• Title/Summary/Keyword: 현조선

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Changes in Acoustic Parameters According to Intensity Increase in Voice Assessment (음성질환자의 음성검사 시 강도 증가에 따른 음향학적 지표의 변화)

  • Nam, Do-Hyun;Rheem, Sung-Sue;Yun, Bo-Ram;Cho, Sun-A;Choi, Hong-Shik
    • Journal of the Korean Society of Laryngology, Phoniatrics and Logopedics
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    • v.22 no.2
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    • pp.143-150
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    • 2011
  • Background and Objectives : Clinically, as a tool for voice assessment before and after the operation or the voice treatment, acoustic analysis is widely used. However, in clinical situations, acoustic parameters vary according to how the assessment is made. Thus, with voice disease patients as subjects, we are to investigate what influence intensity increase exerts on acoustic parameters and how to reduce variation according to the way of assessing. Material and Method : At the voice clinic of the department of otorhinolaryngology in Gangnam Severance Hospital, with 30 female voice-disease patients (40.6 years old on the average) and 23 male voice-disease patients (40.1 years old on the average) as subjects, using the Dr Speech vocal-assessment program, we statistically tested the significance of the difference in each of acoustic parameters between when the "Ah" vowel is produced with a normal voice and when the "Ah" vowel is produced with a loud voice. Results : Acoustic parameters that showed a statistically significant difference according to intensity increase were Jitter, SD F0, and NNE for females, and Jitter, SD F0, HNR, SNR, and NNE for males. Voice quality estimates showed a statistically significant difference according to intensity increase in female hoarse voice, female breathy voice, and male breathy voice. Conclusion : In this research, acoustic analysis, which is generally used for voice assessment before and after the operation or the voice treatment, showed a tendency that acoustic parameters became better under the influence of intensity increase except for the cases where a voice disease was severe. Thus, to raise the reliability of voice assessment, the range of intensity needs to be set up. This should be the topic for the future research.

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Preparation of Protein-coated Cationic Liposomes Containing Doxorubicin and Their Binding Property of Blood Plasma Protein (독소루비신을 함유하고 단백질로 수식된 양이온성 리포솜의 제조 및 혈장 단백흡착 특성)

  • Kim, Sung-Kyu;Jung, Soon-Hwa;Jung, Suk-Hyun;Seong, Ha-Soo;Chi, Sang-Cheol;Cho, Sun-Hang;Shin, Byung-Cheol
    • Journal of the Korean Chemical Society
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    • v.52 no.1
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    • pp.57-65
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    • 2008
  • are nanometer or micrometer scale vesicles that can be used as drug delivery carriers. However, plain liposomes are plagued by rapid opsonization, making their circulation time in bloodstream be shortened. In this study, model protein, bovine serum albumin (BSA)-coated liposomes were prepared by coating cationic liposomes with BSA molecules at higher pH than isoelectric point of BSA. The BSA molecules coated on the liposomal surface were denatured by thermal treatment at above 60oC. While both plain and cationic liposomes had about mean particle diameter of 1041 nm, BSA-coated cationic liposomes (BCL) had mean particle diameter of 1091 nm. Encapsulation of model drug, doxorubicin (DOX), in liposomes were carried out by using remote loading method and the loading efficiency of DOX to liposomes was about 90%. The mean particle diameter of BCL did not increase in blood plasma and adsorption of plasma protein was much less than plain or cationic liposomes. These results suggest that BCL can be used as a long-circulating liposomes in bloodstream.

Development of PLM Prototype for Conceptual Design of Marine Vessels (선박의 초기설계 제품정보관리를 위한 PLM 시스템 원형 개발)

  • Lee, Chan-Woo;Lee, Jang-Hyun;Lee, Kyung-Ho;Lee, Jae-Beom;Kim, Dae-Seok;Seo, Heung-Won
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.21 no.6
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    • pp.543-553
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    • 2008
  • Shipbuilding is a kind of ETO(Engineering To Order) industry which designs and produces a product in accordance to various requirement of customers, rules and regulations. Recently, the number of ordered ships has been increased by up to two or three times in each domestic shipyards. Most shipyards have been adopted 3D ship CAD, ERP(Enterprise Resource Planning) and APS(Advanced Planning System) to get an efficient product development and manufacturing system. However, not only the effective operation of 3D ship CAD, ERP and APS but also the production efficiency can be achieved only if product information management which can manages the product data is implemented in an integrated environment. Present study has suggested a systematic approach to implement a PLM system to manage the product data in early design shipbuilding. Also, a prototype of PLM is implemented to manage the product data in a basic ship-design. In the prototype system, a product structure and architecture of PLM is considered.

GC/MS Analysis of Volatile Constituents from Endemic Acanthopanax koreanum and A. chiisanensis in Korea (한국특산 섬오갈피나무 및 지리산오갈피나무의 정유성분 GC/MS 분석)

  • Im, Sun-Sung;Lee, Yeon-Sil;Jung, Sang-Hoon;Park, Jun-Yeon;Cho, Seon-Haeng;Shin, Kuk-Hyun;Lee, Sang-Hyun
    • Korean Journal of Medicinal Crop Science
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    • v.16 no.2
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    • pp.86-93
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    • 2008
  • The chemical composition of the volatile constituents from the leaves and stems of endemic Acanthopanax koreanum and A. chiisanensis collected from Mt. Deokyu was determined by GC and GC/MS spectrometric analysis with the aid of NBS, Wiley Library and RI indice searches. The major constituents identified were ${\delta}-3-carene$ (31.34%), l-limonene (17.01 %), ${\beta}-elemene$(4.53%), trans-p-menth-2-ene-1,8-diol(3.13%), 1,8-cineole (4.73%), 1-dodecen-3-yne (2.64%) and (Z)-3,7-dimethyl-1,3,6-octatriene (3.21%) in A. koreanum, and ${\delta}-3-carene$ (14.78%), limonene (7.24%), t-ocimene (7.22%), ${\alpha}-terpinolene$ (8.76%), ${\gamma}-elemene$ (4.32%), ${\beta}-selinene$ (7.72%), veridifloral (3.25%) and dodecane (2.44%) in A. chiisanensis.

Design Sensitivity Analysis of Coupled MD-Continuum Systems Using Bridging Scale Approach (브리징 스케일 기법을 이용한 분자동역학-연속체 연성 시스템의 설계민감도 해석)

  • Cha, Song-Hyun;Ha, Seung-Hyun;Cho, Seonho
    • Journal of the Computational Structural Engineering Institute of Korea
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    • v.27 no.3
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    • pp.137-145
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    • 2014
  • We present a design sensitivity analysis(DSA) method for multiscale problems based on bridging scale decomposition. In this paper, we utilize a bridging scale method for the coupled system analysis. Since the analysis of full MD systems requires huge amount of computational costs, a coupled system of MD-level and continuum-level simulation is usually preferred. The information exchange between the MD and continuum levels is taken place at the MD-continuum boundary. In the bridging scale method, a generalized Langevin equation(GLE) is introduced for the reduced MD system and the GLE force using a time history kernel is applied at the boundary atoms in the MD system. Therefore, we can separately analyze the MD and continuum level simulations, which can accelerate the computing process. Once the simulation of coupled problems is successful, the need for the DSA is naturally arising for the optimization of macro-scale design, where the macro scale performance of the system is maximized considering the micro scale effects. The finite difference sensitivity is impractical for the gradient based optimization of large scale problems due to the restriction of computing costs but the analytical sensitivity for the coupled system is always accurate. In this study, we derive the analytical design sensitivity to verify the accuracy and applicability to the design optimization of the coupled system.

Comparative Study on Characteristic of Materials to Restore Traditional Gold Threads (전통 편금사 복원 및 재현을 위한 재료 특성 비교 연구)

  • Yu, Ji A;Kim, Ji Eun;Han, Ye Bin;Lee, Sang Hyeon;Chung, Yong Jae
    • Journal of Conservation Science
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    • v.30 no.3
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    • pp.307-315
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    • 2014
  • The gold textile is Korean traditional weaving technique using the gold thread since 5th century. The making technique of gold thread was written in various references, but it is severed because the gold thread weaving equipment and sumptuous moods were forbidden in the early 18th century. There are some studies of traditional gold thread which are mainly about conservation treatment of cleaning and strength. To restore traditional gold thread, investigation of material and manufacturing technique is vitally required. The gold threads are composed of gold leaf, adhesive and base sheet. Gold leaf and base sheet are available for investigation because they are exposed to the surface, whereas adhesive is not easy to investigate because it is not exposed to the surface. In this study, samples are made of pure and impure gold, animal glue and lacquer, and various types of Hanji based on domestic and foreign references to compare materials for gold threads. As a result of morphological character and stability evaluation, the optimum materials for the restoration of gold threads are pure gold, animal glue and Dochimji(smoothing paper by beating). This study is expected to be basic data for manufacturing gold threads techniques and modernization of traditional gold threads hereafter research.

Effect of Improvement of Storage Properties and Reducing of Sodium Nitrate by Glycyrrhiza uralensis and Curcula longa in Pork Sausage (돈육 소시지에 첨가한 감초 및 강황의 저장성 증진 및 아질산염 소거 효과)

  • Cho, Sun-Hee;Jung, Soon-Ah;Song, Eu-Jin;Lee, So-Young;Kim, Koth-Bong-Woo-Ri;Park, Jin-Gyu;Park, Sun-Mi;Ahn, Dong-Hyun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.35 no.8
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    • pp.997-1004
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    • 2006
  • This study was performed to investigate the storage properties of emulsion-type sausage added with Glycyrrhiza uralensis and Curcula longa hot water extracts (GCHE) extracted at $10^{\circ}C$ for 35 days. The TBARS values of sausages containing 1.0 and 5.0% GCHE were lower than that of control. The bacterial count and VBN contents of all the samples were significantly increased during the storage periods, except the group with 5.0% GCHE. The redness of all the samples was lower than that of control, while yellowness of all the samples was higher than that of control. The nitrite scavenging abilities of the sausages containing 1.0 and 5.0% GCHE were higher than that of the control. It is suggested that the addition of 1.0% hot water extracts extracted from these plants may be a potential substitute for the use of nitrite to extend shelf-life of sausages.

예비구조설계에서의 상호작용방식에 따른 컴퓨터 활용방안

  • 정종현
    • Computational Structural Engineering
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    • v.12 no.1
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    • pp.86-94
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    • 1999
  • 예비구조설계에서는 구조시스템 대안의 생성과 발전, 여러 방법과 대상에 따른 해석과 설계 다양한 요구조건과 구조적 특성을 고려한 여러 구조시스템 대안의 비교 및 선택 과정을 거친다. 그리고, 이러한 각 과정은 구조설계자의 경험적 지식을 바탕으로 하는 종합적인 사고와 판단에 따라서 단계적, 반복적으로 이루어진다. 그러므로, 예비구조설계에서는 정형화된 자료와 작어뿐 아니라 비정형화된 자료와 작업도 처리해야 한다. 따라서, 컴퓨터는 정형화된 자료와 작업을, 구조설계자는 비정형화된 자료와 작업을 직접 처리하고 이를 상호작용을 통하여 교환 및 지시하는 방식, 즉 구조설계자와 컴퓨터의 역할분담에 기초한 상호작용방식을 통하여 예비구조설계에 컴퓨터를 효율적으로 활용할 수 있을 것이다. 구조설계자와 컴퓨터의 역할분담에 기초한 상호작용을 원활히 지원하기 위해서는 구조시스템 대안의 기하학적 향상, 재료에 대한 자료를 효과적으로 제시할 수 있는 3차원 관점, 각 구조시스템 대안을 검토하고 비교하는 사항이 되는 다양한 요구조건에 대한 자료들을 관리하고 제시할수 있는 요구조건 관점이 필요하다. 그리고 예비 구조설계가 진행되어 온 과정, 방향, 설계의도등의 파악을 위한 바탕이 될 수 있는 작업과정관점, 구조시스템 대안 발전 관점이 필요하다. 예비구조설계의 프로세스 조절을 위한 상호작용을 효과적으로 지원하기 위해서는 컴퓨터가 수행 할 수 있는 정형화된 작업들을 예비구조설계의 진행순서인 구조시스템 대안의 생성과 발전, 구조시스템 대안의 해석과 설계, 구조시스템 대안의 선택에 따라서 나열하여 제시할 필요가 있다. 이를 통해서 구조설계자는 자신의 판단에 따라서 다음에 수행해야 할 작업을 결정하고, 그에 해당하는 정형화된 작업을 컴퓨터가 제시한 작업 중에서 선택하고 그 수행을 지시하여 자신의 경험적 지식과 설계의도에 맞추어 예비구조설계의 프로세스를 조절할 수 있다.정조합력은 유의차가 컸으나, 상반조합 능력은 없었다. 교배친의 우성효과는 컸다. 잡종강세 환경변이 및 상가적 작용도 컸다. 우성의 방향은 정의 방향이었으므로 우성귀전자가 크게 작용하였다. 이들 형질들의 귀전자들은 초우성을 나타내었다. 교배친의 자견층중의 우성순서는 잠120>잠114>잠108>잠119>잠118>잠107>잠117>잠113 순이었고, 웅견층중에서는 잠114>잠108>잠120>잠117>잠118>잠107>잠119>잠119>잠113 순이었다. 자견층 비율에서는 광의의 귀전력이 협의의 귀전력보다 컸고, 웅견층 비율에서는 같았다, 견층 비율에서는 일반조합 능력은 크게 나타났으나, 특정조합 능력과 상반조직 능력은 나타나지 않았다. 자견층 비율에서 교배친의 우성효과는 컸다. 자견층 비율에서는 교배친의 우성효과는 적었다. 자웅견층 비율의 잡종 강세는 적게 나타났다. 환경변이와 상가적 작계는 자웅견층 비율에서는 크게 나타났다. 우성의 방향은 자견층 비율에서는 정의 방향으로 우성 귀전자가 크게 작용하였으며, 자견층 비율에서는 정의 방향으로 우성 귀전자가 부분적으로 작용하였다. 교배친의 자견층 비율의 우성순서는 잠117>잠114>잠108>잠120>잠118>잠119>잠107>잠113 순이었고, 자견층 비율에서는 잠114>잠117>잠108>잠118>잠107>잠119>잠113>잠120의 순이었다.지방산의 조성이 많은 차이를 보였다.{2+}$ 26 및 $Na^+$ 26 mg $L^{-1}$이었다. 양액 재배 후 버려지는 폐양액 중의 무기성분 함량은 양액재배에 이용되는 원수에 비해 상당히 높아졌다.료로서 응용 가능성이 있음을 시사한다.약재료인 약초류 등을 이용하였는데 오랫동안 푹 삶아 그물에 곡류 등을 넣어 죽이나 밥으로 조리하였으며 면으로도 조리하였다. 이상과 같이 조선시대 주식류의 종류 및 조리방법에 대한

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A Comparative Study of the Korean, Japanese and Manchurian Railway Policy during the Japan Colonial Period (한국, 일본, 만주의 철도현황 비교연구 -1920년대 중반 일제강점기를 중심으로-)

  • Lee, Yongsang;Chung, Byunghyun
    • Journal of the Korean Society for Railway
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    • v.18 no.2
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    • pp.157-165
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    • 2015
  • At the end of the 19th and in the early 20th centuries, Japan, Korea, and Manchuria, and areas throughout East Asia, suffered a number of cycles of growth and development, for which the railway was a very important development tool and was closely associated with national policy. East Asian affairs, especially at the time, seemed very important to the continent, and their influence on the advance of this remarkable era was especially prominent in Japan. In the midst of this period, the national railway may have evolved under national policy and railway policy and under a variety of organizations and persons of influence. In this paper, we have tried to find the similarities and differences among the three countries that built the East Asia Railway; we consider the characteristics of the East Asia Railway from the perspectives of these three countries. Comparing the characteristics of the three country's railways, first, Japan had the motives of continental expansion and modernization in its pursuit of the railway; in Korea, the railway played the role of a continental rail link; and in Manchuria there was a tendency to pursue direct domination of the railway. Second, the Japanese applied their railway model to Korea; the Korean railway may have been in operation, but it was an extension of the railway of Japan. The railway in Manchuria showed a similar pattern to that which can be found in the state of Asian domination of Europe ; Japan showed aspects of dominance over the railway because it had experience running a private railway.

Health Risk Factors and Ventilation Improvements in Welding Operation at Large-sized Casting Process (대형 주물공정 용접작업장의 건강 위해인자 및 환기 개선)

  • Jung, Jong Hyeon;Jung, Yu Jin;Lee, Sang Man;Lee, Jung Hee;Shon, Byung Hyun;Lim, Hyun Sul
    • Clean Technology
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    • v.20 no.2
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    • pp.171-178
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    • 2014
  • In this study we have examined the health risk factors and analyzing data of laborers working at the welding operation at large-sized casting process. In order to improve the working environment of workplace, an effective ventilation method was proposed after performing CFD (computational fluid dynamics) modeling and measurement of pollutants. As a result of examining the health risk factors of workers, oxidized steel dust is the main pollution source in the company A, welding fume in the companies B and C, and welding fume and oxidized steel dust in the company D. The fume concentration in the workers' breathing zone was $0.05{\sim}4.37mg/m^3$, and the fume concentration in the indoor air at the welding process was $0.13{\sim}7.54mg/m^3$. From a result of CFD, a local exhaust with an exhaust duct adjacent to welding point was found to be most effective in case of the exhaust process. In case of air supply, we found that a desired location of air supply fan would be at the end of the opening. If a standardizing the ventilation system for tunnel-type semi-enclosed space at a large-sized casting process is introduced in welding work places in the future, it would be more effective to protect the health of welding workers working at the casting industry and shipbuilding industry and improve the work environment.