• The Korean Chronic Disease News
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• no.311
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• pp.1-18
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• 2006

경기도 평택시 송탄 보건소 김보섭 소장/만성질환 관리 중추적 단체 위상제고/“앞으로 국민연금 덜 받는다”/건강보험료 환급 사기‘주의’/전공의 보조수당 민간병원 확대/65세이상 60%에 월8만9천원 지급/“의료용 혈액이 부족하다”/남‘암’-여‘순환기’사망확률 높아/수면무호흡증, 남성 발기부전초래/독감백신 국내 생산기반 구축/정부 의약품 가격 정책‘위헌소송’/차별화 된 고품격 보건서비스 제공/보건소 의료기관 서비스 만족도‘1위’/초고령사회 대응, 본격 시동 걸었다/노인의료“의료적 접근 동반돼야”/겨울철 어르신 건강관리 수칙 발표/비영리 의료기관 M&A 근거 마련/병원 서비스산업 주요 육성방안/고령친화 모델지역 기본구상/

• Journal of Korean Academy of Nursing
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• v.41 no.5
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• pp.603-612
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• 2011

Purpose: The purpose of this study was to describe the experience process of adolescents with hematologic malignancies. The question for the study was "What is the experience of adolescents with hematologic malignancies like?" Methods: The grounded theory methodology was used for this study. The data were collected through in-depth interview from 10 adolescents with hematologic malignancies. Data collection was done from January to June 2007. Theoretical sampling was used until the data reached saturation. Results: As a result of the analysis, "Reconstructing self-image from deviated and suspended life" was identified as the core category. And 11 subcategories were identified and they were integrated to the core category. 'Establishment of expanded and matured self' was identified as the consequence. Conclusion: The results of the study provide a frame for effective individualized nursing intervention strategies in helping adjustment of the adolescents with hematologic malignancies.

• Child Health Nursing Research
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• v.15 no.3
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• pp.282-290
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• 2009

Purpose: The main purpose of this study was to observe the adaptation experience process of adolescents with hematologic malignancies. Methods: The Grounded Theory Method, developed by Strauss & Corbin (1998), was used in this study. The data were collected through in-depth. interviews with 10 adolescents with cancer. Data collection and analysis occurred concurrently. Theoretical sampling technique was used until the data reached saturation. Results: "A deviated life" was verified as the central phenomenon for adolescents with cancer. The adaptation experience process was divided into 3 steps: "Self-confusion", "Reinterpretation", and "Regeneration of self". Through these 3 steps, the adolescents with hematologic malignancies fitted a new life by self-integration. Conclusion: The results of this study provide a frame for individualized nursing intervention strategies in helping with the psychosocial adaptation of adolescents with hematologic malignancies.

• The Zoological Society Korea : Newsletter
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• v.18 no.2
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• pp.21-25
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• 2001

대부분의 조직은 여러 가지 세포가 모여서 이루어지기 때문에 그 중의 어떤 특정세포에서 발현하는 물질을 분석하려면 조직을 이루고 있는 각각의 세포를 분리해내야 한다. 이렇게 순수하게 세포를 분리해내는 기술 중의 하나가 Laser Captured Microdissection (LCM)이 다. LCM의 개발로 기존에 사용되던 방법에 비하여 빠르고 간편하면서, 매우 정확하게 원하는 세포를 순수 분리해서 그 세포의 분자생물학적 또는 생화학적인 분석을 할 수 있게 되었다. LCM은 현미경으로 조직절편을 관찰하면서 원하는 세포를 낮은 에너지의 laser를 사용하여 도려내는 방법으로 조직절편 이외에도 도말된 혈액이나 자궁경부 조직, 그리고 배양된 세포를 cytocentrifugation한 후에 원하는 세포를 포획 할 수도 있다. LCM을 이용한 연구는 여러 분야에서 다양하게 진행되고 있으며, 특히 같은 조직 내에 존재하는 정상세포와 전이중인 세포, 그리고 암세포를 구분해 냄으로써 암의 전이기전 및 병인 연구에 매우 큰 공헌을 하고 있다. 이렇게 분리된 세포는 RT-PCR, LOH (loss of heterozygosity), microsatellite instability, differential gene profiling, cDNA microarray, Western blot, 2D PAGE protein analysis 등의 기법을 접목하여 연구하게 된다. 본 논단을 통하여 1996년 개발된 LCM의 원리와 이제까지 LCM을 이용한 연구 성과를 살펴보고자 한다.

• Proceedings of the Korean Information Science Society Conference
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• 2006.10a
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• pp.43-47
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• 2006

개인의 삶의 질과 관련되어 건강과 가장 밀접한 관계가 있는 헬스케어 서비스 분야에서 유비쿼터스 비즈니스 모델의 개발이 활발히 이루어지고 있다. 최근 서구화된 식생활과 고령화로 암, 당뇨, 고혈압 등 만성 질환과 노인성 질환이 우리나라에서도 증가하고 있다. 단순히 혈액 중의 당이 높은 것만으로는 즉각적인 증상을 보이지 않는다. 하지만 당뇨병으로 인한 심각한 합병증이 발생할 수 있으므로 당뇨병의 치료 및 예방이 중요하다. 따라서 본 논문에서는 유비쿼터스의 핵심 기술 중 하나인 RFID를 이용하여 당뇨병 환자들의 혈당 및 혈압을 모니터링 하고 식사, 운동, 인슐린 등을 조절하는 헬스케어 서비스 시스템을 구현한다

• Journal of the Korea Academia-Industrial cooperation Society
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• v.21 no.7
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• pp.645-655
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• 2020

This is a descriptive study investigating the relationships between sexual function, depression, and sleep quality in male hemodialysis patients. The participants of this study consisted of 134 outpatients who were diagnosed with end stage chronic kidney disease and who had undergone hemodialysis. The data were collected from June 10, 2019, to October 30, 2019. The collected data were then analyzed using descriptive statistics, the mean from independent sample t-tests, one-way analysis of variance (ANOVA), the Scheffe test, and Pearson's correlation coefficient using SPSS version 21.0. The lower the overall satisfaction, the lower the sexual function and the higher the degree of depression (r=.-19, p=.028). The greater the depression, the lower the quality of sleep (r=.60, p<.001). This study shows it is necessary to develop a program including symptom management to reduce depression in male hemodialysis patients. When developing nursing interventions to improve sexual function and quality of sleep, it will be necessary to develop a program that includes people who help the subjects.

• Korean Journal of Poultry Science
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• v.44 no.3
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• pp.173-179
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• 2017

This study investigated the effect of bamboo salt (BS) on body gain, feed intake, meat composition, and blood characteristics of broiler chicks. BS was processed by roasting salt at $1,200{\sim}1,300^{\circ}C$ in a bamboo container, with the open end plugged with red clay. In total, 120 broiler chicks were assigned to four treatments. Each treatment was triplicated, with 10 chicks in each treatment group. The supplementation levels of the three BS-treated feeds were 0.1, 0.2, and 0.3%. Body weight gain slightly increased in broiler chicks fed diets supplemented with BS compared to that of the control during the overall test period. However, no significant differences were observed among treatments. Feed intake was also not significantly different among treatments. Feed efficiency was significantly (p<0.05) improved in broiler chicks fed diets supplemented with BS compared to that of the control. Body weight gain was more positively affected by the dietary BS supplement at the beginning of the experimental period than toward the end. Water intake was positively correlated with the dietary 0.3% BS level (p<0.05). Breast meat composition and cholesterol levels were also not affected by BS supplementation. The total protein, albumin, glutamic oxaloacetic transaminase (GOT), glutamic-pyruvic transaminase (GPT), and total cholesterol levels in the blood were not significantly different among treatments.

• Food Science and Preservation
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• v.20 no.3
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• pp.394-403
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• 2013

This study was performed to investigate the four-week repeated-dose toxicity of the crude antifungal compounds produced by Lactobacillus plantarum AF1 (Lb. plantarum AF1), a lactic acid bacterium isolated from kimchi, in male and female rats. Sprague-Dawley male and female rats were divided into four groups, with 10 animals in each group. The test article was administered once daily by gavage to rats at dosage levels of 0, 500, 1,000, and 2,000 mg/kg/day for four weeks. There were no test-article-related deaths or abnormal clinical signs in both the male and female rats during the observation period. Furthermore, no differences in the body weight changes, food intake and water consumption levels of the control and treatment groups were found. The hematological parameters, serum biochemical analysis results, histopathological examination results and all other findings also showed no significant or dose-dependent changes. There were also no changes in the organ weights upon the administration of the crude antifungal compounds produced by Lb. plantarum AF1. These results suggest that the oral administration of the crude antifungal compounds produced by Lb. plantarum AF1 had no adverse effects up to a dosage level of 2,000 mg/kg in both male and female rats.

• Korean Journal of Head & Neck Oncology
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• v.27 no.2
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• pp.183-189
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• 2011

서 론: 5-FU와 cisplatin 병용항암화학요법은 국소진행성 두경부편평상피암의 유도화학요법으로 널리 사용되고 있는 요법이다. 저자들은 5-FU 대신 경구제재인 S-1을 cisplatin과 병용하는 복합항암요법의 효과와 안전성에 대해 연구하였다. 대상 및 방법: 저자들은 2007년 2월부터 2008년 12월까지 S1과 cisplatin의 복합유도화학요법을 시행받은 3/4기 구인두, 하인두, 후두, 구강 편평상피세포암 환자 52명의 치료결과를 후향적으로 분석하였다. 유도항암화학요법은 제 1일에 cisplatin(75 또는 60mg/$m^2$), 제1일부터 14일까지 S-1(40mg/$m^2$)을 1일 2회, 21일 간격으로 투여하였고 가능한 경우에는 항암방사선동시요법 또는 수술을 뒤이어 시행하였다. 결 과: 전체 52명 중 37명(71.2%)에서 부분반응을 보였으나 완전반응은 관찰되지 않았다. 2년 무진행생존율은 56.9%, 2년 전체생존율은 68.2%였다. 유도항암요법과 관련된 유해반응으로는 호중구감소증(71.2%) 및 빈혈(63.5%) 등과 같은 혈액학적 부작용이 가장 흔했다. 결 론: S-1과 cisplatin의 복합항암화학요법은 국소진행성 두경부편평상피암 환자를 대상으로 한 유도화학요법으로 적용이 가능한 것으로 판단된다.

• The Korean Journal of Nuclear Medicine Technology
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• v.19 no.1
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• pp.57-61
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• 2015

Purpose We considered the correlation of Ejection Fraction (EF) which was analyzed by Multi Gated Blood Pool Scan (MUGA) and Echocardiography (ECHO) for the patients who were classified according to the condition of cardiac function. Materials and Methods We analyzed the patients (female 60) who were diagnosed with breast cancer and were examined by both MUGA and ECHO. The 30 patients (age: $58.27{\pm}13.48$) who were analyzed into less than 50% to 70% of EF were categorized as normal group and the other 30 patients (age: $53.70{\pm}8.45$) who were analyzed into less than 50% of EF were categorized as abnormal group. Statistical analysis with SPSS ver. 18 was applied. Results Each of the value of mean and standard deviation of normal group was $66.43{\pm}5.80$ (MUGA), $60.50{\pm}4.93$ (ECHO). There was a significant difference (p<0.001). Each of the value of mean and standard deviation of abnormal group was $41.93{\pm}7.58$ (MUGA), $41.70{\pm}11.49$ (ECHO). There was no significant difference (p>0.001). In the result, all 30 cases of normal group showed the same reading. 8 out of 30 cases in abnormal group showed inconsistency of the reading. Conclusion We could confirm the correlation of the EF in MUGA and ECHO statistically. There was difference between abnormal groups from the result of reading. If we are aware of the result according to the different cardiac function categorization, MUGA and ECHO can be used as even more accurate interchangeable test.