• Korean Journal of Food Science and Technology
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• v.32 no.6
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• pp.1418-1425
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• 2000

Obesity and diabetes mellitus are associated with common pathogenic mechanism, and ${\beta}-glucan$ of Agaricus blazei Murill is potent inhibitor of intestinal ${\alpha}-glycosidase$ and inhibit the digestion of starch and sucrose in the small intestine. In this studies, there was observed the anti-hyperglycemic effect in obese diabetic mice(C57BLKsJ db/db), which were supplied Agaricus and Acarbose for 5 weeks. In db/db mice, food intake and body weight gain were decreased significantly in Agaricus groups(p<0.05). Also these group exhibited lower fasting serum glucose level compared with control group. HbA1c level, triglyceride level, total cholesterol level, HDL cholesterol level, LDL cholesterol level and VLDL cholesterol level were lowered in db/db mice. The activity of disaccharidases on proximal and distal segments of small intestine was decreased. In conclusion, it was assumed that ${\beta}-glucan$ of Agaricus blazei Murill has anti-hyperglycemic and anti-obesitic effects by reducing food intake and body weight gain, and also decreasing serum glucose and lipid level through inhibiting the activity of small intestinal disaccharidases.

• Journal of Marine Life Science
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• v.7 no.2
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• pp.171-179
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• 2022

The present study investigated the survival rate, respiration rate, plasma stress index, and histological changes according to exposure time of cultured red seabream (Pagrus major) and olive flounder (Paralichthys olivaceus) exposed to Cochlodinium polykrikoides red tide. Fish cultured in natural seawater were used as the control group. Cochlodinium polykrikoides density was set to 5,500±200 cells·ml^-1 in the experimental groups. All red seabreams died within 1 hour of exposure to red tide, whereas all olive flounders died within 5 hours of exposure. Analysis of physiological response revealed that in red seabream, plasma glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), catalase (CAT), and glutathione peroxidase (GPx) concentrations were increased; plasma glucose and superoxide dismutase (SOD) concentration were decreased. Meanwhile, in olive flounders, plasma cortisol, GOT, and GPT concentrations were increased; plasma glucose concentrations were increased during the first hour of exposure, followed by decrease after 5 hours; and plasma SOD, CAT, and GPx concentrations decreased during the first hour of exposure. Histological analysis revealed structural damage to the gills of both red seabream and olive flounder. In conclusion, the exposure of red seabream and olive flounder to Cochlodinium polykrikoides red tide at the density of 5,500 cells·ml^-1 induces oxidative stress, which activates antioxidant defense mechanisms, ultimately leading to liver and gill damage.

• Korean Journal of Veterinary Research
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• v.35 no.4
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• pp.683-689
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• 1995

임상적으로 건강한 New Zealand White 종인 수컷 토끼에서 항생제 norfloxacin(NFX)의 체내 동태를 조사하기 위하여 체중 kg당 5mg을 정맥 및 경구 투여하였다. 그 결과 빠른 분포기와 소실기를 갖는 2-콤파트먼트 모델 양상으로 나타났다. 혈장에서의 약물분석은 HPLC로 실시하였는데, 이동상은 acetonitrile/0.01M phosphate buffer/ 10% citric acid 1mM heptane sulfonic acid(10/70/20)이었고, 흡수 파장은 274nm에서 실시하였다. 정맥 투여후, 생물학적 반감기는 3.14시간으로 나타났으며, 분포반감기는 0.38시간으로 빠른 분포를 보여주었다. 최고 혈중농도는 $24.27{\mu}g/ml$로 계산되었으며 청소율은 0.68ml/kg/h로 분석되었다. 경구 투여후, 최고 혈중 농도와 최고 혈중 도달 시간은 $0.86{\mu}g/ml$과 0.43시간으로 각각 계산되었다. 이때의 생물학적 반감기는 3.61시간으로 정맥 투여시와 유의성 있는 차이는 없었으며, 흡수 반감기는 0.17시간으로 빠른 흡수를 보여주었다. 생체이용율은 30%로 나타났으며, 0.2-1.6g/ml인 치료혈중 농도 범위에서 혈장 결합율은 26%로 나타나, 토끼에서 항생요법은 구강 투여시 초기 투여량은 2.71mg/kg이며, 유지 투여량은 12시간마다 2.54mg/kg이 적당한 것으로 분석되었다.

• Child Health Nursing Research
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• v.11 no.3
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• pp.301-307
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• 2005

Purpose: To investigate changes in mother's stress, degree of depression and level of milk secretion hormones when the mothers provided massage to their new born babies. Method: The study was conducted with 65 women who had delivered at a convalescence institute in Incheon between Sep 25, 2003 and Feb 10, 2004. The mothers were assigned to a control group or an experimental group. Infants of mothers in the experimental group received massage from their mothers twice a day for 10 days beginning on the 4th day after delivery. The data were processed using $x^2-test$, paired t-test and repeated measures ANOVA using the SAS program. Results: The level of cortisol, a stress hormone and depression were significantly different between the two groups (p=0.01 ;p=0.02). While fur plasma prolactin level, a milk secretion hormone, there was no significant difference(p=0.14). Conclusions: When massage was provided to new-born babies the cortisol level of the mothers decreased significantly compared to the control group which did not receive the massage. As the level of depression of the control group declined as time passed while the experiment group showed no difference and there was no difference in the plasma prolactin level, further study is suggested.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.14 no.7
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• pp.3374-3382
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• 2013

The purpose of this study was to investigate the effects of 12-weeks' swimming training on BMI, leptin and plasma lipid profiles in limited exercise function and physical activity with cerebral palsy. Swimming training program is scheduled to perform for 12-week and 1h each 4 or more times per week. The results of the this study were as follows; First, Body weight, BMI, total cholesterol, LDL and leptin were slightly decreased trend, although these did not reach statistical significance. HDL was not changed in before vs. after training. Second, in the concentration of plasma triglyceride, after training was significantly higher than before training(p<.05) and free fatty acid level was significantly lower at the after training(p<.001). These results suggest that the 12 weeks' regular swimming program has effect of improving plasma lipid and leptin levels in cerebral palsy. Therefore, we consider that it have effect on prevention of obese-related metabolic diseases in cerebral palsy.

• Korean Journal of Clinical Pharmacy
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• v.21 no.3
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• pp.208-214
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• 2011

목적: 이 연구의 목적은 한국인 성인 환자를 대상으로 아미카신 1일 1회 요법을 시행하였을 때의 약동학적 파라미터를 평가하고, 신기능에 따른 아미카신의 약동학적 파라미터를 비교함으로써 최적의 개인화 약물요법을 설계할 수 있도록 하는 것이다. 방법: 그람 음성균 감염에 대해 1일 1회 요법으로 아미카신을 투여 받았던 353명의 한국 성인 환자를 대상으로 항정상태에서 아미카신의 농도를 2회(약물 투여 전 1시간 이내, 약물투여 종료 후 0.5~1시간 이내) 측정하였다. 각 환자의 약동학적 파라미터(분포용적, 청소율, 반감기) 및 혈중 최고 농도, 최저 농도는 환자의 나이, 체중, 신장, 성별, 혈중 크레아티닌 농도, 투여된 약물용량, 측정된 약물의 혈중농도, 감염의 종류 등을 감안하여 산출하였다. 크레아티닌 청소율에 따라 환자를 4군으로 분류하여 아미카신의 약동학적 파라미터를 비교분석하였다. 결과: 본 연구에서 아미카신 혈중 최저, 최고 농도의 평균 ${\pm}$ 표준편차는 각각 $1.14{\pm}1.95mg/L$, $26.35{\pm}9.28mg/L$이며, 청소율, 분포용적 및 반감기의 평균 ${\pm}$ 표준편차는 각각 $55.40{\pm}23.72mL/hr/kg$, $0.35{\pm}0.12L/kg$, 그리고 $5.22{\pm}3.34hrs$로 산출되었다. 크레아티닌 청소율에 따른 아미카신의 청소율, 분포용적 및 반감기의 유의한 차이가 관찰되었다. 종합적으로 아미카신의 혈중 최저 농도는 크레아티닌 청소율이 40 mL/min 미만인 경우 40 mL/min 이상인 경우에 비해 유의하게 증가하였다. 결론: 아미카신의 약동학적 파라미터들은 신기능에 따라 유의한 차이가 있으므로 최적의 치료효과를 위해서는 환자의 크레아티닌 청소율에 따른 개인화 약물요법이 필요하다.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.20 no.2
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• pp.111-118
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• 2010

연구목적: 본 연구는 일반인의 비직업적 노출에 대한 혈중 16종의 다환방향족탄화수소(PAHs) 의 농도르 분석하여 PAHs의 백그라운드 노출 농도를 평가하는 것이다. 내용 및 방법: 농촌지역에 거주(비직업적 노출로서 16종 다환방향족탄화수소가 특정한 환경오염을 받지 않은 지역에 거주)하는 156명의 연구 참여자의 혈중 16가지 다환방향족탄화수소 농도의 기하평균치를 간접흡연군, 구운 음식물섭취군과 각대조군을 비교 하였다. 혈중 16종의 다환방향족탄화수소의 농도는 질량분석기를 장착한 가스크로마토그라피법과 헤드스페이스 마이크로고체상 추출법에 의하여 분석하였다. 결과: 연구참여자 중, 간접흡연자들에서 4종의 다환방향족탄화수소 아세나프틸렌(p<0.01), 아세나프텐(p<0.1), 플로렌(p<0.01), 피렌(p=0.05)가 대조군 보다 유의하게 높았다. 또한 구운육류와 생선 섭취군에서는 벤조(a)피렌(p<0.1)이 대조군 보다 유의하게 높았다. 결론: 간접흡연과 구운음식물 섭취는 비직업적 노출에서 다환방향족탄화수소 노출원의 가능성이 높다고 추정된다. 혈중 다환방향족탄화수소는 한국일반인의 비직업적 노출 농도로 사용 가능하다고 생각된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.11
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• pp.115-120
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• 2019

This study was undertaken to determine the correlation between β-amyloid, serum lipid levels, and cognitive function in the elderly with mild Alzheimer's dementia. The study was conducted in December 2018, enrolling 45 elderly people with mild Alzheimer's disease. Blood analysis measured the β-amyloid and serum lipid levels, and cognitive function was measured using MMSE-K. The correlation between β-amyloid, serum lipid levels and cognitive function was determined using Pearson's correlation analysis. A significantly negative correlation was observed between the β-amyloid level and cognitive function (p<0.05). Furthermore, serum lipid levels and cognitive function also revealed a significantly negative correlation between TC and LDL levels (p<0.05). These results indicate that increasing levels of β-amyloid, TC, and LDL augments a negative correlation that decreases the cognitive function, signifying that management of pathologic factors related to dementia is important for the prevention and improvement of cognitive function in dementia patients.

• Journal of Digital Convergence
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• v.14 no.4
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• pp.487-494
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• 2016

The purpose of this study was to examine the effect of Health exercise program on insulin resistant and blood lipid factor of elderly women for 12 weeks. The two groups were classified into one group(exercise group: EG) with aerobics exercise and band exercise both, the other group(control group: CG) controled. The group of EG was applied to doing aerobics exercise and band exercise 4 times for 60 minutes a week. The intensity of the exercise was ACSM. Each measurement variable was measured before and after 12 weeks to investigate the effect. During this study the result came out with this step. First, EG have shown interaction with blood lipid(TC, HDL, LDL, TG) and blood pressure(SBP, DBP)factor. Second, EG have shown interaction with insulin resistant(insulin, glucose). Therefore, this study gives us positive result to effect of health exercise program on blood lipid factor and insulin resistant factor of elderly women for 12 weeks.

• Environmental Analysis Health and Toxicology
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• v.21 no.4 s.55
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• pp.337-347
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• 2006

이 연구의 목적은 자원회수시설 근로자 및 인근 지역 거주 주민의 혈중다이옥신류 농도를 평가하고, 혈중 다이옥신류 농도에 영향을 미치는 요인을 평가하는 것이다. $2002{\sim}2004$년까지 대상 자원회수시설에 3년 이상 근무한 근로자 31명과 시설로부터 300 m이내 지역에서 3년 이상 거주한 주민 68명을 선정하여 혈액을 채취하였다. 참고 자료로 대상 자원회수시설에 영향을 받지 않는 도시 지역에 거주하는 일반 주민 11명을 함께 평가하였다. 혈액 채취 시 개인 특성에 대한 설문조사도 함께 실시하였다. 시설 근로자의 혈중 다이옥신류 농도는 평균 $2.09{\sim}66.67pg/g$ lipid, 인근 거주 주민은 $1.00{\sim}29.33pg/g$ lipid, 일반 도시 주민은 $5.29{\sim}35.93pg/g$ lipid로 측정되었다. 시설 인근 지역 거주 주민 및 일반 도시 주민 중 비 흡연자의 인체 부하량은 각각 3.0 ng TEQ/g lipid와 4.5 ng TEQ/g lipid로 평가되었다. 대상군의 특성에 따른 혈중 다이옥신류 농도 차이는 관찰되지 않았으며, 연령과 유의한 양의 상관성이 있었다.