• Tuberculosis and Respiratory Diseases
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• v.53 no.2
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• pp.113-126
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• 2002

Background : DNA repair plays a crucial role in protection from cancer-causing agents. Therefore, a reduced DNA repair capacity can increase the susceptibility to lung cancer. The XPC gene contains 15 exons and encodes a 940 amino acid protein that plays a central role in DNA damage recognition of the nucleotide excision repair pathway, which is a major DNA repair mechanisim removing the bulky-helix distorting DNA lesions caused by smoking. Recently several polymorphisms in the XPC gene were identified. In addition, it is possible that these polymorphisms may affect the DNA repair capacity, which modulate cancer susceptibility. The relationship between codon 499 and 939 polymorphisms, and a poly(AT) insertion/deletion polymorphism in the XPC gene, and the lung cancer risk were investigated. Materials and Methods : The genotypes were determined using either PCR or PCR-RFLP analysis in 219 male lung cancer patients and 150 healthy males controls. Results : The frequencies of the genotypes (Val499Ala, PAT and Lys939Gln) among the cases were not significantly different from those of the controls. There was no significant associantion between these polymorphi는 and the lung cancer risk when the analyses were stratified according to age, smoking status and the pack-years of smoking. Moreover, the genotypes had no apparent relationship with any of the histological types of lung cancer. There was a linkage disequilibrium among the Val499Ala, PAT and Lys939Gln polymorphisms. The PAT polymorphism had a strong linkage disequilibrium with the Lys939Gln polymorphism (kappa value=0.87). The XPC haplotypes showed no significant association with the lung cancer risk. Conclusion : These results suggest that XPC Val499Ala, PAT and Lys939Gln polymorphisms are not major contributors to the individual lung cancer susceptibility in Koreans.

• Journal of the Korean Society of Radiology
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• v.84 no.4
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• pp.900-910
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• 2023

Purpose To assess normal CT scans with quantitative CT (QCT) analysis based on smoking habits and chronic obstructive pulmonary disease (COPD). Materials and Methods From January 2013 to December 2014, 90 male patients with normal chest CT and quantification analysis results were enrolled in our study [non-COPD never-smokers (n = 38) and smokers (n = 45), COPD smokers (n = 7)]. In addition, an age-matched cohort study was performed for seven smokers with COPD. The square root of the wall area of a hypothetical bronchus of internal perimeter 10 mm (Pi10), skewness, kurtosis, mean lung attenuation (MLA), and percentage of low attenuation area (%LAA) were evaluated. Results Among patients without COPD, the Pi10 of smokers (4.176 ± 0.282) was about 0.1 mm thicker than that of never-smokers (4.070 ± 0.191, p = 0.047), and skewness and kurtosis of smokers (2.628 ± 0.484 and 6.448 ± 3.427) were lower than never-smokers (2.884 ± 0.624, p = 0.038 and 8.594 ± 4.944, p = 0.02). The Pi10 of COPD smokers (4.429 ± 0.435, n = 7) was about 0.4 mm thicker than never-smokers without COPD (3.996 ± 0.115, n = 14, p = 0.005). There were no significant differences in MLA and %LAA between groups (p > 0.05). Conclusion Even on normal CT scans, QCT showed that the airway walls of smokers are thicker than never-smokers regardless of COPD and it preceded lung parenchymal changes.

• Korean Journal of Plant Resources
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• v.31 no.2
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• pp.109-116
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• 2018

Erectile dysfunction (ED), also known as impotence, is the inability to attain and sustain an erection firm enough to have sexual intercourse. Frequent ED may be a symptom of health problems including heart disease, obesity, alcoholism, stress, smoking, and depression, that need treatment. This study aimed to effect of complex extract (CPL) including Cornus officinalis on sexual function factor in the erectile dysfunction rat model. The erectile dysfuction rat model was induced by cimetidine (500 mg/kg in 5% ethanol, oral injection 2 weeks). Rats were oral administered with different concentration of CPL in rat erectile dysfunction model. As a results, sexual function factors (NO, cGMP) significantly improved in CPL treated groups (CPL-300, 600, 900 mg/kg) compared to CON group. Serum testosterone was increased in a dose-dependent manner after CPL treatment. Furthermore, administrations of CPL restored lumen areas of the prostate in the erectile dysfunction rat model. These results indicated that CPL alleviated erectile dysfunction by increasing sexual function factor and testosterone in rat model. CPL could be used to natural treatement for erectile dysfunction. However, further study is required to identify active ingredient and its mechanism of erectile dysfunction.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.20 no.2
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• pp.111-118
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• 2010

연구목적: 본 연구는 일반인의 비직업적 노출에 대한 혈중 16종의 다환방향족탄화수소(PAHs) 의 농도르 분석하여 PAHs의 백그라운드 노출 농도를 평가하는 것이다. 내용 및 방법: 농촌지역에 거주(비직업적 노출로서 16종 다환방향족탄화수소가 특정한 환경오염을 받지 않은 지역에 거주)하는 156명의 연구 참여자의 혈중 16가지 다환방향족탄화수소 농도의 기하평균치를 간접흡연군, 구운 음식물섭취군과 각대조군을 비교 하였다. 혈중 16종의 다환방향족탄화수소의 농도는 질량분석기를 장착한 가스크로마토그라피법과 헤드스페이스 마이크로고체상 추출법에 의하여 분석하였다. 결과: 연구참여자 중, 간접흡연자들에서 4종의 다환방향족탄화수소 아세나프틸렌(p<0.01), 아세나프텐(p<0.1), 플로렌(p<0.01), 피렌(p=0.05)가 대조군 보다 유의하게 높았다. 또한 구운육류와 생선 섭취군에서는 벤조(a)피렌(p<0.1)이 대조군 보다 유의하게 높았다. 결론: 간접흡연과 구운음식물 섭취는 비직업적 노출에서 다환방향족탄화수소 노출원의 가능성이 높다고 추정된다. 혈중 다환방향족탄화수소는 한국일반인의 비직업적 노출 농도로 사용 가능하다고 생각된다.

• Korean Journal of Health Education and Promotion
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• v.14 no.1
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• pp.47-62
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• 1997

본 연구는 한국 보건전문가들의 보건행동을 조사하고, 보건행동간의 상호 관련 요인과 보건행동에 영향을 미치는 인구학적 요인을 분석하는데 그 목적이 있다. 본 연구 대상으로는 한국보건협회 산하의 8개의 보건 관련 학회 중에서 보건교육과 가장 관련이 있는 한국보건교육학회(212명)와 한국보건 간호학회 (124명) 회원 336명이 선정되었다. 본 연구의 도구는 미국에서 이미 실시된 여러 보건행동 연구를 기초로 하여 focus group discussion, back-translation, 전문가들의 panel discussion, 그리고 pilot test(사전조사)를 통하여 한국인의 보건행동 연구를 위해 타당하게 개발되었다. 본 연구를 위하여 1995년 약 두달동안(11월, 12월), 3차에 걸친 우편설문조사를 실시하여 64.3%의 응답회수율을 보였고, 응답자들의 보건행동을 분석하기 위해서 factor analysis(요인분석)와 ANOVA (변량분석) 방법을 사용하였다. 본 연구의 결과는 다음과 같다. 1. 조사응답자의 분포는 남자가 33.8%, 여자가 66.2%였고, 응답자의 80.3%가 석사 이상의 학위를 소유하고 있었다. 응답자들의 전공분야는 다양하였고, 그들 중에서 36.3%가 간호학, 24.4%가 공중보건학을 전공하였다. 응답자 중 과반수 이상이 학교에 근무하였고, 서울에 거주하였으며, 응답자의 평균 직장 근무연수는 14년 이였다. 2. 응답자들의 보건행동에 대한 요인분석 적용의 적합성을 사전검증하기 위하여 Bartlett’s Test of Sphericity (630.37, p〈.00)를 실시하였다. 응답자들의 보건행동을 요인분석한 결과, 17개의 보건행동으로 구성된 네가지 보건행동요인들이 추출되었다. 응답자들의 네가지 보건행동요인들은 다음과 같다: (1) 규칙적인 식사 및 과일 섭취 (2) 음주 및 흡연 (3) 외식,간식 및 카페인 음료 섭취 (4) 운동 및 휴식 3. 응답자들의 인구학적 요인과 네가지 보건행동요인들과의 관계를 분석한 결과, 성별(F=69.59, df=1,203, p〈.05), 교육정도(F=3.48, df=3,199, p〈.05) 그리고 직장(F=4.04, df=3,201, p〈.05)에 따라 음주 및 흡연 행동에 커다란 차이를 보였다. 또한 응답자의 직장 근무연수(F=2.39, df=5,185, p〈.05)에 따라 운동 및 휴식 행동에 커다란 차이를 보였다.

• The Journal of the Convergence on Culture Technology
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• v.1 no.1
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• pp.15-26
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• 2015

The purpose of this study was to analyze the sexual related predicting factors for Female University students in Korea. The cross-sectional descriptive study design was used. We selected 320 students from 6 Universities located in Seoul, Chungchung-do and Gangwon-do by convenience random sampling and received IRB from Y Univ. 299 students were included in the final analysis using logistic regression. Among 299 students, 60.2% of students reported to have sexual experience. The result of analyzing the related factors to sexual experience revealed that the students who were having friends who had sexual experience, smokers and those who were high grade, had significantly more sexual experience. According to the results of this study, there should be an intensive and female tailed sexual related program development for the University students, especially for smokers and including smoking cessation program. And the school health services of University combined general staff working should be strengthened to protect the University students from the critical situation caused by unwanted sexual experience.

• The Journal of Korean Society for School & Community Health Education
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• v.10 no.2
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• pp.55-68
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• 2009

연구목적: 본 연구는 미국 인디애나 주에 소재하는 중학교와 고등학교 학생들 사이의 methamphetamine, MDMA, GHB, and Rohypnol과 같은 약물사용 특성을 파악하고 청소년 약물사용과 관련된 성과 학교 환경에 대한 인지된 안전도 특성을 분석하였다. 연구방법: 본 분석에 사용된 데이터는 Indiana Prevention Resource Center (IPRC)에서 2007 년도에 수행한 음주, 흡연, 약물사용 설문조사(ATOD) 응답자료로서 인디애나 주에 거주하고 있는 6-12 학년 사이의 학생들을 편의추출하여 조사가 가능했던 158,632명의 응답을 얻었다. 연구결과: 로지스틱 회귀분석에서 조사한 4개 약물을 사용하는 학생들의 관심도는 교실에 있을 때, 복도에서 혼자 있을 때, 방과후 활동을 위해 학교에 남아있을 때 불안전하다고 느끼는 약물 미사용자보다 더 높은 경향을 보였다. GHB, MDMA, Rohypnol을 사용한다고 응답한 학생이 여자보다 남자에서 더 많았고 상관관계분석 결과, 메탐페타민을 비롯한 네 가지 약물 사용의 상호간 상관도가 모두 유의미하게 높았다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.19 no.1
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• pp.389-397
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• 2018

The purpose of this study is to evaluate the prevalence and related risk factors of problem drinking in the Korean adult population. Participants (n=7,867) aged 19 years or older were selected from the Korea National Health and Nutrition Examination Survey [KNHANES] of 2007-2008. Sociodemographic characteristics and AUDIT score were obtained from the KNHANES dataset. AUDIT scores were categorized into three groups, including low risk, intermediate risk, and high-risk alcohol drinking according to WHO guidelines. In this study, the prevalence of high-risk and intermediate-risk alcohol drinking were 12.2% and 21.0%, respectively. Adjusted mean AUDIT score was higher in men, younger individuals, as well as those with lower education levels and those that smoked. Results revealed that demographic variables, including sex, age, education level, and smoking, were important factors affected high-risk drinking. In particular, since smoking was the most significant risk factor, the adjusted odds ratio for high-risk drinking among participants that smoked was 4.78 [(95% confidence interval (CI)=3.75-6.10, p<.0001)]. This study suggests that men, younger age, low educational level, and smoking are the risk factors for a high-risk alcohol drinking.

• The KIPS Transactions:PartB
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• v.16B no.6
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• pp.471-478
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• 2009

The lung diseases classifying as one of the six incurable diseases in modern days are caused mostly by smoking and air pollution. Such causes the lung function damages, and results in malfunction of the exchange of carbon dioxide and oxygen in an alveolus, which the interest is augment with risk diseases of life prolongation. With this in the paper, we proposed a diagnosis method of lung diseases by applying parameters of voice analysis aiming at the getting the voice feature extraction. Firstly, we sampled the voice data from patients and normal persons in the same age and sex, and made two sample groups from them. Also, we conducted an analysis by applying the various parameters of voice analysis through the collected voice data. The relational significance between the patient and normal groups can be evaluated in terms of speech rates and intensity as a part of analized parameters. In conclusion, the patient group has shown slower speech rates and bigger intensity than the normal group. With this, we propose the method of voice feature extraction for lung diseases.

• Korean Journal of Food Science and Technology
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• v.33 no.6
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• pp.656-663
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• 2001

The most representative nitrosamine derived from nicotine, nitrosamine-4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone(NNK), has been reported to cause lung cancer in A/J mice. It has been also demonstrated that NNK-induced lung tumorigenesis involves $O^6-methylguanine(O^6MeG)$ formation, leading to $GC\;{\rightarrow}\;AT$ transitional mispairing during DNA replication. Our in vitro experiment, modified from the method of DBA assay, examined the ability of phyto-extract mixture to inhibit the metabolism of nicotine to nitrosamines. The production of nitromorpholine from morpholine was inhibited about 75% at the concentration of 20 mg/mL of phyto-extract mixture, which was lower than vitamine C and green tea powder. NNK, which is a pro-carcinogen in laboratory animals, is hydroxylated primarily in liver and lung by CYP 1A2, 2A6 and 3A4. A critical phase. of NNK activation is its change to an unstable metabolite methyl-diazohydroxide via CYP-mediated ${\alpha}-hydroxylation$; and then it provides a methyl group to the DNA to form DNA adducts which can easily induce mutations. $Aroclor^R$ 1254 was used to induce CYPs in the liver of a Sprague-Dawley rat. The ability of various test samples to inhibit CYPs that participate in NNK activation was evaluated, following the removal of the liver from the rat. Microsomal CYPlA2 catalyzing the conversion of NNK into strong carcinogenic chemicals was inhibited more efficiently by phyto-extract mixture than green tea powder. These results indicate that phyto-extract mixture can be used to reduce $O^6MeG$ DNA adducts for chemoprevention.