• 벤처창업연구
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• 제12권1호
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• pp.133-144
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• 2017

본 연구는 1999년부터 2015년까지 상장기업을 대상으로, 순위프로빗 모형을 이용하여 신용등급 관련 이해관계자 중 하나인 기업의 관점에서 신용등급에 영향을 미치는 요인을 투자등급과 투기등급으로 구분하여 분석하였다. 투자등급의 경우 영업이익률, 매출액, 시장가/장부가, 배당지급, 자본적 지출 비율, 유형자산 비율이 양(+)의 계수를, 장 단기 부채비율, 베타, 고유위험이 음(-)의 계수를 보였다. 투기등급의 경우 배당지급, 유보이익률, 자본적 지출 비율이 양(+)의 계수를, 장 단기 부채비율과 연구개발비가 음(-)의 계수를 가졌다. 글로벌금융위기 이후 "신용정보의 이용 및 보호에 관한 법률"이 강화된 2009년 전 후를 기준으로 분석한 결과, 투자등급에서 자본적 지출 비율, 현금비율, 유형자산 비율이 2009년 이전에는 양(+)의 계수를 보였으나 2010년 이후에는 유의하지 않았다. 투기등급의 경우 2009년 이전에 단기부채보다 장기부채가 더 유의한 음(-)의 계수를 보였으나 2010년 이후에는 장기부채보다 단기부채가 더 유의한 음(-)의 계수를 보였다. 흥미롭게도 연구개발비가 2010년 이후 투자등급과 투기등급 모두 유의한 음(-)의 계수를 보였다. 이는 연구개발에 대한 투자가 기업의 성장기회를 높여 더 많은 현금흐름을 창출하며 이것이 신용등급을 상승시킬 것이라는 선행연구와 일치하지 않는다.

• Journal of Ginseng Research
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• 제46권5호
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• pp.628-635
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• 2022

Background: Ulcerative colitis (UC) is the large intestine disease that results in chronic inflammation and ulcers in the colon. Rg3-enriched Korean Red Ginseng extract (Rg3-RGE) is known for its pharmacological activities. Persicaria tinctoria (PT) is also used in the treatment of various inflammatory diseases. The aim of this study is to investigate the attenuating effects of Rg3-RGE with PT on oxazolone (OXA)-induced UC in mice. Methods: A total of six groups of mice including control group, OXA (as model group, 1.5%) group, sulfasalazine (75 mg/kg) group, Rg3-RGE (20 mg/kg) group, PT (300 mg/kg) group, and Rg3-RGE (10 mg/kg) with PT (150 mg/kg) group. Data on the colon length, body weight, disease activity index (DAI), histological changes, nitric oxide (NO) assay, Real-time PCR of inflammatory factors, ELISA of inflammatory factors, Western blot, and flow cytometry analysis were obtained. Results: Overall, the combination treatment of Rg3-RGE and PT significantly improved the colon length and body weight and decreased the DAI in mice compared with the treatment with OXA. Additionally, the histological injury was also reduced by the combination treatment. Moreover, the NO production level and inflammatory mediators and cytokines were significantly downregulated in the Rg3-RGE with the PT group compared with the model group. Also, NLR family pyrin domain containing 3 (NLRP3) inflammasome and nuclear factor kappa B (NF-𝛋B) were suppressed in the combination treatment group compared with the OXA group. Furthermore, the number of immune cell subtypes of CD4⁺ T-helper cells, CD19⁺ B-cells, and CD4⁺ and CD25⁺ regulatory T-cells (Tregs) was improved in the Rg3-RGE with the PT group compared with the OXA group. Conclusion: Overall, the mixture of Rg3-RGE and PT is an effective therapeutic treatment for UC.

• BMB Reports
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• 제48권3호
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• pp.153-158
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• 2015

As FK506 binding proteins (FK506BPs) are known to play an important role in the regulation of a variety of biological processes related to cell survival, this study was designed to examined the protective effects of FK506 binding protein 12 (FK506BP) on low humidity air flow induced dry eye in a rat model using transduced PEP-1-FK506BP. After the topical application of PEP-1-FK506BP, tear volumes were markedly increased and significant prevention of cornea damage was observed compared with dry eye rats. Further, immunohistochemical analysis demonstrated that PEP-1-FK506BP markedly prevented damage to the cornea, the bulbar conjunctiva, and the palpebral conjunctiva epithelial lining compared with dry eye rats. In addition, caspase-3 and PARP expression levels were found to be decreased. These results demonstrated that topical application of PEP-1-FK506BP significantly ameliorates dry eye injury in an animal model. Thus, we suggest that PEP-1-FK506BP can be developed as a new ophthalmic drop to treat dry eye diseases.

• Korean Chemical Engineering Research
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• 제62권3호
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• pp.214-224
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• 2024

밸브는 유량과 압력 조절 등의 중요한 역할을 수행하며, 적절한 밸브 사이즈와 유형 선택이 필요하다. Engineering Procurement Construction (EPC) 산업에선 밸브 사이즈 계수(C_v)의 수식적 계산을 바탕으로 사이즈와 유형을 선정해왔으나 이러한 방식은 전문가의 많은 시간과 비용이 요구되어 비효율적이다. 본 연구는 이를 해결하기위해 머신 러닝기법을 이용한 밸브 사이즈 및 유형 예측 모델을 개발하였다. Artificial neural network (ANN), Random Forest, XGBoost, Catboost의알고리즘을 적용하여 모델들을 개발하였으며, 평가 지표로는 사이즈 예측에는 Normalized root mean squared error (NRMSE)와 R²를, 종류 예측에는 F1 score를 적용하였다. 또한, 유체 상에 따른 영향을 확인하고자 유체 전체, 액체, 기체, 스팀의 4개의 데이터 세트로 사례 연구를 진행하였다. 연구 결과, 사이즈의 경우 전체, 액체, 기체에선 Catboost(R²기준, 전체: 0.99216, 액체: 0.98602, 기체: 0.99300. NRMSE 기준, 전체: 0.04072, 액체: 0.04886, 기체: 0.03619)가, 스팀에선 Random Forest가(R²: 0.99028, NRMSE: 0.03493) 가장 뛰어난 모델임을 확인하였다. 종류의 경우 Catboost가 모든 데이터에서 가장 높은 성과를 제시하였다(F1 score 기준, 전체: 0.95766, 액체: 0.96264, 기체: 0.95770, 스팀: 1.0000). 본 연구에서 제안한 모델들을 적용할 경우, 주어진 조건에 따른 밸브 선택을 도와 의사결정 속도를 높여줄 것으로 기대된다.

• 한국도로학회논문집
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• 제8권1호
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• pp.139-152
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• 2006

Many experimental and numerical approaches have been developed to evaluate paving materials and to predict pavement response and distress. Micromechanical simulation modeling is a technology that can reduce the number of physical tests required in material formulation and design and that can provide more details, e.g., the internal stress and strain state, and energy evolution and dissipation in simulated specimens with realistic microstructural features. A clustered distinct element modeling (DEM) approach was implemented In the two-dimensional particle flow software package (PFC-2D) to study the complex behavior observed in asphalt mixture fracturing. The relationship between continuous and discontinuous material properties was defined based on the potential energy approach. The theoretical relationship was validated with the uniform axial compression and cantilever beam model using two-dimensional plane strain and plane stress models. A bilinear cohesive displacement-softening model was implemented as an intrinsic interface and applied for both homogeneous and heterogeneous fracture modeling in order to simulate behavior in the fracture process zone and to simulate crack propagation. A disk-shaped compact tension test (DC(T)) with heterogeneous microstructure was simulated and compared with the experimental fracture test results to study Mode I fracture. The realistic arbitrary crack propagation including crack deflection, microcracking, crack face sliding, crack branching, and crack tip blunting could be represented in the fracture models. This micromechanical modeling approach represents the early developmental stages towards a 'virtual asphalt laboratory,' where simulations of laboratory tests and eventually field response and distress predictions can be made to enhance our understanding of pavement distress mechanisms, such its thermal fracture, reflective cracking, and fatigue crack growth.

• Wind and Structures
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• 제23권6호
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• pp.595-613
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• 2016

Large amplitude oscillation of steepled main cables usually presents during construction of a long-span bridge. To study this phenomenon, six typical main cables with different cross sections during construction are investigated. Two main foci have been conducted. Firstly, aerodynamic coefficients of a main cable are obtained and compared through simulation and wind tunnel test: (1) to ensure the simulation accuracy, influences of the numerical model's grid size, and the jaggy edges of main cable's cross section on main cable's aerodynamic coefficients are investigated; (2) aerodynamic coefficients of main cables at different wind attack angles are obtained based on the wind tunnel test in which the experimental model is made by rigid plastic using the 3D Printing Technology; (3) then numerical results are compared with wind tunnel test results, and they are in good agreement. Secondly, aerodynamic coefficients of the six main cables at different wind attack angles are obtained through numerical simulation. Then Den Hartog criterion is used to analyze the transverse galloping of main cables during construction. Results show all the six main cables may undergo galloping, which may be an important reason for the large amplitude oscillation of steepled main cables during construction. The flow structures around the main cables indicate that the characteristic of the airflow trajectory over a steepled main cable may play an important role in the galloping generation. Engineers should take some effective measures to control this harmful phenomenon due to the big possibility of the onset of galloping during the construction period.

• Journal of Microbiology and Biotechnology
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• 제20권1호
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• pp.224-228
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• 2010

The encapsulation of bacteria may be used to harness them for longer periods of time in order to make them viable, whereas antibiotic treatment would result in controlled release of therapeutic molecules. Encapsulated Escherichia coli GFP (green fluorescent protein) (E. coli GFP) was used here as a model for therapeutic substance - GFP fragments release (model of bioactive substances). Our aim was to evaluate the performance of bacteria encapsulated in hollow fibers (HFs) treated with antibiotic for induction of cell death. The polypropylene-surface-modified HFs were applied for E. coli encapsulation. The encapsulated bacteria were treated with tetracycline in vitro or in vivo during subcutaneous implantation into mice. The HF content was evaluated in a flow cytometer, to assess the bacteria cell membrane permeability changes induced by tetracycline treatment. It was observed that the applied membranes prevented release of bacteria through the HF wall. The E. coli GFP culture encapsulated in HF in vitro proved the tetracycline impact on bacteria viability and allows the recognition of the sequence of events within the process of bacteria death. Treatment of the SCID mice with tetracycline for 8 h proved the tetracycline impact on bacteria viability in vivo, raising the necrotic bacteria-releasing GFP fragments. It was concluded that the bacteria may be safely enclosed within the HF at the site of implantation, and when the animal is treated with antibiotic, bacteria may act as a local source of fragments of proteins expressed in the bacteria, a hypothetical bioactive factor for the host eukaryotic organism.

• 한국추진공학회지
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• 제18권2호
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• pp.1-9
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• 2014

환형 연소기 내에서의 난류 연소 유동을 해석하고 유동 특성을 도출하기 위해 3차원 large-eddy simulation (LES)를 수행하였다. 연소실 내 복잡한 반응 연소 유동의 화염모사를 위해 level-set flamelet 기법을 적용하였다. 계산 모델로서 GEAE사의 LM6000 환형 싱글 연소기를 이용하였으며 작동 조건은 실험결과에 근거하였다. 연소실 내에서 난류 유동의 중요한 특징인 vortex breakdown과 스월분사기에서 분사되는 연소가스의 팽창으로 인한 중심 재순환 영역, 코너 재순환 영역 등을 관찰하였고, 난류화염 구조를 분석하였다.

• International Journal of Aeronautical and Space Sciences
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• 제16권3호
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• pp.418-424
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• 2015

The chemical response of energetic materials is analyzed in terms of 1) the thermal decomposition under the thermal stimulus and 2) the reactive flow upon the mechanical impact, both of which give rise to an exothermic thermal runaway or an explosion. The present study aims at building a set of chemical kinetics that can precisely model both thermal and impact initiation of a heavily aluminized cyclotrimethylene-trinitramine (RDX) which contains 35% of aluminum. For a thermal decomposition model, the differential scanning calorimetry (DSC) measurement is used together with the Friedman isoconversional method for defining the frequency factor and activation energy in the form of Arrhenius rate law that are extracted from the evolution of product mass fraction. As for modelling the impact response, a series of unconfined rate stick data are used to construct the size effect curve which represents the relationship between detonation velocity and inverse radius of the sample. For validation of the modeled results, a cook-off test and a pressure chamber test are used to compare the predicted chemical response of the aluminized RDX that is either thermally or mechanically loaded.

• 한국추진공학회지
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• 제6권2호
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• pp.1-7
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• 2002

추진기관은 노즐을 통해 추력을 발생하며 축소-확대 형상의 초음속 노즐에서는 노즐의 설계 팽창비가 내부 유동의 전압력과 배압의 압력비보다 매우 클 때 충격파의 발생과 함께 경계층 박리를 유발한다. 노즐 내부에서의 충격파 발생과 유동의 박리는 주어진 유동의 압력비에 가장 적합한 노즐형상을 구현하는 것으로 실제의 구조적 노즐의 형상보다 짧은 노즐에서 나타나는 유동과 같은 현상을 보인다. 수치 해석적 방법으로 고정된 형상의 2차원 노즐 내부의 충격파와 경계층 박리 현상에 관한 연구를 수행하였고 Hunter가 행한 실험적 연구와 비교하였다. 수치해석은 TVD 기법을 이용한 압축성 유체 해석 코드와 SST 2방정식 난류 모델을 이용하여 수행되었다. 낮은 압력비에서의 충격파와 경계층과의 상호작용에 의한 $\lambda$형태의 충격파 시스템을 잘 보여주고 있고 추력 값의 비교를 통해 고정된 형상의 노즐을 이용하여 필요한 운용범위를 충족할 수 있음을 알 수 있었다.