• 한국언어정보학회지:언어와정보
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• 제19권2호
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• pp.37-53
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• 2015

It has been widely accepted that Korean -i/ka, known as the nominative marker, can give rise to exhaustivity effect. However, it has been rarely discussed and still remains unclear how and why the particle can convey exhaustivity. The purpose of this paper is to shed light on this issue, based on Kim's (2014) analysis of the function of -i/ka. The main claim is that the exhaustivity expressed by -i/ka is a pragmatic effect derived from the interaction of the function of -i/ka, namely, unique specification, and the existence of alternatives to the denotation of an -i/ka-marked phrase in discourse context. Thus, the nature of the exhaustive implicature induced by -i/ka is not conventional but conversational.

• 한국언어정보학회지:언어와정보
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• 제19권2호
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• pp.19-36
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• 2015

The aim of this paper is to investigate the usage of Korean markers -(n)un and -i/ka in editorial texts focusing on information structure. Noun phrases ending with the markers -(n)un and -i/ka were annotated semi-automatically using a corpus obtained from an online newspaper. Two important factors to determine the choice of markers were examined with the annotated data: referential givenness/newness and position in a sentence. Referential givenness and newness were adopted as indicators of information structure, topic and focus respectively. In addition to quantitative analysis, qualitative analysis was conducted on the selected data. The results suggest that both the marker -(n)un and -i/ka could carry a topic and a focus reading. Sentence position also played a crucial role in determining the marker, and the marker -i/ka was used more frequently in a later position of a sentence than the marker -(n)un.

• Natural Product Sciences
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• 제16권2호
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• pp.99-106
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• 2010

This experiment was undertaken to investigate whether methanol extract of fruit peel of Dimocarpus longan Lour. (MEFL) protects against kainic acid (KA)-induced seizure. Oral administration of MEFL (1, 2 and 4 mg/kg) increased KA (50 mg/kg)-induced survival rate and latency of convulsion onset, and deceased seizure scores and weight loss induced by intraperitoneal (i.p) injection of KA in mice. In addition, MEFL protected against cell death in the hippocampus of rat brain after KA-administration as analyzed by using TUNEL assay in rats. MEFL also significantly blocked seizure-form of electroencephalogram (EEG) power spectra induced by KA in rats. MEFL also inhibited elevation of [$Ca^{2+}$]i and increased [$Cl^-$]i induced by KA in cultured neuronal cells. Therefore, it is suggested that MEFL protects against seizure induced by KA, decreasing [$Ca^{2+}$]i.

• The Korean Journal of Physiology and Pharmacology
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• 제13권4호
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• pp.265-271
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• 2009

Nitric oxide (NO) has both neuroprotective and neurotoxic effects depending on its concentration and the experimental model. We tested the effects of NG-nitro-L-arginine methyl ester (L-NAME), a nonselective nitric oxide synthase (NOS) inhibitor, and aminoguanidine, a selective inducible NOS (iNOS) inhibitor, on kainic acid (KA)-induced seizures and hippocampal CA3 neuronal death. L-NAME (50 mg/kg, i.p.) and/or aminoguanidine (200 mg/kg, i.p.) were administered 1 h prior to the intracerebroventricular (i.c.v.) injection of KA. Pretreatment with L-NAME significantly increased KA-induced CA3 neuronal death, iNOS expression, and activation of microglia. However, pretreatment with aminoguanidine significantly suppressed both the KA-induced and L-NAME-aggravated hippocampal CA3 neuronal death with concomitant decreases in iNOS expression and microglial activation. The protective effect of aminoguanidine was maintained for up to 2 weeks. Furthermore, iNOS knockout mice ($iNOS^{-1-}$) were resistant to KA-induced neuronal death. The present study demonstrates that aminoguanidine attenuates KA-induced neuronal death, whereas L-NAME aggravates neuronal death, in the CA3 region of the hippocampus, suggesting that NOS isoforms play different roles in KA-induced excitotoxicity.

• 자원환경지질
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• 제39권1호
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• pp.53-61
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• 2006

Geochemical and sedimentological analyses of sediment piston core were used to trace paleoceanographic environmental changes in the East China Sea. The analytical results revealed three lithostratigraphic units (I, II, and III) corresponding to a highstand stage, a transgressive stage, and a lowstand stage, respectively. Accelerator mass spectrometry (AMS) $^{14}C$ dated the boundaries between the units as 7 ka and II ka. That is, Unit I extended from the present to 7 ka, Unit II occupied a transitional episode from 7 to 11 ka, and Unit III was older than 11 ka. The transitional episode was characterized by sudden fluctuations in various geochemical proxies. Most strikingly, there was a gradual upward increase in both carbonate and total organic carbon (TOe) contents post-7 ka, during which time the ${\delta}^{l3}C$ values of organic material increased to a constant value. The gradual upward increase in the TOC and $CaCO_3$ contents in Unit I were accompanied by slight variations in grain size that probably reflect a stable modern oceanographic environment. Within Unit II (7 to 11 ka), the geochemical signals were characterized by abrupt and steep fluctuations, typical of a transgressive stage. Vertical mixing may have provoked an increase in productivity during this interval, with large amounts of terrigenous organic matter and/or freshwater being supplied by neighboring rivers. The geochemical signals remained stable throughout Unit III but exhibited different patterns than signals in Unit I. The high terrigenous organic matter content of Unit III suggests correspondence to a lowstand stage.

• 대한가정학회지
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• 제36권3호
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• pp.77-86
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• 1998

The aims of this study show the purpose of writing[Ka-ryae] and its transmission and operation from the end of Koryo to Chosun dynasty. And Studying of a traditional marriage ceremony as shown in [Ka-ryae], We intend to find a mental meaning and value in it. The major findings this study are as follows. 1. Though [Ka-ryae] was written by Chu-Ja who lived in the period of South-Song of China, it had greatly influenced the thought, system and life of Korean society from the end of Koryo to Chosun dynasty. 2. Studying the content of [Ka-ryae], we learned the respect, discretion and reghtness as the mental meaning and value of a marriage ceremony.

• 한국통신학회논문지
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• 제36권11A호
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• pp.933-940
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• 2011

본 논문에서는 도로 장애물 감시 레이더용 Ka 대역 송수신기를 설계 및 제작하였다. 도로 장애물 감시 레이더용 송수신기는 파형발생기, 주파수발생기, IF 송수신기, RF 상하향 변환기로 구성되어 있다. 송수신기는 탐지 거리별로 모드를 3가지로 구분하여 운용되며 이 때 Ka 대역에서 150MHz의 대역폭을 유지한다. 송신 출력은 22dBm 이상이며, 수신 이득은 30dB, 잡음 지수는 6dB인 성능을 얻었다. 수신 동적 범위는 63.28dB 이며, 수신 I/Q 채널 간 진폭 오차는 0.3dB, 위상 오차는 1.74도를 보였다. 시험 결과, 송수신기는 펄스 도플러 형태의 도로 감시 레이더에서 요구되는 전기적인 성능을 만족하였음을 확인하였다.

• 한국어학
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• 제62권
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• pp.171-194
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• 2014

In this paper, I seek to differentiate the meaning of the auxiliary verb '-e ka-' from imperfective aspect in Korean. The progressive in imperfective is expressed by the 'be+V-ing' in English and '-ko iss-' in Korean. However the '-e ka-' in Korean can express the gradual progress meaning. This is similar to the progressive of some state verbs. These verbs cannot express the progressive aspect but it is possible if they can express the change of state in sentence. It is more corresponding to the '-e ka-' than '-ko iss-' in Korean.

• Journal of Ginseng Research
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• 제47권3호
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• pp.390-399
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• 2023

Background: Gintonin (GT), a Panax ginseng-derived lysophosphatidic acid receptor (LPAR) ligand, has positive effects in cultured or animal models for Parkinson's disease, Huntington's disease, and so on. However, the potential therapeutic value of GT in treating epilepsy has not yet been reported. Methods: Effects of GT on epileptic seizure (seizure) in kainic acid [KA, 55mg/kg, intraperitoneal (i.p.)]-induced model of mice, excitotoxic (hippocampal) cell death in KA [0.2 ㎍, intracerebroventricular (i.c.v.)]-induced model of mice, and levels of proinflammatory mediators in lipopolysaccharide (LPS)-induced BV2 cells were investigated. Results: An i.p. injection of KA into mice produced typical seizure. However, it was significantly alleviated by oral administration of GT in a dose-dependent manner. An i.c.v. injection of KA produced typical hippocampal cell death, whereas it was significantly ameliorated by administration of GT, which was related to reduced levels of neuroglial (microglia and astrocyte) activation and proinflammatory cytokines/enzymes expression as well as increased level of the Nrf2-antioxidant response via the upregulation of LPAR 1/3 in the hippocampus. However, these positive effects of GT were neutralized by an i.p. injection of Ki16425, an antagonist of LPA1-3. GT also reduced protein expression level of inducible nitric-oxide synthase, a representative proinflammatory enzyme, in LPS-induced BV2 cells. Treatment with conditioned medium clearly reduced cultured HT-22 cell death. Conclusion: Taken together, these results suggest that GT may suppress KA-induced seizures and excitotoxic events in the hippocampus through its anti-inflammatory and antioxidant activities by activating LPA signaling. Thus, GT has a therapeutic potential to treat epilepsy.

• 자원환경지질
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• 제41권1호
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• pp.93-113
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• 2008

제주도 동부 저지대 (해발 200m 이내), 한동-종달-우도-수산-삼달-하천 지역의 20개 시추공에서 얻어진 화산암류의 암석학적 특징과 $^{40}Ar/^{39}Ar$절대연대를 보고하고, 이에 근거하여 이 지역의 지형형성과 화산활동에 대해 고찰한다. 이 지역의 지하에 분포하는 화산암류는 주로 현무암류(알칼리 현무암, 전이질 현무암, 솔리아이트질 현무암)와 솔리아이트질 안산암 및 현무암질 조면안산암으로 구성된다. 솔리아이트질, 전이질 및 알칼리암류가 서로 호층을 이루어 분포하는 것은 이 지역에서 이들 화산활동이 동시에 일어났었음을 지시한다. 특히, 조면현무암 혹은 현무암질 안산암이 이 지역의 기저부에 분포하는 점은 비교적 분화된 알칼리 화산활동이 먼저 시작되었음을 의미한다. 이 지역에 분포하는 화산암류의 $^{40}Ar/^{39}Ar$ 절대연대는 최고 $526{\pm}23Ka$에서 최저 $38{\pm}4Ka$이다. 동부 지역 저지대에서 용암류의 분출과 같은 하와이형 화산활동은 퇴적층의 관계, 화산암류의 전암 화학성분 및 $^{40}Ar/^{39}Ar$ 절대연대의 변화로 부터 다섯 단계로 구분된다. 즉, 서귀포층이 퇴적할 동안의, I-U기$(550{\sim}400Ka)$, II기$(400{\sim}300Ka)$, III기$(300{\sim}200Ka)$와 퇴적 이후 IV기$(200{\sim}100Ka)$, V기(100Ka이후)이다. 화산암류의 성분 변화 및 분포 지역의 차이 그리고 이들 시기 간에 분포하는 다양한 퇴적층(수성화산기원퇴적층 포함)의 존재는 화산활동이 오랜 기간 동안 간헐적으로 진행되었으며, 저지대의 육지지형이 화산활동 및 퇴적작용에 의해 내륙에서 해안으로 점진적으로 확대되면서 만들어졌음을 지시한다. 특히 시추코어 화산암의 $^{40}Ar/^{39}Ar$ 절대연대 자료는 제주도 동부 저지대 지역 대부분이 IV와 V 화산활동기 동안 분출된 200Ka 이내의 비교적 젊은 화산암류로 이루어져 있음을 지시한다. 이는 제주도 화산활동 시기 및 지형 형성에 대한 기존의 연구와는 상이한 결과이며, 화산암류의 K-Ar절대연대 자료를 바탕으로 한 기존의 제주도 화산활동 시기 구분이 재고되어야함을 확인하였다. 또한, 시추공에 근거한 화산 층서의 해석은 암석기재, 암석화학적 특징과 함께 절대연대 자료를 바탕으로 이루어져야 함을 강조한다.