• Journal of Nutrition and Health
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• v.21 no.1
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• pp.36-46
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• 1988

This study was carried out to investigate the effects of different protein and fat levels on the growth and on immune response in rats. In experiment 1, Sprague-Dawly male rats were fed diets containing 6%, 15%, or 30% casein with 2 levels of fat(2% and 30%) at each protein level. In experiment 2 and 3, rats were devided into 8 diet groups ; 4 different sources of proteins(casein, meat protein, fish protein, and gluten) were used at 15% level of the diet with 2% or 30% of dietary fat. The results show as follows 1) The rats in 6% casein group showed lower body weight gain and organ weight than those in 15% and 30% casein groups. There was no significant difference between 15% and 30% casein groups. In experiment 2, the gluten diet group showed the lowest growth rate and epididymal fat pad weight among 4 different dietary protein groups regardless the level of dietary fat. 2) There was no significant difference in immune response according to the sources and levels of dietary protein. However, the rats fed high fat diet showed the lower plaque-forming cell response than those fed low fat diet regardless dietary protein.

• Journal of Nutrition and Health
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• v.33 no.4
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• pp.403-410
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• 2000

The effects of dietary Ca and Na levels on lipid metabolism in hyper lipidemic/hypercholesterolemic rats were examined. In Expt. 1, normal rats were divided into six groups and fed high fat(15%, w/w)/cholesterol(1%, w/w) diet containing two levels of Na, low (0.05) or high(1.5%) and three levels of Ca, low(0.1%), normal (0.5%), or high(1.5%) for 8 weeks. In Expt. 2, hyperlipidemia / hypercholesterolemia rats were induced by feeding high fat / cholesterol diet for 4 weeks. They were divided into four groups and fed the high fat / cholesterol diet, containing two levels of Na, low or high and two levels of Ca, low or high for 4 weeks. In Expt. 1, total lipid and total cholesterol contents in serum and liver were significantly lower in rats fed high Ca diet than in rats fed normal or low Ca diet regardless of dietary Na levels. Serum TG was the highest in rats fed low Ca and low Na diet. In Expt. 2, Serum total lipid, TG, and total cholesterol levels decreased by 24, 35, 26% respectively in rats fed high Ca diet regardless of dietary Na levels. Serum total lipid level tended to increased in rats fed low Na diet. The total lipid and TG contents in liver slightly decreased in rats fed high Ca diet. Another observation was that high Ca intake significantly faciliated the fecal lipid and cholesterol excretion regardless of dietary Na levels. There results suggest that the hypolipidemidc/hypocholesterolemic effects of high Ca diet could be partly due to increase in lipid and cholesterol excretion and these effects may be independent of dietary Na levels.

• Journal of Nutrition and Health
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• v.39 no.8
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• pp.733-741
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• 2006

The study was conducted to investigate the effects of dietary calcium and soy isoflavone on body fat and lipid metabolism in high fat-induced obesity. Four week old female C57/BL6J mice, known as a good model of diet-induced obesity, were fed low Ca and high fat diet for 6 weeks. After induced obesity, mice were divided into six groups according to diets varying calcium contents (0.1 or 1.5%) and genistein contents (0 or 500 or 1,000 ppm). Body weight, fat pad (perirenal fat and parameterial fat), adipocyte size, serum total lipid and total cholesterol were significantly decreased by both high Ca intake and genistein supplementation. However, the effect of genistein supplementation showed in low Ca-fed groups. Serum LDL-cholesterol and TG were significantly decreased by high Ca intake and genistein supplementation, respectively. In liver, lipogenic enzymes (fatty acid synthase and malic enzyme) activity and TG were significantly decreased by both high Ca intake and genistein supplementation. This inhibitory effect of genistein on lipogenic enzymes showed in low Ca-fed groups. But liver total cholesterol and total lipid were significantly decreased by high Ca intake and genistein supplementation, respectively. Fecal excretion of total lipid, total cholesterol and TG were significantly increased by high Ca intake, not by genistein supplementation. In conclusion, high calcium intake and genistein supplement may be beneficial for suppression of obesity through direct anti-adipogenesis by decreasing fat weight and size and indirect anti-lipo-genesis by inhibiting lipogenic enzymes activity and improving lipid profile.

• Journal of Korean Academy of Nursing Administration
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• v.16 no.4
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• pp.475-487
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• 2010

연구목적: 노인을 위한 건강정보 웹사이트들이 사용성과 접근성을 높이기 위해 지켜야 할 디자인 요소를 어떻게 반영하고 있는지 평가·비교함으로써 개선 방향을 제언하고자 하였다. 연구방법: 국내 및 미국에서 개발된 노인 대상의 건강정보 웹사이트를 각각 9개씩 선정하였다. 근거 기반의 웹디자인 지침서인 Make Your Website Senior Friendly: Checklist와 Research-based Web Design & Usability Guideline을 통합 수정하여 얻은 4개 영역의 평가 항목 48개를 적용해 두 명의 평가자가 선정된 총 18개 웹사이트를 평가하였다. 연구결과: '가독성' 영역 중 서체 선택, 줄 간격, 배경색과 글자색 선택 등은 양호하였으나 국내 웹사이트들 중에는 글자 크기가 조절되지 않는 경우가 빈번하였다. '정보의 표현과 구성' 영역에서 다수의 웹사이트들은 정보 배치 등이 우수하고 소비자 용어를 사용하는 노력을 보였다. 그러나 일부 국내 웹사이트들은 프린트 기능을 제공하지 않거나, 노인들의 저하된 인지 능력을 배려하려는 노력이 부족하였다. '미디어 사용' 영역에서 국내 웹사이트들은 글자 외에 다른 매체를 사용하는 빈도가 미국 웹사이트들에 비해 낮았고, 시청각 매체를 사용할 때는 동일한 내용을 문자로도 볼 수 있도록 하라는 권고안을 준수하지 않았다. '내비게이션과 검색의 용이성'에서는 메뉴나 링크의 명칭이 명확하며, 이용 중에도 쉽게 홈페이지로 돌아갈 수 있도록 구성되었다. 그러나 다수의 국내 사이트들이 사이트맵을 제공하지 않거나, 검색어의 철자오류 등에 대한 배려가 부족하였다. 결론: 국내 웹사이트들은 미국 웹사이트들에 비해 노인들의 사용성과 접근성을 높이는 것으로 밝혀진 연구 근거들을 제대로 반영하지 못하고 있었다. 노인 대상의 인터넷과 웹을 활용한 교육이 지속적으로 증가할 것이므로, 그 효과성을 높이기 위해 간호사들은 정보의 질 뿐만 아니라 디자인 측면의 중요성을 인식하고 실천할 수 있어야겠다.

• KOMUNHWA
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• no.69
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• pp.5-40
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• 2007

The research against Youngdong area Bronze Age settlement structure the condition where the investigation against the area and the remains which are limited becomes accomplished and Only the dwelling site will be investigated from the early settlement of most and recognition there is not a possibility which it will investigate synthetically. The Early settlement to the time which reaches the size of the settlement is small and From Bangnae-ri phases the house possession area increases inside the hill and it follows on south and if dwelling site numbers under increasing, from the aspect where the size of the settlement is magnified seems and it is a position. The Middle settlement currently was confirmed as the beginning from the room village A ruins, it investigates a settlement structure to, the increase of data is necessary. Is Pottery with clay stripes, phases the Later Settlement which Dwelling site, Storeage, Earthenware Kiln, Ditch enclosure and Tomb, the Public dwelling site back large scale Pottery with clay stripes settlement of formation will be investigated from Bangdong-ri settlements which correspond to Songhyun-ri settlement which is a hill characteristic settlement which is located in rivers circumference and the higShland characteristic settlement to provide the data the cultural aspect and character and a settlement structure of Bronze Age postscript and it will be able to grasp.

• Convergence Security Journal
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• v.15 no.6_2
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• pp.79-87
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• 2015

In order to clearly recognize illegality of insurance crime, declaring the provisions on insurance crime is preferable. An insurance fraud differentiated from Configuration Requirements of general fraud should be established And differentiation in accordance with the act type of insurance crime the degree of organizational involvement is required. Also the introduction of civil sanctions and creation of additional punishment provision about Organized insurance fraud are required. To notice duplicate insurance when sign up life insurance, the revision of the provisions is required. To limit unnecessary long-term hospitalization, hospitalization standard is required. Introduction of private investigator is required as a method for endowing with investigation to the staff of insurance companies. By providing information sharing laws between relevant agencies including insurance companies and law enforcement agencies, the foundation of information database, and the introduction of SNA Techniques in the IFAS,, you can detect Organized collusion crime.

• Journal of Advanced Marine Engineering and Technology
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• v.36 no.4
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• pp.430-436
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• 2012

This study was conducted to measure battery's voltage drop in a compact electric vehicle to get driving performance in various driving situations. In the experiment, to evaluate the energy consumption and milage, system performance have measured with changing of the driving speed and the reduction of driving distance when the heater was operating. The battery of the car in this study is lead type storage battery. The driving velocity was changed from 10km/h to 50 km/h with 20km/h intervals and the operating step of the heating device. As results, the electronic consumption rate was maximum at 35 km/h of vehicle speed and if the driver turning the heater at maximum, capacity will lead to 35% of energy consumption increment.

• Clean Technology
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• v.13 no.4
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• pp.237-243
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• 2007

Phase behavior of the ternary systems of water-insoluble simvastatin drug, which is well known to be effective drugs for hypercholesterolemia therapy, in solvent mixtures of dimethyl ether (DME) and supercritical carbon dioxide was investigated to present a guideline of establishing operating conditions in the particle formation of the drugs by a supercritical anti-solvent recrystallization process utilizing DME as a solvent and carbon dioxide as an anti-solvent. The solubilities of simvastatin in the mixtures of DME and carbon dioxide were determined as functions of temperature, pressure and solvent composition by measuring the cloud points of the ternary mixtures at various conditions using a high-pressure phase equilibrium apparatus equipped with a variable-volume view cell. The solubility of the drug increased as the DME composition in solution and the system pressure increases at a fixed temperature. A lower solubility of the drug was obtained at a higher temperature.

• Korean Journal of Pharmacognosy
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• v.38 no.1
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• pp.50-55
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• 2007

This study was designed to investigate the effects KH-204 on erectile dysfunction in hyperlipidemic rat. KH-204 has been evaluated antihyperlipidemic and antierectile dysfunction effects on experimental hyperlipidemic rats induced by high fat diet. After oral administration of the water extract KH-204 (50, 100, 200, 300 mg/kg) to hyperlipidemic rats for 8 weeks, the variables including body weight, total cholesterol, HDL and LDL levels in serum, the expression of eNOS and nNOS in penis were measured. And erectile function was determined by measurement of intracavernosal pressure (ICP) and maximal arterial pressure (MAP) after electrical stimulation of the cavernosal nerve. Oral administration of KH-204 significantly inhibited the increases of serum total cholesterol and LDL-cholesterol levels and the decreased of serum HDL-cholesterol levels in hyperlipidemic rats induced by high fat diet. The penile expression level of the two enzyme (eNOS, nNOS) were increased significantly after oral administration of the KH-204 50 mg/kg. Erectile function after 10 volts stimulation was significantly decreased in the hyperlipidemic rat compared with the normal rat, but increased in KH-204 group compared with hyperlipidemic group. These results suggest that KH-204 is effective for erectile dysfunction in hyperlipidemia.

• Journal of Plant Biotechnology
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• v.47 no.3
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• pp.227-234
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• 2020

To produce the miraculin protein in suspension cultures, rice (Oryza sativa L.) was transformed with Agrobacterium tumefacience EHA105 containing the miraculin AB512278 gene. The cell suspension cultures were established using cell lines selected from transgenic rice callus. The integration of the miraculin gene into the rice chromosome was confirmed using genomic PCR analysis. In addition, RT-PCR analysis indicated that the miraculin gene is expressed in the selected suspension cell lines. Thus, the recombinant miraculin was expressed in the transgenic suspension cell line, HK-2. Therefore, we have successfully developed a HK-2 line that produces miraculin. These results demonstrate that transformed cell suspension cultures can be used to produce a taste-modifying protein such as miraculin.