• The Journal of Korean Obstetrics and Gynecology
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• v.21 no.1
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• pp.83-98
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• 2008

Purpose: This study was performed to determine the inhibitory effect of Soyosangagamhwajae(SYG) on melanin synthesis in B16F10 mouse melanoma cell. Methods: The Inhibitory effects of Soyosangagamhwajae(SYG) on melanin synthesis were determined by in-vitro assay. To elucidate inhibitory effects of SYG on melanin synthesis, we determined the melanin release in B16F10 cell. And to investigate the action mechanism, we assessed the gene expression of tyrosinase, TRP-1, TRP-2. PKA, $PKC{\beta}$ in B16F10 cell. Results: 1. SYG significantly inhibited melanin-release in B16F10 cell. 2. SYG significantly inhibited mushroom tyrosinase activity in vitro. 3. SYG significantly suppressed the expression of tyrosinase in B16F10 cell. 4. SYG significantly suppressed the expression of TRP-1, TRP-2 in B16F10 cell. 5. SYG significantly suppressed the expression of PKA, $PKC{\beta}$ in B16F10 cell. Conclusion: From these results, it may be concluded that SYG has the antimelanogenetic effect.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.16 no.11
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• pp.2503-2510
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• 2012

This paper proposes a parallel operation intra predictor for H.264/AVC decoder. In previous intra predictor design, common operation units were designed for 17 prediction modes in order to compute more effectively. However, it was designed by analyzing the equation applied to one pixel. So, there are four operation units for computing 16 pixels in a $4{\times}4$ block and they need four cycles. In this paper, the proposed intra predictor contains T3(Three Type Transform) operation unit for parallel operation. It divides 17 modes into 3 types to calculate 16 pixels of a $4{\times}4$ block in only one cycle and needs 16 cycles minimum in 16x16 block. As the result of the experiment, in terms of processing cycle, the performance of proposed intra predictor is 58.95% higher than the previous one.

• Korean Journal of Microbiology
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• v.41 no.2
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• pp.125-128
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• 2005

A 16S ribosomal RNA gene from S. chungbukensis DJ77 has been sequenced. This sequence had a length of 1,502 bp and was extended for 29 bp at 5' and for 37 bp at 3' from the partial sequence (1,435 bp) registered in 2000 year. Besides, 1 bp was newly added near to the 3' end. We made the secondary structure of the 16S rRNA based on E. coli model and found four specific regions. We found constant and variable regions in genus Sphingomonas as the result of multiple alignment of 16S rRNA gene sequences from Sphingomonas spp. and S. chungbukensis DJ77. We found a stem loop structure in S. chungbukensis DJ77, which was only discovered in C. jejuni to date. It showed the structural agreement despite the difference of the sequences from the both organisms. Finally, S. chungbukensis DJ77 belonged to cluster II (Sphingobium) group, after the classification using phylogenetic analysis and nucleotide signature analysis.

• International Journal of Oral Biology
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• v.38 no.1
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• pp.21-27
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• 2013

Anginosus group streptococci (AGS) were classified based on the nucleotide sequences of the 16S rRNA gene (16S rDNA) and comprised Streptococcus anginosus, Streptococcus intermedius, and Streptococcus constellatus. It is known that AGS is a causative factor of oral and systematic diseases. The purpose of this study was to discriminate the 56 clinical strains of AGS isolated from Korean oral cavities using phylogenetic analysis of 16S rDNA and species-specific PCR at the species-level. The 16S rDNA of clinical strains of AGS was sequenced using the dideoxy chain termination method and analyzed using MEGA version 5 software. PCR was performed to identify the clinical strains using species-specific primers described in previous studies and S. intermedius-specific PCR primers developed in our laboratory. The resulting phylogenetic data showed that the 16S rDNA sequences can delineate the S. anginosus, S. intermedius, and S. constellatus strains even though the 16S rDNA sequence similarity between S. intermedius and S. constellatus is above 98%. The PCR data showed that each species-specific PCR primer pair could discriminate between clinical strains at the species-level through phylogenetic analysis of 16S rDNA nucleotide sequences. These results suggest that phylogenetic analysis of 16S rDNA and PCR are useful tools for discriminating between AGS strains at the species-level.

• Journal of IKEEE
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• v.2 no.2 s.3
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• pp.233-238
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• 1998

In this paper, the implementation of dual rate ADPCM using G.726 16Kbps and 40Kbps speech codec algorithm is handled. For small signals, the low rate 16Kbps coding algorithm shows almost the same SNR as the high rate 40Kbps coding algorithm , while the high rate 40Kbps coding algorithm shows the higher SNR than the low rate 16Kbps coding algorithm fur large signal. To obtain the good trade-off between the data rate and synthesized speech quality, we applied low rate 16Kbps for the small signal and high rate 40Kbps for the large signal. Various threshold values determining the rate are applied for good trade-off between data rate and speech quality. The simulation result shows the good speech quality at a low rate comparing with 16Kbps & 40Kbps.

• Biomedical Science Letters
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• v.19 no.3
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• pp.239-244
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• 2013

Serum liver enzyme levels are widely used in the clinical diagnosis of liver diseases and the assessment of liver status. They also have epidemiological significance to be prospective risk factors for type 2 diabetes, cardiovascular disease. In the previous study, single nucleotide polymorphisms (SNPs) in several genes have been reported to be associated with serum liver enzyme levels in American population. We aimed to confirm whether the genetic variation of C16orf47 (chromosome 16 open reading frame 47) gene also influence the serum liver enzyme levels in Korean population. We genotyped variants in or near C16orf47 in a population-based sample including 994 unrelated Korean adult. Here, we performed association analysis to elucidate the possible relations of genetic polymorphisms in C16orf47 gene with serum liver enzyme levels. By examining genotype data of a total of 944 subjects in 5 hospital health promotion center, we discovered the C16orf47 gene polymorphisms are associated with serum liver enzyme levels. The common and highest significant polymorphism was rs7203412 (${\beta}$=3.68, P=3.66E-06) with glutamic oxaloacetic transferase (GOT) and rs7203412 (${\beta}$=6.2, P=7.06E-05) with glutamic pyruvate transaminase (GPT) in all group. Furthermore, the SNP rs7203412 was consistently associated with GOT (${\beta}$=6.41, P=6.78E-08) and GPT (${\beta}$=11.53, P=2.81E-06) in men group. Consequently, we found statistically significant SNP in C16orf47 gene that are associated with serum levels of GOT and GPT. In addition, these results suggest that the individuals with the minor alleles of the SNP in the C16orf47 gene may be more elevated serum liver enzyme levels in the Korean population.

• Korean Journal of Microbiology
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• v.37 no.2
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• pp.137-144
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• 2001

In order to investigate the diversity of bacterial community in the mud flat of Sunchon Bay, Chunnam province, diversity of amplified 16S rDNA was examined. Total DNA was extracted from sediment soils and 16S rDNAs were amplified using PCR primers based on the universally conserved sequences in bacteria. Clonal libraries were constructed and 111 clones were examined by amplified rDNA restriction analysis (ARDRA) using HaeIII. Clones were clustered based on restriction patterns using computer program, GelCompar II. One hundred different RFLP types were detected from 111 clones. The 20 clones were selected and sequenced according to dendrograms derived from ARDRA, to cover most of the bacterial diversity in the clone libraries. None of the clones were identical to any representatives in the Ribosomal Database Project small subunit RNA databases and GenBank. All sequences showed between 77 and 96.8% similarity to the known 16s rRNA sequence from cultured organisms. The 20 clones sequenced fell into seven major lineages of the domain Bacteria: alpha-, delta-, gamma-Proteobacteria, low G+C Gram positive bacteria, high G+C Gram positive bacteria, Sphingobacteria (Cytophaga) and Cyanobacteria (chloroplast). Among the clones, the Proteobacteria were dominant.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.36 no.9A
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• pp.767-775
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• 2011

In this paper, we propose a new multi-input multi-output (MIMO) channel modeling method for mobile-to-mobile (M2M) communications based on IEEE 802.16n. To reflect the mobilities at the transmitter and the receiver, we propose a new channel model by invoking the geometrical two-ring scattering model and modifying the conventional IEEE 802.16m fixed-to-mobile (F2M) channel model considering M2M communication environments. Through computer simulations, we analyze the statistical properties of proposed channel model in terms of the time correlation and the spatial correlation. Finally, the performance of the system using the proposed M2M channel model is compared with that using the conventional 802.16m F2M channel model by link level simulations.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.35 no.11B
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• pp.1651-1658
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• 2010

As indicators of life quality have recently shown great improvement, early stage medical examination and health care patterns are usually preformed before diseases occur. Thus, hand acupuncture, as an alternative medicine to reflect these movements of preventative work and health care, is widely used these days. Therefore, in this paper, we measured the change of voice signals elements associated with heart by stimulating the heart A16 acupuncture point, and then we investigated possible improvements of cardiac function through analysis of cross-comparisons between measurements of cardiac changes. With this in mind, we collected voice samples associated with heart before and after stimulating the corresponding A16 acupuncture point, and we performed an experiment by applying the second formant bandwidth and Jitter. As result, stimulating the A16 acupuncture point results to lowering the second formant bandwidth and Jitter. The result has proven that using voice signal processing technology can help improvement of heart function.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.32 no.12A
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• pp.1267-1275
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• 2007

An improved backoff algorithm for retransmission randomization for OFDMA/CDMA/slotted ALOHA used in the ranging subchannel of IEEE 802.16 network is proposed. Exploiting the fact that a base station coordinates channel access using UL-/DL-MAP in the IEEE 802.16 networks, we propose a minor modification of the existing IEEE 802.16 in order to increase throughput, decrease delay variation and achieve a graceful performance degradation in case of overload channel condition of the random access protocol. The algorithm basically estimates the number of backlogged users and arrival rate using which, the BS calculates retransmission probability for the subscriber stations involved in a collision. Computer simulation is performed to demonstrate the effectiveness of the proposed algorithm and to compare the performance with existing binary exponential backoff algorithm.