• Clinical and Experimental Pediatrics
• /
• v.46 no.9
• /
• pp.839-845
• /
• 2003

우유 알레르기는 영유아에서 흔하고 중요한 질환이다. 유병률은 1-3% 정도 되고 이를 진단하기 위해 자세한 문진을 시행하여야 한다. 피부반응검사 및 특이 IgE 검사로 도움을 받을 수 있으며 확진을 위해서는 경구유발검사가 필요하다. 실제 우유 알레르기 환자로 진단하였으면 치료 지침에 따라 대응하여야 한다.

• Korean Journal of Veterinary Pathology
• /
• v.6 no.2
• /
• pp.61-68
• /
• 2002

모빌리 바이러스에 의한 급성, 아급성, 전염성, 열성, 질환으로 전신형, 호흡기형, 소화기형, 신경형, 안형, 피부형으로 구분할 수 있다. 이 바이러스는 사람의 홍역 바이러스와 밀접한 관련이 있기 때문에 일명 개홍역 또는 모빌리 바이러스 감염증이라고도 한다. (중략)

• Clinical and Experimental Pediatrics
• /
• v.50 no.3
• /
• pp.306-310
• /
• 2007

Restrictive dermopathy is a rare autosomal recessive disorder in which rigidity or tautness of the skin from the second trimester causes a fetal akinesia deformation sequence (FADS) and early death. Characteristic features include taut skin with prominent subcutaneous vessels, widely open fontanelles and cranial sutures, distinctive facies, flexion contractures, pulmonary hypoplasia, sparse eyelashes and and eyebrows, thin dysplastic clavicles. The histologic abnormalities of the skin are located in a thin dermis, consisting of compactly arranged collagen fibers, scanty elastic fiber. The dermoepidermal junction is flat, and epidermal appendages are absent, miniaturized or immature. The presence of adipose tissue may be increased. We report on the first Korean case of restrictive dermopathy with typical clinical features and histological findings.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.31 no.3 s.52
• /
• pp.227-235
• /
• 2005

Skin aging is not a disease nor an abnormal phenomenon but a collection of degenerative changes with age, characterized by skin dryness, wrinkle formation, and loss of skin elasticity. The skin wrinkles are caused by either genetically predisposed factors or environmental factors such as UV irradiation or physical/chemical stimulus. The histological manifestations of wrinkles are changes in both amount and integrity of elastic and collagen fibers. Here we report the isolation and characterization of 3 active compounds, prangenidin, 8-hydroxybergapten, and xanthotoxol from Angelica dahurica root. The anti-wrinkle activities of these compounds were also investigated.

• Journal of Oral Medicine and Pain
• /
• v.22 no.1
• /
• pp.137-143
• /
• 1997

두개하악장애는 가장 흔히 발병하는 질병중의 하나이다. 이때 저작계에 흔히 호소하는 주소가 근육의 통증이다. 통증의 정도를 측정하는 방법으로 촉진이 가장 널리 사용되고 있으나 정량화하기 어렵다는 단점이 있다. 따라서 통증 측정기 등과 같이 다양한 시도가 진행되고 있다. 근육이나 관절의 병적 소견은 해당조직의 혈액순환장애나 염증반응과 종종 관련이 있다. 이러한 상태는 신체의 표면과 밀접한 관계가 있어 피부온도에 영향을 미치며, 따라서 thermography로 측정할 수 있다. 피부온도의 측정은 질병의 활성 상태를 평가하는 데 유익하며, 또한 치료결과를 평가하는 데에도 효과적이다. 객관적 피부온도 측정장치가 있다면 턱관절이나 저작근의 이상상태를 평가하는데 매우 도움이 될 것이다. 따라서 본 연구의 목적은 경제적이면 양측성으로 특정 부위의 피부온도를 측정할 수 있는 기기를 사용하여 검사자내 및 검사자간 신뢰도를 측정하고 좌우 온도차이를 확인함으로써 향후 질환 및 치료 겨오가에 대한 임상적 평가시 객관적 측정방법의 하나가 될 수 있는 지를 알고자 하는 데 있다. 구강내 염증이나 이상이 없으며 두개하악장애가 없는 치과대학생 15명을 대상으로 조사하였다. 평균연령은 24.9세, 범위는 24-30세이었다. 사용한 기기는 미국산 YSI Precision 4000이다. 18-2$0^{\circ}C$의 일정한 실내온도에서 두 검사자가 각각의 검사를 알지 못하는 상태에서 별도로 정해진 부위에 검사를 시행하고, 약 1주일후 이전 검사에 대한 기억이 없어진 상태에서 두 검사자중 한 검사자가 다시 동일한 검사를 시행하였다. 측정치들을 이용하여 상관관계를 계산하고 이에 대한 유의성을 검정하였다. 1. 검사자내 상관관계(r)는 좌 .798(p=<.0001), 우 .757(p=<.0001)이었다. 2. 두검사자간 상관관계(r)는 좌 .958(p=<.0001), 우 .951(p=<.0001)이었다. 3. 좌우 측정치간의 차이는 유의한 차이가 없었다. 4. 근육부위별 측정에서는 inferior masseter muscle의 검사자간에서만 유의한 상관관계가 없었을 뿐 anterior masseter muscle, anterior temporalis 모두 검사자내 및 간에 유의한 상관관계를 나타내었다. 이상의 결과로 보아 정상인에 있어 근육내 발통점의 피부온도는 검사자간에는 특정부위에 따라 다소 차이가 있을 수 있으나 일반적으로 높은 재현성을 보여줌으로서 향후 교근 및 측두근의 임상연구 평가에 피부온도조사는 도움이 되리라 사료된다.

• Microbiology and Biotechnology Letters
• /
• v.44 no.2
• /
• pp.208-217
• /
• 2016

Pinus densiflora Sieb. et Zucc. (P. densiflora) contains several phenolic compounds that exhibit biological activities, such as antimicrobial, antioxidant, and antihypertensive effects. However, the anti-inflammatory effect of P. densiflora on skin has rarely been reported. Malassezia furfur (M. furfur) is a commensal microbe that induces skin inflammation and is associated with several chronic disorders, such as dandruff, seborrheic dermatitis, papillomatosis, and sepsis. The aim of our study was to identify the anti-inflammatory effects of P. densiflora needle extracts on skin health subjected to M. furfur-induced inflammation. The methanolic extract of the pine needles was partitioned into n-hexane, EtOAc, n-BuOH, and water layers. We measured the anti-inflammatory effects (in macrophages) as well as the antioxidant, antifungal, and tyrosinase inhibitory activity of each of these layers. The antioxidant activity of the individual layers was in the order EtOAc layer > n-BuOH layer > water layer. Only the n-BuOH, EtOAc, and n-hexane layers showed antifungal activity. Additionally, all the layers possessed tyrosinase inhibition activity similar to that of ascorbic acid, which is used as a commercial control. The EtOAc layer was not cytotoxic toward the RAW 264.7 cell line. Interleukin 1 beta and tumor necrosis factor (TNF)-α expression levels in M. furfur-stimulated RAW 264.7 cells treated with the EtOAc layer were decreased markedly compared to those in cells treated with the other layers. Taken together, we believe that the needle extracts of P. densiflora have potential application as alternative anti-inflammatory agents or cosmetic material for skin health improvement.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.19 no.3 s.31
• /
• pp.180-188
• /
• 2006

Objectives : The purpose of this study is to investigate the differences of skin disease, particularly Acne between the rotating shift work nurses and the nurses on a fixed day schedule. Methods : Questionnaries were distributed to 30 rotating shift work nurses(the rotating group) and 34 nurses on a fixed day schedule(the daytime group). The questionnaris included questions on general health concepts, insomnia skin disease(particularly Acne), gastroenteric trouble, menstrual irregularity. Result : 1. There was significant difference on skin disease(particularly Acne) between two groups. 2. There was no significant relation between Gastroenteric trouble and Acne. But, in particular, there was significant relation between Constipation, Gastritis and Acne. 3. There was no significant relation between menstrual irregularity and Acne. 4. In Acne group, more than 70% felt the necessity of treatment, but only 2.5% used Korean Oriental Medical therapy. Conclusion : Disorder of circadian rhythm affects the skin disease(particularly Acne) more than Gastroenteric trouble and menstrual irregularity. But in this study, the total number of the nurse is not enough. So we need more accurate study about the aspects of skin disease. And about the Acne, publicity of Korean Oriental Medical therapy is required.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.20 no.2 s.33
• /
• pp.151-160
• /
• 2007

Objective : This study was performed to examine the patterns of skin disease in patients that had visited Dept. of Dermatology Hospital of Oriental Medicine, Dongguk University. We also compared on disease, age and treatment. Methods : We analysed statistic study in 505 patients, who had visited to our hospital from July, 2005 to February, 2007. Results : The results were as follows; 1. Distribution of dermatology classification was 40.6%, males were 41 % and females were 59%. 2. Distribution of aging was 18.2% in 0-9 years old and 18.8% in 10-19 years old and 17.4% in 20-29 years old. 3. Common disease group were Atopic dermatitis (24.55%); Acne (10.89%); Eczema (10.89%); Urticaria (10.30%). 4. Distribution of treatment according to diagnosis were external preparation in atopic dermatitis, acne, eczema, dermatitis seborrheica ; herbal-medication in urticaria ; herbal-medication and external preparation in facial redness. 5. Distribution of treatment according to aging were external preparation in all group except 50-59 years old; acupuncture treatment in 20-29 years old; herbal-medication in 10-19 years old; consultation in 70-79 years old. Conclusion : This study suggests that oriental medical treatments is popular in dermatologic diseases, especially atopic dermatitis and acne. We have to take steps for effective management and treatment for special diseases and ages.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.37 no.1
• /
• pp.107-112
• /
• 2024

Objectives : This case report aims to demonstrate the effectiveness of incisional needle therapy in treating facial scars resulting from autoimmune disorder. Methods : A single case of a 29-year-old female patient with facial scars due to systemic sclerosis was treated with incisional needle therapy. The treatment was applied over 14 sessions from February to September 2023. The efficacy of the treatment was evaluated using clinical photographs and the Physician's Global Assessment(PGA). Results : The treatment significantly improved scar appearance and reduced blood vessel visibility. The PGA scores, with an average of 2.66, indicating moderate improvement. Conclusions : Incisional needle therapy demonstrated potential as an effective treatment for scars caused by autoimmune disorders, due to minimal side effects and non-interference with ongoing treatments. It offers a promising alternative to conventional treatments, suggesting a need for further research for wider applications.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.19 no.1
• /
• pp.115-122
• /
• 2006

기관지 천식은 가역적 기도 폐색, 호산구에 의한 만성기관지 염증 및 기관지 수축 물질에 대한 기관지 평활근의 과민반응 등 3가지 주 증상을 갖는 만성 염증성 호흡기 질환의 일종으로서 천식은 항원에 대한 노출이 과민반응으로 이어져 기도 내 염증 유발로 이어지면 조직 내 백혈구 침윤이 일어나게 되어 기도 상피세포의 손상 및 기도 폐색이 일어나게 된다. 이 때 백혈구를 혈액에서 조직으로 끌어오는 것이 chemotactic cytokine, 즉 chemokine이다. 본 실험은 사람의 폐 상피세포를 이용하여 염증유발 매개물질인 $TNF-{\alpha}$와 IL-4를 단독 혹은 병용 투여하여, 폐 상피세포에서 chemokine 중 호중구의 화학주성에 관여하는 TARC, eotaxin, RANTES의 생성을 유도하였고, 이러한 chemokine의 생성과정에서 청열소독음(淸熱消毒飮)이 미치는 영향에 대하여 연구하였다. 본 연구를 통하여 청열소독음(淸熱消毒飮)이 사람의 폐 상피세포에서 $TNF-{\alpha}$와 IL-4로 유발시킨 TARC, exotain, RANTES의 생성을 농도 의존적으로 억제하는 효과를 볼 수 있었다. 따라서 청열소독음(淸熱消毒飮)은 TARC, eotaxin, RANTES와 같은 chemokine 생성을 억제함으로써 천식을 포함한 알레르기 질환 치료 전반에 유의적인 효과를 보일 것으로 사려 된다.