• Toxicological Research
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• 제26권2호
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• pp.101-108
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• 2010

Halogenated organic compounds, such as 1-bromobutane (1-BB), have been used as cleaning agents, agents for chemical syntheses or extraction solvents in workplace. In the present study, immunotoxic effects of 1-BB and its conjugation with glutathione (GSH) were investigated in female BALB/c mice. Animals were treated orally with 1-BB at 375, 750 and 1500 mg/kg in corn oil once for dose response or treated orally with 1-BB at 1500 mg/kg for 6, 12, 24 and 48 hr for time course. S-Butyl GSH was identified in spleen by liquid chromatography-electrospray ionization tandem mass spectrometry. Splenic GSH levels were significantly reduced by single treatment with 1-BB. S-Butyl GSH conjugates were detected in spleen from 6 hr after treatment. Oral 1-BB significantly suppressed the antibody response to a T-dependent antigen and the production of splenic intracellular interlukin-2 in response to Con A. Our present results suggest that 1-BB could cause immunotoxicity as well as reduction of splenic GSH content, due to the formation of GSH conjugates in mice. The present results would be useful to understand molecular toxic mechanism of low molecular weight haloalkanes and to develop biological markers for exposure to haloalkanes.

• 대한화학회지
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• 제34권2호
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• pp.179-183
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• 1990

배추좀나방의 성 페로몬을 새로운 방법으로 합성하여 EAG감응반응을 수행하였다. 프로파길알코올의 이중음이온을 알킬화하여 2-도데신-1-올을 얻고 이를 아세틸렌-지퍼반응에 의해 11-도데신-1-올로 전환시킨 다음, 다시 이중음이온 알킬화반응에 의해 11-헤사데신-1올을 얻었다. 이를 수소환원시켜 (Z)-11-헥사데센-1-올 (3)을 얻었고 이 알코올을 산화시켜 (Z)-11-헥사데센-1-알(1)을, 아세틸화시켜 (Z)-11-헥사데센-1-일 아세테이트(2)를 각각 얻었다. 이렇게 합성하여 얻어진 화합물 각각 또는 혼합물에 대해 배추좀나방의 ESG감응반응을 측정하였다.