• The Korean Journal of Food And Nutrition
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• v.24 no.3
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• pp.442-450
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• 2011

Numerous studies have suggested that dietary flavonoids contribute to prevent cardiovascular disease. Onion contains many functional phytochemicals such as quercetin. The aim of this study was to examine whether onion peel extracts supplementation affect blood lipid profiles and blood coagulation in animal model. Total 48 Sprague-Dawley male rats at 5 weeks old were divided into 6 groups with different diets(C: control, HF: high fat diet, HFOE 0.01%: high fat+onion peel extract 0.01% diet, HFOE 0.02%, HFOE 0.05%, HFOE 0.1%) for 8 weeks. Onion peel extract supplementation significantly decreased serum levels of LDL-cholesterol and increased HDL-cholesterol, while total cholesterol and triglyceride levels were not affected. Hematological parameters(hematocrit, white blood cell, red blood cell, and platelet count) and blood coagulation parameters(prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen) were not significantly different among 6 groups. However, activated partial thromboplastin time of HFOE 0.05% group was significantly longer than that of HF group. These results indicate that onion peel extract supplementation displays hypocholestrolemic effects but does not seem to have anti-coagulation effects in high fat fed SD rats.

• Applied Biological Chemistry
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• v.39 no.2
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• pp.159-164
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• 1996

Screening of anticoagulant activity was conducted for the hot water extracts of 73 kinds of medicinal herbs, 41 kinds of Korean edible plants, and 5 kinds of sea weeds using plasma recalcification test(Tr). In the first screening several extracts of the plants, Alisma calndiculatum, Corydalis ternata Panax notoginseng, Allium sativum, Ganderma luidum, Codium fragile, showed high activities. When the plants were reextracted with various solvent conditions, acidic water extracts of Codium fragile showed the highest activity in APTT. A crude polysaccharide fraction(CF-1) was prepared by methanol reflux, ethanol precipitation, dialysis and Iyophilization of the acid extracts. CF-1 comprised 80.8% total sugar consisting of arabinose, galactose and glucose as the main monomers, 8.7% protein, and 13.3% sulfate. The anticoagulant activity of CF-1 was not changed by pronase digestion, but decreased by periodate oxidation, and this indicated that the anticoagulant activity was attributed to the polysaccharide portion.

• Journal of Biomedical Engineering Research
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• v.10 no.2
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• pp.117-124
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• 1989

The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan`s method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements.

• Journal of Chest Surgery
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• v.30 no.11
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• pp.1092-1096
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• 1997

Thromboelastography(TEG) enables a global assessment of hemostatic function to be made from a single blood sample, documenting the interaction of platelets with protein coagulation cascade from the time of the initial platelet-fibrin interaction, through platelet aggregation, clot strengthening and fibrin cross linking to eventual clot Iysis. Thirty-five patients(mean age 34$\pm$ 12) undergoing open heart surgery from April 1st, 1996 to August 31th, 1996 were investigated at preoperatively and immediate, one hour, and 24 hours after cessation of cardiopulmonary bypass using TEG. Comparisons were made between classic hematological indices and TEG data. There were statistically significant correlation between maximal amplitude(MA) and platelet count before CPB, activating clotting time(ACT) and TEG date(R time, K time and a angle) at 24-hour after CPB. The data on the predictive accuracy for postoperative bleeding at 24-hour after CPB, the TEG was significantly better than ACT(57%) or the coagulation profiles(43%) as a predictor of postoperative bleeding, with an accuracy rate of 100% (P=0.0043). In conclusion, TEG seems to be easy to use, clinically accurate, cost effective and provides data which can effectively manage a patient's hemostasis.

• Korean Journal of Veterinary Research
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• v.28 no.1
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• pp.193-198
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• 1988

Blood coagulation time, bleeding time, clot retraction ability, thrombocytes counts and hematological values under electroacpuncture anesthesis and medicament anesthesia, using 10 mongrel dogs were compared. The results were summarized as follows: 1. Blood coagulation time under electroacupuncture anesthesia was shorter than that under medicament anesthesia (p<0.001). 2. Bleeding time under electroacupuncture anesthesia was shorter than that under medicament anesthesia (p<0.01). 3. Clot retraction ability under electroacupuncture anesthesia was better than that under medicament anesthesia (p<0.01). 4. Thrombocytes counts under electroacupuncture anesthesia was more increased than that under medicament anesthesia (p<0.05). 5. Erythrocytes counts, hematocrit values, hemnglobin contents and leukocytes counts were decreased (p<0.01) under medicament anesthesia in comparison with control group, but there was no significant difference under electroacupuncture anesthesia.

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.4
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• pp.1213-1217
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• 2004

Many ischemic disease patients have been taking herbal medicine and there are some papers that prescription of herbal medicine to ischemic disease patients are useful. Mechanism of herbal medicines on ischmeic disease have been investigated in many ways, but anticougulation or anti platelet effect of herbal medicines is not known obviously. And recently patients receiving anticougulation therapy are discouraged from taking herbal medicines. In this study, we investigate PT, INR, platelet of patients receiving herbal medicine therapy to study whether herbal medicines effect coagulation system of ischemic patients. In PT, INR, platelet values obtained from the patients, before and after administering herbal medicine, there were no significant changes.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1996.04a
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• pp.241-241
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• 1996

새로운 항암성 백금(II)착제 SA: ([Pt( trans-1-dach) (DPPE)]ㆍ2NO$_3$, SB: [Pt (cis-dach)(DPPP)]ㆍ2NO$_3$, SC: [Pt(cis-dach)(DPPE)]ㆍ2NO$_3$에 대한 일반 약리작용이 rat, mouse 및 rabbit에서 검토되었다. Rota-rod test에 의한 운동 협조능, thiopental-Na의 수면 작용, 현수에 의한 근이완 작용, 정상체온, strychnine 유발 경련, 담즙분비, 수정관, 자궁각, 피부혈관 투과성, 국소마취, 용혈 및 심전도에 대하여 SA, SB. SC는 별다른 영향을 미치지 않았단. 적출회장과 십이지장에 대하여 SA는 수축반응을 나타내었으나 SB와 SC는 하등의 영향이 없었으며 혈액 응고에 대하여 SA는 prothrombine time을 단축시켰으나 SB, SC는 별다른 영향이 없었고 호흡에 대해서는 SA, SB, SC 다같이 호흡수를 억제하였다. 적출심장 기능에 대하여 SA, SB, SC 다같이 고농도에서 억제적으로 작용하였다.

• The Journal of Korean Orthopaedic Ultrasound Society
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• v.5 no.1
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• pp.27-30
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• 2012

There are various diseases in soft tissue tumors that occur in subcutaneous tissue, and hematoma generally would be occurred in traumatic or coagulopathic condition. We report a case of hematoma on left gluteal area that was diagnosed by ultrasonography and was resected in 70 year old woman who visited the hospital because of left gluteal mass detected by chance two month ago and slowly growing.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.11a
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• pp.81-90
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• 1994

리포좀은 1960년대 초 Bangham등에 의해 혈액응고시 인지질의 영향에 관한 연구 중 우연히 발견하게 되었다. 즉 인지질이 물에 분산되어 2 분자막 (Bilayer)을 형성함을 알았고, 이때 생긴 폐쇄소포체를 리포좀이라 하였다. 이러한 리포좀은 원형질 막이나 세포내의 소기관의 막과 유사한 구조를 갖고 있기 때문에 이것을 이용하여 생화학자나 생물리학자들은 생체막의 모델시스템으로 이용하여 생체막의 기능 연구에 널리 이용하여 왔다. 1970년 초반부터 리포좀을 이용한 약물의 생체내 공급(Drug Delivery System, DDS)에 대하여 많은 연구가 이루어져 왔고, 지금까지도 의약품외 전달매체로 이용할려고 많은 시도를 하고 있는 실정이다. 최근에는 리포좀을 이용하여 항원을 전달하는 면역보조제(Adjuvant System)로 이용하려는 시도를 하고 있다. 현재까지 리포좀을 이용한 상품들은 화장품과 임상용 진단시 약, DNA transfection system (Lipopectin)으로 활용되고 있다.

• The Journal of the Korean dental association
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• v.27 no.7 s.242
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• pp.609-610
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• 1989

국소적 소인에 의한 구강내 출혈은 구소적 감염이나 원인 혹은 외상등에 의해 야기되는 것으로 혈액응고에 관여하는 여러인자의 양적, 질적 이상으로 유발되는 출혈성 소인에 의한 출혈과는 구별되어 진다. 대부분의 치과의사가 접할 수 있는 가장 흔한 출혈은 국소적 소인에 의한 것이며, 명심해야 될 사항은 이런 국소적 소인에 전신적 출혈성 소인의 한 요소일 수도 있다는 점이다. 이에 치과의사들은 구강내에서 국소적 원인을 쉽게 발견 치료할 수도 있으나, 전신적 출혈성 소인에 대한 연관성 조사를 항시 염두에 두어야 하겠다. 출혈성 소인에 의한 출혈은 특별한 외상 없이도 되부, 점막, 관절등에 자연히 출혈이 일어나며, 가벼운 외상에 의해서도 쉽게 출혈하는 경향이 있는 점이 국소적 소인에 의한 출혈과의 감별사항이다. 가장 관찰하기 쉬운 곳이 피부 및 점막으로 출혈하여 피가 모인 것을 자반(Purpura)이라 하며, 크기 및 정도에 따라 모세혈관에서의 출혈은 점상출혈(Petechia), 세동맥 및 세정맥에서의 출혈은 반상출혈(Ecchymosis), 좀더 심부에서 출혈하여 촉지되는 혈종(Hematoma)으로 나눌 수 있다. 임상적으로 구별되는 이런 양상을 잘 관찰하고 주의해야 하겠다.