• Journal of Veterinary Clinics
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• v.14 no.1
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• pp.108-111
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• 1997

지방친화성 진균인 M. pachydermatis가 두 마리의 수캐에서 피부병의 원인균으로 증명되었다. 두 마리의 환축에서 흥반, 인설, 탈모 등이 여러 부위에서 발생하였으며, 광역항생물질과 코르티코스테로이드의 45일간 투여에 대해 아무런 임상적 반응을 나타내지 않았다. 발아를 나타내는 난원형 내지 원주형의 효모균이 KOH 및 PHOL 방법에 의해 환축의 피부병변으로부터 다수 증명되었고, 이들은 형태학적으로 M. pachydermatis와 일치하였다. 두 환축의 피부 병변부위 시료를 chloramphenicol을 첨가한 %37{\diamond}C$의 Saubouraud dextrose agar에 배양하면 이 진균이 반복하여 배양되었다. ketoconazole의 경구투여와 sulphur lime의 국소적용에는 치료반응을 잘 나타내었다.

• 보건세계
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• v.40 no.10 s.446
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• pp.4-7
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• 1993

1944년 임상적으로 사용되기 시작한 스트렙토마이신은 전세계 결핵환자의 치료약제로 널리 사용되고 있다. 그러나 스트렙토마이신의 알레르기성 과민반응의 경우 그 발생빈도가 대단히 낮고 그로인한 사망률도 극히 낮은 안전한 약제임에도 불구하고, 오히려 그 부작용이 과장되게 알려져 있어 사용하기를 꺼리는 경향이 있다. 임상증세로는 주로 피부, 호흡기, 순환기, 소화기의 장기와 관련되어 발생한다. 초회 주사시의 쇼크는 자신도 모르는 사이에 이미 감작되었을 가능성이 있으며 주사를 계속 맞다가 발생하는 수도 있다. 무엇보다도 예방이 가장 중요하며 혼자의 과거 알레르기반응의 유무 및 약물 사용력을 정확히 파악한 후 사용하여야 한다

• Science of Emotion and Sensibility
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• v.1 no.1
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• pp.135-143
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• 1998

이 연구에서는 국제 사진 정서체계(International Affective Picture System: IAPS)중에서 가장 강한 부적 정서를 유발하는 6장의 슬라이드를 1분 동안 연속적으로 보여주어 스트레스 상태를 야기한 뒤 1분동안 정서를 유발하는 청각자극인 1/f음악이나 which noise를 들려주거나 또는 아무소리도 들려주지 않는 각 조건에서 뇌파의 상대적 출현량(reltive power)및 호흡률, 심박률, 피부전도수준 등의 자율신경계 반응의 변화를 분석하였다. 스트레스 정서 상태에서 이완상태로의 회복을 촉진시켜줌을 시사한다. 한편, 스트레스정서유발 상태에서 1/f 음악과 white noise이 제시되었을 때의 자율신경계 반응은 현저한 대비를 보여주었다. 그러나 스트레스 정서유발 이전의 기저선 수준과 비교할 때 1/f 음악에 의한 반응수준이 white noise 에 의한 반응수준 보다 기서선 수준에서 훨씬 더 벗어나 있었다. 따라서 이 결과는 부적정서상태에 부가된 정적 유발이 활성화된 자율신경계 반응의 안정상태로의 회복을 촉진한다는 가설을 지지하거나 부정하기에는 불충분하다. 이 연구에서 정서자극 제시 후의 회복단계에서 뇌파 반응과 자율신경계 반응의 시간경과에 따른 변화가 일치하지 않는 이유는 이들 생리신호의 반응속도가 다르기 때문일 수 있다. 이 실험은 시각과 청각의 복합 감각체계를 사용하여, 스트레스 정서상태에 정적정서유발자극이 부가되었을 때 스트레스 뇌파반응에서 이완된 뇌파반응으로의 회복이 촉진됨을 보여준 최초의 연구이다.

• Journal of the Korean Society of Clothing and Textiles
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• v.26 no.1
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• pp.74-82
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• 2002

The present study is aimed to investigate the effect of the safety hat on the balance of body temperature by observation of the physiological response under hot working environment. The experiment was carried out in a climate chamber of 3$0^{\circ}C$, 50%RH for 70 minutes. To compare the two kinds of safety hat, 5 healthy male subjects worn safety hat without hole (called 'without hole') or safety hat with hole (called 'with hole') according to a randomized cross-over design. The main results of this study are as fellows: Rectal temperature and heart rate were significantly lower level in 'with hole'than in 'without hole'. The mean skin temperature was significantly higher in 'without hole'than in 'with hole'. Blood pressure were significantly low in 'with hole'. Sweat rate which was measured by weight loss before and after experiment was higher in 'without hole'. In subjective ratings, subjects replied more hot, more uncomfortable and more wet, they felt more fatigue in condition of 'without hole'. Work ability which was measured by a grip strength dynamometer was higher in 'with hole'. Safety hat which can be used for safety of the brain in work place is meaningful device of behavioral thermoregulatory response under the hot working environment. The safety hat which is designed for proper ventilation and hygiene can maintain the homeostasis of body temperature by releasing body temperature efficiently.

• Journal of Applied Biological Chemistry
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• v.60 no.2
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• pp.155-159
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• 2017

This study was to evaluate the effect of the moisturizing cream containing five kinds of plants extracts for human facial improvements such as hydrating ability, transepidermal water loss and erythema reaction. The antioxidant activities of yellowish natural colorants, extracted from five kinds of plants (Ceramium kondoi, Phellodendron amurense, Carthamus tinctorius, Gardenia jasminoides for. grandiflora and Aphis chinensis) were tested. Twenty-one volunteers were subjected to analyze the effects, and each result was determined by treating the complex cream containing plants extracts on their skin in three times. The moisture content on skin was significantly increased more than 50% by treating the cream containing five kinds of plants extracts. The transepidermal water loss was reduced and the level of the skin erythema reaction was improved after treatment of the complex cream. Survey analysis showed that the volunteers had highly satisfaction on the tested creams. The results suggest that the complex cream containing five plants extracts had an improved effect on facial skin, and therefore can be used as moisturizing ingredients in the related industry.

• Journal of Preventive Medicine and Public Health
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• v.9 no.1
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• pp.117-122
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• 1976

The occupational skin diseases in an industry of silk reeling located in Daegu city of Korea were analyzed by inspection through a mass survey for improving the workers' health, November, 1975. The subjects, 177 persons were all females, and were distributed at 18-38 years old. About two thirds were under 25 years old. The meanage was 23.6 years. The incidence of skin diseases was about 53%. It was generally divided into three groups;- the epidermic changes of those were most frequent, 47.5%, the allergic reactions were 14.7%, and athlete's foot was only four cases, 2.3%. Most frequent signs of epidermic changes was the worn-out nail, 32.3%; and the keratolysis, 28.8%; and the callus, 15.3% were followed in order. Theses were significant in five per cent level between the sections of the silk reeling and the manufacturing;-Allergic reactions and worn-out nail were more frequent in the manufacturing group than the silk reeling, and keratolysis and callus were inverted proportionally. Allergic reactions were occurred within a few months from first entrance time, and it was more frequent in the group exposed to same allergen in the past than the continuing group from first. Most of the appearing sites of theses were hands, and infrequently, it was occurred in the face, neck, trunk, knee anfeet. These epidermic changes except allergic phenomena were appeared in the fingers, palmal and dorsal surface of hands frequently contacted. But these changes and allergic reactions were generally combined with two or more kinds.

• Journal of the Society of Cosmetic Scientists of Korea
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• v.42 no.4
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• pp.393-401
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• 2016

Ultraviolet (UV) irradiation from the sun is the primary environmental factor that causes skin damages including skin cancer and premature skin aging. Because, even the most powerful sunscreen can't always afford enough protection, it is necessary to enhance the defensive power of skin against UV. Recently, constitutive photomorphogenic protein-1 (COP1) has shown to contribute to the regulation of UVB response of keratinocytes. In this study, we represent that COP1 and its associated protein, de-etiolated 1 (DET1), might participate in photoaging process in human skin as Arabidopsis COP1 does sun-protective function in plants. After UVB irradiation, the decrease of COP1 and DET1 mRNA expression was followed by the increase of c-Jun total protein. Moreover, transfection with DNA vectors expressing COP1 and DET1 down-regulated the c-Jun total protein. We found that Zanthoxylum piperitum extract (ZE) up-regulated the expression of COP1 and DET1 on human keratinocytes, and inhibited the expression of MMP1 which is one of the genes regulated by c-Jun signal. In addition, ZE has been reported to stimulate PPAR-${\alpha}$ and strengthen the skin barrier. We found that ZE decreased the UVB-induced IL-6 and IL-8 in NHEK cells. In human study, ZE protected skin against UV-B induced erythema and erythema-induced pigmentation. These results indicate that ZE could be useful for the protection against the adverse effects of UV irradiation through various mechanisms.

• Journal of fish pathology
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• v.5 no.2
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• pp.159-164
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• 1992

The skin of fishes is also the important external barrier against a variety of the environmental detrimental agents, allowing normal internal physiological function, so its condition is very important in many disease processes. Since fishes are aquatic, morphologically and physiologically they posses specific characteristics lacking in terrestial animals. Thus, it is necessary to keep in mind various specific histologic characteristics for a precise interpretation of the histopathological lesions. In the normal environment the fish skin is more subtly adapted for its physiological requirements as a limiting barrier than the skin of higher terrestial vertebrates. However, its delicacy makes it high vulnerable to damage in fish culture facilities or polluted waters. Although changes in the skin of fish such as discoloration, ulcerative lesions, are the the most readily observed clinical features of fish, there is a wide variety of possible responses, which are best considered in terms of their site within the skin. Up to now, there are relatively few sytematically described information on the histological structure of the teleost skin as well as integrated reviews of the range of pathological processes that can occur in teleost skin. Therefore it was tried in this article to rearrange the information already described by other investigators on the histological structure and histopathological changes of teleost skin.

• Journal of Oral Medicine and Pain
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• v.35 no.2
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• pp.155-163
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• 2010

Dermatomyositis (DM) is an idiopathic inflammatory connective tissue disorder and a systemic autonomic immune disease which shows a progressive muscle weakness and characteristic rash. It is identified by a characteristic rash accompanying, or more often preceding muscle weakness. Pathognomonic skin lesions are a blue-purple discoloration on the upper eyelids with edema (heliotropic rash), a flat red rash on the face and upper trunk, and erythema of the knuckles with a raised violaceous scaly eruption (Gottron's papule). The myopathy represents inflammatory and degenerative changes primarily affecting proximal muscles. DM often involves GI tract and respiratory system with as risk of 15-25% internal malignancy. It's managed with sun protection since muscle weakness as well as a rash could be aggravated by sun exposure. Systemic corticosteroid is an initial therapy and other immunosuppressive agent has been used as alternatives. Facial muscles are unaffected and masticatory muscles are rarely affected in DM. We present trismus close to muscle contracture in a patient with DM. Therefore, it needs continuous mouth-opening exercise to prevent progressive muscle contracture and to ensure normal mouth opening.

• Journal of the Korean Society of Food Science and Nutrition
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• v.33 no.4
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• pp.641-645
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• 2004

Crude chondroitin sulfates extracted from midduck tunics (Styela clava) and munggae tunics (Halocynthia roretzi) were examined in vivo in order to be utilized as a cosmetic material which was followed by an in vitro assay. Examinations, such as acute oral toxicity, skin sensitization, acute eye irritation, and primary skin irritation, were peformed with a variety of laboratory animals. Phototoxic and photosensitization tests were not conducted since all chondroitin sulfates failed to absorb U.V. light at the range of 280 to 420 nm. In acute dermal and eye irritation, both specific clinical signs and dead cases were not demonstrated during the test period, but crude chondroitin sulfates from midduck and munggae tunics, and standard chondroitin sulfate from bovine trachea were showed 2.5, 1 and 1.25 of acute ocular irritation index (A.O.I.), respectively. In the case of skin sensitization, crude chondroitin sulfate from midduck tunics exhibited neither specific clinical signs nor dead cases in the entire course of the examination. While in acute oral toxicity, crude chondroitin sulfates from both midduck and munggae tunics found neither specific clinical signs nor dead cases during the test, and LD50 was suspected to be over 2 g/kg. Based on this study, it was proven that crude chondroitin sulfates from either midduck or munggae tunics can be used safely as a cosmetic material.