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$^{99m}Tc-MDP$골스캔을 이용한 초기 골수염의 진단과 이의 평가

  • Lee, Sang-Rae;Kim, Won-Cheol
    • The Journal of the Korean dental association
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    • v.25 no.6 s.217
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    • pp.541-548
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    • 1987
  • 골수염은 조기에 적절한 치료를 하지않으면 중대한 후유증이 초래되므로 신속한 진단과 치료가 요구된다. 골수염을 진단하기 위해서는 구강검진, 방사선검사, 병리조직학적 검사, 혈액 및 세균배양검사와 골스캔등이 필요하다. 골수염의 감염과정은 골에 파괴적 및 재생적 변화의 양자를 모두 일으키지만 X선사진소견에서는 임상증상이 발현된 후 약 10내지 14일이 경과되어야만 골변화를 관찰할 수 있으며 그 이전에는 대체로 비특이적 연조직의 종창만을 보인단. 반면에 골스캔을 이용하면 급성염증기의 골질환을 감견하기가 용이하다. 골스캔제의 국소골섭취의 증가는 골의 어떤 부위에서 대사능이나 혈류가 증가된 경우에 일어나기 때문에, 실제로 임상증상이 발현된 후 24시간정도의 조기에 골스캔상은 양성반응을 보인다. 즉 골의 국소적 병변은 어느정도 신생골 형성과 골파괴가 같이 수반되어있고 이러한 신생골은 골스캔제와 친화력이 강하므로 골형성반응을 야기하는 어떠한 병변이라도 골스캔에 의하여 발견될 수 있다. 임상적으로 골수염에 대하여 골스캔을 시행하는 경우는 골수염의 조기진단, 골수염과 봉와직염과의 감별진단, 만성 공수염의 악화여부 및 치료에 대한 반응을 monitoring하기 위해서 시행된다.

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Operating Room Reservation Problem Considering Patient Priority : Modified Value Iteration Method with Binary Search (환자 우선순위를 고려한 수술실 예약 : 이진검색을 활용한 수정 평가치반복법)

  • Min, Dai-Ki
    • IE interfaces
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    • v.24 no.4
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    • pp.274-280
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    • 2011
  • Delayed access to surgery may lead to deterioration in the patient condition, poor clinical outcomes, increase in the probability of emergency admission, or even death. The purpose of this work is to decide the number of patients selected from a waiting list and to schedule them in accordance with the operating room capacity in the next period. We formulate the problem as an infinite horizon Markov Decision Process (MDP), which attempts to strike a balance between the patient waiting times and overtime works. Structural properties of the proposed model are investigated to facilitate the solution procedure. The proposed procedure modifies the conventional value iteration method along with the binary search technique. An example of the optimal policy is provided, and computational results are given to show that the proposed procedure improves computational efficiency.

A Stochastic Dynamic Programming Model to Derive Monthly Operating Policy of a Multi-Reservoir System (댐 군 월별 운영 정책의 도출을 위한 추계적 동적 계획 모형)

  • Lim, Dong-Gyu;Kim, Jae-Hee;Kim, Sheung-Kown
    • Korean Management Science Review
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    • v.29 no.1
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    • pp.1-14
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    • 2012
  • The goal of the multi-reservoir operation planning is to provide an optimal release plan that maximize the reservoir storage and hydropower generation while minimizing the spillages. However, the reservoir operation is difficult due to the uncertainty associated with inflows. In order to consider the uncertain inflows in the reservoir operating problem, we present a Stochastic Dynamic Programming (SDP) model based on the markov decision process (MDP). The objective of the model is to maximize the expected value of the system performance that is the weighted sum of all expected objective values. With the SDP model, multi-reservoir operating rule can be derived, and it also generates the steady state probabilities of reservoir storage and inflow as output. We applied the model to the Geum-river basin in Korea and could generate a multi-reservoir monthly operating plan that can consider the uncertainty of inflow.

A Study of Adaptive QoS Routing scheme using Policy-gradient Reinforcement Learning (정책 기울기 값 강화학습을 이용한 적응적인 QoS 라우팅 기법 연구)

  • Han, Jeong-Soo
    • Journal of the Korea Society of Computer and Information
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    • v.16 no.2
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    • pp.93-99
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    • 2011
  • In this paper, we propose a policy-gradient routing scheme under Reinforcement Learning that can be used adaptive QoS routing. A policy-gradient RL routing can provide fast learning of network environments as using optimal policy adapted average estimate rewards gradient values. This technique shows that fast of learning network environments results in high success rate of routing. For prove it, we simulate and compare with three different schemes.

Seamless Mobility of Heterogeneous Networks Based on Markov Decision Process

  • Preethi, G.A.;Chandrasekar, C.
    • Journal of Information Processing Systems
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    • v.11 no.4
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    • pp.616-629
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    • 2015
  • A mobile terminal will expect a number of handoffs within its call duration. In the event of a mobile call, when a mobile node moves from one cell to another, it should connect to another access point within its range. In case there is a lack of support of its own network, it must changeover to another base station. In the event of moving on to another network, quality of service parameters need to be considered. In our study we have used the Markov decision process approach for a seamless handoff as it gives the optimum results for selecting a network when compared to other multiple attribute decision making processes. We have used the network cost function for selecting the network for handoff and the connection reward function, which is based on the values of the quality of service parameters. We have also examined the constant bit rate and transmission control protocol packet delivery ratio. We used the policy iteration algorithm for determining the optimal policy. Our enhanced handoff algorithm outperforms other previous multiple attribute decision making methods.

Deep Q-Network based Game Agents (심층 큐 신경망을 이용한 게임 에이전트 구현)

  • Han, Dongki;Kim, Myeongseop;Kim, Jaeyoun;Kim, Jung-Su
    • The Journal of Korea Robotics Society
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    • v.14 no.3
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    • pp.157-162
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    • 2019
  • The video game Tetris is one of most popular game and it is well known that its game rule can be modelled as MDP (Markov Decision Process). This paper presents a DQN (Deep Q-Network) based game agent for Tetris game. To this end, the state is defined as the captured image of the Tetris game board and the reward is designed as a function of cleared lines by the game agent. The action is defined as left, right, rotate, drop, and their finite number of combinations. In addition to this, PER (Prioritized Experience Replay) is employed in order to enhance learning performance. To train the network more than 500000 episodes are used. The game agent employs the trained network to make a decision. The performance of the developed algorithm is validated via not only simulation but also real Tetris robot agent which is made of a camera, two Arduinos, 4 servo motors, and artificial fingers by 3D printing.

An Experimental Study on the Pumping Performance of Molecular Drag Pumps

  • Kwon, Myoung-Keun;Hwang, Young-Kyu
    • Journal of Mechanical Science and Technology
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    • v.20 no.9
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    • pp.1483-1491
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    • 2006
  • The pumping performance of molecular drag pumps (MDP) has been investigated experimentally. The exporimented MDPs are a disk-type drag pump (DTDP), helical-type drag pump(HTDP) and compound drag pump (CDP), respectively In the case of the DTDP, spiral channels of a rotor are cut on both upper surface and lower surface of a rotating disk, and the corresponding stator is a planar disk. In the case of the HTDP, the rotor has six rectangular grooves. The CDP consists with the DTDP, at lower part, and with the HTDP, at upper part. The experiments are performed in the outlet pressure range of $0.2{\sim}533Pa$. The inlet pressure and compression ratio are measured under the various conditions of outlet pressure and throughputs, and nitrogen is used for the test gas. At the outlet pressure of 0.2Pa, the ultimate pressure has been reached to $1.0{\times}10^{-2}Pa$ for the HTDP, $1.3{\times}10^{-4}Pa$ for the DTDP, and $3.6{\times}10^{-5}Pa$ for the CDP. The maximum compression ratio of the CDP is much higher than those of the DTDP or HTDP. Consequently, the ultimate pressure of the CDP is the lowest one.

Scintigraphic Evaluation of Alveolar Bone Following Dental Implantation in Dogs (개에서 치아 임플란트 식립후 치조골의 신티그라피 평가)

  • Kim, Joong-hyun;Lee, Jae-yeong;Kim, Myoung-hwan;Lee, Won-guk;Kang, Seong-soo;Choi, Seok-hwa
    • Korean Journal of Veterinary Research
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    • v.43 no.2
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    • pp.289-294
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    • 2003
  • This study aimed to determine of osseointegration following dental implantation in the dog mandible using bone scintigraphy. Five mongrel dogs, weighing approximately 8.5 kg and averaging 1.8 years of age, without active periodontal disease were used. During the entire study period, all dogs were fed a soft commercial diet and water ad libitum to minimize functional loading of the implant. Titanium alloy implant systems 10 mm in length and 4 mm in diameter were chosen for insertion. Twelve weeks prior to implantation, the second and third left mandibular premolars in each dog were extracted for the dental implant insertion. Before the dental implantation procedures and 0, 4, 8, and 12 weeks after the insertions, clinical observation, radiography and bone scintigraphy were conducted. The scintigraphy was obtained using a large field of view gamma camera equipped with a paralled-hole, low-energy collimator about 3 hours after intravenous injection of Tc-99m-MDP (8 mCi/dog) to the dogs. There were not inflammation sign after insertion of dental implants on the mandible in dogs. Implants were slightly movable at the first and fourth weeks, and there was no mobility after 8 weeks. Twelve weeks after dental implantation, the bone uptake scintigraphy of peri-implant bone was similar to that of normal alveolar bone, indicating that peri-implant bone was completely regenerated by new bone. In conclusion, we recommend stable implant fixation with alveolar bone for the accurate and safe repair of teeth loot due to decacy, trauma or peridontal disease. Titanium alloy implants were optimal due to their biocompatibility.

Scintigraphic Evaluation of Dogs with Experimentally Transected Cranial Cruciate Ligaments Treated Using Tibial Plateau Leveling Osteotomy (실험적으로 전십자 인대를 단열한 개에서 TPLO의 핵의학적 평가)

  • Lee Jae yeong;Kim Joong-hyun;Lee Won guk;Kang Seong soo;Bae Chun sik;Choi Seok hwa
    • Journal of Veterinary Clinics
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    • v.22 no.1
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    • pp.21-25
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    • 2005
  • This study was performed to assess therapeutic effect of the tibial plateau leveling osteotomy (TPLO) in dogs with experimentally transected cranial cruciate ligaments (CrCL). Nine healthy adult Beagle dogs were transected left CrCL under general anesthesia. The dogs were assigned to TPLO and non-TPLO control groups. The TPLO procedures for correcting the CrCL rupture in the left stifle of dogs were performed under sterile conditions. Before TPLO procedures, all dogs were screened by orthopedic and radiographic examinations. Dogs were lameness free for the previous three months, and when examined at the walk and trot on a hard surface, in a straight line and on a circle. Lateral and craniocaudal radiographs were done to confirm the soundness of the both knee joint in dogs and not detectable lesions were diagnosed. The dogs were intravenously injected with a 10 mci/kg of 99mTechnetium-methylene diphosphonate (99mTc-MDP) under general anesthesia. Scintigraphs were obtained using a large field of view gamma camera equipped a parallel-hole, low-energy about 3 hours after intravenous injection of 99mTc-MDP. Before CrCL transection and 4, 8, and 12 weeks after the procedures, scintigraphy were conducted. Bone uptake of the left stifle joint increased after the procedures in all dogs. When the bone uptake from the TPLO procedure was compared with that of the control, there was a significant difference (p < 0.05). At 12 weeks after the TPLO procedure, the dogs showed normal anatomical posture and gait. It is concluded that TPLO procedure was effective in reconstruct of the stifle joint in dogs with CrCL rupture.

Bone Marrow Immunoscintigraphy for the Detection of Skeletal Metastasis in Malignant Tumors: A Comparison with $^{99m}Tc$-MDP Bone Scan (악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : $^{99m}Tc$-MDP 뼈스캔과의 비교)

  • Lee, Kyung-Han;Choi, Chang-Woon;Bang, Yung-Jue;Chung, Jun-Key;Chung, Hong-Keun;Lee, Myoung-Chul;Kim, Byoung-Kook;Kim, Noe-Kyeong;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.28 no.1
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    • pp.89-97
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    • 1994
  • Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, $^{99m}Tc$ labeled anti-granulocyte monoclonal antibody (anti-NCA-95 MAb) has been introduced as a new bone marrow imaging agent. To evaluate the usefulness of $^{99m}Tc$ anti-NCA MAb bone marrow scans for detecting skeletal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan findings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the remaining 50% did not. Most of these non matched lesions were suggested to be nonspecific lesions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, bit metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus $^{99m}Tc$ anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.

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