• Journal of Microbiology and Biotechnology
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• v.23 no.9
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• pp.1339-1346
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• 2013

Conventional chemotherapeutic regimens often accompany severe side effects and fail to induce complete regression of chemoresistant or relapsing metastatic cancers. The need for establishing more efficacious anticancer strategies led to the development of a combined modality treatment of chemotherapy in conjunction with immunotherapy or radiotherapy. It has been reported that poly-gamma-glutamate (${\gamma}$-PGA), a natural polymer composed of glutamic acids, increases antitumor activity by activating antigen-presenting cells and natural killer (NK) cells. Here, we investigated the antitumor effect of ${\gamma}$-PGA in combination with cyclophosphamide in a murine melanoma model. Whereas cyclophosphamide alone directly triggered apoptosis of tumor cells in vitro, ${\gamma}$-PGA did not show cytotoxicity in tumor cells. Instead, it activated macrophages, as reflected by the upregulation of surface activation markers and the secretion of proinflammatory factors, such as nitric oxide and tumor necrosis factor ${\alpha}$. When the antitumor effects were examined in a mouse model, combined treatment with cyclophosphamide and ${\gamma}$-PGA markedly suppressed tumor growth and metastasis. Notably, ${\gamma}$-PGA treatment dramatically increased the NK cell population in lung tissues, coinciding with decreased metastasis and increased survival. These data collectively suggest that ${\gamma}$-PGA can act as an immunotherapeutic agent that exhibits a synergistic antitumor effect in combination with conventional chemotherapy.

• Proceedings of the Korea Water Resources Association Conference
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• 2008.05a
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• pp.1339-1343
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• 2008

오래전부터 물은 천부(天賦)의 자원으로 인식되어 왔으나 근래 들어 수자원의 한정성과 용도의 다양성등으로 무한자원이 아닌 유한자원으로서 확고한 경제적 위치를 점하게 되었다. 이러한 경제재로서의 물을 가장 이상적이고 합리적으로 이용하기 위해서는 용수 수요에 대응하여 적기에 적량의 물을 공급할 수 있는 효율적인 물관리가 필요하다. 효율적인 물관리를 위해 현재까지 우리나라에서는 매 10년 마다 수자원장기종합계획을 세우고, 5년에 한번씩 보완하도록 하고 있으며 이를 장기적인 국가 수자원관리의 지침으로 사용하고 있다. 그동안 국내에서도 컴퓨터 모형의 발달과 자료의 축척으로 어느 정도 정확한 물수급 평가(water balance assessment)는 가능해졌으나 아직 가용한 자료의 부족으로 장기 물수급 전망에 왜곡이 발생되고 있는 게 현실이다. 그 중 대표적 문제점을 살펴보면, 지하수 공급량 자료가 전무한 점, 농업용 중소규모 저수지의 공급가능량을 유효저수량으로 제한한 점, 행정구역 및 유역별 분석 결과 제시가 동시에 자유롭지 못한 점 등이 있다. 이러한 문제점은 근본적으로 모형의 불완전성과 자료의 부족으로부터 기인하며, 이를 해결하기 위하여 좀 더 정확한 물수급 평가방안의 제시가 필요하다 할 수 있다. 본 연구에서는 앞서 제시된 물수급 평가모형의 문제점을 보완할 수 있는 방법을 제안하였다. 이를 위해 먼저 기존의 물수급 평가의 문제점을 파악하였고, 다음으로 파악된 문제점의 개선방안을 금강유역에 적용하여 기존 방법의 결과와 비교를 실시하였다. 개선방안을 시범유역에 적용한 결과 K-WEAP과 K-MODSIM 모두 큰 결과의 차이는 발생하지 않았다. 또한 개선방안 적용 결과와 비교하여 기존 모의방법의 결과가 농업용수 물부족량을 과소평가하는 것으로 나타났다.

• Journal of Korean Neurosurgical Society
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• v.59 no.1
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• pp.11-16
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• 2016

Objective : We conducted a retrospective cohort study to elucidate the natural course of unruptured intracranial aneurysms (UIAs) at a single institution. Methods : Data from patients diagnosed with UIA from March 2000 to May 2008 at our hospital were subjected to a retrospective analysis. The cumulative and annual aneurysm rupture rates were calculated. Additionally, risk factors associated with aneurysmal rupture were identified. Results : A total of 1339 aneurysms in 1006 patients met the inclusion criteria. During the follow-up period, 685 aneurysms were treated before rupture via either an open surgical or endovascular procedure. Six hundred fifty-four UIAs were identified and not repaired during the follow-up period. The mean UIA size was $4.5{\pm}3.2mm$, and 86.5% of the total UIAs had a largest dimension <7 mm. Among these UIAs, 18 ruptured at a median of 1.6 years (range : 27 days to 9.8 years) after day 0. The annual rupture risk during a 9-year follow-up was 1.00%. A multivariate Cox proportional hazards analysis revealed that the aneurysm size and a history of subarachnoid hemorrhage (SAH) were statistically significant risk factors for rupture. For an aneurysms smaller than 7 mm in the absence of a history of SAH, the annual rupture risk was 0.79%. Conclusion : In our study, the annual rupture risk for UIAs smaller than 7 mm in the absence of a history of SAH was higher than that of Western populations but similar to that of the Japanese population.

• The Journal of Dong Guk Oriental Medicine
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• v.6 no.2
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• pp.135-143
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• 1998

This experiment was performed in order to study the effects of Sojadodamgangkitang on the injured tracheal tissue induced $SO_2$ in rats. Healthy adult male rats weighting about 250g were divided into 4 groups-the Normal group, the Control group, the group of Sojadodamgangkitang administration for 5 days after $SO_2$ gas exposure (Sample I), and the group of Sojadodamgangkitang administration for 10 days before and for 5 days after $SO_2$ gas exposure (Sample II). The results were obtained as follows ; 1. In the trachea Control group. the lesion of the ciliated epithelium was severe and the mucus secretion of the respiratory tract was increased iginificantly. 2. In the trachea of Sample I group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control group. 3. In the trachea of Sample II group, the lesion of the ciliated epithelium and the mucus secretion of the respiratory tract were decreased compared with Control and Sample I group. According to the above results, Sojadodamgangkitang has significant effect on the injuried tracheal tissue caused by $SO_2$ in rats.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.23 no.10
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• pp.1327-1339
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• 1999

Characteristics of two-phase flow and heat transfer were numerically investigated in a submerged gas Injection system. Effects of both the gas flow rate and bubble size were investigated. In addition, heat transfer characteristic and effects of heat transfer were investigated when temperature of the injected gas was different from that of the liquid. The Eulerian approach was used for the formulation of both the continuous and the dispersed phases. The turbulence in the liquid phase was modeled by the use of the standard $k-{\varepsilon}$ turbulence model. The interphase friction and heat transfer coefficient were calculated by means of correlations available in the literature. The turbulent dispersion of the phases was modeled by introducing a "dispersion Prandtl number". The plume region and the axial velocities are increased with increases in the gas flow rate and with decreases in the bubble diameter. The turbulent flow field grows stronger with the increases in the gas flow rate and with the decreases in the bubble diameter. In case that the heat transfer between the liquid and the gas is considered, the axial and the radial velocities are decreased in comparison with the case that there is no temperature difference between the liquid and the gas when the temperature of the injected gas is higher than the mean liquid temperature. The results in the present research are of interest in the design and the operation of a wide variety of material and chemical processes.

• Korean Journal of Pharmacognosy
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• v.37 no.3
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• pp.190-195
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• 2006

Obesity is associated with a number of pathological disorders such as non-insulin-dependent diabetes, hypertension, hyperlipidemia, and cardiovascular diseases. Bangpoongtongsungsankamibang (BTSK) has been widely used in the oriental medicine for the treatment of several diseases associated with inflammatory abnormalities in cardiovascular and nervous system. The BTSK is the modified prescription of Bangpoongtongsungsankamibang in which sea tangle (Laminaria japonica) were added. This study was carried out to detemine the anti-obestic effects of BTSK. Pretreatment with the BTSK at daily dose of 100 or 200 mg/kg (p.o.) far 4 weeks reduced serum triglyceride, total cholesterol contents in rat induced by Poloxamer-407 or Triton WR-1339, respectively. Furthermore, post-treatment with BTSK far four weeks also inhibited body weight gain, adipose tissue mass and hyperlipidemia induced by the high fat diet for six weeks. The BTSK shifted serum total-, HDL- and LDL-cholesterol levels toward the values of normal group, suggesting that BTSK has hypolipldemlc effects. The rats fed BTSK reduced lipid peroxide and hydroxy radical in the rat blood and increased superoxide dismutase (SOD) activity compared to the control group. Taken together, these results superoxide that BTSK improve hyperlidemia and obesity via the upregulation of anti-oxidative mechanism.

• Journal of Trauma and Injury
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• v.19 no.1
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• pp.41-46
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• 2006

Purpose: Hypovolemia is not uncommon among trauma patients in the emergency department (ED). Successful resuscitation of a hypovolemic patient often requires rapid intravenous administration of massive amounts of fluid. A rapid fluid infuser is used in the ED for this purpose, there have been no studies of their clinical uses and effectiveness. We studied clinical experience with a rapid fluid infuser at an urban university hospital in Seoul, Korea. Methods: We reviewed the medical records of 38 patients admitted to the ED with a history of application of a rapid fluid infuser from January 2004 to July 2005. Adult trauma patients older than 15 years of age were included in this study. Clinical data on the patients and the volume of fluid used to achieve a stable blood pressure were extracted from their medical records. Results: The total number of adult trauma patients with a history of application of a rapid fluid infuser from January 2004 to July 2005 in the ED was 16. The mean systolic blood pressure for deciding to apply the rapid fluid infuser was $74.9{\pm}12.7mmHg$. The mean time and volume used to achieve a stable blood pressure were 40.4 min and$2947.3{\pm}1339.2ml$, respectively. In all patients, the amount of fluid infused before using the rapid fluid infuser was between 500 ml and 10,000 ml, compared to 1,000 ml and 6,200 ml with the rapid fluid infuser. The mean amount of fluid per min. via the rapid fluid infuser was 85.5 ml. Vital signs were stabilized in 11 patients, 6 of the 11 were discharged alive. Conclusion: The mean amount of fluid delivered per min. via the rapid fluid infuser was much less than expected; thus, there should be clinical guidelines on volume resuscitation with a rapid fluid infuser in the ED. In the future, prospective, multicenter, clinical-data collection is needed for a more sophisticated study.

• Journal of the Korean Data and Information Science Society
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• v.24 no.6
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• pp.1331-1339
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• 2013

The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. Oh etc (2013) investigated the relationship between unsaturated fatty acids and five novel SNPs, and had confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. We have used generalized linear model for adjusted environmental effects and multifactor dimensionality reduction (MDR) method to identify gene-gene interaction effect of statistical model in general. We applied the MDR method on the identify major interaction effects of exonic single nucleotide polymorphisms (SNPs) in the LPL gene for economic traits in Korean cattles population.

• Journal of Environmental Science International
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• v.25 no.9
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• pp.1329-1339
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• 2016

The purpose of this study was to obtain the basic data needed to identify the impact of the odor, emitted from the Ochang Scientific Industrial Complex area on the surrounding residential areas by measuring and confirming odor compounds. The analysis showed that complex odors were diluted from around 4 to 1. The offensive odor measurement results showed that among the sites, site 1 was highest in sulfur compounds, site 2 was highest in toluene, site 3 was highest in trimethylamine, and site 4 was highest in buthylaldehyde. It cannot be decided to be odor-causing compounds for higher odor concentration because each odor substance has a different odor threshold value. According to the odor contribution analysis for each site, site 1, site 2, and site 4 contained high buthylaldehyde concentrations, and site 3 had a high level of trimethylamine. It could be determined that highly evaluated substances were main causes to result in substance for each site.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.10
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• pp.1333-1339
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• 2010

The present study was conducted to determine plasma acetate, glucose and protein metabolism using dilution of isotopes [[1-$^{13}C$]Na acetate, [U-$^{13}C$]glucose and [1-$^{13}C$]leucine (Leu)] in sheep fed rice straw (Oriza japonica L.). Four sheep were assigned to either rice straw (RS-diet) or mixed hay (MH-diet) with a crossover design. Nitrogen (N) intake and N digestibility were lower (p = 0.002 and p = 0.02, respectively) for RS-diet than MH-diet, but N retention did not differ (p>0.10) between the diets. Concentrations of rumen acetate tended to be lower (p = 0.07), and propionate was higher (p = 0.02) for RS-diet than MH-diet. Concentrations of plasma lactate, non-esterified fatty acids, Leu and ${\alpha}$-ketoisocaproic acid did not differ (p>0.10) between the diets, but plasma glucose and urea concentrations were lower (p = 0.01 and p = 0.003, respectively) for RS-diet than MH-diet. Turnover rate of plasma acetate did not differ (p = 0.39) between the diets, and plasma glucose and Leu turnover rates were numerically lower (p = 0.15 and p = 0.14, respectively) for RS-diet than MH-diet. Whole body protein synthesis and degradation did not differ (p>0.10) between the diets. Thus it can be concluded that the intermediary metabolism of acetate, glucose and protein on rice straw is comparable to mixed hay in sheep.