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Characterization of the Mutant of Streptomyces sp. SL-387(KCTC 0102BP) Producing Aminopeptidase M Inhibitors (Aminopeptidase M 저해제를 생산하는 Streptomyces sp. SL-387 (KCTC 0102BP) 변이주의 특성)

  • Chung, Myung-Chul;Chun, Hyo-Kon;Lee, Ho-Jae;Lee, Choong-Hwan;Kho, Yung-Hee
    • Microbiology and Biotechnology Letters
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    • v.23 no.1
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    • pp.47-52
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    • 1995
  • Since the original productivity of new aminopeptidase M inhibitors MR-387A and B by Streptomyces sp. SL-387 (KCTC 0102BP) was not enough for further chemical and biological evaluation, mutation of parent strain by the treatment of N-methyl-N'-nitro-N-nitrosoguanidine was performed in order to obtain a clone with greater inhibitory activity. Mutant N-3 was selected due to a 6-fold greater productivity (40 $\mu$g/ml) than that of the wild type(6.7 $\mu$g/ml). This mutant was resistant to 3,4-dehydro-DL-proline, an antimetabolite of proline, with 25 $\mu$g/ml of minimum inhibitory concentration. Furthermore, the characteristic morphological change from spiral spore chain in wild type to straight in mutant was observed. An aminopeptidase M nhibitor different from MR-387A and B was isolated from the culture broth of the mutant. This inhibitor was composed of 2 proline, 1 valine, and an unknown amino acid which is presumably 3-amino-4-phenylbutanoic acid. IC$_{50}$ value (89.1 $\MU$g/ml) of the purified inhibitor was lower than that of other inhibitors, which may be due to the absence of 2(S)-hydroxyl group within the structure of 3-amino-4-phenyl- butanoic acid.

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An Improved Weak-Lensing Analysis of the Galaxy Cluster ACT-CL J0102-4915 with New Wide-Field HST Imaging Data

  • Kim, Jinhyub;Jee, Myungkook James
    • The Bulletin of The Korean Astronomical Society
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    • v.45 no.1
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    • pp.29.5-30
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    • 2020
  • We present an improved weak-lensing (WL) study of the high-z (z=0.87) merging galaxy cluster ACT-CL J0102-4915 ("El Gordo"), the most massive system known to date at z > 0.6. El Gordo has been known to be an exceptionally massive and rare cluster for its redshift in the current ΛCDM cosmology. Previous multi-wavelength studies have also found that the cluster might be undergoing a merging event showing two distinctive mass clumps and radio relics. The previous WL study revealed a clear bimodal mass structure and found that the entire system is indeed massive (M200a = (3.13 ± 0.56) × 1015 Msun). This mass estimate, however, was obtained by extrapolation because the previous HST observation did not extend out to the virial radius of the cluster. In this work, we determine a more accurate mass estimate of the cluster using WL analysis utilizing a new set of WFC3/IR and wide-field ACS observations. While confirming the previous bimodal mass structure, we find that the new data yield a ~20% lower mass for the entire system (M200a = (2.37 ± 0.28) × 1015 Msun). We also discuss the rarity of the cluster in the ΛCDM paradigm and suggest an updated merging scenario based on our new measurement.

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Zermelo 이후의 선택공리

  • 홍성사;홍영희
    • Journal for History of Mathematics
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    • v.9 no.2
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    • pp.1-9
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    • 1996
  • This paper is a sequel to [26]. We investigate how the Axiom of Choice has been accepted after Zermelo introduced the Axiom in 1904. The response to the Axiom has divided into two groups of mathematicians, namely idealists and empiricists. We also investigate how the Zorn's lemma (1935) has been emerged. It was originally formulated by Hausdorff in 1909 and then by many other mathematicians independently.

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A Multichannel TDMA MAC Protocol to Reduce End-to-End Delay in Wireless Mesh Networks

  • Trung, Tran Minh;Mo, Jeong-Hoon
    • ETRI Journal
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    • v.32 no.5
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    • pp.819-822
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    • 2010
  • Supporting QoS over multihop wireless mesh networks is difficult because end-to-end delay increases quickly with the increasing number of hops. This paper introduces a novel multichannel time-division multiple-access media access control (McTMAC) protocol that can help to efficiently reduce delay over multihop networks. Performance evaluation results demonstrate that McTMAC outperforms existing alternative protocols. The max-delay can be reduced by as much as 60% by using McTMAC.

Strength Prediction of Corbels Using Strut-and-Tie Model Analysis

  • Kassem, Wael
    • International Journal of Concrete Structures and Materials
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    • v.9 no.2
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    • pp.255-266
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    • 2015
  • A strut-and-tie based method intended for determining the load-carrying capacity of reinforced concrete (RC) corbels is presented in this paper. In addition to the normal strut-and-tie force equilibrium requirements, the proposed model is based on secant stiffness formulation, incorporating strain compatibility and constitutive laws of cracked RC. The proposed method evaluates the load-carrying capacity as limited by the failure modes associated with nodal crushing, yielding of the longitudinal principal reinforcement, as well as crushing or splitting of the diagonal strut. Load-carrying capacity predictions obtained from the proposed analysis method are in a better agreement with corbel test results of a comprehensive database, comprising 455 test results, compiled from the available literature, than other existing models for corbels. This method is illustrated to provide more accurate estimates of behaviour and capacity than the shear-friction based approach implemented by the ACI 318-11, the strut-and-tie provisions in different codes (American, Australian, Canadian, Eurocode and New Zealand).

Vector space based augmented structural kinematic feature descriptor for human activity recognition in videos

  • Dharmalingam, Sowmiya;Palanisamy, Anandhakumar
    • ETRI Journal
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    • v.40 no.4
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    • pp.499-510
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    • 2018
  • A vector space based augmented structural kinematic (VSASK) feature descriptor is proposed for human activity recognition. An action descriptor is built by integrating the structural and kinematic properties of the actor using vector space based augmented matrix representation. Using the local or global information separately may not provide sufficient action characteristics. The proposed action descriptor combines both the local (pose) and global (position and velocity) features using augmented matrix schema and thereby increases the robustness of the descriptor. A multiclass support vector machine (SVM) is used to learn each action descriptor for the corresponding activity classification and understanding. The performance of the proposed descriptor is experimentally analyzed using the Weizmann and KTH datasets. The average recognition rate for the Weizmann and KTH datasets is 100% and 99.89%, respectively. The computational time for the proposed descriptor learning is 0.003 seconds, which is an improvement of approximately 1.4% over the existing methods.

Contralateral Superior Cerebellar Artery Syndrome : A Consequence of Brain Herniation

  • Mohseni, Meysam;Habibi, Zohreh;Nejat, Farideh
    • Journal of Korean Neurosurgical Society
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    • v.60 no.3
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    • pp.362-366
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    • 2017
  • Vascular compromise is a well-known consequence of brain herniation syndromes. Transtentorial brain herniation most often involves posterior cerebral arteries. However, isolated involvement of contralateral superior cerebellar artery (SCA) during unilateral impending brain herniation is reported only once and we present another case of this exceedingly rare entity. A 24-year-old man was referred to us with impending herniation due to a multiloculated hydrocephalus, and during the course of illness, he developed an isolated SCA ischemia in the opposite side of the most dilated entrapped horn. In the current article we discuss the probable pathophysiologic mechanisms of this phenomenon, as well as recommending more inclusive brain studies in cases suspected of Kernohan-Woltman notch phenomenon in unilateral brain herniation. The rationale for this commentary is that contralateral SCA transient ischemia or infarct might be the underdiagnosed underlying pathomechanism of ipsilateral hemiparesis occurring in many cases of this somehow vague phenomenon.

Analysis of Relationship between Body and Gimbal Motion Through Experiment of a Single-wheel Robot Based on an Inverse Gyroscopic Effect (외바퀴 로봇의 역자이로 효과에 의한 바디 모션과 김벌 모션의 실험을 통한 관계 분석)

  • Lee, Sang-Deok;Jung, Seul
    • Journal of Institute of Control, Robotics and Systems
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    • v.21 no.11
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    • pp.1064-1069
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    • 2015
  • Control Moment Gyro (CMG) has been used as an indirect actuator of a single-wheel robot system GYROBO, developed at Chungnam National University. The flip motion of the gimbal system produces the gyroscopic motion onto the body system while the body motion also produces the gyroscopic motion onto the gimbal system inversely. In this paper, the intuitive equation of the inverse gyroscopic effect is derived as the direct relation between the rate of the body system and the rate of the gimbal system. Experiments on the inverse gyroscopic effect under the chaotically generated disturbance are conducted. Experimental data are approximated by a linear equation using the least square method.

Pollination of Cleisostoma scolopendrifolium (Orchidaceae) by megachilid bees and determinants of fruit set in southern South Korea

  • Son, Hyun-Deok;Im, Hyoung-Tak;Choi, Sei-Woong
    • Journal of Ecology and Environment
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    • v.43 no.1
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    • pp.9-13
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    • 2019
  • We investigated the pollinators of Centipede's foot orchid (Cleisostoma scolopendrifolium) at five locations in southern Korea. Only one species of megachilid bee (Megachile yasumatsui) was observed at three of the sites (Mokpo, Haenam, and Wando). We assumed that the megachilid bee worked as a sole pollinator of C. scolopendrifolium based on the visiting behavior of the bees the attached pollinia. Fruits were observed at the three locations that bees visited: 74% fruit set at Mokpo, 59% at Wando, and 31% at Haenam. By contrast, at two of the locations where megachilid bees did not visit the plants (Naju and Jindo), there were no fruits set. The differences in fruit set rates at the three orchid populations where bees were observed appear to be related to bee abundance and flower visitation rate rather than to differences in flower abundance. The pollination interaction between C. scolopendrifolium and megachilid bees appears to involve sexual deception since only male bees were attracted to the flowers. The underlying mechanism involved in this interaction needs investigation.

An Improved PSO Algorithm for the Classification of Multiple Power Quality Disturbances

  • Zhao, Liquan;Long, Yan
    • Journal of Information Processing Systems
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    • v.15 no.1
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    • pp.116-126
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    • 2019
  • In this paper, an improved one-against-one support vector machine algorithm is used to classify multiple power quality disturbances. To solve the problem of parameter selection, an improved particle swarm optimization algorithm is proposed to optimize the parameters of the support vector machine. By proposing a new inertia weight expression, the particle swarm optimization algorithm can effectively conduct a global search at the outset and effectively search locally later in a study, which improves the overall classification accuracy. The experimental results show that the improved particle swarm optimization method is more accurate than a grid search algorithm optimization and other improved particle swarm optimizations with regard to its classification of multiple power quality disturbances. Furthermore, the number of support vectors is reduced.