• Molecules and Cells
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• 제41권2호
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• pp.119-126
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• 2018

microRNA (miR)-612 shows anticancer activity in several types of cancers, yet its function in melanoma is still unclear. This study was undertaken to investigate the expression of miR-612 and its biological relevance in melanoma cell growth, invasion, and tumorigenesis. The expression and prognostic significance of miR-612 in melanoma were examined. The effects of miR-612 overexpression on cell proliferation, colony formation, tumorigenesis, and invasion were determined. Rescue experiments were conducted to identify the functional target gene(s) of miR-612. miR-612 was significantly downregulated in melanoma tissues compared to adjacent normal tissues. Low miR-612 expression was significantly associated with melanoma thickness, lymph node metastasis, and shorter overall, and disease-free survival of patients. Overexpression of miR-612 significantly decreased cell proliferation, colony formation, and invasion of SK-MEL-28 and A375 melanoma cells. In vivo tumorigenic studies confirmed that miR-612 overexpression retarded the growth of A375 xenograft tumors, which was coupled with a decline in the percentage of Ki-67-positive proliferating cells. Mechanistically, miR-612 targeted Espin in melanoma cells. Overexpression of Espin counteracted the suppressive effects of miR-612 on melanoma cell proliferation, invasion, and tumorigenesis. A significant inverse correlation (r = -0.376, P = 0.018) was observed between miR-612 and Espin protein expression in melanoma tissues. In addition, overexpression of miR-612 and knockdown of Espin significantly increased the sensitivity of melanoma cells to doxorubicin. Collectively, miR-612 suppresses the aggressive phenotype of melanoma cells through downregulation of Espin. Delivery of miR-612 may represent a novel therapeutic strategy against melanoma.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.243-255
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• 2019

Objective : Although traumatic brain injury (TBI) occurs in people of all age groups, the elderly population is at a particular risk. The proportion of elderly population in the society is markedly increasing and Korea is one of the most rapidly aging societies. Here, we analyzed the data from 904 patients older over 65 years who were registered in the Korean Neuro-Trauma Data Bank System (KNTDBS). Methods : The Korean Society of Neurotraumatology recorded data from 20 institutions between September 2010 and March 2014. This retrospective study examined the clinical epidemiology, sex difference, outcome epidemiology, sociodemographic variables, and outcomes in the geriatric population related to TBI based on data from the KNTDBS. Results : The study included 540 men and 364 women. The age distributions in the male and female groups were statistically significantly different. The most common cause of trauma was a fall and diagnosis was acute subdural hematoma. The incidence was the highest in men aged 80-84 years and in women aged 75-79 years. The most common time of arrival to hospital after TBI was within 1 hour and 119 rescue team provided first aid earliest to patients with TBI. The mortality rate stratified according to the cause of trauma was significantly different, with mortality rates of 3.77% in fall and 11.65% in traffic accident. The mortality rates according the severity of brain injury, Glasgow Coma Scale score, and treatment were statistically significant. Conclusion : To our knowledge, this study is the first to focus on elderly patients with TBI in Korea and particularly investigate mortality and characteristics related to TBI-related death based on data from the KNTDBS. Although the study has some limitations, our results may be used to obtain useful information to study targeted prevention and more effective treatment options for older TBI patients and establish novel treatment guidelines and health polish for the geriatric population.

• 한국응급구조학회지
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• 제25권1호
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• pp.7-22
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• 2021

Purpose: This study aimed to identify the differences in pre-hospital and in-hospital triage (pre-hospital triage and KTAS(Korean Triage and Acuity Scale)) of patients with abdominal pain and the characteristics of high hospitalization probability in the treatment results. Methods: We analyzed 941 people who visited the area C emergency center for 2 years from January 2017 to December 2018. The collected data were analyzed using SPSS 26. Results: Among the transfer hospitals, 84.8% (798) of patients were selected by the 119 rescue service, and the most common diagnosis was simple abdominal pain (46.5%, 438 patients). A total of 50.7% (477) of patients classified as severe pre-hospital cases changed to mild in-hospital cases. There was a difference of 5.3% (50 cases) in cases where patients classified as mild pre-hospital were changed to severe in-hospital cases. The Kappa coefficient did not match with 0.04 (p=.051). Pre-hospital overtriage was 58.2% (548 cases), and 71.2% (670) of patients were discharged from the emergency room as a result of the treatment. Conclusion: The results of this study showed that pre-hospital and in-hospital triage were not consistent. The rates of pre-hospital overtriage were quite high. Most patients with abdominal pain were classified as mild cases, and pre-hospital triage classifiers should be trained to reduce errors in selecting transfer hospitals.

• 대한안전경영과학회지
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• 제24권3호
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• pp.1-14
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• 2022

This study is a plan on the way to strengthen the survival ability by increasing the use time of air respirator by applying emergency breathing method in the situation where firefighter has to wait for RIT (Rapid Intervention Teams) because it is impossible to escape by himself or emergency escape during isolation during field activities. The research procedure first drew problems by conducting a survey on fire fighters under the Seoul Fire and Disaster Headquarters, and conducted an experiment to compare normal breathing and emergency breathing with 20 members of the Seoul 119 Special Rescue Team, and suggested emergency breathing method and training process modeling that can be applied to each field situation based on the data obtained. The experiment was conducted over 9 weeks, and it was divided into three categories: field activity situation, movement (emergency escape assumption) situation, and place (assume waiting for RIT). In the field activity situation experiment, it was confirmed that the application of skip breathing method was appropriate and the use time of air respirator increased about 1.6 ~ 1.9 times. In the moving situation or the in-situ situation, wheel breathing method was appropriate and the use time of air respirator increased about 1.6 ~ 2.4 times. However, when conducting intense activities in the field activity situation, it is recommended to use it limitedly because it is difficult to apply the emergency breathing method. If emergency breathing is not clearly learned in the body, it is difficult to use in the field, so I think systematic and continuous training is necessary. This study suggests that the application of emergency breathing method is effective enough to strengthen the survival ability of firefighters in the field.

• 한국콘텐츠학회논문지
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• 제19권11호
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• pp.111-121
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• 2019

화재 현장에서 드론을 활용하여 현장상황과 도로상황 등을 파악하여 상황실에 전달하는 서비스와 사람이 접근하기 불가능한 사고 현장에서 인명구조 활동이나 구급용품 전달로 위급한 상황에 대처하는 경우가 늘어나고 있다. 따라서 본 연구에서는 주택가 밀집지역에서 발생하는 화재에 대한 초기 대응단계에서 드론을 활용한 서비스디자인을 연구해 화재현장 출동 및 화재진압 등 대응단계의 서비스디자인 영역을 구체화하고자 하였다. 이를 위해 먼저 문헌연구를 통해 서비스디자인의 개념 및 프로세스 고찰과 서비스디자인을 활용한 적용 사례를 분석해 연구의 방향을 모색하였다. 연구의 타당성을 위해 현직 소방관들을 대상으로 드론 사용과 문제점 파악을 일대일 면접조사로 실시하였으며, 드론 전문가를 대상으로 드론의 화재현장 적용가능성을 파악하였다. 연구의 표본으로 서울시 중 화재 대응에 가장 취약한 용산구를 대상으로 인근 도로상황과 현장 실태조사, 119 안전센터 등의 위치와 거리를 파악하는 필드리서치를 진행하고 서비스디자인 방법론 중 이해관계자들의 경험 가치와 행위 분석을 가상시나리오를 통해 페르소나와 고객여정맵을 작성하고 인사이트를 도출하였다. 이런 프로세스를 통해 화재 초기대응 서비스디자인을 제시하고 우리나라 화재발생 초기대응 서비스디자인 방향을 수립하는데 도움이 되고자 하였다.

• 한국중재학회지:중재연구
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• 제25권4호
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• pp.119-136
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• 2015

The contracting parties must be provided a litigation scheme in order to resolve a dispute. This means taking advantage of effective measures for mediation or arbitration. A lease transaction is likely to occur mainly after a dispute. It is necessary to take the appropriate measures in advance. In general, when a variety of contracts are created, conflicts arise and disputes have to be resolved through mediation and arbitration documents, and adjustment or intervention is called for. Arbitration system is a system that is established based on the trust of the arbitral tribunal. For such system, quality education for enhancing professionalism required of the arbitrator is important. A party responding to an arbitration agreement presents a problem. The current system must ensure that there are no disadvantaged parties. However, a party must depend on an arbitration agreement that is part of the law rescue system. A litigation support by the local Bar Association must be carried out. It should be notified of the contents of the contract to select a strategy that will best resolve the conflict. In the case of lease transactions, there is a need to create a scheme to make a standard agreement that inserts an arbitration clause. Lease sale and purchase agreement or lease agreement is a form of contract that has been frequently used. Here, the arbitration agreement clause for a lawyer that will serve as arbitrator should be inserted. It is a scheme that can be activated for individuals in poor areas. In addition, it is possible to see it taking a scheme to take advantage of the lawyer system for the future of the town. The Attorney System of a town is a system that the Korean Bar Association, Legal Department has put in place since 2013. If a real estate trade dispute occurs, the role of the intermediary attorney should be to carry out his duties efficiently. In the case of real estate transaction conflicts, the lawyer of the village should be registered as the arbitrator. It is important to establish a basis of regulations through this type of real estate transaction accident analysis. Before proceeding with various adjustment systems, it is desirable to expand the arbitration region. Now we need a realtor amendment. It is the part where fragmentation of intermediary qualification is required, along with the eligibility of a subdivision.

• 항공우주정책ㆍ법학회지
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• 제24권1호
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• pp.119-152
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• 2009

한국은 우주 탐사 프로그램에 대한 포부와 함께 급속하게 확장내지 발전하고 있다. 정부는 항공우주산업에 우선권을 주고 있으며, 더 좋은 기반위에, I987년의 항공우주산업개발촉진법, 2005년의 우주개발진흥법과 2007년의 우주손해배상법을 제정하여 시행 해오고 있다. 필자는 위성의 발사허가, 우주물체의 등록, 위성정보의 이용, 우주비행사의 구조, 손해배상, 지상 제3자에 대한 책임보험, 우주개발지원계획 등이 포함된 전기 세 가지 우주관계법의 입법경위, 주요내용 및 논평을 하고자 한다. 더욱이 필자는 한국의 우주산업을 효율적으로 개발하기 위하여 일본의 우주항공연구개발기구(JAXA), 영국의 국립우주센터(BNSC), 국립우주연구센터(CNES), 독일의 항공우주센터(DLR), 스웨덴의 우주공사(SSC), 중국의 항천과공집단공사(CASIC) 등과 유사한 한국의 새로운 우주항공개발공사 (KADA: 가칭)의 창설할 수 있는 입법이 필요로 하며 또한 정부기구로서 캐나다의 우주청(CSA), 러시아의 우주청(RSA), 이탈리아의 우주청(ISA), 이스라엘의 우주청(ISA), 인도의 우주성(IDS), 미국의 항공우주청(NASA)과 중국의 국가항천국(CNSA)등과 유사한 한국의 새로운 우주청(KSA: 가칭)을 창설할 수 있는 입법조치가 필요하다. 만약 한국 정부가 장차 정부 조직으로 한국의 우주청을 설립시키려면 정부조직법의 개정이 필요하다. 동양적인 사고와 창의력에 근거하여 아시아 여러 나라들 간에 우주산업을 발전시키기 위하여 연구협력을 증진시킬 수 있는 "아시아우주기구(ASA)" 의 설립이 필요하다.

• 한국구조물진단유지관리공학회 논문집
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• 제20권6호
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• pp.106-112
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• 2016

본 연구에서는 각기 다른 각도와 시트장수(3T, 5T 및 7T)로 제작된 카본시트 튜브로 구속된 원형 콘크리트 기둥의 압축강도 실험을 수행한 후 압축강도 실험실과 강도감소계수를 제안하였다. 실험체는 $300mm{\times}600mm$ 크기로 제작하였으며, 탄소섬유의 각도는 $90^{\circ}{\pm}0^{\circ}$, $90^{\circ}{\pm}30^{\circ}$, $90^{\circ}{\pm}45^{\circ}$, $90^{\circ}{\pm}60^{\circ}$, $90^{\circ}{\pm}75^{\circ}$ 및 $90^{\circ}{\pm}90^{\circ}$이다. 압축강도 실험은 10,000 kN UTM을 이용하여 0.01 mm/sec 가력속도의 변위 제어법으로 실험을 수행하였다. 실험결과의 회귀분석을 통하여 각도별 압축강도 및 극한변형률을 예측하는 실험식을 제안하였으며, 국내 콘크리트 부재의 설계법인 극한강도 설계법 적용을 위한 강도감소계수를 제안하였다. 강도감소계수는 Monte Carlo Analysis를 이용하여 해석을 수행하였으며 그 값은 0.64로 제안하였다. 탄소섬유시트를 이용하여 카본튜브를 제작하는 것은 시공자의 기술력에 따라 구조성능이 좌우될 수 있으므로 카본튜브 제작 및 시공 시 각별한 현장관리가 요구된다.

• 한국산학기술학회논문지
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• 제17권12호
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• pp.285-291
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• 2016

본 연구의 목적은 유공강판 전단연결재로 보강된 강관말뚝의 인발실험을 통하여 구조성능을 평가하는 것이다. 인발실험에 앞서 재료의 특성을 파악하기 위하여 콘크리트 압축장도 실험을 수행하였으며, 실험에 사용되는 철근 및 철판의 항복하중, 인장강도 및 연신율 등의 재료적 특성을 미리 파악하였다. 유공강판 전단연결재로 보강된 강관말뚝의 인발실험은 2,000kN 용량의 UTM을 이용하여 0.01mm/sec 재하속도의 변위제어 방법으로 실험을 수행하였다. 계측을 위하여 철근 및 유공강판 중앙에 strain gauge를 부착하였으며, 가력판과 충전콘크리트 사이의 상대변위 측정을 위하여 변위계(LVDT)를 설치하였다. 유공강판 전단연결재로 보강된 실험체의 항복하중은 각각 923.8kN과 981.1kN으로 기존 설계법에 의하여 제작된 실험체의 항복하중인 641.7kN에 비하여 1.44배 ~ 1.53배 증가됨을 알 수 있었다. 또한 유공강판 전단연결재로 보강된 실험체의 극한하중은 각각 1004.4kN과 1055.5kN으로 기존 설계법에 의하여 제작된 실험체의 극한하중인 813.7kN에 비하여 1.23배 ~ 1.29배 증가됨을 알 수 있었다. 반면, 유공강판 전단연결재로 보강된 실험체의 항복변위 및 극한상태의 변위는 기존 설계법에 의하여 제작된 실험체에 비하여 각각 0.61배 및 0.42배 감소됨을 알 수 있었다. 따라서 유공강판 전단연결재로 보강된 강관말뚝은 강성은 증가하고 상대변위 및 변형률은 낮게 측정되어 기존 말뚝머리 보강방법을 대체할 수 있는 적절한 보강방법임 알 수 있었다.

• 한국산업보건학회지
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• 제17권2호
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• pp.111-119
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• 2007

Firemen are directly exposed to various harmful chemicals, physical factors and mental stress during rescue and fire-fighting. In fire extinguishing, unstable posture, poisonous gas, dust, high temperature and heavy equipments are possible hazardous factors. The alertness for emergency, shift work, job strain and stress are also possibly hazardous. Therefore, this study aimed to investigate the prevalence of musculo-skeletal symptoms and job stress and to determine risk factors in firemen. This study was carried out in a group of 226 firemen in Busan City, Korea. Standardized Nordic Questionnaire was used to investigate the prevalence of musculo-skeletal symptoms and Psycho-social Well-being Index (abbreviated PWI) was used to investigate the prevalence of job stress. General and occupational characteristics were included education, marital status, alcohol and smoking history, working duration, and work shift system. Body mass index (BMI) scores were calculated by physical examination including height and weight. Concerning musculo-skeletal complaints, the commonest site was neck, and shoulder, lower back, upper back were the next. Complaint site above one area of body was about 80%. From multiple logistic regression analysis, working duration was significant variable in musculo-skeletal symptoms. Odds ratio were 15.4 in working duration. About 16.8% was high risk stress group. From multiple logistic regression analysis, shift work and alcohol drinking were significant variables in PWI scores. Odds ratios were 2.25 in shift work. Accordingly, interventions are needed for health promotion of long term and shift worker.