• 대한화장품학회지
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• 제30권1호
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• pp.117-122
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• 2004

과도한 자외선은 피부에 많은 문제를 일으킨다. 화장품에서 안전하게 사용할 수 있는 자외선 흡수제를 찾기 위해서 자외선 흡수 효과를 갖는 다야한 종류의 천연추출물을 검색하였다. 몇 가지 천연 추출물들은 항산화 활성이 있으며 본 연구에서도 산화 반응을 억제하는 것으로 나타났다. 7-Hydroxvcymopol, baicalein 그리고 그 외 다른 천연 성분들은 화학적 변형을 통하여 자외선 보조흡수제로 전환시킬 수 있었다 화장품에서는 실리콘과 W/S 타입의 에멀젼을 사용함으로써 자외선이나 산소 및 다른 요인에의 노출에 대항하여 이들 천연 성분들의 안정성을 개선시킬 수 있었다. 화장품 처방에 이들 천연 추출물을 첨가할 때 최소 홍반량(MED)은 0.10 $\pm$ 0.02∼0.11 $\pm$ 0.02 만큼 개선되었다. 연구 결과는, 천연 추출물이 안정화만 된다면 자외선 보조 흡수제로로도 사용 가능함을 시사하고 있다.

• 대한화장품학회지
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• 제20권1호
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• pp.1-13
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• 1994

솔잎으로부터 프리 라디칼 소거 작용이 있는 물질을 분리하고, 여러 기기 분석 결과에 근거하여 4-hydroxy-5-methyl-3[2H]-furanone (HMF) 으로 동정하였다. 이 물질이 1, 1-diphenyl-2-picrylhydrazyl 프리 라디칼에 대한 소거 작용이 공지의 항산화 물질인 a-tocopherol, ascorbic acid와 유사하였다. HMF는 흰쥐 간 microsome분획에서 Fe(II)/ascorbate에 의해 유도된 지질 과산화를 억제하였으며, 배양 fibroblast 세포에서 자외선에 대한 보호효과를 나타내었다. 이 물질은 또한 tyrosine의 효소적 산화와 Dopa의 자동 산화를 억제하였을 뿐만 아니라 배양 murine melanoma 세포에서도 강력한 멜라닌 생성 억제 작용을 보였다. 피부 세포에서의 멜라닌 생성이 산화적 스트레스에 의해 유발되고 또 효소, 비효소적인 산화 반응을 통해 진행된다고 볼 때, HMF는 이러한 각 단계에서 항산화제로 작용하여 궁극적으로 세포에서의 멜라닌 생성을 막는 것으로 추론되었다.

• 한국의류학회지
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• 제22권8호
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• pp.1020-1031
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• 1998

This study was done to investigate thermal reponses and to obtain the basic information of thermal comfort by sex and posture under the Ondol heating system. Six healthy males and females were exposed to Ondol(Room Temp.: 25$\pm$1$^{\circ}C$, 50$\pm$10%R.H, Floor Temp.:30$\pm$1$^{\circ}C$) on the of posture such as sitting, lying aside and supine on the floor for 30 minutes after 30 minutes' control phase. During the experiment, rectal temperature, skin temperature of 10 areas, local sweating rate, clothing microclimate, subjective sensation were measured. Rectal temperature gradually decreased and mean skin temperature grad-ually increased both male and female in any posture. There was not significant difference between male and female in rectal temperature and mean skin temperature. There were significant difference among the postures in rectal temperature(p<0.001) and mean skin temperature(p<0.001). In lying aside and supine on the floor, appearances of change and changes in rectal temperature and mean skin temperature were large, changes of weight were small. In sitting on the floor, appearances of change and changes in rectal temperature and mean skin temperature were small, changes of weight were large. The trunk skin tem-perature was higher in female than in male, but the extremity skin temperature was higher in male than in female. In sitting on the floor, foot skin temperature(p<0.001) was higher than any other local skin temperature. In supine on the floor, back skin temperature(p<0.001) was higher than any other local skin temperature.

• 대한감각통합치료학회지
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• 제13권2호
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• pp.75-84
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• 2015

목적 : 본 연구의 목적은 감각조절과 각성과의 신경학적인 메커니즘을 알아보는 것이다. 본 론 : 감각통합치료에서 아동의 적절한 각성유지는 중요한 이슈이다. 감각입력을 통한 각성 조절을 위해 둘레계 및 그물체는 중요한 관계가 있고, 특히 그물체에서 대뇌피질로 가는 오름그물활성계통은 주요 처리 경로이다. 이때 콜린성 뉴런 및 단가아민계 뉴런 집단 등에서 분비되는 다양한 신경전달물질이 영향을 미친다. 각성을 위한 메커니즘은 중추신경계 및 자율신경계 기능을 측정하는 뇌파나 피부전기반응 등으로 측정한다. 객관적 신경생리학적 측정을 통해 일반아동과 장애아동에서 중추신경계 및 자율신경계 기능이 차이가 있음이 보고되었다. 감각통합치료를 통해 장애아동에게 적절한 감각을 입력하는 것은 그물체와 둘레계, 대뇌피질을 활성화시켜 최적의 각성상태를 유지하도록 돕는다. 결 론 : 객관적 측정도구를 사용한 연구결과의 제시는 감각통합치료에 대한 근거기반 임상을 위한 기초자료가 된다.

• Clinical and Experimental Pediatrics
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• 제52권3호
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• pp.389-391
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• 2009

AHS는 항경련제에 의한 부작용으로 드물게 발생하지만 생명을 위협할 수 있는 지연형 면역반응이다. 보통 항경련제 복용 후 1-8주 사이에 고열, 피부발진, 림프절병증의 임상 증세를 나타내고, 혈액, 간, 신장, 또는 폐 등의 내부 장기를 침범한다. AHS는 항경련제에 의한 부작용으로 증상이 전신적으로 다양하게 나타날 수 있다. 그리고 전염성 단핵구증이나 가와사키병과 같은 전신적 질환들과도 유사한 임상증상들을 보이기 때문에 이런 질환들과 감별하는 것이 중요하고 사망률도 10%에서 보고되고 있어 조기에 발견하고 치료하는 것이 중요하다. 저자들은 임상증상과 초기 검사가 전염성 단핵구증과 비전형적 가와사키병과 매우 유사한 lamotigine에 의한 AHS 1예를 보고하는 바이다.

• 대한간호학회지
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• 제30권2호
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• pp.488-497
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• 2000

The purpose of this study was to explore the effect of a postpartum massage program on stress response in the Cesarean section mothers. The study focused on evaluating the effect of postpartum massage program on mood, anxiety, skin temperature and concentration of saliva and breast milk immunoglobulin A in the Cesarean section mothers. This study was designed as a nonequivalent control group pretest-posttest quasi-experimental study. Twenty-eight Cesarean section mothers were selected as experimental group, whereas twenty- seven were control group. The postpartum massage program consisted of 20 minutes of warm-up, massage and ending phases and used once a day. During each program, there were 4 minutes of warm-up, 14 minutes of massage on back, axillary and breasts, and 2 minutes of ending. Massage were used for the experimental group by the same investigator 20 times per minute. The massage technique used were efflurage, petrissage, accupressure, kneading and vibration. Skin temperature was monitored with YSI Tele-thermometer(Simpson electric Co., USA) before and after massage program. The concentration of immunoglobulin A in saliva and breast milk was analyzed by immunoturbididimeter assay(Cobas INTEGRA, Swiss) before and after massage program. Also at this time mood and anxiety were measured by self-report. The data were analyzed using SPSS version 7.5 and hypothesis was tested with ANCOVA analysis and Pearson coefficient correlation. The results were as follows : 1) Score of mood increased significantly after use of postpartum massage program. 2) Level of anxiety decreased significantly after use of postpartum massage program. 3) Skin temperature increased significantly after use of postpartum massage program. 4) Concentration of saliva immunoglobulin A increased significantly after use of postpartum massage program. 5) Concentration of breast milk immunoglobulin A did not change significantly after use of postpartum massage program. 6) After use of postpartum massage program, there was significant correlation between psychological stress response and physiological stress response.The results suggest that postpartum massage program can be effective nursing intervention to reduce stress response in the postpartum mothers under stress.

• 한국의류학회지
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• 제32권7호
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• pp.1129-1136
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• 2008

The gaiter is one of the personal protective equipments worn in various industrial sites. This study was performed on humans to investigate the physiological strain of wearing gaiters and to compare control gaiters that are currently on the market and new gaiters that are developed for alleviating heat stress. Experiments were conducted in a climatic chamber of WBGT $30.0\pm0.7^{\circ}C$ under five differed experimental conditions: None, Control A, Control B, New A, New B. The results were as follows. The temperature inside gaiters was significantly lower in both New A and New B than in both Control A and Control B and the difference between news and controls was 1$^{\circ}C$ (p<.01). The humidity inside gaiters in both New A and New B were higher than that in Control A, and lower than that in Control B (p<.01). The outermost surface temperature of the gaiter was the lowest in None and it increased in the following order: New B < New A < Control A < Control B. Mean skin temperature was higher by 0.14$^{\circ}C$ in wearing gaiters than in no gaiters. Skin temperatures in lower body were lower in Control than in New and skin temperature in upper body were higher in Control than in New (p<.01). Local sweat rate, total weight loss and subjective sensations did not show a significant difference according to the gaiters. It was concluded that wearing gaiters affected distribution of skin temperature and local sweat rate.

• 공업화학
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• 제10권6호
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• pp.939-943
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• 1999

최근에 생분해성 고분자를 이용한 의료용재료로의 응용에 대한 관심이 고조되고 있다. 본 연구에서는 천연고분자(xanthan, locust bean, guar gum, chitosan 및 algin)를 생체재료로 사용할 목적으로 용액주조법에 의하여 분해성 필름을 제조하였다. 천연고분자로부터 제조한 생체재료의 가능성을 피부이식제로서 생체적합성 측정에 의하여 평가하였다. 이들을 실험동물의 등부위에 피하 삽입하여 필름의 시간에 따른 구조적, 중량적변화와 랫드의 혈액학적 변화를 측정하여 생체적합성을 연구하였다. 랫드에 대한 테스트결과 locust bean과 guar gum은 삽입 24시간, 48시간 후 조직에서의 생체 이물 반응에 의한 생체 부적합성을 나타내었으며, 일부 천연고분자로부터 제조한 분해성 필름은 단기간의 이상적인 생체재료로서의 가능성을 나타내었다.

• 한국식품영양학회지
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• 제33권2호
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• pp.174-182
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• 2020

Probiotics improve the immune system. However, the effects of its lactic acid bacteria on atopic dermatitis relief and inflammation improvement is not fully understood. Recently, one of the probiotics, Lactobacillus helveticus HY7801 (HY7801), was found to have an anti-inflammatory effect. In this study, we investigated the effects of HY7801 on atopic dermatitis-induced animal models. After four weeks of oral administration, the group treated with HY7801 showed amelioration of the atopic dermatitis compared to the group receiving placebo. In the HY7801 treated group, the epidermal hyper-proliferation and collagen deposition were inhibited compared to the placebo group, and the secretion amount of the inflammatory factors, such as TNF-α, IL-4 were reduced. In conclusion, these results suggest that HY7801 acts as a functional probiotic via amelioration of the atopic dermatitis such as a decrease of epidermal hyper-proliferation, and collagen deposition and anti-inflammatory effects.

• 한국의류학회지
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• 제41권4호
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• pp.687-697
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• 2017

To figure out an appropriate pressure level for a body warming base layer, human responses were observed when the pattern reduction of base layers varied. Under the condition of $2^{\circ}C$, 60% RH, 0.1m/s, ten male subjects participated in the experiment with four sizes of experimental vests where heating pads were attached. The subjective evaluations of the heating vests with different sizes were reported using 7 or 9 point scales. We simultaneously observed chest, abdomen and scapula skin temperatures and microclimate humidity. It was found that the tight pattern as in the case of A or B provided a warmer subjective sensation and skin temperature than C or D; however, there were no differences in skin temperature at the chest. Eventually, the chest temperature decreased after about 30 mins of heating; however, temperature of abdomen increased and indicated that heating with two commercial pads used was inadequate for whole body warming. The pressure sensation of 'tight' was improved after warming the abdomen in a cold environment. Overall, the gaps beyond the original circumference of the abdomen, as in C or D, were not desirable for the local heating of abdomen under the conditions of this experiment where walking was included in the protocol. The experiment garment B with nude waist circumference was the best, and D with the largest ease, was the worst for a comfortable warming vest.