• Child Health Nursing Research
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• 제11권3호
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• pp.301-307
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• 2005

Purpose: To investigate changes in mother's stress, degree of depression and level of milk secretion hormones when the mothers provided massage to their new born babies. Method: The study was conducted with 65 women who had delivered at a convalescence institute in Incheon between Sep 25, 2003 and Feb 10, 2004. The mothers were assigned to a control group or an experimental group. Infants of mothers in the experimental group received massage from their mothers twice a day for 10 days beginning on the 4th day after delivery. The data were processed using $x^2-test$, paired t-test and repeated measures ANOVA using the SAS program. Results: The level of cortisol, a stress hormone and depression were significantly different between the two groups (p=0.01 ;p=0.02). While fur plasma prolactin level, a milk secretion hormone, there was no significant difference(p=0.14). Conclusions: When massage was provided to new-born babies the cortisol level of the mothers decreased significantly compared to the control group which did not receive the massage. As the level of depression of the control group declined as time passed while the experiment group showed no difference and there was no difference in the plasma prolactin level, further study is suggested.

• 한국발생생물학회지:발생과생식
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• 제5권2호
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• pp.181-187
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• 2001

포유동물의 혈중 프로락틴 농도는 일주기와 연주기의 변화를 나타내며 송과체에서 분비되는 멜라토닌이 조절인자로 관여한다. 인위적인 송과체의 기능 억제는 혈중 프로락틴 농도를 증가시킨다. 임신 후반기에 태반에서는 수종의 프로락틴군 호르몬들이 분비되어 태반기능 및 배아발생에 중요한 역할을 한다. 그러나 이들 호르몬 유전자들의 발현 조절기작과 조절 인자들에 관한 연구 결과는 미비하다. 본 연구에서는 RT-PCR과, in situ hybridization 방법으로 흰쥐의 태반에서 Me $l_{la}$ 유전자의 발현을 확인하였다. 발현되는 주요 세포는 junctional zone과 labyrinth zone의 spongiotrophoblast 세포와 trophoblast giant세포였다. 특이한 것은junctional zone의 Me $l_{la}$ 유전자의 발현이 밤시간(22:00)에 비하여 낮시간(16:00)에 높게 조사되었다. 그리고 멜라토닌 수용체 agonist인 chloromelatonin은 PLP-A 유전자의 발현을 억제하였다. 이러한 결과들로 보아 흰쥐의 태반에서 Me $l_{la}$ 유전자가 발현되며, 멜라토닌에 의해 유도되는 Me $l_{la}$ 의 활성화는 PLP-A유전자의 발현에 중요한 조절인자로 작용할 것이다.

• 생물정신의학
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• 제10권2호
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• pp.177-185
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• 2003

Object:We investigated the relationship between prolactin response to antipsychotics and clinical courses of psychotic symptoms and DAT gene polymorphisms. Method:Twenty-four acute psychotic inpatients completed the 12-week trial of risperidone. Serum prolactin, BPRS, ESRS and hyperprolactinemia-related symptoms were measured at baseline, 2, 4, 8 and 12 weeks after medication. The DAT gene polymorphisms were analyzed. Results:The serum prolactin was significantly increased over time. According to the prolactin level at 2-week, the subjects were divided into the severe group(serum prolactin>60ng/mL, N=15) and the mild group (serum prolactin<60ng/mL, N=9). The prolactin levels of the mild group didn't increase beyond 60ng/mL throughout 12 weeks. Severe group had slower decrement of BPRS scores than those of mild group. Six females in severe group complained of irregular menstruations, but no female in mild group. Most patients had 10 allele of DAT gene. Conclusion:This study suggests that the magnitude of prolactin elevation at the 2-week of risperidone medication is correlated with severity of hyperprolactinemia throughout treatments. Our results did not show the relationship between prolactin responses and DAT gene polymorphisms.