• Journal of the korean veterinary medical association
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• v.50 no.2
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• pp.104-111
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• 2014

안구표면은 자연스럽게 형성되는 세균집단의 거처로 항시 소독이 되어 있지 않은 상태로 존재한다고 봐야 한다. 예방 또는 치료를 목적으로 사용되는 적절한 항생제를 선택하려면 안구표면에 항시 산재하는 세균들에 관한 것은 물론 병원균에 효력이 있는 약품 그리고 그 약품의 부작용에 관한 사항들을 숙지해야 한다는 것은 수의사로서 자명한 사실이다. 이 글은 문헌들을 토대로 하여 개와 고양이 안구부(眼口部)에 서식하는 세균 그리고 병원균들과 그에 응용해야 할 항생물질들을 사용하는 데 조금이라도 도움이 될 수 있도록 간단히 분류 적절하게 이용할 수 있기를 바라는 마음에서 정리한 것이다.

• The Microorganisms and Industry
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• v.20 no.1
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• pp.42-45
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• 1994

아미노산은 식품이나 사료의 첨가물로, 의약품으로 그리고 화학합성에 있어서의 단위구조체(building block)로써 널리 이용되어 왔는데, 위에서 광학적으로 순수한 single enantiomer로서 D- 혹은 L-form의 .alpha.-아미노산은 의약품의 합성에 있어서 그 산업적 중요성이 날로 증대되고 있다. 이중 D-form의 아미노산은 .betha.-lactam계 항생제, peptide hormone, 살충제 등의 합성에서 중간 물질로 사용되고 있는데, 특히 D-p-hydroxyphenylglycine(이하 D-HPG)의 경우 amoxicillin, cefadroxil, cefatrizine, cefaparole, cefaperazone등의 penicillin이나 cephalosporin계의 반합성항생제의 전구체로서 전 세계적으로 널리 사용되고 있다.

• Monthly Korean Chicken
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• v.16 no.4
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• pp.65-71
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• 2010

안전한 축산물에 대한 소비자의 신뢰 제고를 위해 사료에 첨가되는 항생제의 종류를 단계적으로 감축하고 있다. 정부는 2011년 하반기부터 사료첨가용 항생제 사용을 전면 금지하는 관련법령을 추진하고 있고, 친환경 축산업을 정책적으로 육성하고, 천연물질을 활용한 대체물질 개발 보급에 전력을 다한다는 방침이다. 그동안 각 계열사들도 무항생제 인증 및 HACCP 인증 등 농가의 축사 시설 현대화 사업과 더불어 중점적으로 농가에 지원하고 연구하고 있는 상황이다. 하지만 아직 전체적인 양계 농장들의 시설이 열악하고 방역시스템도 갖추어져 있지 않는 농장이 대부분이어서 아직은 정부 정책의 속도가 너무 빠른 결정이 아닌가 걱정하는 분들의 목소리도 무시 못할 상황이다. 이번 호에서는 무항생제 인증 사육에 대한 우리의 과제를 뒤돌아 보고 문제 해결을 위한 방향성에 대해 고민해 보고자 한다.

• Korean Journal of Microbiology
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• v.42 no.1
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• pp.54-58
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• 2006

Dried roots of Paeonia japonica were extracted with dichloromethane, methanol and water aerially. Silica gel column chromatography and thin layer chromatography were used to separate the fractions with antimicrobial activities, and mass spectrometry was used to determine the mass. Dichloromethane extract showed the highest antimicrobial activity. Dichloromethane extract from Paeonia japonica could be a candidate for a new antimicrobial agent against MRSA.

• Korean Journal of Microbiology
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• v.40 no.1
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• pp.17-22
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• 2004

Scutellaria baicalensis and Phellodendron amurense, which have been used traditionally in treatment of many kinds of illness including infectious diseases, were extracted with hexane, dichloromethane, methanol and water, respectively and serially. Antimicrobial activities of the extracts were examined by disk diffusion method. Methanol extract from Scutellaria baicalensis revealed high antimicrobial activities against MRSA, Gm-bacteria and Candida albicans, dichloromethnane extract from Phellodendron amurense showed lower activity than the extract of Scutellaria baicalensis. Results suggest that methanol extract from Scutellaria baicalensis could be one of the candidates for new antimicrobial agent against the antibiotic-resistant microorganisms by further steps for the purification, determination of structure and synthesis.

• Journal of Digital Convergence
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• v.14 no.4
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• pp.371-378
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• 2016

An aim of current study was to investigate the prevalence and the mechanism of quinolone-resistance in E. coli isolates obtained from chicken cecum in Korea. In addition, multilocus sequence typing (MLST) was also performed for the molecular characterization of E. coli isolates. In an antimicrobial susceptibility test by the disk diffusion method, the 63.5% (54/85) of E. coli isolates showed the resistance to quinolone group of antimicrobial agents. All of the 54 E. coli isolates showing resistant to quinolone group had sense mutations in gyrA gene and point mutations at the $57^{th}$, $80^{th}$, or $84^{th}$ residues in parC gene were detected in 90.7% of the isolates. Interestingly, E. coli ST was closely related to amino acid substitutions in parE gene. Our results indicated that the long-term use of antimicrobial agents in food-producing animals was strongly associated with a prevalence of antimicrobial resistance in commensal Enterobacteriaceae, suggesting the need for continuous surveillance and monitoring of antimicrobial resistant determinants in bacterial isolates from food animals.

• Journal of Food Hygiene and Safety
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• v.35 no.1
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• pp.6-12
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• 2020

Prevalence of toxin genes and profiles of antibiotic resistance in Vibrio vulnificus were investigated for prevention of Vibrio sepsis and selection of effective antibiotics. A total of 23 V. vulnificus strains were isolated from Vibrio sepsis patients, fish, and water samples collected from fish tanks in restaurants in Jeonnam province during 2015-2017 period. Prevalence of toxin genes including, RtxA, viuB and vvhA were assessed and susceptibilities to 15 different antibiotics were determined. As a result of the toxin gene profile, the RtxA toxin gene was detected in 19 (82.6%) out of 23 strains, and vvhA and viuB toxin genes were positive in all strains. These results showed that V. vulnificus tested in this study possessed at least one more toxin gene, and the toxin gene detection rate was higher than in previous reports. Therefore, there is always a risk of Vibrio sepsis through eating fish or having contact with aquarium water at seafood restaurants. Especially, it was deemed necessary to provide preventive education about Vibrio sepsis for workers in such restaurants. The results of antibiotic susceptibility tests presented 94.4% resistance to cepoxitin antibiotics but all strains showed susceptibility to 14 kinds of antibiotics including chloramphenicol and tetracycline. The currents antibiotic therapy using chloramphenicol and teteracycline against Vibrio sepsis was judged to be useful.

• Clean Technology
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• v.27 no.1
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• pp.55-60
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• 2021

Antibiotics are compounds broadly used to treat patients with infectious diseases and to enhance productivity in agriculture, fisheries, and livestock industries. However, due to the overuse of antibiotics and their low biodegradability, a substantial amount of antibiotics is leaking into the sewer, subsequently resulting in pollution and the emergence of antibiotic-resistant bacteria. This study explores biodegradable serum albumin's potential as an adsorbent to remove antibiotics from water. Serum albumin is a natural blood protein that transports various metabolites and hormones to all tissues' extravascular spaces. While serum albumin is highly water-soluble, it has intrinsic binding sites which readily accommodate ionic, hydrophilic, or hydrophobic molecules, rendering it a good building block for a nano-adsorbent. To induce coacervation, a desolvating agent, ethanol, was added dropwise into the aqueous albumin solution, resulting in dehydration and liquid-liquid phase separation of albumins into albumin nanoparticles within a size range of 150 ~ 170 nm. The addition of glutaraldehyde as a cross-linker improved the size stability and homogeneity of albumin nanoparticles. Adsorption of amoxicillin antibiotics on albumin nanoparticles was dependent upon glutaraldehyde concentration used in desolvation and pH during adsorption. The maximum adsorption capacity measured by spectrophotometry was found to be 12.4 micrograms of amoxicillin per milligram of albumin nanoparticle. These results demonstrate serum albumin's potential as a building block for fabricating a natural nano-adsorbent to remove antibiotics from water.

• The Korea Swine Journal
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• v.11 no.2 s.114
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• pp.139-143
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• 1989

• Feed Journal
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• v.1 no.2
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• pp.80-83
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• 2004