• Journal of the Korean Society of Food Science and Nutrition
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• v.42 no.10
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• pp.1576-1584
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• 2013

This study is carried out to assess the relative effects of different doses of dietary glucose or fructose on non-alcoholic fatty liver disease (NAFLD) and hepatic metaflammation in a rodent model of type 2 diabetes. KK/HlJ male mice were fed experimental diets as follows: 1) control (CON), 2) moderate glucose (MG, 30% of total calories as glucose), 3) high glucose (HG, 60% of total calories as glucose), 4) moderate fructose (MF, 30% of total calories as fructose), and 5) high fructose (HF, 60% of total calories as fructose) for three weeks. Food intake was not affected by treatments. Compared with HF, HG not only increased serum fasting glucose and area under the curve during oral glucose tolerance test, but also decreased the levels of serum insulin and adiponectin. It indicated that glucose control was complicated via high glucose intake. High fructose treatment led to increased triglyceride in the serum and liver. In comparison to HG, high fructose diet activated NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome consisting of apoptosis-associated speck-like protein containing a CARD (ASC), NLRP3 and caspase 1, which increases interleukin (IL)-$1{\beta}$ maturation and secretion. The activation of NLRP3 inflammasome was accompanied by increased levels of tumor necrosis factor alpha (TNF-${\alpha}$) and IL-6. However, the expression of NLRP3 inflammasome components and pro-inflammatory cytokines did not differ between CON and HG. These data suggested that dietary fructose triggers hepatic metaflammation accompanied by NLRP3 inflammasome activation and has deleterious effects on NAFLD.

• Journal of the Korea Convergence Society
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• v.6 no.6
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• pp.95-103
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• 2015

The purpose of this study was to identify convergence factors related to glycemic control in workers with diabetes mellitus. A secondary data analysis was conducted using the data of "The Korea National Health and Nutrition Examination Survey, 2009-2013." The survey included 44,085 adults aged over 19 under 65 years with diabetes mellitus and 764 samples with worker were used for this study. Data analysis was conducted using SPSS 18.0 program and descriptive statistics, Pearson's correlations, and multiple regression analyses were performed. The general characteristics variables shown statistically significant difference between the good and the poor glycemic control group was gender. The Health behavior-related and disease-related variables shown statistically significant difference between the good and the poor glycemic control group were diabetes mellitus duration, diabetes mellitus treatment, hypertension diagnosis, smoking, moderate physical activity, walking exercise practice. Factors related to glycemic control were gender, diabetes mellitus treatment, walking exercise practice. These findings suggest that researchers need more active treatment and walking exercise as important factors affecting glycemic control of Korean worker with diabetes mellitus and intervention focusing on the issues needs to be developed in workplace environment.

• Journal of the Korean Society of Food Science and Nutrition
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• v.36 no.12
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• pp.1553-1559
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• 2007

The purposes of this study were to investigate the effect of Saengshik on blood glucose level of normal subject and to explore the marketing possibility of four kinds of Saengshik (ES, HS, BS, SS) as alternative diabetic meals. Blood glucose levels of healthy volunteers was measured at 15, 30, 45, 60, 75, 90, 105 and 120 minutes after taking Saengshik and 50 g glucose. Blood glucose response areas, glycemic index (GI) and glycemic load (GL) were calculated from the glucose response. The Saengshik showed a significantly lower glucose level than the glucose. The glycemic index (GI) of ES showed $43.1{\pm}12.6$, which belonged to low GI foods (GI of 55 or less). Other samples (HS, BS, SS) could be classified as intermediate GI foods ranging $56{\sim}69$ of GI. Saengshik showed a gentle rising and falling pattern showing moderate left area ratio and right area ratio on blood glucose curve. The GL of ES showed 14.1 while HS, BS and SS did $19.2{\sim}19.5$. The results indicated that Saengshik may have a beneficial effect on a diabetic.

• The Monthly Diabetes
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• s.258
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• pp.44-45
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• 2011

최근 발표된 고대구로병원 최경묵 교수의 연구에 따르면 당뇨병환자의 근육감소증 발병률이 일반인에 비해 3배나 높은 것으로 나타났다. 실제 근육이 많으면 당 조절에도 효과적인 것으로 알려져 있다. 당뇨병에서 걷기나 달리기 등 유산소운동의 중요성에 대해서 많이 알려져 있고, 실제 대부분의 환자들이 실천하고 있지만, 근력운동은 소홀한 경우가 많다.

• The Monthly Diabetes
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• s.213
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• pp.34-38
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• 2007

직장동료와 점심 외식을 하거나 가족과 저녁식사를 함께 하는 등 외식은 우리 일상 생활의 일부분입니다. 이처럼 외식이 필요할 때, 외식을 하고 싶을 때 혈당조절을 잘 하면서 외식을 즐길 수 있다면 장기적인 당뇨병이 식사조절이 즐거운 일 중의 하나가 될 수 있을 것입니다. 가능하면 외식의 횟수를 줄이는것이 좋겠지만 꼭 필요한 경우 기억하고 지켜야 할 외식시의 주의사항은 다음과 같습니다.

• The Monthly Diabetes
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• s.192
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• pp.12-16
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• 2005

소아 당뇨병은 성인 당뇨병의 축소판이 아니며 성장과 발육을 고려하여야 하고 성장에 따른 지속적인 추구관리가 이루어져야 한다는 점이 중요하다. 또한 아동들의 식욕을 조절하며 간식과 외식, 추가 운동, 여행, 생일 파티 참석 등 발생될 수 있는 특별한 경우에는 상황에 맞춰 혈당조절을 해야 한다.

• The Monthly Diabetes
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• s.259
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• pp.48-49
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• 2011

고지혈증은 뇌졸중, 협심증 및 심근경색 등 심혈관질환을 일으키는 주요 위험인자이다. 당뇨병이 있으면 일반인에 비해 관상동맥심질환이 발생할 확률이 2~4배까지 증가하고, 사망률 또한 높다. 대혈관 합병증을 예방하려면 혈당조절과 함께 중성지방이나 콜레스테롤을 적절하게 조절해야 한다.

• Korean journal of food and cookery science
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• v.31 no.2
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• pp.118-127
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• 2015

In this study, the effect of Cheonggukjang powder were investigated on the regulation of blood glucose and inflammatory in STZ-induced diabetic rats. The experimental diet used this study were three kinds of Cheonggukjang, which were soybean Cheonggukjang, Yakkong Cheonggukjang and black foods such as black rice, black sesame seeds, and sea tangle added Yakkong Cheonggukjang powder. The experimental animals were divided into 5 groups and fed experimental diets for 7 weeks; non-diabetes with normal diet group (C), diabetes with normal diet (DC), diabetes with soybean Cheonggukjang (DS), diabetes with Yakkong Cheonggukjang (DY), and diabetes with Yakkong black foods added Cheonggukjang (DYB). Blood glucose and insulin resistance of STZ-induced diabetic groups were were significantly higher than C group. But insulin levels and insulin secertory of STZ-induced diabetic groups were significantly lower than C group. However, supplementation of Yakkong or black foods added Yakkong Cheonggukjang were proven to regulation them. In diabetic group, free fatty acid level was significantly increased than C group, but this contents was significantly decreased supplementation of soybean Cheonggukjang. Leptin and adiponectin levels were significantly decreased in STZ-induced diabetic groups.

• Journal of Nutrition and Health
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• v.47 no.3
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• pp.157-166
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• 2014

Purpose: Rice bran is a byproduct of the hulling of rice and contains a variety of bioactive components. Various studies have reported on the antioxidative, anticancer, immune-enhancing, and hypocholesterolemic effects of rice bran. However, few studies about the physiological activity of stabilized rice bran supplement on dietary intake of sugars is limited. The aim of this study was to investigate the effect of stabilized rice bran supplement on blood glucose in C57BL/6 mice fed a high sucrose diet. Methods: Animals were randomly divided into three groups respectively, and were fed a normal diet (ND group), a high sucrose diet (HSD group) or a high sucrose diet containing 20% stabilized rice bran (HSD-SRB group) for 12 weeks. Results: In the oral glucose tolerance test (OGTT), after seven weeks of feeding on the experimental diets, a significantly lower result was observed for HSD-SRB than for HSD at 30 and 60 minutes after oral administration in glucose solution (2 g/kg body weight). The incremental area under the curve (IAUC) of HSD-SRB was significantly lower than that of HSD. After 12 weeks, fasting blood glucose level of HSD-SRB was significantly lower than that of HSD. No significant difference in the serum insulin level was observed between HSD and HSD-SRB. However, HOMA-IR was significantly decreased in HSD-SRB compared to HSD. In addition, HOMA ${\beta}$-cell was significantly increased in HSD-SRB compared to HSD. Triglyceride in liver of HSD-SRB was significantly lower than that of HSD. Conclusion: Feeding diets containing 20% rice bran improved insulin resistance and insulin secretion by decreasing triglyceride in liver. Thus, rice bran has a positive effect on glycemic control. In addition, the results are expected to be utilized as a basis for human study and development of food products with added rice bran.

• Journal of Korean Clinical Nursing Research
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• v.15 no.3
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• pp.27-38
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• 2009

Purpose: The purpose of this study was to develop a blood glucose control protocol for medical intensive care unit (ICU) patients. Methods: The blood glucose control protocol was developed through the following process: selection of preliminary protocols, clinical application, and evaluation. The clinical validity of the protocol was measured by application, along with examination of the effects of the Yale and the Mayo blood glucose protocols. Seventeen medical ICU adults patients whose blood glucose levels exceeded 200 mg/dL consecutively participated in the study. The development protocol was evaluated by an expert group. Results: Incidence of normal blood glucose levels (p=.041) increased significantly in the Yale protocol application group. Also, incidence of severe hyperglycemia (p=.029) decreased significantly and time to target range of glucose (p=.023) decreased significantly after application of the Yale protocol. However, there was no significant difference in incidence of hypoglycemia (p=.666) between three groups. Conclusion: Using the developed protocol as a basis for the modified Yale protocol was found to be effective in improving the state of blood glucose control for medical ICU patients and is expected to be used for nursing intervention in critical care.