• Proceedings of the Korean Society of Applied Pharmacology
• /
• 2001.04a
• /
• pp.45-59
• /
• 2001

최근 급속한 산업화와 경제발전으로 인해 소득수준이 향상되면서, 고단백질 및 고지방질 식품의 섭취 및 운동부족으로 인한 성인병, 특히 비만증, 고지혈증, 당뇨병 및 심장순환기계질환이 급속히 증가되어 사회문제로 대두되었고, 한국을 포함한 선진각국의 고지혈증 및 심장순환기계질환의 발병빈도가 여전히 증가추세에 있다. 보건위생의 여건이 좋아지면서 전염성질환이 줄어들었으나, 심장 순환기 질환의 발병률은 계속 증가추세에 있고, 순환기질환은 고지혈증에 의하여 발병되며 이 질환의 사망률은 전체 사망률 중 상위를 차지하고 있다. 인간은 고지혈증에 의한 동맥경화로 인한 사망률은 전체 사망률 중에서 상위를 차지하고 있으며, 그에 따른 의약품의 개발이 요구되고 있고, 현재 임상적으로 사용되고 있는 고지혈증 치료제로는 체내의 cholesterol 생합성 저해제가 있으나, 보다 제한사항이 없고, 작용기작이 확실하며 부작용이 적은 새로운 고치혈증 치료제의 개발이 요구되고 있다. 콜레스테롤은 세포막의 구성과 스테로이드 호르몬의 전구체로서 생체를 구성하는데 필수적인 요소이지만 과다하게 공급되었을 경우 동맥경화와 같은 심혈관계 질환을 유발할 수 있다. 체내에 콜레스테롤의 공급은 체외 음식물로부터 섭취하는 방법과 체내에서 생합성에 의해 공급되는 방법이 있는데, 서로 유기적인 보완관계를 유지하면서 필요한 콜레스테롤의 양을 유지한다. 그러나, 현대인의 식생활이 급격한 서구화로 체외로부터 필요량 이상으로 콜레스테롤이 유입되어 각종 성인병 발명의 상승 요인이 되고 있다.

• 건강소식
• /
• v.35 no.9
• /
• pp.22-24
• /
• 2011

고지혈증은 유전적인 요인으로 인해 혈액 내에 특정 지질이 증가하여 발생하는 경우도 있지만, 기름진 음식을 많이 섭취하는 서구식 식습관이나 비만, 음주, 운동부족 등에 의해서도 발생한다. 따라서 고지혈증에는 꾸준한 식사 관리가 필수적이다. 고구마는 고지혈증에 좋은 음식으로 칼륨, 엽산, 섬유질 비타민 C가 다량 함유되어 있다.

• Journal of Navigation and Port Research
• /
• v.38 no.5
• /
• pp.511-518
• /
• 2014

The history of the Korean lighthouse have been known to be begun from which installed by the purpose of the Japanese invasion of the outside. Modern navigational aid system have configured during the Japanese ruling era since the Incheon Palmido Lighthouse was built in 1903 as the first lighthouse in Korea. But in this regard it needs to be considered more carefully. Busan, as the city of international port and of Choryang Waegwan, had been a center of foreign relations between Korea and Japan since early 15th century. Because that reason, International port facility has been developed for a long time ago in Busan for example lighthouse, breakwater, wharf, jetty and so on. Nevertheless the lack of historical data and basic research related to the marine caused the proper history could not be established until now. In recently the basic translation of Korean Maritime Customs documents started to finish, and a compilation book of old pictorial maps on Choryang Waegwan was issued. As a result, more objective history of Busan Aids to Navigation can be investigated.

• Journal of the Korean association of regional geographers
• /
• v.10 no.3
• /
• pp.511-538
• /
• 2004

The aim of this paper is to investigate the characteristics of place-names in old map of Andong-Bu mapped in Chosun Dynasty. A place-name is a linguistic expression whose function is to identify a topographic feature. The place-names in old map of Andong-Bu normally involve physical, administrative, military, economic, transport, and cultural features. The cultural place-names are more meaningful in Andong-Bu which was a center of confucianism in Chosun Dynasty. The generic place-names, including cultural place-names such as school, pavilion, temple, etc., served as indicators to identify regional characteristics of Andong in the past and present. A study on the place-names, using old maps, is regarded as advisable attempt in regional approach in geography.

• Journal of the Korea Institute of Information and Communication Engineering
• /
• v.25 no.4
• /
• pp.523-529
• /
• 2021

In the era of the Fourth Industrial Revolution, technological changes are being applied in various fields. Automation digitization and data management are also in the field of bills. There are more than tens of thousands of forms of bills circulating in society and bill recognition is essential for automation, digitization and data management. Currently in order to manage various bills, OCR technology is used for character recognition. In this time, we can increase the accuracy, when firstly recognize the form of the bill and secondly recognize bills. In this paper, a logo that can be used as an index to classify the form of the bill was recognized as an object. At this time, since the size of the logo is smaller than that of the entire bill, FPN was used for Small Object Detection among deep learning technologies. As a result, it was possible to reduce resource waste and increase the accuracy of OCR recognition through the proposed algorithm.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.25 no.6
• /
• pp.958-962
• /
• 1996

Hypolipidemic effect of methanolic extract of marine algae, Pachymeniopsis elliptica was examined in hyperlipidemic rats. Male $Sprague-Dawley(120\pm5g)$ rats were divided into five groups and fed high fat diets for four weeks. Each group was orally administered with methanolic extract of P. elliptica (PEM, 250, 500mg/kg), benzofibrate(BZF, 30mg/kg) and cholestyramine resin(CSR, 100mg/kg) daily for one week. Significant decreases in cholesterol, total lipid and triglyceride of both blood and liver were observed by the administration of the extract. But the levels of LDL- and HDL-cholesterol and the activity of lipase were not changed. Such results suggest that the extract may promote the fecal excretion of bile acid in hyperlipidemic rats.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.45 no.2
• /
• pp.161-166
• /
• 2016

This study was designed to investigate whether or not onion peel extract can lower blood lipid levels in rats exposed to cigarette smoke (CS) extract with a high-fat diet. Initially, male Sprague-Dawley rats were housed individually in a stainless steel, wire-bottomed cage with free access to AIN-93G diet. Rats were weight-matched and assigned to the following five groups: 1) control rats (CT) fed standard AIN-93G diet alone, 2) control rats exposed to CS extract (CT+CS), 3) high-fat group (HF) fed standard AIN-93 diet supplemented with 3% lard and 0.2% cholesterol, 4) high-fat group exposed to CS extract (HF+CS) fed standard AIN-93 diet supplemented with 3% lard and 0.2% cholesterol plus CS extract, and 5) high-fat plus onion peel (OP) extract group exposed to CS extract (HF+CS+OP) fed standard AIN-93 diet supplemented with 3% lard, 0.2% cholesterol, and onion peel extract (20 mg/17 g diet) plus CS extract. Using this feeding protocol, all animals completely consumed their respective diets throughout the 6 week duration. Blood was collected via the orbital sinus at weeks 0, 3, and 6, following overnight food deprivation. OP extract feeding resulted in significant reductions in blood triglyceride, total cholesterol, and non-HDL-cholesterol. Further, serum activities of aspartate transaminase and alanine transaminase were significantly reduced by OP extract at 6 weeks. These results provide clear evidence that onion peel extract has a profound inhibitory effect on blood lipids in rats exposed to CS extract. These findings suggest that OP extract can be used as an effective means in alleviating the serum lipid concentration after CS exposure.

• Journal of the Korean Society of Food Science and Nutrition
• /
• v.35 no.8
• /
• pp.1005-1009
• /
• 2006

The extracts of hoelen was evaluated for protective effects against the adverse effects of a high fat diet. Mice were divided into four groups; normal diet (control), high fat (HF) diet, high fat+water extract (HF+WE) and high fat+ethanol extract (HF+EE) and fed for 4 weeks. Food calorie consumptions were not significantly different between groups. Weight gain was significantly lower in HF+EE than the high fat group. Also, liver weight was significantly lower in HF+EE than the control group. The weight of epididymal fat tissue was 1.4 fold higher in high fat groups than control group. The concentration of serum triglyceride, total cholesterol and LDL-cholesterol increased in high fat group, but decreased by hoelen ethanol extract administration. Also serum HDL-cholesterol was decreased in the high fat group, but increased by the hoelen ethanol extract administration. Liver triglyceride and total cholesterol were not significantly different among groups. These data suggest that hoelen ethanol extract administration improves the serum lipid profiles of mice.

• Journal of Nutrition and Health
• /
• v.42 no.1
• /
• pp.14-22
• /
• 2009

This study was conducted to investigate the effects of powdered young barley leaf and its water extract on body weight and lipid metabolism in high-fat fed mice. Male mice were divided into normal group, high-fat (HF) group, high-fat group supplemented with powdered young barley leaf (HF-YBL) and high-fat group supplemented with water extract of the powdered young barley leaf (HF-WYBL). The powdered young barley leaf or its water extract was added to a standard diet based on 1% dried young barley leaf (1 g YBL/100 diet and 0.28 g WYBL/100 g diet) for 8 weeks. Supplementation of YBL and WYBL significantly reduced body weight and epididymal adipose tissue weight in high-fat fed mice. Food intake and daily energy intake were significantly lower in the YBL group than in the HF group. After 8 weeks, plasma triglyceride and cholesterol concentrations were significantly higher in the HF group than in the Normal group; however, both YBL and WYBL significantly lowered those of the high-fat fed mice. The ratio of HDL-cholesterol/total cholesterol of the YBL and WYBL groups were significantly elevated compared to that of HF group. Both YBL and WYBL significantly increased fecal excretion of triglyceride in high-fat fed mice, whereas they did not affect fecal cholesterol concentration. The triglyceride levels of liver, adipose tissue and heart were significantly lower in the YBL and WYBL groups than in the HF group. Supplementation of WYBL also lowered the kidney triglyceride and heart cholesterol concentrations compared to those of HF group. Hepatic lipid regulating enzyme activities, fatty acid synthase, HMG-CoA reductase and acyl-coenzyme A: cholesterol acyltransferase, were significantly lower in the YBL and WYBL groups than in the HF group. Accordingly, these results suggest that YBL and WYBL improve plasma and organ lipid levels partly by increasing fecal lipid excretion and inhibiting fatty acid and cholesterol biosynthesis in the liver.

• Proceedings of the Korea Society of Costume Conference
• /
• 2002.05a
• /
• pp.34-34
• /
• 2002