• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.392-392
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• 2022

세계적 규모의 팬데믹 감염병의 출현은 전 세계적으로 경제적, 문화적, 사회적 파급효과가 매우 강력하며 전 인류를 위협하고 있다. 최근에 발병한 중증급성 호흡기질환 코로나바이러스 2(Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2)는 2019년 12월 중국 우한에서 첫 보고 되었고 2022년 현재까지 종식되지 않고 있으며 바이러스의 전파력과 치명률이 높고 무증상 감염상태일 때에도 전염이 가능하여 현재 역학조사의 사후적 대응에 대한 한계가 있어 선제적 대응을 위한 수단이 필수 불가결해지고 있는 실정이다. 하수기반역학(Waste Based Epidemiology, WBE)이란 하수처리장으로 유입되기 전의 하수를 분석하여 하수 집수구역 내 도시민의 생활상을 예측하는 것으로 하수로 배출된 감염자의 분비물 및 배설물 속 바이러스를 하수관로에서 신속하게 검출함으로써 특정지역의 감염성 질환 전파 정도와 유행하는 타입(변이)등을 분석하고 기존 역학조사의 문제점을 극복할 수 있으며 선제적인 대응이 가능하다. 현재 COVID-19의 대유행과 관련하여 WBE를 기반으로 한 다양한 연구가 진행되고 있으며 실제 환자의 발생과 상관관계가 있음이 확인되고 있고 백신 접종과 새롭게 발생한 변이바이러스의 관계 속에서 발생하는 변수를 고려한 모델이 없다는 점을 들어 새로운 감염병 확산 예측 모델에 대한 필요성 또한 커지고 있다. 본 연구에서는 병원에서부터 하수처리장까지의 하수관거와 하수처리장에서의 SARS-CoV-2 검출농도 및 거동을 파악하는 것을 목적으로 하고 있으며 COVID-19의 감염규모 확산에 관한 방법론에서 수학적모델 (Euler Method, RK4 Method, Gillespie Algorithm)과 딥러닝 기반의 Nowcasting model과 Fore casting model을 살펴보고자 한다.

• Korean Journal of Remote Sensing
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• v.38 no.6_1
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• pp.1191-1205
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• 2022

Particulate matter(PM) among air pollutants with complex and widespread causes is classified according to particle size. Among them, PM_2.5 is very small in size and can cause diseases in the human respiratory tract or cardiovascular system if inhaled by humans. In order to prepare for these risks, state-centered management and preventable monitoring and forecasting are important. This study tried to predict PM_2.5 in Seoul, where high concentrations of fine dust occur frequently, using two ensemble models, random forest (RF) and extreme gradient boosting (XGB) using 15 local data assimilation and prediction system (LDAPS) weather-related factors, aerosol optical depth (AOD) and 4 chemical factors as independent variables. Performance evaluation and factor importance evaluation of the two models used for prediction were performed, and seasonal model analysis was also performed. As a result of prediction accuracy, RF showed high prediction accuracy of R² = 0.85 and XGB R² = 0.91, and it was confirmed that XGB was a more suitable model for PM_2.5 prediction than RF. As a result of the seasonal model analysis, it can be said that the prediction performance was good compared to the observed values with high concentrations in spring. In this study, PM_2.5 of Seoul was predicted using various factors, and an ensemble-based PM_2.5 prediction model showing good performance was constructed.

• Journal of the Korean Association of Geographic Information Studies
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• v.21 no.2
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• pp.94-106
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• 2018

The epidemiological model is useful for creating simulation and associated preventive measures for disease spread, and provides a detailed understanding of the spread of disease space through contact with individuals. In this study, propose an agent-based spatial model(ABM) integrated with spatial big data to simulate the spread of MERS-CoV infections in real time as a result of the interaction between individuals in space. The model described direct contact between individuals and hospitals, taking into account three factors : population, time, and space. The dynamic relationship of the population was based on the MERS-CoV case in Seoul Metropolitan Government in 2015. The model was used to predict the occurrence of MERS, compare the actual spread of MERS with the results of this model by time series, and verify the validity of the model by applying various scenarios. Testing various preventive measures using the measures proposed to select a quarantine strategy in the event of MERS-CoV outbreaks is expected to play an important role in controlling the spread of MERS-CoV.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.22 no.4
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• pp.595-601
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• 2018

Recently, as the fine dust level has risen rapidly, there is a great interest. Exposure to fine dust is associated with the development of respiratory and cardiovascular diseases and has been reported to increase death rate. In addition, there exist damage to fine dusts continues at industrial sites. However, exposure to fine dust is inevitable in modern life. Therefore, predicting and minimizing exposure to fine dust is the most efficient way to reduce health and industrial damages. Existing fine dust prediction model is estimated as good, normal, poor, and very bad, depending on the concentration range of the fine dust rather than the concentration value. In this paper, we study and implement to predict the PM10 level by applying the Artificial neural network algorithm and the K-Nearest Neighbor algorithm, which are machine learning algorithms, using the actual weather and air quality data.

• Journal of the Korea Society for Simulation
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• v.30 no.1
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• pp.43-54
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• 2021

Since COVID-19 (Severe acute respiratory syndrome coronavirus type 2, SARS-Cov-2) was first discovered at the end of 2019, it has spread rapidly around the world. This study introduces an agent-based simulation model representing COVID-19 spread in South Korea to investigate the effect of detect level (contact tracing) on the virus spread. To develop the model, related data are aggregated and probability distributions are inferred based on the data. The entire process of infection, quarantine, recovery, and death is schematically described and the interaction of people is modeled based on the traffic data. A composite logistic functions are utilized to represent the compliance of people to the government move control such as social distancing. To demonstrate to effect of detect level on the virus spread, detect level is changed from 0% to 100%. The results indicate active contact tracing inhibits the virus spread and the inhibitory effect increases geometrically as the detect level increases.

• Proceedings of the Korea Information Processing Society Conference
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• 2018.10a
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• pp.673-676
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• 2018

4차 산업혁명이 도래하면서 정보 통신 기술 및 융합 기술의 발전에 힘입어 소리 데이터를 이용한 연구가 활발하게 진행되고 있다. 소리 데이터를 이용한 학술적 프로토타입 연구들을 실제 환경에서 운용하기 위해서는 소리 취득 시 발생하는 다양한 잡음 환경에서도 원시 데이터(raw data)에 근접한 정보를 취득할 수 있는 시스템의 강인함이 보장되어야 한다. 본 논문에서는 SEGAN(Speech Enhancement Generative Adversarial Network) 모델을 활용하여, 전처리 및 후처리 과정이 필요 없이 원시 데이터를 대상으로 하는 end-to-end 방식의 소리 음질 향상 시스템을 제안한다. 제안하는 시스템은, 축산업 분야의 돼지 호흡기 질병 소리 데이터를 이용하여 실험하였으며, 여러 가지 잡음 상황(인위적인 잡음, 실제 환경 잡음)에서 소리 음질이 개선됨을 실험적으로 검증하였다.

• Proceedings of the Korea Information Processing Society Conference
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• 2023.11a
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• pp.641-643
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• 2023

Deep Learning(DL)을 사용한 호흡음의 자동 분석은 폐 질환의 조기 진단에 중추적인 역할을 한다. 그러나 현재의 DL 방법은 종종 호흡음의 공간적 및 시간적 특성을 분리하여 검사하기 때문에 한계가 있다. 본 연구는 컨볼루션 연산을 통해 공간적 특징을 캡처하고 시간 컨볼루션 네트워크를 사용하여 이러한 특징의 공간적-시간적 상관 관계를 활용하는 새로운 DL 프레임워크를 제한한다. 제안된 프레임워크는 앙상블 학습 접근법 내에 컨볼루션 네트워크를 통합하여 폐음 녹음에서 호흡 이상 및 질병을 검출하는 정확도를 크게 향상시킨다. 잘 알려진 ICBHI 2017 챌린지 데이터 세트에 대한 실험은 제안된 프레임워크가 호흡 이상 및 질병 검출을 위한 4-Class 작업에서 비교모델 성능보다 우수함을 보여준다. 특히 민감도와 특이도를 나타내는 점수 메트릭 측면에서 최대 45.91%와 14.1%의 개선이 이진 및 다중 클래스 호흡 이상 감지 작업에서 각각 보여준다. 이러한 결과는 기존 기술보다 우리 방법의 두드러진 이점을 강조하여 호흡기 의료 기술의 미래 혁신을 주도할 수 있는 잠재력을 보여준다.

• Korean Journal of Remote Sensing
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• v.36 no.5_3
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• pp.1053-1066
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• 2020

Sulfur dioxide (SO₂) is primarily released through industrial, residential, and transportation activities, and creates secondary air pollutants through chemical reactions in the atmosphere. Long-term exposure to SO₂ can result in a negative effect on the human body causing respiratory or cardiovascular disease, which makes the effective and continuous monitoring of SO₂ crucial. In South Korea, SO₂ monitoring at ground stations has been performed, but this does not provide spatially continuous information of SO₂ concentrations. Thus, this research estimated spatially continuous ground-level SO₂ concentrations at 1 km resolution over South Korea through the synergistic use of satellite data and numerical models. A stacking ensemble approach, fusing multiple machine learning algorithms at two levels (i.e., base and meta), was adopted for ground-level SO₂ estimation using data from January 2015 to April 2019. Random forest and extreme gradient boosting were used as based models and multiple linear regression was adopted for the meta-model. The cross-validation results showed that the meta-model produced the improved performance by 25% compared to the base models, resulting in the correlation coefficient of 0.48 and root-mean-square-error of 0.0032 ppm. In addition, the temporal transferability of the approach was evaluated for one-year data which were not used in the model development. The spatial distribution of ground-level SO₂ concentrations based on the proposed model agreed with the general seasonality of SO₂ and the temporal patterns of emission sources.

• Journal of the Korea Society of Computer and Information
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• v.26 no.11
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• pp.21-31
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• 2021

As the COVID-19 pandemic rapidly changes healthcare around the globe, the need for smart healthcare that allows for remote diagnosis is increasing. The current classification of respiratory diseases cost high and requires a face-to-face visit with a skilled medical professional, thus the pandemic significantly hinders monitoring and early diagnosis. Therefore, the ability to accurately classify and diagnose respiratory sound using deep learning-based AI models is essential to modern medicine as a remote alternative to the current stethoscope. In this study, we propose a deep learning-based respiratory sound classification model using data collected from medical experts. The sound data were preprocessed with BandPassFilter, and the relevant respiratory audio features were extracted with Log-Mel Spectrogram and Mel Frequency Cepstral Coefficient (MFCC). Subsequently, a Parallel CNN network model was trained on these two inputs using stacking ensemble techniques combined with various machine learning classifiers to efficiently classify and detect abnormal respiratory sounds with high accuracy. The model proposed in this paper classified abnormal respiratory sounds with an accuracy of 96.9%, which is approximately 6.1% higher than the classification accuracy of baseline model.

• Tuberculosis and Respiratory Diseases
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• v.57 no.2
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• pp.125-131
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• 2004

Tuberculosis (TB) remains an enormous global health problem, and a new vaccine against TB more potent than the current inadequate BCG vaccine is urgently needed. We constructed three recombinant Mycobacterium bovis BCG (rBCG) strains over-expressing antigen (Ag) 85A, Ag85B, or both of M. tuberculosis using their own promoter and secretory sequence, or hsp60 promoter. SDS-PAGE analysis of rBCG proteins showed overexpression of Ag85A and Ag85B proteins in higher level than of those in their parental strain of BCG. In addition, rBCG(rBCG/B.FA) over-expressing Ag85A and Ag85B induced strong IFN-${\gamma}$ production in splenocytes. However, there was no significant difference in protective efficacy between rBCG and their parental BCG strain. In this study, therefore, rBCG over-expressing Ag85A, Ag85B, or both failed to show enhanced protection against M. tuberculosis infection in a mouse model.