• Journal of Physiology & Pathology in Korean Medicine
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• v.20 no.4
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• pp.919-923
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• 2006

Sebum is an oily substance produced by sebaceous glands in human skin. The differentiation of the sebaceous gland is remarkably species-specific and sebocytes may play crucial parts in the pathophysiologic processes and disorders of pilosebaceous unit. In this study, we investigated the inhibitory effect of Ficis folium on the lipid production using the human sebocyte cell line 5195. Our results showed that Ficis folium significantly inhibits synthesis of sebaceous lipids such as cholesterol esters, triglycerides, and total lipid. And Ficis folium supressed cytoplasmic lipid droplets. On the other hand, Ficis folium didn't effect on cell proliferation. These results suggest treatment with Ficis folium resulted in a lower lipid synthesis in SZ95 cells without cytotoxicity.

• Journal of Practical Engineering Education
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• v.10 no.1
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• pp.35-39
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• 2018

More and more universities are enforcing SW education for non-major undergraduates. However, they are experiencing difficulties in educating non-major students to understand computational thinking processes. In this paper, we did not use the mathematical operation problem to solve this problem. And we proposed a basic problem-solving process teaching method based on computational thinking using simple physical devices. In the proposed educational method, we teach a LED circuit using an Arduino board as an example. And it explains the problem-solving process with computational thinking. Through this, students learn core computational thinking processes such as abstraction, problem decomposition, pattern recognition and algorithms. By applying the proposed methodology, students can gain the concept and necessity of computational thinking processes without difficulty in understanding and analyzing the given problem.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.44 no.3
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• pp.231-238
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• 2018

The facial skin condition expresses physical healthy as well as is considered one of important factors for attractiveness. Especially, most people prefer shiny skin. So various cosmetics has been manufactured for expression of shiny skin. However, shiny skin is subjectively evaluated, and difficult to evaluate clear shininess using the existing method in oily skin. Moreover, there is no clear classification criteria between shininess and glossiness, which is assessed negatively in the skin. So there has not been a reference value by mechanical measurement to define and classify shiny skin from greasy skin. In this study, we measured skin biophysical parameters (gloss, hydration, translucency and sebum) and facial images which are selected by volunteers using sensory evaluation. According to the measurement results, the values of gloss, sebum, and translucency were similar in both shiny and greasy skin; the values of sebum and gloss increased, whereas those of translucency decreased. However only skin moisture values statistically increased in shiny skin. In conclusion, we propose objective assessment criteria for classifying shiny and greasy skin using device measurement and quantitative assessment.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.3
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• pp.298-305
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• 2019

This study was aimed to examine kindergarten teachers' concerns in physical computing, which corresponds to the innovative teaching method, based on CBAM. For this, a questionnaire survey was conducted targeting 118 kindergarten teachers. Percentile analysis and MANOVA using CBAM model were carried out. As a result of the research, the kindergarten teachers' concern level is analyzed to be a critical non-user pattern on the whole. However, a pattern aspect was shown with a slightly high concern in stage 1, stage 2 and stage 3 compared to a typical type, and with a low concern level in stage 4. In consequence of having implemented MANOVA, the private kindergarten teachers' concern level appeared to be significantly high in stage 4 and stage 6 compared to a public kindergarten. Also, compared to the teachers who plan to utilize physical computing from now on, the teachers who don't have a plan of the application had significantly high concern level in stage 0. The concern level score was significantly low in 1~6 stages excluding stage 3.

• Korean Journal of Microbiology
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• v.55 no.3
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• pp.206-212
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• 2019

Propionibacterium acnes (P. acnes) lives in the hair follicles and pores, and it uses cell debris, sebum and metabolic byproducts of surrounding skin tissues as energy and nutrients. Increased production of sebum due to sebaceous hyperplasia or blockage of the follicle can cause growth and proliferation of P. acnes. The rapid growth of P. acnes in follicles produces cell damage, metabolic byproducts and bacterial chips, which can cause inflammation. In this study, we examined the possibility of Senecio iscoensis Hieron. (S. iscoensis) extract to regulate P. acnes-induced inflammatory signaling pathways. We observed that S. iscoensis extract effectively inhibited P. acnes-induced pro-inflammatory cytokine expressions such as IL-$1{\beta}$, TNF-${\alpha}$, and iNOS in mouse macrophage cell line Raw 264.7. The inhibitory effect of S. iscoensis in pro-inflammatory cytokine levels was accompanied by the inhibition of the transcription factors NF-${\kappa}B$ and NF-AT. However, S. iscoensis did not alter the P. acnes-induced MAPK signaling pathways. This study first suggests the potential of using S. iscoensis extract as an alternative agent for the treatment of acne.

• Journal of Life Science
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• v.33 no.4
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• pp.343-348
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• 2023

Acne is one of the most common skin diseases, mainly occurring in adolescence. The pathophysiology of acne involves not only hormonal, genetic and environmental factors, but also other factors including hyperseborrhea, inflammation, over-keratinization of follicular keratinocytes and overgrowth of Cutibacterium acnes (C. acnes). Cannabidiol (CBD) is known to relieve pain, stress and inflammation. Moreover, cannabis extracts containing CBD have been reported to be effective in treating acne. However, the therapeutic effect of CBD on acne remains unclear. Therefore, this study aimed to investigate the effect and mechanism of CBD on lipogenesis in SEB-1 sebocytes. We treated sebocytes with CBD and found that it not only inhibited lipid synthesis, but also inhibited cell proliferation by inducing apoptosis. We then demonstrated that sterol response element-binding protein-1 (SREBP-1) mediates the inhibitory effect of CBD on lipogenesis. Furthermore, Akt and adenosine monophosphate-activated protein kinase (AMPK), upstream regulators of SREBP-1, were regulated by CBD treatment. Taken together, our studies demonstrate that CBD inhibits adipogenesis by regulating the Akt/AMPK-SREBP-1 signaling pathway, providing potential for use as a therapeutic agent for acne. Further research is needed to confirm the effect of CBD on inflammation caused by hyperkeratosis, which will increase the possibility of using CBD for acne treatment.

• Proceedings of the Korean Fiber Society Conference
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• 2003.04a
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• pp.417-418
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• 2003

섬유제품을 착용하면, 땀ㆍ피지ㆍ때 등 피부로부터 대사 노폐물이 섬유표면에 부착되고, 의복이 오염되어 비위생적이 된다. 오염물이 부착된 섬유제품에서는 악취가 발생함과 더불어, 보온성이나 통기성이 저하하기 때문에 착용감이 나빠진다. 피부에 상존하는 세균이나 외부로부터 부착된 미생물은 섬유에 부착된 인간의 노폐물이나 오염물질 등의 유기화합물을 소화시켜 휘발성 악취물질을 발생한다.$^{1)}$ 항균 방취 가공은 미생물의 부착과 번식을 억제하고 나아가서 불쾌감을 없애주는 기술이다. (중략)

• JOURNAL OF ELECTRICAL WORLD
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• no.10 s.106
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• pp.40-46
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• 1985

전기중앙연구소는 물위에 원자력발전소를 띄우는 해상입지의 연구를 금년도부터 본격적으로 착수했다. 이 방식은 거대한 버어지 위에 원자로건물 발전소 본관등의 설비를 건설하는 것으로서 지진의 영향이 적으며 플랜트의 설계상 매우 유리하게 된다. 이 때문에 원자력 발전소의 입지가 확대될 뿐 아니라 플랜트의 표준화에 의해 건설코스트의 삭감, 건설기간의 단축등이 도모된다. 동연구소에서는 연구의 제1스텝으로서 2개년계획으로 피지비리티이 스타디이를 실시하여 부양식 원자력발전소의 기술적$\cdot$경제적인 실현가능성을 평가할 예정이다. 동연구소의 연구내용과 현재 진행되고 있는 다른 6개부문 연구내용을 소개하면 다음과 같다.

• Proceedings of the Korean Environmental Sciences Society Conference
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• 2000.05a
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• pp.130-131
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• 2000

알루미늄판만 있는 경우보다 구리판이 첨가되었을 때 인 제거율은 높았으나 알루미늄판만 첨가하여도 수중의 인 제거가 가능하였고, 알루미늄판 표면적이 클수록 인제거 시간이 빨랐으며, 수중 전해질농도가 높을수록 인제거 시간은 단축되었고, 알루미늄판을 재 사용하였을 때는 구리판과 전해질 농도의 영향과는 상관없이 24시간만에 제거되었으며, 또한 비폭기시에는 공식이 일어나지 않아 인이 제거피지 않고 증가됨을 알 수 있었다. 또한 인이 제거되는 과정에서 COD와 질소 제거에는 영향을 주지 않음을 알 수 있었다.

• Journal of the Korean Graphic Arts Communication Society
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• v.12 no.1
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• pp.117-132
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• 1994

New methodolgies for the syntheses of unsymmetrical squarylium(SQ) dyes for organic photoconductors(OPC) were developed and photostabilities for these dyes were dicucced. These dyes absorbed at 640-690nm and exhibit high molecular extinction coefficient about 10. photodegradation rate of these dyes is acceralated in the presence if singlet oxygen sensitizer. On the other hand, the photodegradation rate os retarded by adding effective singlet oxygen quencher, such as 2:1 metal dithiolate. It is suggested that the photodegration of unsymmetrical SQ dye may be due to a photo-oxidation involving singlet oxygen.