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Experimental Studies on Lead Toxicity in Domestic Cats 1. Symptomatology and Diagnostic Laboratory Parameters (고양이의 납중독에 관한 실험적 연구 1. 임상증상 및 실험실적 평가)

  • Hong Soon-Ho;Han Hong-Ryul
    • Journal of Veterinary Clinics
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    • v.10 no.1
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    • pp.111-130
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    • 1993
  • Lead toxicity was evaluated in forty-five cats on a balanced diet, Treated with 0(control), 10, 100(low), 1, 000, 2, 000, and 4, 000(high) ppm of lead acetate orally on a body weight basis. The objectives were to establish toxic dosage level of leaf in cats, to characterize changes in behavior and clinical pathology, and to demonstrate what blood lead concentrations correlate with the known dosages of lead. Some high dose cats showed projectile vomiting, hyperactivity, and seizures. The growth rates did not appear to be altered in any of the dosed groups. Normal blood lead concentration in cats were lower than that of humans, dogs, and cattle. Blood lead concentrations of 3 to 20$\mu\textrm{g}$/100$m\ell$ could be termed a 'subclinical' range in the cat. Clinical lead toxicity in cats may have blood lead concentrations ranging 20 to 120$\mu\textrm{g}$/100$m\ell$. Zinc protoporphyrin concentrations were proportional to lead dosages and a significant ZPP elevation, greater than 50$\mu\textrm{g}$/100$m\ell$, may be indicative of clinical lead toxicity. The enzyme aminolevulinic acid dehydratase showed an inverss dose response relationship for all lead dosages and a significant ZPP elevation, greater than 50$\mu\textrm{g}$/100$m\ell$, may be indicative of clinical lead toxicity. The enzyme aminolevulinic acid dehydratase showed an inverse dose response relationship for all lead dosages and appears to be a good indicator of lead exposure in cats. Urinary aminolevuliruc acid concentrations generally increased with lead dosage, but individual values varied. Hair lead concentrations rose proportionately to lead dosages. Lead at least in high doses appears to inhibit chemotactic activity of polymorphonuclear cells and monocytes. No consistent dose response relationships were observed in hemoglobin, RBC, WBC, neutrophil, lymphocyte, monocyte, and eosinophil counts. There were no consistent dose related changes in total protein, plasma protein, BUN, and ALT values. Reticulocyte counts did not increase significantly in most lead dosage levels, and are probably of little value in diagnosing lead toxicity in cats. The fact that no significant changes were found in nerve conduction velocities may support that there was no segmental demyelination resulting from lead ingestion. The lethal dose in cats appear to range from 60 to 150mg/kg body weight. A reliable diagnosis of lead poisoning can be made utilizing blood lead, ZPP, and ALAD, and hair lead.

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Characteristics of Seafloor Morphology and Manganese Nodule Occurrence in the KODES area, NE Equatorial Pacific (태평양 한국심해환경연구(KODES) 지역 해저변 지형과 망간단괴 분포특성)

  • Jung, Hoi-Soo;Ko, Young-Tak;Chi, Sang-Bum;Kim, Hyun-Sub;Moon, Jai-Woon
    • The Sea:JOURNAL OF THE KOREAN SOCIETY OF OCEANOGRAPHY
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    • v.4 no.4
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    • pp.323-337
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    • 1999
  • Seafloor morphology and manganese nodule occurrence were studied in the Korea Deep-sea Environmental Study (KODES) area, northeast equatorial Pacific, to understand their relationship. Study area is composed of three elongated valleys and hills with about 100~200 m height along NNE-SSW direction. Valley region is generally flat. However, hill region is very rugged with big cliffs of about 100m height and small depressions of several tens of meters depth. Tectonic movement along the Clarion-Clipperton fracture zone, consequent formation of elongated abyssal hills and Valleys, erosion of siliceous bottom sediments by bottom currents, and dissolution of carbonate sediments on the abyssal hills below CCD result in the rugged morphology. Manganese nodule occurrence is closely related to the morphology of the study area; mostly rounded-shaped manganese nodules with about 5 cm diameter are abundant on the flat valley region, whereas irregular shaped nodules (or manganese crust) with less than 5 cm to about 1 m diameter occur on the hill. These results supports the previous reports that nodule abundance, composition, and morphology are variable both on regional and local small scales on the seafloor even within some abundant nodule provinces depending on oceanographic characteristics such as bathymetric features, surface sediment type, sediment thickness, and so on. We suggest that such oceanographic characteristics affect interrelatedly on the formation of manganese nodules, and tectonic movement of the Pacific plate ultimately constrain the nodule occurrence. A potential mining place in the KODES area seems to be the valley region, which is elongated to the NNW-SSE direction with 3-4 km width.

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Dynamic-Response-Free SMPS Using a New High-Resolution DPWM Generator Based on Switched-Capacitor Delay Technique (Switched-Capacitor 지연 기법의 새로운 고해상도 DPWM 발생기를 이용한 Dynamic-Response-Free SMPS)

  • Lim, Ji-Hoon;Park, Young-Kyun;Wee, Jae-Kyung;Song, In-Chae
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.49 no.1
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    • pp.15-24
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    • 2012
  • In this paper, we suggest the dynamic-response-free SMPS using a new high-resolution DPWM generator based on switched-capacitor delay technique. In the proposed system, duty ratio of DPWM is controlled by voltage slope of an internal capacitor using switched-capacitor delay technique. In the proposed circuit, it is possible to track output voltage by controlling current of the internal capacitor of the DPWM generator through comparison between the feedback voltage and the reference voltage. Therefore the proposed circuit is not restricted by the dynamic-response characteristic which is a problem in the existing SMPS using the closed-loop control method. In addition, it has great advantage that ringing phenomenon due to overshoot/undershoot does not appear on output voltage. The proposed circuit can operate at switching frequencies of 1MHz~10MHz using internal operating frequency of 100 MHz. The maximum current of the core circuit is 2.7 mA and the total current of the entire circuit including output buffer is 15 mA at the switching frequency of 10 MHz. The proposed circuit has DPWM duty ratio resolution of 0.125 %. It can accommodate load current up to 1 A. The maximum ripple of output voltage is 8 mV. To verify operation of the proposed circuit, we carried out simulation with Dongbu Hitek BCD $0.35{\mu}m$ technology parameter.

Analysis of Power Requirement for 105 HP Agricultural Tractor during Rotary Tillage Operation (로타리 작업 시 105마력급 농업용 트랙터의 소요동력 분석)

  • Kim, Wan-Soo;Choi, Chang-Hyun;Park, Seong-Un;Kim, Yong-Joo
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2017.04a
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    • pp.8-8
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    • 2017
  • 본 연구는 로타리 작업에 따른 105마력급 농업용 트랙터의 소요동력을 분석하기 위하여 수행되었다. 소요동력 측정 시스템은 차축 토크미터, PTO 토크미터, 주/보조 유압센서, 데이터 수집장치를 이용하여 구성하였다. 시험에 사용된 트랙터는 동양물산 105 HP급 트랙터 (S07, TYM, Korea)이며, 작업기는 로타베이터 (SW 230GL, Sungwoo Industrial Co. Ltd, Korea)를 사용하였다. 포장시험은 전라북도 부안군에 죽림길에 위치한 $4,000m^2$ ($100m{\times}40m$) 크기의 경작지 2곳에서 수행하였다. 포장시험 시 작업 단수는 주행단수 L3단 (2.38 km/h)에서 PTO 단수 1단 (540 rpm)과 2단 (750 rpm)으로 설정하였고, 로타리 작업 시 경심은 13 cm 조건에서 실시하였다. 트랙터 작업은 동양물산의 성능시험 업무를 맡고 있는 숙련된 작업자가 숙달된 방법으로 수행하였다. 포장시험지의 토양환경은 임의의 15곳에서 채취한 시료를 이용하여 토성, 함수율, 원추 관입지수에 대하여 미국 농무부 (USDA)법을 기준으로 분석하였다. 토양환경 분석 결과 토성은 Sandy loam (사양토), 평균 함수율은 35.15%, 평균 원추관입지수는 1,562 kPa로 나타났다. PTO 1단 작업 시 트랙터의 평균 소요동력은 차축, PTO, 주 유압, 보조 유압에 대하여 각각 1.8, 54.0, 1.3, 그리고 1.1 hp로 나타났다. PTO 2단 작업 시 트랙터의 평균 소요동력은 차축, PTO, 주 유압, 보조 유압에 대하여 각각 1.2, 79.4, 1.2, 그리고 1.0 hp로 나타났다. PTO 1단 작업 시 소요동력의 합은 58.2 hp로, 정격 마력 (105 hp) 대비 55.43 % 사용한 것으로 나타났으며, PTO 2단 작업 시 소요동력의 합은 82.8 hp로, 정격 마력 대비 78.85% 사용한 것으로 나타났다. PTO 1단 대비 2단에서는 PTO를 제외한 차축, 주 유압, 보조 유압의 소요동력이 감소하였으나, PTO에서 약 1.47배로 크게 증가하여 전체적으로 소요동력이 증가한 것으로 나타났다. 향후 다양한 작업기 및 작업 단수에 따른 소요동력을 분석하여 농업용 트랙터의 모든 부하 조건에 대한 데이터베이스 구축에 관한 연구를 수행할 예정이다.

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High-Resolution MRI Study on Mouse Brain Using Micro-Imaging (초고해상도 미세영상 기법을 이용한 Mouse 뇌의 자기공명영상 연구)

  • Han, Doug-Young;Yoon, Moon-Hyun;Choe, Bo-Young
    • Investigative Magnetic Resonance Imaging
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    • v.12 no.2
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    • pp.142-147
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    • 2008
  • Purpose : By using the micro-imaging unit modified from NMR spectrometer, the high resolution MRI protocols of finer than 100 micron in 5 minutes, is sought for mouse, which plays a central role in animal studies Materials and Methods : C57BL/6 mouse, lighter than 50 gram, is used for the experiments. The superconducting magnet is vertical type with 89 mm inner diameter at 4.9 Tesla. The diameter of rf-coil is 30 mm. Mostly used techniques are the fast spin echo and the gradient echo pulse sequence. Results : For 2D images, proton density and T2 weighted images are obtained and their optimum experimental variables were sought. Minute structure of mouse brain can be recognized and 3D brain image is also obtained additionally. 3D image will be useful particularly for the dynamic contrast study using various contrast agents. Conclusion : Like the case of human and other small animals, the high resolution of mouse brain is enough to recognize the minute structure of it. Recently, similar studies are reported domestically, but it seems only a beginning stage. Due to easiness of breeding/control, mouse MRI study will soon play a vital part in brain study.

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Enhancement and Quenching Effects of Photoluminescence in Si Nanocrystals Embedded in Silicon Dioxide by Phosphorus Doping (인의 도핑으로 인한 실리콘산화물 속 실리콘나노입자의 광-발광현상 증진 및 억제)

  • Kim Joonkon;Woo H. J.;Choi H. W.;Kim G. D.;Hong W.
    • Journal of the Korean Vacuum Society
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    • v.14 no.2
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    • pp.78-83
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    • 2005
  • Nanometric crystalline silicon (no-Si) embedded in dielectric medium has been paid attention as an efficient light emitting center for more than a decade. In nc-Si, excitonic electron-hole pairs are considered to attribute to radiative recombination. However the surface defects surrounding no-Si is one of non-radiative decay paths competing with the radiative band edge transition, ultimately which makes the emission efficiency of no-Si very poor. In order to passivate those defects - dangling bonds in the $Si:SiO_2$ interface, hydrogen is usually utilized. The luminescence yield from no-Si is dramatically enhanced by defect termination. However due to relatively high mobility of hydrogen in a matrix, hydrogen-terminated no-Si may no longer sustain the enhancement effect on subsequent thermal processes. Therefore instead of easily reversible hydrogen, phosphorus was introduced by ion implantation, expecting to have the same enhancement effect and to be more resistive against succeeding thermal treatments. Samples were Prepared by 400 keV Si implantation with doses of $1\times10^{17}\;Si/cm^2$ and by multi-energy Phosphorus implantation to make relatively uniform phosphorus concentration in the region where implanted Si ions are distributed. Crystalline silicon was precipitated by annealing at $1,100^{\circ}C$ for 2 hours in Ar environment and subsequent annealing were performed for an hour in Ar at a few temperature stages up to $1,000^{\circ}C$ to show improved thermal resistance. Experimental data such as enhancement effect of PL yield, decay time, peak shift for the phosphorus implanted nc-Si are shown, and the possible mechanisms are discussed as well.

Estimation of MineRo's Kinematic Parameters for Underwater Navigation Algorithm (수중항법 알고리즘을 위한 미내로 운동학 파라미터 예측)

  • Yeu, Tae-Kyeong;Yoon, Suk-Min;Park, Soung-Jea;Hong, Sup;Choi, Jong-Su;Kim, Hyung-Woo;Kim, Dae-Won;Lee, Chang-Ho
    • Ocean and Polar Research
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    • v.33 no.1
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    • pp.69-76
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    • 2011
  • A test miner named MineRo was constructed for the purpose of shallow water test of mining performance. In June of 2009, the performance test was conducted in depth of 100 m, 5 km away from Hupo-port (Korean East Sea), to assess if the developed system is able to collect and lift manganese nodules from seafloor. In August of 2010, in-situ test of automatic path tracking control of MineRo was performed in depth of 120 m at the same site. For path tracking control, a localization algorithm determining MineRo's position on seabed is prerequisite. This study proposes an improved underwater navigation algorithm through estimation of MineRo's kinematic parameters. In general, the kinematic parameters such as track slips and slip angle are indirectly calculated using the position data from USBL (Ultra-Short Base Line) system and heading data from gyro sensors. However, the obtained data values are likely to be different from the real values, primarily due to the random noise of position data. The aim of this study is to enhance the reliability of the algorithm by measuring kinematic parameters, track slips and slip angle.

Assessment of Laryngeal Function by Pitch Perturbation Analysis and Hilbert Transform of EGG Signal (ECG신호의 피치변동해석 및 Hilbert변환에 의한 후두기능의 평가)

  • 송철규;이명호
    • Journal of Biomedical Engineering Research
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    • v.16 no.1
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    • pp.95-100
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    • 1995
  • In this study, we have evaluated the effect of amplitude and frequency perturbation of EGG signal for single vowels associated with laryngeal pathology. The normal EGG signal was properly characterized by an autoregressive model which has an optimal order of ninth using the parametric method. This can be analyzed by determining the transfer function. Perturbations in the fundamental pitch and in the peak amplitude of EGG signal measured with a four-electrode system using the modulation/demodulation techniques were investigated for the purpose of developing a decision criteria for the laryngeal function analysis. The abnormal EGG signal has nonperiodic and unstable characteristics. It can be discriminated by the calculation of opening and closing time of glottis using the EGG signal. In case of normal and abnormal subjects, m$\pm$0.5*sd was discriminating line for frequency perturbation and m$\pm$2*sd for normal amplitude perturbations, respectively. Also, The normal and abnormal cases of the subjects can be discriminated effectively using the pattern of attractor derived with Hilbert transform of EGG signal.

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Signal Transmission Properties Improvement of Serial Advanced Technology Attachment Connector Using Analysis of Differential Impedance (차동 임피던스 분석을 사용한 SATA 커넥터의 신호 전달 특성 개선)

  • Yang, Jeong-Kyu;Kim, Moonjung
    • Journal of the Institute of Electronics and Information Engineers
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    • v.50 no.2
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    • pp.47-53
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    • 2013
  • In this work, signal transmission properties of SATA connector have been improved using its differential impedance calculation and its design revision to closer impedance matching. Using 3 dimensional electromagnetic field simulator, the differential mode S-parameter was calculated to investigate its signal fidelity. The differential impedance is calculated from the equation of the odd mode impedance with inductance, capacitance, mutual inductance, and mutual capacitance. The differential impedance of SATA connector was calculated to be $107.3{\Omega}$ and did not meet the design specification with $100{\Omega}{\pm}5%$. In order to achieve its impedance range and improve its signal transmission properties, SATA connector's design has been revised with two different directions and analyzed through the calculation of differential impedance, differential reflection loss, and differential insertion loss.

Hydrogen-Related Gate Oxide Degradation Investigated by High-Pressure Deuterium Annealing (고압 중수소 열처리 효과에 의해 조사된 수소 결합 관련 박막 게이트 산화막의 열화)

  • 이재성
    • Journal of the Institute of Electronics Engineers of Korea SD
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    • v.41 no.11
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    • pp.7-13
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    • 2004
  • Experimental results are presented for the degradation of 3 nm-thick gate oxide under -2.5V $\leq$ V$_{g}$ $\leq$-4.0V stress and 10$0^{\circ}C$ conditions using P and NMOSFETs that are annealed with hydrogen or deuterium gas at high-pressure (5 atm). The degradation mechanisms are highly dependent on stress conditions. For low gate voltage, hole-trapping is found to dominate the reliability of gate oxide both in P and NMOSFETs. With increasing gate voltage to V$_{g}$ =-4.0V, the degradation becomes dominated by electron-trapping in NMOSFETs, however, the generation rate of "hot" hole was very low, because most of tunneling electrons experienced the phonon scattering before impact ionization at the Si interface. Statistical parameter variations as well as the gate leakage current depend on and are improved by high-pressure deuterium annealing, compared to corresponding hydrogen annealing. We therefore suggest that deuterium is effective in suppressing the generation of traps within the gate oxide. Our results therefore prove that hydrogen related processes are at the origin of the investigated oxide degradation.gradation.