furthermore, species showing delayed timing of mean flight was more abundant than species showing earlier timing of mean flight. Hence, the results do not confirm the predicted changes of phonology due to global warming. We discussed reasons on the non-apparent phenological changes despite the increase of temperature, and the problems and solutions in butterfly study on Korean butterfly fauna in utilization of butterflies as indicator for global warming.

• Korean Journal of Veterinary Research
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• v.1 no.1
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• pp.53-53
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• 1961

During the period from 1956 to 1959, a serological survey was conducted in au effort to assessing the incidence of brucellosis in various domestic animals in Korea. The following results were obtained. 1. Seventy-six dairy cattle which were imported in the year of 1956 had 9 positive reactors (11.84%). Of 1127 goats imported in 1956 and 1958, eleven(0.98%) were reactor animals. 2. In 1956, of 108 dairy cattle tested 10(9.25%) were reactors. In 1937 and 1958, a total of 155 dairy cattle examined hid ten (6.45%) positive reactors. In 1959, of 127 dairy cattle examined two were reactor animals. 3. In 1958 and 1959, 432 goats in some districts in Korea were subject to test for brucellosis and the test revealed five (1.15%) reactors. In 1958, 683 swine serum samples were examined and eleven (1.04%) were positive. In 1959, 1133 Korean cattle were tested and seven samples (0.64%) showed positive reactions. 4. In the month of July in 1939, 580 beef cattle in Cheju National Ranch and Branch were examined and 111 (19.13%) were found to be reactors. In October of the same year, 157 cattle, consisting of reactor and suspicious cattle groups, were tested, of which 71 samples reacted positive and 47 remained suspicious. 5. In December of the year of 1958, there occurred. an outbreak of brucellosis in a swine herd in the Sachon Branch Experimental Station. Seven serological tests on 438 swine serum samples were conducted, of which 122 (27.87%) were found positive. 6. Dairy cattle No. 33 and No. 35 which had been imported in 1956 and detected as highly positive, were examined for a prolonged period to follow the variation of antibody titers. A marked drop in antibody titer was seen two months after the initial test while the re-increase in titer was observer our months after the first examination.

• The Korean Journal of Zoology
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• v.1 no.2
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• pp.1-5
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• 1958

1. 저자가 1957년 5월부터 1958년 9월까지 남한 10개지역 즉 광릉(경기도), 네주도, 오대산(강원도), 울릉도, 강화도, 작약도(경기도), 주안(경기도 ), 이리(전북), 홍릉(서울), 남한산성(경기도)에서 복숭아, 사과등의 과실 Trap 방법과Sweeping 법으로 채집한 초파리는 4 속, 7 아문, 44종 2198 마리였다. 2. 급번채집에서 얻은 한국산미기록종은 D.(H.) trivittata Strobl Mycodrosophila splendida okada, D.(S.) auraria Peng(Type C)의 3 종이며 미지 10 종은 현재 검색중이거니와 그 결과는 멀지않아 발표할 예정이다. 3. 울릉도채집은 1958년 8월 1일부터 13일까지에 이루어졌으며 채집지는 도동, 사동, 천부, 대무, 남양 난봉, 성인봉이며 그 결과 채집된 22종은 울릉도산동물목록에 새로이 부가하는 바이다.

• Journal of Plant Biology
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• v.8 no.3
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• pp.4-8
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• 1965

Wir wollten beobachten, ob die Chlorophyllbnahme von Chlorella luteoviridis(211/2b) bei Glukose-Zugabe durch Stickstoffmangel hervorgerufen worden ist, wie viele Leute bei mineralsalzmangel(Aach (1952, Fogg 1956 Eyster et al (1958), oder Photooxydationschlorose (Kandler 1958) vermuteten. Chlorella luteoviridis bildete nicht Chlorophyll bei Glukosezugabe wie bei Autotrophkultur, obwohl Stickstoffsynthese bei Autotrophkultur stark gef rdert worden ist. Bei Nitratanzucht mit Glukose (Mixotroph) waren die Zellvermehrung und Kohlenhydratbildung nicht so stark wie bei der Glukoseanzucht mit NH4Cl2 trotzdem nahm Chlorophyll ab. Chlorella luteoviridis bildete Chlorophyll im Dunkeln und St rkeakkumulation erschien nicht bei Glukoseanzucht.