• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2011.05a
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• pp.459-462
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• 2011

해양생물다양성 자원에 대한 국가 주권을 인정하는 해양생물다양성협약의 발효로 생물다양성 자원을 확보하기 위한 세계 각국의 경쟁이 치열한 상황이다. 현재 우리나라 각 기관 및 대학들이 보관하고 있는 해양생물자원 정보가 산재되어 있고, DB에 대한 관리 미흡으로 인하여 학술적, 산업적 활용이 어려운 상황임을 인지하여, 통합적으로 관리할 수 있는 정보체계가 필요한 시점이다. 본 논문에서는 해양생물다양성 자원 중 고품질 해양생물자원에 대한 현황을 분석한다. 그리고 해양생물다양성 데이터 고품질 확보 방안을 위한 DB 품질 오류율 산정 기준을 적용하여 메타DB 구축 방안을 제시한다. 본 연구는 향후 해양생물자원에 대한 국가전략수립에 기여할 것으로 기대한다.

• Journal of Marine Bioscience and Biotechnology
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• v.15 no.2
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• pp.59-66
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• 2023

Dictyopteris divaricata, a type of marine brown algae, has been studied for its various biological properties, including anti-inflammatory, antidiabetic, and whitening effects. However, its potential antiobesity effects have not been extensively explored. This study aimed to examine the impact of D. divaricata ethanol extract (DDE) on adipocyte differentiation and adipogenesis using 3T3-L1 preadipocytes. Our results showed that when 3T3-L1 preadipocytes were treated with noncytotoxic concentrations of DDE there was a concentration-dependent decrease in fat accumulation rate and triglycerid production compared with the control. Furthermore, DDE significantly reduced the expression of transcription factors (PPARγ, C/EBPα, and SREBP-1) and fatty acid transport protein (FABP4), which are crucial for 3T3-L1 preadipocyte differentiation. These findings suggest that DDE may exhibit antiobesity effects by suppressing the expression of lipogenic transcription factors and fatty acid transport proteins. Therefore, DDE holds potential as a therapeutic agent for obesity.

• Journal of Marine Bioscience and Biotechnology
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• v.15 no.1
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• pp.1-11
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• 2023

In the present study, the antioxidant and anti-inflammatory activities of ethanolic extracts from Lathyrus japonicus at concentrations of 50, 100, and 200 ㎍/mL were investigated in LPS-stimulated, RAW264.7 cells. Antioxidant properties were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging assays and ferric reducing antioxidant power assay. In addition, the production of reactive oxygen species (ROS) was measured using the 2',7'-dichlorofluorescein diacetate (DCFH-DA) probe by flow cytometry. To examine the anti-inflammatory activity of the extracts of L. japonicus, their effects on the levels of nitric oxide (NO); production of cytokines such as interleukin (IL)-1β, IL-10, and tumor necrosis factor-α (TNF-α); and the activities of enzymes such as inducible NOS (iNOS) and cyclooxygenase-2 (COX-2) were assessed. The IC₅₀ values of the DPPH and ABTS radical scavenging assays were 476.09 ± 1.50 and 34.91 ± 0.37 ㎍/mL, respectively. In addition, L. japonicus extracts not only inhibited ROS production, but also the production of NO, IL-1β, and IL-10, and the activity of iNOS in a dose-dependent manner. In summary, the ethanolic extracts of L. japonicus could be used as a functional food additive and an anti-inflammatory agent owing to their antioxidant and anti-inflammatory activities

• Journal of Marine Life Science
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• v.8 no.2
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• pp.136-149
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• 2023

Basic bioactivities (antioxidant, anti-inflammatory, antibacterial, anticancer, antiviral) were investigated from 370 strains of marine bacteria, fungi, and microalgae obtained from various marine environmental regions in Korea, and the activity results were obtained at the collection site, isolation source, and species level was compared. In the case of marine bacteria, strains belonging to the generally useful genera Streptomyces and Bacillus were observed to have particularly strong efficacy and useful resources were mainly isolated from marine sediments. In the case of marine fungi and microalgae, results showing strong species-specific activity were confirmed, and results showing efficacy-specific activity were also obtained. Based on these results, it is a research result that can facilitate priority access as a strategic material for industrial revitalization and the establishment of a strategy to secure resources based on usefulness when conducting research on chemicals that are selectively effective against specific diseases or when conducting resource-based research. In addition, we believe that by using these results as material for sale through the Marine BioBank (MBB), academia and industry can use them to help accelerate the revitalization of the marine bio industry.

• The Microorganisms and Industry
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• v.18 no.1
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• pp.9-12
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• 1992

현대산업의 급속한 발전으로 에너지 또는 유용 광물자원의 고갈, 오염문제와 식량문제는 전지구적 차원에서 매우 심각해지고 있다. 지구표면의 대부분을 차지하고 있는 해양에는 풍부하고 다양한 생물자원과 광물자원이 아직도 대부분이 미개발 상태로 남아있다. 현재 전지구적 차원의 문제점을 해결하기 위해서 해양에 관한 연구개발은 세계 각국에서 활발하게 수행되고 있으며 최대의 관심사가 아닐 수 없다. 이와 같은 세계의 조류 속에서 일본 해양 생물공학 연구분야의 최근 움직임은 심상치가 않다. 따라서 일본의 최신 동향을 살펴보기 위해 본고에서는 일본 해양 생물공학 연구소와 해양과학기술센터에 관한 자료를 소개하고 우리의 대처방안에 대한 소견을 밝히고자 한다.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2000.05a
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• pp.29-30
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• 2000

최근, 전자 및 컴퓨터 기술이 눈부신 발달과 더불어 개발된 과학어군탐지기는 해양생물자원을 신속하고도 정확히 평가하는 수단으로서 인정받아 실용화 단계에 있다. 그러나, 계량어군탐지기를 이용한 자원량 추정기술을 보다 더 정도 높고, 효율적인 방법으로서 정착하기 위해서는 선결해야 할 문제점이 몇 가지 있다. 먼저 대상생물의 식별로서 조사하고자 하는 생물과 다른 해양생물과를 식별하는 것이며, 나아가 같은 생물에 있어서도 분포수심, 유영 자세 등에 의해서도 자원의 추정정도가 다르므로 이에 대한 연구가 필요 불가결하다. (중략)

• Journal of Food Hygiene and Safety
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• v.32 no.1
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• pp.70-74
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• 2017

Recently, the area of marine resources has become concerned with sources for the next generation of the bio-industry. Until present, development of the marine resources has remained limited, although a large number of these resources are considered to have potential for various significant biological activities. Most marine sponges, marine algae and coral could be used to create specific compounds for survival against a harsh environment. Therefore, it was necessary that these materials needed to be elucidated with biological activities, such as like anti-inflammatory, anti-viral or anti-cancer effects for their utilization in the bio-industry. In this study, we screened extracts of marine resources for their anti-cancer effect on human colorectal cancer cells. These resources were collected at Kosrae of Micronesia on April, 2013 and extracted with methanol. Cytotoxicity of marine resources was observed. Of a total of 20 specimens, three specimens dose-dependently demonstration inhibition of cell viability. Furthermore, cells treated with these specimens for 48h were induced p53, p21, Bax and caspase-3. The results suggest that they involved p53-mediated apoptosis. Two positive specimens (1304KO-327 and 1304KO-329) were verified as the identical materials, which are Hyrtios sp. Unfortunately 1304KO-207 was not yet classified and needed to identify in the further study. There results suggested that marine resources with positive potential in anticancer effect would be good candidates as useful bio-resources.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.54 no.2
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• pp.162-169
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• 2021

Global warming has affected the distribution of organisms for decades and has displayed rapid ascent recently. Research into the effects on tropical organisms are vital. Padina boryana is a resourceful marine microalgae in the Maldives Sea in the Laccadive region. A 70% ethanol extraction (PBE) of this seaweed was used to investigate its antioxidant potential. Both in vitro and in vivo models were implemented. PBE exhibited protective potential against H₂O₂ induced apoptosis. ROS levels were suppressed due to PBE. PBE expressed a cytoprotective nature. In vivo experiments involving the zebra fish model conformed its validity. The antioxidant efficacy of PBE was dose dependent. Study outcomes suggest PBE has potential as a novel and valuable marine resource to aid the functional food and cosmeceutical industries.

• Proceedings of the Korean Society of Fisheries Technology Conference
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• 2003.05a
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• pp.33-36
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• 2003

해양생물은 매우 다양하고 양적으로도 풍부하며, 지구상의 전체 동물 중 약 80%가 바다에 서식하고 있는 것으로 알려져 있다. 바다 속에 살고 있는 3만종 이상의 어류를 포함한 해양자원은 육상 생물자원의 부족량을 보완할 수 있는 생물자원으로 인간의 3대 영양소인 단백질, 지방 및 탄수화물의 공급원으로서 식품산업뿐만 아니라 건강기능성 식품 및 의약산업분야에서의 원료로서도 그 중요성이 점점 높아지고 있다. (중략)

• Korean Journal of Environmental Biology
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• v.32 no.4
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• pp.397-402
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• 2014

In June 1992, Convention on Biological Diversity (CBD) was concluded by 158 countries in Rio de Janeiro. And now, 194 member nations are participating in discussions for their own profit. Recently, Nagoya Protocol regarding Access to genetic resources and Benefit-Sharing (ABS) was approved and took effect from October $12^{th}$, 2014. Thus, it is important to understand the impact of CBD and ABS functioning on researchers studying marine biodiversity. Until now, in the previous Conference of the parties to the Convention on Biological Diversity, the interest towards researching marine and marine living resources was relatively low, and accordingly, the discussions regarding marine and marine living resources were delayed. However, in the $12^{th}$ Pyeongchang Conference of the Parties to the Convention on Biological Diversity, the arguments concerning Ecologically or Biologically Significant marine Areas (EBSA) and the other marine related issues were discussed. Although, South Korea has not yet officially joined Nagoya Protocol, however the consultations in regard to Prior and Informed Consent (PIC), Mutually Agreed Terms (MAT) and Global Multilateral Benefit-Sharing Mechanism (GMBSM) were discussed. We belive that as a possessing nation of biological resources, South Korean government authorities should revise their management systems protocol and regulations concerning domestic biological resources, in order to strengthen the information system and help academia and industry to utilize the biological resources abroad easily and effectively.