• Radiation Oncology Journal
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• v.26 no.1
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• pp.65-73
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• 2008

Purpose: Women with breast cancer diagnosed at an age of 40 years or younger have a greater prevalence of germline BRCA1 and BRCA2 mutations than the prevalence of women with breast cancer diagnosed at older ages. Several immunohistochemical characteristics have been identified in breast cancers from studies of Caucasian women with BRCA1/2 mutations having familial or early-onset breast cancers. The aim of this study is to determine whether early-onset breast cancer in BRCA1 or BRCA2 mutation carriers, who were not selected from a family history, could be distinguished by the use of immunohistochemical methods and could be distinguished from breast cancer in women of a similar age without a germline BRCA1 or BRCA2 mutation. We also analyzed the prognostic difference between BRCA1/2 related and BRCA1/2 non-related patients by the use of univariate and multivariate analysis. Materials and Methods: Breast cancer tissue specimens from Korean women with early-onset breast cancers were studied using a tumor tissue microarray. Immunohistochemical staining of estrogen receptor(ER), progesterone receptor(PR) and HER-2, as well as the histology and grade of these specimens, were compared. The prognostic impact of immunohistochemical and histological factors as well as the BRCA1/2 mutation status was investigated separately. Results: There were 14 cases and 16 deleterious BRCA1/2 mutations among 101 patients tested. A family history(4/14) and bilateral breast cancers(3/9) were high risk factors for BRCA1/2 mutations. BRCA1/2-associated cancers demonstrated more expression of ER-negative(19.4% versus 5.1%, p=0.038) and HER-2 negative than BRCA1/2 negative tumors, especially for tumors with BRCA1 tumors The BRCA1/2 mutation rate for patients with triple negative tumors(negative expression of ER, PR and HER-2) was 24.2%. Tumor size, nodal status, and HER-2 expression status were significantly associated with disease free survival, as determined by univariate and multivariate analysis, but the BRCA1/2 status was not a prognostic factor. Conclusion: Breast cancer that occurs in women with a germline BRCA1 or BRCA2 mutations have recognizable immunohistochemical features, which may be useful in identifying individuals that are more likely to carry germline mutations. Although the BRCA1/2 mutation status was not a prognostic factor in Korean women with early-onset breast cancer, more cases with a longer follow-up period are needed for further study.

• Korea journal of population studies
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• v.25 no.2
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• pp.69-105
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• 2002

This paper is aimed at three points. Firstly the size and trend of women self-employed in korea are analysed during 30 years. Second the demographic characteristics and labor condition like working hour, income and etc. of them are presented. Last, when did they begin or end their own work as their life stages were changed.

• Journal of the Korea Computer Graphics Society
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• v.16 no.3
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• pp.1-10
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• 2010

In this paper, we propose a novel noiseless method of BRDF rendering on a GPU in real-time. Illumination at a surface point is formulated as an integral of BRDF producted with incident radiance over the hemi-sphere domain. The most popular method to compute the integral is the Monte Carlo method, which needs a large number of samples to achieve good image quality. But, it leads to increase of rendering time. Otherwise, a small number of sample points cause serious image noise. The main contribution of our work is a new importance sampling scheme producing a set of incoming ray samples varying continuously with respect to the eye ray. An incoming ray is importance-based sampled at different latitude angles of the eye ray, and then the ray samples are linearly connected to form a curve, called a thread. These threads give continuously moving incident rays for eye ray change, so they do not make image noise. Since even a small number of threads can achieve a plausible quality and also can be precomputed before rendering, they enable real-time BRDF rendering on the GPU.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.42 no.7 s.337
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• pp.27-34
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• 2005

Iterative detection (ID) has proven to be a near-optimal solution for concatenated Finite State Machines (FSMs) with interleavers over an additive white Gaussian noise (AWGN) channel. When perfect channel state information (CSI) is not available at the receiver, an adaptive ID (AID) scheme is required to deal with the unknown, and possibly time-varying parameters. The basic building block for ID or AID is the soft-input soft-output (SISO) or adaptive SISO (A-SISO) module. In this paper, Reduced State SISO (RS-SISO) algorithms have been applied for complexity reduction of the A-SISO module. We show that serially concatenated CPM (SCCPM) with AID has turbo-like performance over fading ISI channels and also RS-A-SISO systems have large iteration gains. Various design options for RS-A-SISO algorithms are evaluated. Recently developed density evolution technique is used to analyze RS-A-SISO algorithms. We show that density evolution technique that is usually used for AWGN systems is also a good analysis tool for RS-A-SISO systems over frequency-selective fading channels.

• Korean Journal of Childcare and Education
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• v.7 no.3
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• pp.43-65
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• 2011

The purpose of this study was to investigate the current status of English education for toddlers at home and institutes, and influential variables upon mothers' demand on English education for their toddlers. Four hundred forty-one mothers who have toddlers under 36 months-old were surveyed using a questionnaire. Data were analyzed using frequency and logistic regression. Results of this study were as follows: It was found that 30.9% of mothers were providing English education to their toddlers. They started English education when their toddlers were between 24 months and 36 months because of parents' decision or English education in child care centers. English education was mostly given to their toddlers once or twice a week, less than 30 minutes a time with Korean teachers who majored in English. English lessons were focused on simple dialogue using multi media, worksheets, and workbooks. In other sense, 66.0% of mothers showed a positive perspective toward English education for toddlers. The higher salary, years of education, and degree of agreement on English education based on physiological, linguistic, and social perspectives were, the stronger the demand on English education was. Results of this study suggested that appropriate guidance for English education for toddlers needs to be provided.

• Journal of the Korean association of regional geographers
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• v.17 no.4
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• pp.432-442
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• 2011

Climatic variables such as temperature and precipitation tend to vary both in space and in time simultaneously. Thus, it is necessary to include space-time autocorrelation into conventional spatial interpolation methods for reliable time-series mapping. This paper introduces and applies space-time variogram modeling and space-time kriging to generate time-series temperature maps using hourly Automatic Weather System(AWS) temperature observation data for a one-month period. First, temperature observation data are decomposed into deterministic trend and stochastic residual components. For trend component modeling, elevation data which have reasonable correlation with temperature are used as secondary information to generate trend component with topographic effects. Then, space-time variograms of residual components are estimated and modelled by using a product-sum space-time variogram model to account for not only autocorrelation both in space and in time, but also their interactions. From a case study, space-time kriging outperforms both conventional space only ordinary kriging and regression-kriging, which indicates the importance of using space-time autocorrelation information as well as elevation data. It is expected that space-time kriging would be a useful tool when a space-poor but time-rich dataset is analyzed.

• Journal of Intelligence and Information Systems
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• v.19 no.4
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• pp.55-79
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• 2013

In this paper, we propose a hybrid genetic algorithm (HGA) approach to effectively solve the reverse logistics network with centralized centers (RLNCC). For the proposed HGA approach, genetic algorithm (GA) is used as a main algorithm. For implementing GA, a new bit-string representation scheme using 0 and 1 values is suggested, which can easily make initial population of GA. As genetic operators, the elitist strategy in enlarged sampling space developed by Gen and Chang (1997), a new two-point crossover operator, and a new random mutation operator are used for selection, crossover and mutation, respectively. For hybrid concept of GA, an iterative hill climbing method (IHCM) developed by Michalewicz (1994) is inserted into HGA search loop. The IHCM is one of local search techniques and precisely explores the space converged by GA search. The RLNCC is composed of collection centers, remanufacturing centers, redistribution centers, and secondary markets in reverse logistics networks. Of the centers and secondary markets, only one collection center, remanufacturing center, redistribution center, and secondary market should be opened in reverse logistics networks. Some assumptions are considered for effectively implementing the RLNCC The RLNCC is represented by a mixed integer programming (MIP) model using indexes, parameters and decision variables. The objective function of the MIP model is to minimize the total cost which is consisted of transportation cost, fixed cost, and handling cost. The transportation cost is obtained by transporting the returned products between each centers and secondary markets. The fixed cost is calculated by opening or closing decision at each center and secondary markets. That is, if there are three collection centers (the opening costs of collection center 1 2, and 3 are 10.5, 12.1, 8.9, respectively), and the collection center 1 is opened and the remainders are all closed, then the fixed cost is 10.5. The handling cost means the cost of treating the products returned from customers at each center and secondary markets which are opened at each RLNCC stage. The RLNCC is solved by the proposed HGA approach. In numerical experiment, the proposed HGA and a conventional competing approach is compared with each other using various measures of performance. For the conventional competing approach, the GA approach by Yun (2013) is used. The GA approach has not any local search technique such as the IHCM proposed the HGA approach. As measures of performance, CPU time, optimal solution, and optimal setting are used. Two types of the RLNCC with different numbers of customers, collection centers, remanufacturing centers, redistribution centers and secondary markets are presented for comparing the performances of the HGA and GA approaches. The MIP models using the two types of the RLNCC are programmed by Visual Basic Version 6.0, and the computer implementing environment is the IBM compatible PC with 3.06Ghz CPU speed and 1GB RAM on Windows XP. The parameters used in the HGA and GA approaches are that the total number of generations is 10,000, population size 20, crossover rate 0.5, mutation rate 0.1, and the search range for the IHCM is 2.0. Total 20 iterations are made for eliminating the randomness of the searches of the HGA and GA approaches. With performance comparisons, network representations by opening/closing decision, and convergence processes using two types of the RLNCCs, the experimental result shows that the HGA has significantly better performance in terms of the optimal solution than the GA, though the GA is slightly quicker than the HGA in terms of the CPU time. Finally, it has been proved that the proposed HGA approach is more efficient than conventional GA approach in two types of the RLNCC since the former has a GA search process as well as a local search process for additional search scheme, while the latter has a GA search process alone. For a future study, much more large-sized RLNCCs will be tested for robustness of our approach.

• Magazine of the Korean Society of Agricultural Engineers
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• v.37 no.5
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• pp.62-72
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• 1995

공학분야에 널리 사용되고 있는 신뢰도 분석 방법 중에서 Monte Carlo simulation (MC), Mean-value First-Order Second-Moment Method(MFOSM), and Advanced First-Order Second-Moment(AFOSM) method들을 강물의 오염물질 농도와 수질기준치사이의 신뢰도 분석에 적용하였다. 미 환경 보건국에서 개발 보급한 QUAL2E를 이용하여 Mew Jersey에 위치한 Passaic강의 수질예측에서 4가지 주요인자(용존산소, 생물학적 산소요구량, 암모니아 그리고 조류)들이 정해진 수질기준치를 유지 할 수 있는 확률을 세가지 방법에 의해 추정한 후에 상호 비교하였다. MC방법에 의해 2,000회 simulation시켜서 그 결과가 시스템의 추계학적 성질을 잘 반영한 것으로 판단하여 비교기준으로 삼고 MFOSM과 AFOSM에 의해 추정한 결과와 비교하였다. MFOSM의 결과보다는 AFOSM의 결과가 전체적으로 MC의 결과에 더 근접하였으며, 이유는 AFOSM의 계산방법이 MFOSM의 선형근사로 인한 오차를 줄일 수 있었기 때문인 것으로 판단된다. MC방법의 결과와 다른 방법들의 결과사이의 차이가 입력 변수들이 평균값에서 멀어질 때가 많았는데 이는 MC의 경우 입력 변수들이 일정범위를 벗어나서 비현실적인 상황이면 model이 정지하는데, 다른 방법들은 simulation에 의한 것이 아니고 수학적인 계산에 의해서 신뢰도가 추정되기 때문에 이러한 상황이 반영될 수 없기 때문이다. 강물의 수질을 취급하는 공학적인 측면에서 보면, 이중에 가장 간편한 MFOSM이 많은 simulation이 필요한 MC나 계산방법이 상대적으로 복잡한 AFOSM에 비해 오차가 크지 않아서 이들을 대시하여 사용될 수 있다고 판단된다. 유래의 PAF가 분비된다는 것을 알 수 있었으며, 이러한 인자는 동결처리에서도 그 기능은 전혀 변하지 않는다고 본다. 이후에 있어서 mouse LIF의 첨가는 돼지의 수정란을 배반포 이후의 단계에까지 발달시킬 수 있었다. 있어서 더 적합한 것으로 판단되었다. 5. 개발된 모형은 논 관개의 물리적 측면과 관리목표 모두를 고려한 것으로 계산된 효율은 벼, 생육 각 단계에서의 효율 비교에 양호한 방법임을 알 수 있다.은 Sharpsburg 점질양토에 대한 S.C.S 한계허용치 10ton/ha/year 이내로 나타났다. 비처리구에서의 토양유실량은 평균 2.56ton/ha/year로 높게 나타난 반면 3개의 서로 다른 추리구인 비수구, 초생수로구 및 Bromegrass구에서는 각각 0.152, 0.192 및 0.290ton/ha/year로 낮은 결과를 가져왔다. 6. 평균 침전량에 대한 L.S.D. 검정 걸과 전시험구중 비처리구가 고도의 유의차를 나타낸 반면 비수구, 초생수로구 및 Bromegrass 목초구 간에는 아무런 유의차가 인정되지 않았다. 7. 농지보전 처리구인 배수구와 초생수로구는 비처리구에 비해 낮은 침두 유출량과 낮은 토양유실량을 나타내었다.구보다 14% 절감되는 것으로 나타났다.작용하는 것으로 사료된다.된다.정량 분석한 결과이다. 시편의 조성은 33.6 at% U, 66.4 at% O의 결과를 얻었다. 산화물 핵연료의 표면 관찰 및 정량 분석 시험시 시편 표면을 전도성 물질로 증착시키지 않고, Silver Paint 에 시편을 접착하는 방법으로도 만족한 시험 결과를 얻을 수 있었다.째, 회복기 중에 일어나는 입자들의 유입은 자기폭풍의 지속시간을 연장시키는 경향을 보이며 큰 자기폭풍일수록 현저했다. 주상에서 관측된 이러한 특성은 서브스톰 확장기 활동이 자기폭풍의 발달과 밀접한 관계가

• Asia-Pacific Journal of Business Venturing and Entrepreneurship
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• v.15 no.3
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• pp.207-221
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• 2020

This study conducted a meta-analysis on the effects of innovation, risk-taking, and enterprising on entrepreneurship. From 2013 to 2020, 392 papers, which were judged as quantitative research from doctoral and master thesis, and academic journals published in Korea were selected as research subjects. 28 duplicates of thesis and thesis are excluded. A total of 52 papers were finally selected, excluding 312 papers that were insufficient to be used as research data because there were no statistical values such as correlation coefficients. For the 52 selected papers, the homogeneity of the variables was first verified. As a result of the homogeneity test, the innovativeness, risk-taking, initiative, and entrepreneurship education all showed great effects on heterogeneity, and the average effect size was analyzed by random effect model. The average effect size analyzed was 0.38 ~ 0.49, and all four variables showed moderate average effect size. As a result of analyzing the average effect size by forest plot, all showed proper results. From the results of funnel plot analysis of entrepreneurship education, published errors were confirmed asymmetric. Research data on entrepreneurship education shows that it cannot represent the whole. It is a structural equation model with entrepreneurship and entrepreneurial intention as a parameter. Iinnovation and risk-taking have an impact on entrepreneurship by taking entrepreneurship education as a parameter. Initiative had an effect on the entrepreneurial intention a business, regardless of entrepreneurship education. In a number of studies, university entrepreneurship education has had an impact on the entrepreneurial intention. It should be changed to entrepreneurship education that combines theory and practice. Entrepreneurship education should be transformed into continuous and field-oriented education.

• KIPS Transactions on Computer and Communication Systems
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• v.3 no.10
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• pp.357-364
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• 2014

The first mission for the IoT based hyper-connectivity communication is developing a device-to-device communication technique in infra-less low-power and lossy networks. In a low-power and lossy wireless network, IoT devices and routers cannot keep the original path toward the destination since they have the limited memory. Different from the previous light-weight routing protocols focusing on the reduction of the control messages, the proposed scheme provides the light-weight IPv6 address auto-configuration, IPv6 neighbor discovery and routing protocol in a IoT capable infra-less wireless networks with the bloom filer and enhanced rank concepts. And for the first time we evaluate our proposed scheme based on the modeling of various probability distributions in the IoT environments with the lossy wireless link. Specifically, the proposed enhanced RPL based light-weight routing protocol improves the robustness with the multi-paths locally established based on the enhanced rank concepts even though lossy wireless links are existed. We showed the improvements of the proposed scheme up to 40% than the RPL based protocol.