• KSBB Journal
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• 제24권2호
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• pp.156-162
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• 2009

과메기를 표준화하는 일환으로 감압건조기 (vacuum drying)를 사용하여 CA (chitosan-ascorbate)로 표면을 coating한 것과 시중에서 판매되고 있는 일반 과메기와 미생물오염도를 비교분석 하였다. Total aerobacter에서 SCA (CA 처리한 꽁치 과메기)는 1.41, SGRW (ginseng steamed red, wine으로 처리한 꽁치 과메기)에서 1.63, SNT (CA 비처리한 시중판매 과메기) 에서는 1.9 log cycle 오염된 것을 비교하면 SCA가 0.22-0.49 log cycle 항균효과를 보인다. HCA (CA 처리한 청어과메기)에서는 2.27, HDW (심층수로 처리한 청어과메기) 2.32, HNT (비처리한 청어과메기) 2.72로서 오염도를 비교하면 HCA는 0.05-0.45 log cycle을 억제시켰다. GCA (CA 처리한 전어과메기)에서는 0.95, GDW (심층수로 처리한 전어과메기)와 GNT (비처리한 전어과메기)가 1.4의 수치를 나타내어서, GCA는 비처리한 GNT와 비교할 때 0.45 log cycle을 저해시켰다. Coliform과 E. coli에서는 오염미생물이 검출되지 않았다. S. aureus는 SCA 에서 0.47, SGRW 1.15, SNT 1.27로 조사되어 미생물 오염도를 비교하면 SCA는 0.68-0.8 log cycle의 오염미생물을 억제시킨다. HCA는 1.15, HDW 1.11, HNT 1.36과 비교하면 HCA는 오염미생물 0.21 log cycle을 저해시켰다. GCA는 0.47, GDW와 GNT가 1.08과 1.34로 검출되었다. 즉 GCA에서는 오염된 미생물 0.26-0.61 log cycle 오염미생물을 억제시킨다. 수분함량 측정의 결과는 GDW 29%, HCA 31%, HNT 32%로 조사되어서 적당한 수분함량을 보유하고 있으나, SGW, GCA, HDW, SCA는 7-15%가 부족하며, SNT 와 GNT는 과메기 표준수분함량 (30%) 보다 10%가 더 많아서 미생물의 오염과 과산화물 증가 및 산패를 더 빨리 초래 한다. CA를 첨가하였을 때 과산화물은 SCA 41, HCA 45, GCA 49 meq로 조사되었으며, 항균성을 첨가하지 않은 시중과메기 (SNT, HNT, GNT)와 비교할 때 과산화물이 12 meq 더 낮게 조사되었다. SEM 관찰에서는 SCA, HCA가 조직표면이 선명하고 과산화물이 낮게 검출되었으며, 반면 항균성을 처리하지 않은 SGRW, HDW는 과산화물이 많으며 조직표면이 불투명하였다. 관능평가에서는 SCA, SGW 등의 순으로 꽁치 과메기 선호도가 가장 높았으며, 다음으로 청어, 전어 과메기 순으로 조사되었다.

• 대한기계학회논문집
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• 제19권9호
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• pp.2133-2141
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• 1995

The thermo-mechanical fatigue tests were performed on the specimens extracted from 1.5Cr-0. 67Mo-0.33V alloy. The characteristics of thermo-mechanical fatigue crack propagation were examined and reviewed in view of fracture mechanics. The results obtained from the present study are summarized as follows : (1) The propagation characteristics of isothermal low-cycle fatigue crack are dominated by .DELTA.J$_{f}$ in case of PP waveform, and .DELTA.J$_{c}$ in case of CP waveform. (II)The propagation characteristics of thermo-mechanical fatigue crack are dominated by .DELTA.J$_{c}$ for in-phase case, and by .DELTA.J$_{c}$ for out-of-phase. The present results were in good agreement with the equation of propagation law for isothermal low-cycle fatigue crack in case of thermo-mechanical fatigue.tigue.e.

• Tribology and Lubricants
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• 제14권4호
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• pp.7-14
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• 1998

A correlation between the low-cycle fatigue life and the scuffing-failure life is demonstrated using the plastic strain increment in boundary lubricated sliding. Loadings proportional to hardness with three different lubricated conditions were used to evaluate the plastic strain increments. As the results of scuffing tests using vacuum pump oils in nitrogen gas, plastic strain increment shows 0.0062, and in the mineral oils and commercial engine oils in air, plastic strain increments show 0.0042 and 0.00092. Those are very useful to describe quantitatively the real lubricated sliding conditions, and are very effective to find the relation between the low-cycle fatigue life and the scuffing-failure life.

• Reproductive and Developmental Biology
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• 제35권4호
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• pp.463-468
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• 2011

This study investigated the changes of plasminogen activators (PAs) activity, expression and localization of tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) during the estrous cycle in pigs. Estrous cycle was sorted into three group by pre-ovulation (Pre-Ov), post-ovulation (Post-Ov) and early to mid-luteal stages (Early to mid-L). Analysis for immunohistochemistry was confirmed by location of tPA and uPA. Porcine uterus tissue was cut into $1{\times}1$ cm squares, and were incubated in DMEM/F-12 medium for 1 h at $38^{\circ}C$, 5% $CO_2$ for measurement of PA activity. Western blotting was implemented for measurement of PA quantity. In results, the blood vessels and secretory glands were increased in Post-Ov stage than Pre-Ov and Early to mid-L stages. The tPA and uPA was located mainly within lumen of blood vessels and secretory glands. The PA activity in Post-Ov ($0.99{\pm}0.03$) stage were significantly (p<0.01) higher than Pre-Ov stage ($0.51{\pm}0.03$) and Early to mid-L stage ($0.21{\pm}0.04$). Expression of PAs were significantly (p<0.05) higher in Early to mid-L stage than other stages. These results indicate that PAs activity and expression may change in uterus tissue during the estrous cycle in pigs.

• Clinical and Experimental Reproductive Medicine
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• 제37권1호
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• pp.73-81
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• 2010

목 적: 클로미펜을 이용한 배란유도 주기에서 불량한 자궁내막 발달을 보이는 불임 여성에서 레트로졸의 효용성을 알아보고자 하였다. 연구방법: 2004년 3월부터 2009년 8월까지 분당서울대학교병원에서 클로미펜을 이용한 배란유도 주기에서 자궁내막 두께가 6.5 mm 이하여서 다음 주기에 레트로졸을 사용하였던 18명의 불임 여성을 선정하였다. 환자들의 평균 연령은 $30.7{\pm}2.8$세, 불임 기간은 $33.1{\pm}26.6$개월이었다. 불임의 인자는 자궁내막증이 1명, 다낭성난소증후군이 5명, 원인불명의 불임증이 12명이었다. 레트로졸은 2.5 mg의 용량으로 월경 3~5일 사이에 시작하여 5일간 투여하였다. 결 과: 이전 클로미펜 사용시와 비교하였을 때 레트로졸 주기에서 우성난포의 개수는 더 적었으나 ($1.1{\pm}0.3$ vs. $2.2{\pm}1.5$, p=0.011) 자궁내막 두께는 유의하게 증가하였으며 ($8.4{\pm}1.7$ mm vs. $5.8{\pm}0.5$ mm, p<0.001) 자궁내막 패턴 중 type C의 빈도는 이전 클로미펜 주기에서 50%이었던 것이 레트로졸 사용시 94.4%로 유의한 증가를 보였다 (p=0.036). 레트로졸을 이용한 배란 유도 주기에서 임신율은 11.1%였다. 결 론: 얇은 자궁내막 발달을 보였던 클로미펜 주기에 비해 레트로졸 사용시 자궁내막이 좀 더 두꺼워지고 패턴이 호전되는 것으로 보아 클로미펜에 불량한 자궁내막을 보이는 여성에서 이차 선택약제로 레트로졸의 사용은 유용한 방법으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7701-7705
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• 2015

Background: Thyroid hormones (TH) are regulated by the hypothalamic-pituitary axis, which plays an important role in cell growth, differentiation, development and other aspects of metabolism. It is believed that an active hypothalamic-pituitary axis increases the susceptibility of thyroid dysfunction during systemic chemotherapy. In order to investigate the relation between thyroid function and chemotherapy the present study was designed to investigate TH in breast cancer patients receiving at least three cycles of chemotherapy. The levels of TH were measured at the baseline and before each cycle of chemotherapy. Materials and Methods: Blood samples for estimation of TH levels were collected from 80 (pre-menopausal-40; post-menopausal-40) breast cancer patients just before they were undergoing - $1^{st}$, $2^{nd}$, $3^{rd}$ and $4^{th}$ cycle of chemotherapy. The serum was separated and $T_3$, $T_4$ and TSH levels were determined by chemiluminescence method. Results: $T_3$ and $T_4$ were found significantly decreased and TSH was found significantly increased after $1^{st}$ (p<0.001), $2^{nd}$ (p<0.0001) and $3^{rd}$ cycle of chemotherapy (p<0.0001). The variation of $T_3$ levels (decreased) and TSH levels (increased) was found more in post-menopausal (p<0.0001) women then in pre-menopausal women after $3^{rd}$ cycle of chemotherapy as compared to baseline (p<0.001). Conclusions: TH were remarkably altered after each cycle of chemotherapy leading to decline in thyroid function of breast cancer patients. Further, the results also indicated that post-menopausal women were more prone towards decline in thyroid function then pre-menopausal women. The present study proposes the monitoring of TH after each cycle of chemotherapy in breast cancer patients.

• 대한지역사회영양학회지
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• 제7권2호
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• pp.188-198
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• 2002

This study was conducted to compare families eating-out behavior in relation to family life cycle in order to provide basic information on nutritional education about eating-out. The data were collected by the survey method from 440 families who lived in apartment complexes in Kyong-ju and Seoul. The structured questionnaire included items about the frequency of eating out, the choice of eating-out menus, the decision maker of the eating-out process, the attitudes toward eating out and the general characteristics of the families. The major results are as follow: 1) In the cafe of telephone delivery service, and eat-in restaurants, the subjects showed statistical significance (p < 0.01). With respect to telephone delivery service, families in Step II used it most frequently, but families in Step I rarely used it. With respect to eat-in restaurants, families in Step II used them most frequently but families in Step IV rarely used them. 2) In all the family life cycle steps, the most favorable menu was fried chicken for take-out type, Chajang noodles, fried chicken and pizza fur telephone delivery, pizza for internet delivery, raw fish and beef for eat-in restaurant, Docbokki, laver rolled rice and ramyun for convenience flood stores. 3) The wife was most influential in making decisions about the take-out type (p < 0.001). In the case of telephone deliveries (p < 0.001), the wife was the most influential in the families of Steps I and II, but the children were the most influential in the families of Steps III and IV. In the case of eat-in restaurants (p < 0.001), the husband had the most effect on the decision-making process. In the case of convenience flood stores (p < 0.001), the children were the most influential in the families in Steps III and IV. In most family life cycle steps, each of them chose their own meal. 4) from a factor analysis perspective, attitudes toward eating out have been grouped according to two factors, namely 'Advantage' and 'Nutrition'. No factor showed a significant difference among the family life cycle steps.

• 미생물학회지
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• 제44권4호
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• pp.299-304
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• 2008

마이엘로이드 계열의 단핵세포는 인체세포거대바이러스(human cytomegalovirus, HCMV)의 잠복 부위로 알려져 있다. 다양한 세포에서 HCMV에 의한 세포주기의 촉진 또는 억제에 관한 연구는 많이 있었지만, 단핵세포에서의 연구는 거의 없는 상태이다. 이에 본 연구에서는 단핵세포에 HCMV가 감염되면 세포주기에 어떤 변화가 나타나는지 알아보고자 하였다. Propidium iodide를 이용한 유세포 분석을 통한 세포주기 분석에서 HCMV에 감염된 THP-1 세포에서는 G0-G1기가 증가하고, 그만큼 S가 감소함을 보았다. 반면 HL-60 세포에서는G0-G1기와 S기의 상대적인 비율에 큰 변화가 없었다. BrdU 유입 실험에서 THP-1세포의 DNA 합성이 HCMV 감염에 의해 억제됨을 알 수 있었다. 세포주기의 G1기에서 S기로의 전환을 억제하는 p21 단백질은HCMV에 감염된 THP-1 세포에서는 발현이 유도되었지만 HL-60 세포에서는 거의 발현이 되지 않았다. 따라서 HCMV는 promocyte THP-1 세포에서 p21 단백질의 유도에 의해 세포주기를 G0-G1기에서 억류함에 따라 세포중식을 억제하는 것으로 생각된다.

• 상하수도학회지
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• 제29권4호
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• pp.447-457
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• 2015

Water cycle within the human civilization has become important with urbanization. To date, water cycle in the eco-system has been the focus in identifying the degree of water cycle in cities, but in practicality, water cycle within the human civilization system is taking on an increasing importance. While in recent years plans to reuse water have been implemented to restore water cycle in cities, the effect that such reuse has on the entire water cycle system has not been analyzed. The analysis on the effect that water reuse has on urban areas needs to be go beyond measuring the cost-savings and look at the changes brought about in the entire city's water cycle system. This study uses a SWAT model and water balance analysis to review the effects that water reuse has on changes occurring in the urban water cycle system by linking the water cycle within the eco-system with that within the human civilization system. The SWAT model to calculate the components of water cycle in the human civilization system showed that similar to measured data, the daily changes and accumulative data can be simulated. When the amount of water reuse increases in urban areas, the surface outflow, amount of sewer discharge and the discharged amount from sewage treatment plants decrease, leading to a change in water cycle within our human civilization system. The determinant coefficients for reduced surface outflow amount and reduced sewer discharge were 0.9164 and 0.9892, respectively, while the determinant coefficient for reduced discharge of sewage treatment plants was 0.9988. This indicates that with an increase in water reuse, surface flow, sewage and discharge from sewage treatment plants all saw a linear reduction.

• 한국해양공학회지
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• 제25권1호
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• pp.80-84
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• 2011

The cycle performance of closed ocean thermal energy conversion (OTEC) system with 50 kW gross power was evaluated to obtain the basic data for the optimal design of OTEC using waste heat such as solar power, discharged heat from condenser of power plant. The basic thermodynamic model for OTEC is Rankine cycle, and the surface seawater and deep seawater were used for the heat source of evaporator and condenser, respectively. The cycle performance such as efficiency, heat exchanger capacity, etc. was analyzed on the variation of temperature increase by waste heat. The cycle efficiency increased and necessary capacity of evaporator and condenser decreased under 50kW gross power with respect to the temperature increase of working fluid. Also, when the temperature increase is about $13.5^{\circ}C$, the heat which can be used is generated. By generator with 0.9 effectiveness under the simulated condition, the cycle efficiency was improved approximately 3.0% comparing with the basic cycle.