• Title/Summary/Keyword: 효종

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Study on Antiestrogenic Effects of Tamoxifen in Immature Rat Uterus: III. Effects on Content of DNA and Protein and Uterine Wet Weight (미성숙 쥐 자궁에서 Tamoxifen의 Antiestrogen 효과에 관한 연구 : III. DNA 함량, 단백질 함량 및 자궁의 중량에 관하여)

  • Lee, Hyo-jong;Jo, Choong-ho;Park, Moo-hyun
    • Korean Journal of Veterinary Research
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    • v.27 no.1
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    • pp.9-17
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    • 1987
  • The present study has been carried out to elucidate the antiestrogenic effects of tamoxifen in immature rat uterus. The content of DNA and protein and uterine wet weight were measured after the injections of $5{\mu}g$ of estradiol-$17{\beta}$, $50{\mu}g$ of tamoxifen, a combination of both, or vehicle only subcutaneously. The results obtained were summarized as follows: 1. DNA content in uterus was increased at 48 hours after estradiol-$17{\beta}$ or tamoxifen injection (p<0.01). 2. The increament rate of uterine DNA content was significantly (p<0.01) lower in tamoxifen treated group than that in estradiol-$17{\beta}$ treated group. 3. Antiestrogenic effect of tamoxifen on protein content in uterus was apparent at 72 hours after simultaneous administration of both drugs. 4. The uterine wet weight was started to increase at three hours after the injection of estradiol-$17{\beta}$ or tamoxifen. 5. While estradiol-$17{\beta}$ increased steadily uterine wet weight up to 138.5mg at 72 hours after the injection, but tamoxifen failed to increase it after 48 hours. Tamoxifen inhibited significantly (p<0.01) the effect of estradiol-$17{\beta}$ on it thereafter.

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Characterization of the SnAg Electrodeposits according to the Current Density and Cross-sectional Microstructure Analysis in the Cu Pillar Solder Bump (전류밀도에 따른 SnAg 도금층의 특성 및 Cu 필라 솔더 범프의 단면 미세구조 측정)

  • Kim, Sang-Hyuk;Hong, Seong-Ki;Yim, Hyunho;Lee, Hyo-Jong
    • Journal of the Korean institute of surface engineering
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    • v.48 no.4
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    • pp.131-135
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    • 2015
  • We investigated the surface morphology and the change of Ag concentration for SnAg electrodeposits according to the current density using labmade and commercial plating solutions. The concentration of Ag in the SnAg electrodeposits decreased with increasing the current density. The Ag concentrations at the conditions of over $50mA/cm^2$ were below 3 wt% and the surface was relatively smooth. Cu pillar bump was fabricated by using SnAg electroplating, and it was reflowed at $240^{\circ}C$ for 90 sec. The cross-sectional microstructure was investigated by using EBSD measurement and it was found that the grain size of SnAg became smaller by increasing the number of reflow treatments.

Impact of SAPHIR Data Assimilation in the KIAPS Global Numerical Weather Prediction System (KIAPS 전지구 수치예보모델 시스템에서 SAPHIR 자료동화 효과)

  • Lee, Sihye;Chun, Hyoung-Wook;Song, Hyo-Jong
    • Atmosphere
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    • v.28 no.2
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    • pp.141-151
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    • 2018
  • The KIAPS global model and data assimilation system were extended to assimilate brightness temperature from the Sondeur $Atmosph{\acute{e}}rique$ du Profil $d^{\prime}Humidit{\acute{e}}$ Intertropicale par $Radiom{\acute{e}}trie$ (SAPHIR) passive microwave water vapor sounder on board the Megha-Tropiques satellite. Quality control procedures were developed to assess the SAPHIR data quality for assimilating clear-sky observations over the ocean, and to characterize observation biases and errors. In the global cycle, additional assimilation of SAPHIR observation shows globally significant benefits for 1.5% reduction of the humidity root-mean-square difference (RMSD) against European Centre for Medium-Range Weather Forecasts (ECMWF) Integrated Forecast System (IFS) analysis. The positive forecast impacts for the humidity and temperature in the experiment assimilating SAPHIR were predominant at later lead times between 96- and 168-hour. Even though its spatial coverage is confined to lower latitudes of $30^{\circ}S-30^{\circ}N$ and the observable variable is humidity, the assimilation of SAPHIR has a positive impact on the other variables over the mid-latitude domain. Verification showed a 3% reduction of the humidity RMSD with assimilating SAPHIR, and moreover temperature, zonal wind and surface pressure RMSDs were reduced up to 3%, 5% and 7% near the tropical and mid-latitude regions, respectively.

Reduction of Postoperative Adhesions by a Synthetic Solution of Sodium Carboxymethylcellulose and Dextran or Interceed Following Intestinal Anastomosis in Dogs (개의 장문합술에 있어서 Sodium Carboxymethylcellulose와 Dextran의 합제 및 Interceed)

  • Jang Young-kyu;Kim Hyeon-hui;Lee Hee-chun;Yeon Seong-chan;Lee Hyo-jong
    • Journal of Veterinary Clinics
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    • v.21 no.4
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    • pp.349-354
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    • 2004
  • The effectiveness of a synthetic solution of sodium carboxymethy1cellulose (SCMC) and dextran in the prevention of adhesion formation following intestinal anastomosis of intestine in dogs was elucidated and compared with Interceed. Following induction of adhesion on jejunum of dogs by resection and intestinal anastomosis, the dogs were infused with a synthetic solution of 1% SCMC and 10% dextran in saline in the abdominal cavity at the dose of 5ml/kg of body weight or treated with Interceed membrane. Fourteen days after operation, all the dogs showed adhesion of anastomotic sites to surrounding tissues. The average score of adhesion was 0.50, 0.60 and 0.80 in the dogs infused with the synthetic solution, Interceed membrane and saline solution, respectively. The synthetic solution showed better result of adhesion prevention than Interceed or saline solution. No significant change of body weight, vital signs, hematological values and side effects after operation was found in each group. Therefore, a synthetic solution which is combined with 1% SCMC and 10% dextran in saline can be effectively used for the prevention of adhesion formation comparable to Interceed membrane following intestinal anastomosis in the dogs.

The Effect of grain size on the damping capacity of Fe-26Mn-2Al alloy (Fe-26Mn-2Al 합금의 진동 감쇠능에 미치는 결정립 크기의 영향)

  • Kang, C.Y.;Eom, J.H.;Kim, H.J.;Sung, J.H.
    • Journal of Power System Engineering
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    • v.11 no.1
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    • pp.115-120
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    • 2007
  • The effect of grain size on the damping capacity of Fe-26Mn-2Al alloy studied in this paper has been investigated after changing the microstructure by cold rolling and changing grain size. Micro structures in Fe-26Mn-2Al at room temperature consist of a large quantity of austenite and a small quantity of ${\varepsilon}\;and\;{\alpha}'$ martensite. And ${\varepsilon}\;and\;{\alpha}'$ martensite was increased by increasing the degree of cold rolling. The content of deformation induced martensite was increased with increasing the degree of cold rolling. Damping capacity was linearly increased with increasing ${\varepsilon}$ martensite content, which suggests that stacking faults and ${\varepsilon}$ martensite variant boundaries are the principle damping sources. With increasing the grain size in Fe-26Mn-2Al alloy, the damping capacity was increased due to increasing the volume fraction of ${\varepsilon}$ martensite by decrement in stability of austenite phase. With decreasing the grain size, the content of deformation induced martensite was decreased and the damping capacity was decreased.

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Ultrasonographic Diagnosis of Pneumoperitoneum Associated with a Mast Cell Tumor in a Dog (개에서 비만세포종과 관련된 기복증의 초음파학적 진단례)

  • Wang, Ji-Hwan;Park, Ki-Tae;Lee, Kyung-Woo;Yeon, Seong-Chan;Lee, Hyo-Jong;Lee, Hee-Chun
    • Journal of Veterinary Clinics
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    • v.27 no.4
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    • pp.483-487
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    • 2010
  • A 7-year-old female maltese dog with anorexia and vomiting for a week, and left axillary and perineal mass was admitted to Gyeongsang National University Veterinary Teaching Hospital. CBC revealed mild leukocytosis and severe anemia. Abdominal radiography revealed multiple gas opacities in upper abdomen. On ultrasonography, large amount of echogenic free abdominal fluid were detected. In addition, There are enhanced peritoneal strip sign (EPSS) indicating peumoperitoneum in the upper abdomen. Fine needle aspiration of the mass was performed and the result was mast cell tumor. Duodenal perforation caused by mast cell tumor was identified on laparotomy.

Medical Imaging of Pyothorax in a Dog (개에서 농흉증의 영상의학적 접근)

  • Choi, Ho-Jung;Lee, Young-Won;Park, Ki-Tae;Wang, Ji-Hwan;Kim, Young-Ki;Yeon, Seong-Chan;Lee, Hyo-Jong;Lee, Hee-Chun
    • Journal of Veterinary Clinics
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    • v.27 no.1
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    • pp.107-112
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    • 2010
  • A 3-years-old female Pointer was evaluated for anorexia, dyspnea and exercise intolerance for 10 days. Auscultation revealed muffling of heart sound. There were leukocytosis, anemia, hypoalbuminaemia and hyperglobulinaemia on the blood profiles. Radiography showed severe pleural effusion. Thorax ultrasonographs described traped pleural effusion, pericardial effusion and collapsed right lung lobe(s). On CT images, thoracic neoplasia and lung torsion were ruled-out. Thoracocentesis with thoracoscopy and bacterial culture revealed pyothorax and pleuritis. The diagnosis of pyothorax in dogs and cats is based on clinical signs, radiography, thoracocentesis and cytology and culture of the exudate. In this case, various diagnostic medical imaging techniques (radiography, ultrasonography, CT and thoracoscopy) were used for diagnosis of pyothorax.

Medical Imaging of Ventricular Septal Defect in Two Dogs (개에서 심실중격결손의 영상의학적 진단 2례)

  • Choi, Ho-Jung;Lee, Young-Won;Wang, Ji-Hwan;Park, Ki-Tae;Yeon, Seong-Chan;Lee, Hyo-Jong;Lee, Hee-Chun
    • Journal of Veterinary Clinics
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    • v.25 no.5
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    • pp.420-423
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    • 2008
  • Ventricular septal defects (VSDs) is an opening in the ventricular septum that allows blood to flow between the ventricles. Most ventricular septal defects are located in the upper ventricular septum and can be identified by auscultation. In this report, 2 dogs with heart murmur were diagnosed as VSD using radiography and echocardiography. In radiographs, bulging sign of the main pulmonary artery or the enlargement of the left ventricle was observed. The color Doppler examination showed the left-to-right shunting of blood via interventricular septal defect.

A Study on Antiestrogenic Effects of Tamoxifen in Immature Rat Uterus; I. Effects on Concentrations of Cytosol and Nuclear Estradiol Receptor (미성숙 쥐 자궁에서 Tamoxifen의 Antiestrogen 효과에 관한 연구 : I. 세포질 내 및 핵 내 Estradiol 수용체 농도의 변화에 관하여)

  • Lee, Hyo-jong;Jo, Choong-ho;Park, Moo-hyun
    • Korean Journal of Veterinary Research
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    • v.25 no.2
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    • pp.187-195
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    • 1985
  • The Present study has been carried out to elucidate the antiestrogenic effects of tamoxifen in uteri of immature rats. Immature female Sprague-Dawley rats were allocated into 4, groups and injected with $5{\mu}g$ of estradiol-$17{\beta}$, $50{\mu}g$ of tamoxifen, a combination of both or vehicle only subcutaneously three times after an interval of 24 hours respectively. The concentrations, of cytosol estradiol receptor in uterus were measured by DCC method before and 1, 3, 6, 12, 24, 48 and 72 hours after the above treatments and those of nuclear estradiol were measured by protamine exchange method 72 hours and those of nuclear estradiol were measured by protamine exchange method 72 hours after the above treatments. The results obtained were summarized as follows: 1. The binding affinity of tamoxifen to estradiol receptor in uterine cytosol was lower than that of estradiol-$17{\beta}$, accordingly the translocation of estradiol receptor into the nucleus was found to be delayed. 2. Tamoxifen caused the retention of estradiol receptor in nucleus over 24 hours and inhibited the replenishment of the receptor from nucleus to cytosol in uterus.

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In vitro maturation of porcine follicular oocytes (돼지 난포내 난모세포의 체외성숙에 관하여)

  • Park, Mi-hee;Lee, Hyo-jong
    • Korean Journal of Veterinary Research
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    • v.32 no.1
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    • pp.135-142
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    • 1992
  • This experiment was carried out to establish an effective technique of in vitro maturation of porcine follicular oocytes. Porcine ovaries were collected from an abbatoir and delivered to the laboratory in phosphate buffered saline in an hour. Immatured follicular oocytes were collected from the ovaries and divided into groups by the size of follicles and by the attachment of granulosa cells. The follicular oocytes were cultured in m-KRB solution supplemented with FCS(10%), follicular fluid(10%) or hormones of PMSG(10IU/ml), hCG(10IU/ml ) and $estradiol-17{\beta}(1{\mu}g/ml)$ for 48 hours at $39^{\circ}C$ under an atmosphere of 5% $CO_2$ in air. The results are as follows ; 1. The mean recoveration rate of follicular oocytes was 61.8%. 2. The maturation rate was significantly(p<0.05) higher when the oocytes were collected from large-sized follicles and under good state of granulosa cell attachment. 3. The maturation rate was significantly(p<0.01) promoted when the follicular oocytes were cultured in m-KRB solution supplemented with follicular fluid(74.8%) or hormones and fetal calf serum(70.6%).

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