• 제목/요약/키워드: 1, 1-Dichloro-1-fluoroethane

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S.D. Rats를 1, 1-Dichloro-1-fluoroethane의 아만성 흡입독성 연구 (Study on Subchronic Inhalation Toxicity of 1, 1-dichloro-1-fluoroethane using S.D. Rats)

  • 김현영;이성배;임철홍;김철우;정용현;한정희;전윤석;최수영;강대봉
    • Environmental Analysis Health and Toxicology
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    • 제17권1호
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    • pp.81-93
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    • 2002
  • There were no specific effects for test materials on Sprague-Dawiey (S.D.) rats in clinical symptoms, amounts of food intakes, weight changes, laboratory findings, and pathology after whole body 1, 1-Dichloro-1-fluoroethane (used as coolant, metal cleaner and solvents) exposure (0, 1,500, 3,000, and 6,000 ppm) for 13 weeks (6 hour/day, 5 days/week). However, the loss of capillary vessels in eyeball (pupil) was observed in a female rat among 6,000 ppm group. Though there was a tendency for MCHC (Mean Corpuscular Hemoglobin Concentration) in rat to be decreased (p<0.05), it was not regarded as abnormal because the values were within normal limits. In asthma-stimulation related evaluations. there was also a tendency for inflammatory cell counts in bronchoalveolar lavages to be increased. But it had no statistical significance, and also no dependency on sex and the exposed concentration . Based on this result, the non observed effect level (NOEL) induced by 1, 1-Dichloro-1-fluoroethane inhalation was evaluated in groups with 3,000 ppm below (S.D. Rats, 13 weeks). Finally, it was concluded that the short term exposal of 1, 1-Dichloro-1-fluoroethane is not considered as a asthma stimulant by inhalation despite of some study limitations such as test animals use and short-term exposure.

1,1-Dichloro-1-fluoroethane Induces Micronuclei in Bone Marrow Cells by Repeated Inhalation Exposure but not by the Single Peritoneal Injection

  • Maeng, Seung-Hee;Kim, Hyun-Young;Lim, Cheol-Hong;Lee, Jong-Yoon;Lee, Yong-Mook;Chung, Ho-Keun;Chung, Hai-Won;Yu, Il-Je
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Signal transduction in Toxicology
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    • pp.150-150
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    • 2001
  • To investigate the genotoxic effect of 1, 1-dichloro-1-fluoroethane, which was widely used as a cleaning solvent at the electronic part industry, the micronucleus frequencies were recorded by examining polychromatic erythrocytes in bone marrows of the rodents exposed to it with different routes.(omitted)

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MICRONUCLEI INDUCTION BY REPEATED INHALATION EXPOSURE TO THE 1,1-DICHLORO-1-FLUOROETHANE BUT NOT BY THE SINGLE PERITONEAL INJECTION

  • Maeng, Seung-Hee;Chung, Hai-Won;Kim, Hyun-Young;Lim, Cheol-Hong;Lee, Jong-Yoon;Chung, Yong-Hyun;Lee, Yong-Mook;Chung, Ho-Keun;Yu, Il-Je
    • 한국독성학회:학술대회논문집
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    • 한국독성학회 2001년도 International Symposium on Dietary and Medicinal Antimutgens and Anticarcinogens
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    • pp.179-179
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    • 2001
  • To investigate the genotoxic effect of 1, 1-dichloro-1-fluoroethane which was widely used as a cleaning solvent at the electronic part industry, the micronucleus frequencies were recorded by examining polychromatic erythrocytes in bone marrows of single i.p. injected mice at high doses and of the repeatedly inhaled rats for 13 weeks at relatively low concentrations.(omitted)

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Rational Design of Extractive Distillation Toward Enhanced Separation of HFPO from HFP/HFPO Mixture

  • Lee, Yongtaek
    • 청정기술
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    • 제24권1호
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    • pp.15-20
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    • 2018
  • Hexafluoropropyleneoxide ($C_3F_6O$, HFPO) is highly expensive and it may be used as a raw material for the synthesis of various fluorine based compounds. Currently, extractive distillation method has gained considerable attention to collect the HFPO from a mixture of HFPO / hexafluoropropylene ($C_3F_6$, HFP). Optimized operating conditions are studied using a theoretical method for the extraction process. Among available solvents for the purification process, the use of 1,1-dichloro-1-fluoroethane exhibits a high purity of HFPO as a top product and minimize the required heat duty. Since the boiling point of the solvent increases as the pressure in the column increases, the enhanced extractive capability of the solvent led to the high purity of HFPO at the high pressure.

계면중합에 의한 역삼투용 복합막 제조에 관한 연구 (Manufacture of the Thin-Film Composite Membranes for the Reverse Osmosis Process using Interfacial Polymerization Technique)

  • 박종원;김희진;민병렬
    • 멤브레인
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    • 제8권1호
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    • pp.29-41
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    • 1998
  • 수용상 MPD(m-phenylene diamine)와 유기상 TMC(trimesoyl chloride)를 사용하여 역삼투 복합막의 활성층 고분자인 aromatic polyamide 제조를 행하고 그 성능을 고찰하였다. 또한 polysulfone 다공성 지지막 위에 박막을 회분, 연속식으로 계면중합 제조한 후, 제조변수에 따른 역삼투 성능을 비교하였다. 회분식으로 복합막을 제조한 결과 유기상 용매의 종류, 단량체의 농도와 함침시간, 열처리 온도, 중화제, 알코올 후처리, 산 후처리 등에 의해 다양한 성능을 나타내었다. 이때, 투과량 향상에는 알코올 후처리 효과가, 또 선택도의 향상에는 단량체의 농도와 함침시간이 변수이었다. 최적조건에서 연속식 공정으로 막모듈을 제조하여 NaCl 5,000 ppm, $25kg_f/cm^2$에서 상용막과 비교할때, 투과량은 33% 증가하고 배제율은 5% 감소하였다.

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