• YAKHAK HOEJI
• /
• v.56 no.5
• /
• pp.314-319
• /
• 2012

Age-related macular degeneration (AMD) is the leading cause of vision loss and blindness among the elderly. In this study, extract of Vaccinium uliginosum L. that has potent antioxidant activity was evaluated as effective preventive supplement for AMD using AMD animal model induced by high fat diet and UV A irradiation. Treatment with VU extract protected photoreceptor cells of retina and blocked the accumulation of lipofuscin pigment-granules induced by high fat diet and UV A light irradiation. This study suggests that VU extract may be a useful agent for prevention of progress of AMD.

• Proceedings of the Korea Information Processing Society Conference
• /
• 2024.05a
• /
• pp.580-581
• /
• 2024

고령화 사회에 접어들면서 황반 변성과 당뇨 망막 병증 등 시야결손을 동반하는 안구 질환의 발병률은 증가하지만 이러한 질환의 조기 발견에 인공지능을 접목시킨 연구는 부족한 실정이다. 본 논문은 안구 질환 자가 검사용 인공 신경망을 학습시키기 위한 데이터 베이스 구축 방법을 제안한다. MNIST와 CIFAR-10을 합성하여 중첩 이미지 데이터셋인 G-Dataset을 생성하였고, 7개의 인공신경망에 학습시켜 최종적으로 90% 이상의 정확도를 얻음으로 그 유효성을 입증하였다. G-Dataset을 안구 질환 자가 검사용 딥러닝 모델에 학습시켜 모바일 어플에 적용하면 사용자가 주기적인 검사를 통해 안구 질환을 조기에 진단하고 치료할 수 있을 것으로 기대된다.

• Journal of Korean Clinical Nursing Research
• /
• v.27 no.1
• /
• pp.54-65
• /
• 2021

Purpose: The purpose of this study was to identify influencing factors on vision-related quality of life in patients with retinal diseases receiving intravitreal injections by examining relationships among anxiety, depression, coping, eye health behaviors and vision-related quality of life. Methods: One hundred and five outpatients who were diagnosed with macular degeneration and diabetic retinopathy were recruited from one university hospital during August 16, 2019 to March 25, 2020. Data were analyzed using descriptive statistics (frequency and percentage, mean, standard deviation), and t-tests, ANOVA, Scheffé test, Pearson's correlations, and stepwise multiple regressions using the IBM SPSS Statistics 25.0. Results: The vision-related quality of life according to general characteristics of retinal disease patients with intravitreal injection showed significant differences in age (F=3.01, p=.034), subjective economic status (F=5.83, p=.004), types of retinal disease (t=2.62, p=.010), and disease in both eyes (t=-3.04, p=.003). The vision-related quality of life showed a significant positive correlation with age (r=.24, p=.012), and negative correlations with anxiety (r=-.66, p<.001), depression (r=-.48, p<.001), and emotion-focused coping (r=-.20, p=.036). The hierarchical regression analysis indicated that factors affecting vision-related quality of life in patients with retinal diseases were anxiety and subjective economic status, accounting for 47.0% of the variances of the vision-related quality of life. Conclusion: Based on our results, health professionals need to pay attention to patients with low socioeconomic status due to frequent treatments. Also, a program needs to be developed to decrease anxiety for outpatients receiving intravitreal injections to improve their vision-related quality of life.

• Journal of Internet Computing and Services
• /
• v.25 no.3
• /
• pp.19-25
• /
• 2024

The worldwide aging population trend is causing an increase in the incidence of major retinal diseases that can lead to blindness, including glaucoma, cataract, and macular degeneration. In the field of ophthalmology, there is a focused interest in diagnosing diseases that are difficult to prevent in order to reduce the rate of blindness. This study proposes a deep learning approach to accurately diagnose ocular diseases in fundus photographs using less data than traditional methods. For this, Convolutional Neural Network (CNN) models capable of effective learning with limited data were selected to classify Conventional Fundus Images (CFI) from various ocular disease patients. The chosen CNN models demonstrated exceptional performance, achieving high Accuracy, Precision, Recall, and F1-score values. This approach reduces manual analysis by ophthalmologists, shortens consultation times, and provides consistent diagnostic results, making it an efficient and accurate diagnostic tool in the medical field.

• Journal of Korean Ophthalmic Optics Society
• /
• v.16 no.2
• /
• pp.209-217
• /
• 2011

Purpose: In this study, eye-health inequity was investigated by analyzing the relationship between household incomes and eye-health of senior citizens. Further, this study suggested the preliminary data for establishment of public eye-health policy in order to improve low income senior citizens' life quality. Methods: The data from the 2009 Survey of Korea National Health and Nutrition Examination were analyzed in this study. The objectives of the KNHNE survey were over 65 year old group (1,668 people). Main factors of eye-health (visual acuity, cataract, pterygium, intraocular pressure, retinophathy, age-related macular degeneration, diabetic retinophathy, myopia, hyperopia, astigmatism, and anisometropia prevalence) were analyzed with t-test and chi square test. Results: Low income group revealed that refractive error rate and intraocular pressure were low, however, naked eye visual acuity and corrected visual acuity were high at 0.1 to less than 0.5. On the other hands, in the high income group, there was high prevalence of hyperopia. Cataract mainly occurred at low income group besides group which maximum corrected visual acuity was below 0.8 also highly showed cataract. Moreover, the prevalence of cataract showed that it related with smoking, drinking, occupation, and education level. Conclusions: Results revealed that there was inequity of eye-health which related with socioeconomic status of the elderly. Especially, the prevalence of cataract was correlated with life quality. Consequently, establishment of public eye-health policy seems to be required for eye-health inequity of low income senior citizens.

• Journal of Korean Ophthalmic Optics Society
• /
• v.18 no.4
• /
• pp.489-493
• /
• 2013

Purpose: This study was to investigate peripheral vision and provide people with macular degeneration with a guideline for eccentric viewing training. Methods: 30 adult subjects with normal vision took part in this study. The lateral area of $20^{\circ}$ eccentricity from the fovea of right eye was only used to measure the physiological summation. The target was sinusoidal vertical gratings within a circular aperture. The critical points in spatial and temporal summation was found to compare each other for 0.7 cpd and 3.0 cpd, respectively. Results: Critical duration and contrast sensitivity for 0.7 cpd were 540 ms and 1.1, and 315 ms and 0.98 for 3.0 cpd respectively. The critical degrees and contrast sensitivity for 0.7 cpd were $11.3^{\circ}$ and 2.8, and $5^{\circ}$ and 2.63 for 3.0 cpd respectively. Conclusions: The critical point in peripheral vision reaches relatively faster than the one in central vision. It is recommended to train the peripheral retina under the lower spatial frequency more frequently for a short time than constantly for a long time.

• Journal of Korean Ophthalmic Optics Society
• /
• v.10 no.1
• /
• pp.27-34
• /
• 2005

Photochromic lens is the color changing lens from colorlessness to colorness when exposed to UV light. It can protect eyes from UV-B light which cause the cataract and can be used as sunglass in the summer since it can cut off 70~80% of sun light. Surface coating technique was used to develop lens which has 70% light transmittance and of which fading time of color change is within 5 min. Various color lenses were developed so that these had various color such as blue, green, brown, violet, yellow and red etc. Lens has an excellent physical properties, 100% adhesion and 4~5H hardness. The chemical and the scratch resistance of this lens were the greatest and the thermal stability was also higher. The clinical trial of developed lens were applied to 65 patients who had photophobia by various reasons at ophthalmology of Soonchunhyang University Hospital. Results showed that glaring was significantly reduced and the visual health were remarkably improved. Especially, anti-glaring effect in the night was great for the patient who had the LASIK operation. Protection of UV-B and blue light also can prevent the patient from cataract and the yellowish crystalline lens at old ages. Through the result of clinical. trial, we know that photochromic lens could be a new technique for both cure and precaution of photophobia.

• Journal of Life Science
• /
• v.32 no.11
• /
• pp.865-871
• /
• 2022

Tenebrio molitor larvae is well known as edible insect. Then, although it has been widely studied that Tenebrio molitor larvae has various bioactive functions such as antioxidant, anti-wrinkle, and anticancer. Nevertheless, antioxidant effects of Tenebrio molitor larvae water extract (TMH) has not been well described in Adult Retina Pigment Epithelial cell line (ARPE-19). In this study, we demonstrated that antioxidant effects of TMH against H₂O₂-induced oxidative stress in ARPE-19. Thus, we selected for our studies and performed a series of dose-response assay to determine the working concentration that lead to a consistent and high degree of cytotoxicity, which we defined as the level of H₂O₂ that killed 40% of the ARPE-19 cells. ARPE-19 cells were pre-treated with various concentrations of TMH (0.1 up to 2 mg/ml) before exposure to 300 µM H₂O₂. As we expected, TMH effectively prevented ARPE-19 cells from 300 µM H₂O₂-induced cell death in a dose-dependent manner. Furthermore, TMH inhibited the phosphorylation of mitogen-activated protein kinases (MAPKs) such as extracellular signal regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. Overall, the inhibitory effects of TMH on H₂O₂-induced apoptosis and oxidative stress were associated with the protection cleaved caspase-3, Bax, Bcl-2, and HO-1. The TMH suppressed H₂O₂-induced cell membrane leakage and oxidative stress in ARPE-19 cells. Thus, these results suggest that the TMH plays an important role in antioxidant effect in ARPE-19.

• Journal of Korean Ophthalmic Optics Society
• /
• v.21 no.1
• /
• pp.69-76
• /
• 2016

Purpose: The study was conducted to determine that photoreceptors of mouse having pigment in RPE(retinal pigment epithelium) can be damaged by blue-light and apoptosis of specific cells among photoreceptors are induced by blue-light, and to assist the investigation of AMD(Age-related macular degeneration) mechanisms and development of AMD drugs. Methods: C57Black mice were injured by irradiating $2800{\pm}10lux$ of 463 nm LED for 6 hours after 24 hours dark adaptation and eyes were enucleated 1, 3, 7 days. Damage of retina induced by blue-light was determined by western blotting GFAP(Glial fibrillary acidic protein) expression. In the light-injured retina, cell death of photoreceptors was determined by TUNEL(Terminal deoxynucleotidyl transferase dUTP nick end labeling) assay. ERK(Extracellular signal-regulated kinases), JNK, and SRC(sarcoma) expression were assessed by western blotting to determine regulated pathway. Blue light-injured retina were immunostained with antibodies against Opsin and Rhodopsin as markers of photoreceptors to compared the damage cone cells with rod cells. Results: After 1, 3 and 7 days from exposure to blue-light, thickness of retina was more decreased than control, and more decreased at nuclear layer than at outer plexiform layer and GFAP expression was increased day 1 after blue-light injured. While phosphorylated ERK and SRC protein expressions at day 1 were increased after blue-light injured, phosphorylated c-JUN was decreased. Fluorescence intensity analysis showed that markers of cone and rod cells were decreased after blue-light injured and Opsin was more decreased than Rhodopsin. Conclusions: The study suggests possibilities that the blue-light promotes retinal damage and causes apoptotic cell death via ERK and SRC pathway in mouse retina, and blue-light retinal damage is more induced cone cells apoptosis than rod cells directly.

• Journal of Life Science
• /
• v.29 no.11
• /
• pp.1273-1280
• /
• 2019

Age-related macular degeneration (AMD) is one of the leading causes of blindness in the elderly population, and damage to retinal pigment epithelial (RPE) cells due to oxidative stress contributes to the development of AMD. Glycyrrhiza uralensis Fischer is one of the most widely used herbal medicines for the treatment of various diseases in Asian countries. Although recent studies indicated that treatment with G. uralensis can protect cells from oxidative stress, its mechanisms in RPE cells remain unknown. We evaluated the effect of a G. uralensis ethanol extract (GU) on $H_2O_2$-induced oxidative injury in ARPE-19 RPE cells. The GU pretreatment attenuated reactive oxygen species (ROS) generation induced by $H_2O_2$, which was associated with induced expression of nuclear factor erythroid-derived-2-like 2 (Nrf2) and heme oxygenase-1 (HO-1). GU also suppressed $H_2O_2$-induced DNA damage and mitochondrial dysfunction. The inhibitory effect of GU on $H_2O_2$-induced apoptosis was associated with the protection of caspase-3 activation. Overall, GU appeared to protect RPE cells from oxidative injury by inhibiting DNA damage and reducing apoptosis. Further studies are needed to determine the regulation of Nrf2-mediated HO-1 expression, but our results suggest the possibility of using GU to reduce the risk of AMD.