• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.187-187
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• 1994

선경인더스트리 연구소에서 개발된 100 여종의 새로운 백금착체 항암제 중 그 동안의 전임상연구를 통해 항암효과가 우수하고 안정성이 확인된 항암제인 SKI 2053R의 인체내 최대내약용량을 결정하고 부작용 및 항암효과를 평가하고 약제의 인체내 약동학적 특성을 검토하기 위해 각종 악성종양 환자들을 대상으로 제 1상 임상연구를 시행하였다. 약제의 투여는 500m1의 5% 포도당용액에 용해하여 1시간에 걸쳐 정주하였으며 병의 악화나 심한 독성이 없으면 치료를 매 4주마다 반복하였다. SKI 2053R의 초기용량은 생쥐에서의 LD$_{10}$의 1/10에 해당하는 40 mg/$m^2$로 하였고, 용량의 단계별 증가는 modified Fibonacci법에 따랐다. 각 단계별로 3명이상의 환자를 치료하여 WHO 기준상 3도 이상의 부작용이 2/6 이상에서 나타날 때의 용량을 최대내약용량으로 설정하였다.

• Journal of The Korea Institute of Healthcare Architecture
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• v.8 no.2
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• pp.67-72
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• 2002

본 연구는 경제성장과 함께 빠르게 발전하고 있는 중국의료시설의 최근 의료 환경과 의료시설의 변화 동향을 분석한 것으로 병원의 디자인, 병동 유니트 계획, 의료자원의 지역적 불균형과 건축기준 등 다각도의 변화 동향을 사진, 도면과 함께 제시하였으며, 중국 의료시설의 문제점과 과제를 정리하였다. 중국의 의료시설은 현재 급속한 성장기에 놓여 있으며, 그 과정에서 의료자원의 대도시 집중과 병원의 대형화 현상으로 지역적 의료자원의 불균형 문제가 나타나고 있고, 환자부족으로 중소병원의 경영문제가 심각한 반면, 대규모 병원은 환자집중으로 긴 대기시간과 혼잡함 등의 문제가 나타나고 있다. 또한 대규모병원과 중소병원 간 의료자원의 과다한 중복으로 비효율성 문제가 지적되고 있어 합리적인 경제기반에 기초한 효율적인 의료시설과 건물시스템을 어떻게 개발할 것인가 하는 점이 중국 의료시설의 큰 과제중의 하나가 되고 있다.

• Journal of IKEEE
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• v.20 no.1
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• pp.16-25
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• 2016

Turnaround time (called, TAT) for imaging test, which is necessary for making a medical diagnosis, is directly related to the patient's waiting time and it is one of the important performance criteria for medical services. In this paper, we measured the TAT from major imaging tests to see it met the reference point set by the medical institutions. Prediction results from the algorithm of classification regression tree (called, CART) showed "clinics", "diagnosis", "modality", "test month" were identified as main factors for timely processing. This study had a contribution in providing means of prevention of the delay on medical services in advance.

• Journal of radiological science and technology
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• v.29 no.2
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• pp.93-98
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• 2006

Satisfaction of the patient against the medical service in department of radiology and it evaluated the different recognition of radiological technologist and patient. and investigates it's improvement direction. It sent the reply the above the which is a usual result in question result of the most that, the receipt process it was complicated in the portion which is insufficient,"The receipt process is complicated", "waiting time is long"and "don't radiation protection for patient and guardian". Also these a facts was recognizing patients and radiological technologist all. And the effort of the radiological technologist is necessary with the method which reduces a recognition difference. The periodical medical service satisfaction investigates and must endeavor in reform measure preparation.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6201-6213
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• 2015

The purpose of this study was to investigate the effect of Reality Orientation Therapy and Spaced Retrieval Therapy of the applied of CERAD-K type cognitive rehabilitation program for mild Alzheimer's patients. The tool used to this study was CERAD-K neuropsychological test consists of Boston Naming, a simple mental status, the word list recall, and configure behavior. A non-equivalent control group pretest-posttest design was used. The participants were 85 mild Alzheimer's patients (experimental group: 32, control group: 53) who registered G Health Center, in Gyeonggi province. Those Data were collected from 10:00 to 11:00, 14:00 to 15:00, twice a week on Tuesday and Friday, 8 session, from September 1 to September 30, 2014. Control group was participated daily routine program only in the G public health center.The data were analyzed using SPSS WIN 21.0 program. The results of this study were as follows;Boston Naming(F=3.22, p<.001), simple mental status(F=5.92, p<.001), and configure behavior(F=4.67, p<.001) were accepted, but word list recall(F=.75 p>.05) was not accepted. The study findings indicate that the Reality Orientation Therapy and Spaced Retrieval Therapy of the applied of CERAD-K type cognitive rehabilitation program is effective and can be recommended as intervention for mild Alzheimer's patients.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.9
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• pp.5578-5584
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• 2014

In this study, 46 patients from a local hemodialysis center were enrolled to assess the effects of a self-motivated virtual reality (VR) exercise program on the heart rate variability and quality of life control in hemodialysis patients. The VR group (n = 23) completed a VR exercise program, where the subjects performed the exercise 40 min per session, 3 sessions per week, for 8weeks. After the exercise program, the heart rate variability and quality of life were measured. The VR group showed significant improvement in the heart rate variability and quality of life. The self-motivated VR exercise program provided both the role of supervisor as well as feedback, which is important for hemodialysis patients.Therefore, a self-motivated VR exercise program may be a useful tool for improving the psychosocial function in chronic disease patients undergoing hemodialysis.

• Journal of Convergence for Information Technology
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• v.8 no.3
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• pp.71-77
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• 2018

In this paper, considering the oxygen sensitivity and preference pattern of the patient, the profile of the oxygen therapy of the individual is specified. And, we design a three-compartment, single compartment oxygen chamber that automatically adjusts the oxygen pressure according to the specified profile. Hyperbaric oxygen therapy is a method of providing patients with 100% oxygen higher than atmospheric pressure for therapeutic purposes. However, there is a disadvantage that the ear pain is caused by the pressure difference depending on the individual. Based on the embedded system, the proposed system creates a patient-tailored oxygen therapy profile by DB of patient's preference patterns and treatment records of oxygen therapy. If only the patient's name is entered, the oxygen chamber system can adjust the oxygen pressure automatically according to the profile pattern to maximize the oxygen treatment effect.

• Progress in Medical Physics
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• v.20 no.2
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• pp.112-118
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• 2009

The source position and source dwelling time in a given source arrangement in the applicators is very high effect to determine the expose time which in general is derived from the brachytherapy planning system. In high dose rate (HDR) intracavitary radiation therapy (ICRT), the treatment is often performed in based out-patient during the whole fractionation irradiations. However, the patient should be waited on coutch for ICR treatment in first start fraction as unconvinent and immobilized state until perform the dose plannings. In our experiments, the HDR source contributed dose for$55.89{\pm}4.20%$ for straight tandem source, $38.14{\pm}4.46%$ for the right ovoid soucre on the fornix and$5.97{\pm}0.50%$ for left ovoid source. It also showed the $60.33{\pm}6.53%$ for the tandem, $33.10{\pm}6.74%$ for right ovoid and $6.58{\pm}0.30%$ for the left ovoid source in 10 degrees of applicator. The authors designed the source template dose planning software for ICRT of uterine cervix results average $-0.55{\pm}2.15%$ discrepancy of the full charged brachytherapy dose planning. Developed Source temperate ICRT plaanning software guide a minimized the complains and operating times within a ${\pm}3%$ of dose discrepancies.

• Tuberculosis and Respiratory Diseases
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• v.47 no.1
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• pp.42-49
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• 1999

Background: In patients with chronic obstructive pulmonary disease(COPD). it is well known that hypoxemia increases the frequency of VPB, which is associated with the poor prognosis such as sudden death. The aim of this study is to evaluate the effect of short and long-term low flow oxygen therapy on the development of VPBs in patients with COPD by correcting the hypoxemia. Method: In 19 patients with COPD, oxygen saturation and VPB's were monitored by pulse oxymeter and 24-hour Holter EKG, with room air and oxygen saturation and VPB's were monitored on the 1st and on the 8th day during oxygen therapy with nasal prong (2L/min). Results : The arterial oxygen saturation was significantly higher on the 1st day of oxygen therapy compared with breathing room air, and was also higher on the 8th day of oxygen therapy than on the 1st day. We found that there was significant correlation between the lowest value of the arterial oxygen saturation and the mean value of the arterial oxygen saturation. The number of VPB's per hour was significantly lower on the 1st day of oxygen therapy compared with breathing room air, and also lower on the 8th day of oxygen therapy than on the 1st day. Our results showed positive correlation between the decrease in the frequency of VPB's and the increase in the lowest arterial oxygen saturation, even though correlation was not significant(p=0.056). Conclusion: With oxygen therapy, the arterial oxygen saturation was increased and the number of VPB's was decreased. Long-term oxygen therapy more than 7days, would be helpful to decrease the number of VPB' s in patients with COPD.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.14 no.3
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• pp.655-662
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• 2010

By using lotus notes server-client system, the database related to general information of cancer patients, radiation treatment simulation, cancer treatment information and all kinds of information of radiation oncology department need to be developed for effective information management and also user interface was developed for input and output of information. This database also could be used for clinical study, patient care research and medical education. By the development of this electronic chart of the department of radiation oncology, the clinic datum and medical information management could be connected effectively and treatment information according to treatment machine also could be acquired and contributed for improving treatment efficiency, cutting down the waiting time for clinic.