• Proceedings of the Korean Society for Emotion and Sensibility Conference
• /
• 2001.05a
• /
• pp.169-174
• /
• 2001

정서와 생리 반응간의 관계에 대한 연구는 주로 성인을 대상으로 이루어졌고, 최근에는 아동정서에 대하나 생리반응 연구도 증가하고 있다. 본 연구는 교감신경계의 활성화 지표인 피부전기 반응을 이용하여 아동의 정서를 구분하는데 목적이 있다. 실험참여자들은 남녀 학령 전\ulcorner학령 아동 132명이었다. 다섯 정서를 유발하기 위해 사용한 자극세트는 각 정서를 유발하는데 적합하다고 평가되는 배경음악과 조명 하에서 인형을 통해 들려주는 정서유발이야기로 구성되었다. 정서가 유발되기 전 안정상태와 정서를 경험하는 동안 피부전기활동을 측정하였다. 안정상태에 비해 모든 정서상태에서 피부전기반응이 통계적으로 유의미하게 변화하였다. 다섯 정서간에 피부전기반응의 변인들인, 피부전도수준, 피부전도수준의 수와 피부전도반응의 크기에서 유의미한 차이가 나타났다. 이 결과는 피부전기반응을 이용하여 아동의 정서 구분이 가능함을 시사한다.

• Journal of Radiation Protection and Research
• /
• v.20 no.3
• /
• pp.181-186
• /
• 1995

UV irradiation causes a variety of biologic effects on the skin. These effects can be devided to acute reactuons and chronic reacxtions by duration of UV irradiation. Acute reactions are erythema reaction, pigment reactions and changes in epidermal thickness. Among them erythema reaction is most common and conspicuous acute effects of the skin. Upon exposure to sun or artificial UV soures, a faint redness response of skin may begin. Larger exposure causes sunburn reaction which is exaggerated erythema reactionassociated with pain, swelling, vesicle and dulla. Extent and time course of erythema reaction depend upon several factors including wavelength and dose of UVR, skin conditions likeas skin type, site, color, temperature, humidity and environmental factors. Evaluation of erythema erythema induced by UV irradiation is difficult to quantify. Degree of redness of skin are usually estimated by subjective visual evaluation. The lowest exposure dose required to protuce erythema is called minimal erythema dose (mod). Repeated exposures of UVR result in photaging skin. In this condition we can see wrinkling, skin atrophy, dilated blood vessels and keratoses. In sensitive persons photocarcinogenesis is can Be developed on exposed area of skin. Recently skin canser is increasing now in our country. An effective public education and photopreventive method must be developed.

• Science of Emotion and Sensibility
• /
• v.1 no.1
• /
• pp.79-91
• /
• 1998

이 연구의 목적은 IAPS(국제정저사진체계) 사진자극에 의해 유발된 각각의 주관적 정서상태에 특정적인 자율신경계 반응이 존재하는지를 규명하는 것이다. 부정적 정서(분노, 슬픔, 놀람)와 긍정적 정서(행복, 흥분)를 유발하는 IAPS사진을 각 60초 동안 제시하였을 때 유발되는 심박률, 호흡률, 피부전도반응을 측정하였다. 시각자극이 주어진 초리 30초 동안 통계적으로 유의미한 심박률 감속 및 호흡률 감소를 보여주었으며, 뚜렷한 피부전도반응이 출현하였다. 심박률 감속은 혐오보다 흥분에서 더 크게 나타났고, 피부전도반응의 진폭은 혐오보다 흥분에서 더 큰 것으로 나타났다. 한편, 피부전도반응의 진폭이 상승하는 시간은 슬픔, 행복, 놀람보다 혐오에서 더 짧아지는 경향을 보여주었다. 이와 같은 자율신경계 반응(심박률, 호흡률, 피부전도반응)은 정서상태간에 뚜렷한 차이를 보여주며, 특정 정서상태에서 자율신경계 반응은 개인차가 있기는 하지만 전체적으로 매우 전형적인 반응패턴을 보여주었다. 본 연구의 결과는 정서 특정적인 자율신경계 반응이 존재할 가능성을 시사해주며, 생리신호분석을 통해서 심리적 정서를 결정할 수 있는 형판(template)의 구성을 위해서 다양한 자율신경계 정서반응의 지표를 포괄적으로 측정 분석하는 후속연구가 요구된다.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2006.05a
• /
• pp.355-358
• /
• 2006

본 연구에서는 아동이 유머와 슬픔을 느낄 때 나타나는 자율신경계 및 안면근육반응의 차이를 밝히고자 하였다. 11-13세의 아동 47명(남: 23명, 여: 24명)에게 각 정서를 유발하는 동영상 자극을 2분 동안 제시하고, 이때의 심리반응과 생리반응(SKT, EDA, ECG, EMG)을 측정하였다. 각 정서는 적합하고 효과적으로 유발되었고, 자율신경계반응에서는 유머가 슬픔보다 피부 전도수준, 피부전도반응, 피부전도반응의 수, 심박률분산에서 유의하게 큰 반응을 보였다. 반면 피부온도는 유머에 비하여 슬픔에서 크게 증가하였다. 안면근육반응 결과, 유머가 Orbicularis oris muscle에서 슬픔보다 더 큰 근육활동의 증가를 나타내었다. 결론적으로 아동은 유머와 슬픔에서 서로 다른 자율신경계와 안면근육의 반응을 보였다.

• Journal of the Society of Cosmetic Scientists of Korea
• /
• v.38 no.1
• /
• pp.43-50
• /
• 2012

The safety of cosmetics or cosmetic ingredients on human skin is generally evaluated by visual assessment but some early subtle skin changes may not be noticed by the naked eyes. Thus, the present study was conducted to detect skin reactions induced by mildly irritating cosmetic ingredients by using a laser Doppler perfusion imager (LDPI) method that measures blood flow, a $Vapometer^{(R)}$ that measure strans epidermal water loss (TEWL), and a spectrophotometer that measures the skin color as the erythema values ($a^*$). Visual assessment showed that all tested oils and humectants except propylene glycol belong to the low skin irritation ranges (grades 0+ to 2.9+) while all tested surfactants and propylene glycol belong to the moderate-to strong-skin irritation ranges (grades 3+ to 5+). Among three instrumental methods, TEWL assessment appeared to be more sensitive than spectrophotometric or LDPI method and suitable for the detection of subtle skin response invisible to the naked eye (grades 0+ to 2.9+). Skin reactions of grade 3+ to 5+ could be detected by all three instrumental methods. In conclusion, the current study suggested that the sub-clinical skin reactions due to mild irritants contained in cosmetics can be best assessed by TEWL measurements.

• Radiation Oncology Journal
• /
• v.7 no.1
• /
• pp.15-22
• /
• 1989

Investigations were carried out into the time-and dose-related changes in acute skin reaction following graded single dose (20,30 and 40 Gy) of x-ray irradiation in Wistar rats, in order to evaluate the radioprotective effect of Diethon on skin. For the duration of skin response over 1. 5 score in dose of 40 Gy, the Diethone group of 24.7 days was significantly different (p<0.02) from that of control (29.8 days) and vaseline (29.2 days) groups, it was $17.1\%$ diminution of skin response period compared with that of control group. By the averaging daily scores for 10 days during peak skin reaction the mean scores were obtained. Mean score of Diethone group $(2.43\pm0.22)$ was significantly different (p<0.01) from that of control $(2.91\pm0.23)$ and vaseline $(2.81\pm0.18)$ groups of 40Gy dose. By iso-effect dose obtained at level of 2.5 score the dose reduction factor (DRF) was 1.41 which reduced radiation dose of $41\%$ by radioprotective effect of Diethone. From this experimental data, it may be possible to give higer radiation dose to large and/or radioresistant tumor mass rather than conventional treatment doses for improving therapeutic ratio by using topical application of skin radioprotector.

• Proceedings of the Korean Institute of Intelligent Systems Conference
• /
• 2005.11a
• /
• pp.373-376
• /
• 2005

본 연구에서는 뇌의 반응과 말초신경계의 변화를 통하여 유머와 기쁨의 긍정적인 정서의 구분이 가능한가를 밝히고자 하였다. fMRI와 말초신경계 반응 측정 실험 각각을 수행하는 동안, 유머와 기쁨정서를 유발하는 동영상 자극(2분)이 제시되었고, 실험이 끝난 후 심리적인 평가도 함께 수행되었다. fURI 실험은 boxcar design으로 한 session 내에 두 block으로 구성되었다. 말초신경계 반응실험에서는 안정상태와 정서상태에서의 피부전기 반응을 측정하였다. fMRI 결과, 유머자극과 기쁨자극 제시 시 공통적으로 precentral Cortex, temporal Cortex, precuneus 가 활성화 되었고, 유머자극은 기쁨자극에 비하여 우측 middle temporal cortex, 우측 inferior frontal cortex, 좌측 middle frontal cortex 에서 큰 활성화를 보였다. 피부전기 반응(EDA) 분석 결과 두 정서 모두 안정상태에 비하여 유의하게 증가하였고, 유머자극은 기쁨자극에 비하여 피부전도수준(SCL)과 피부전도반응의 수(NSCR)에서 유의하게 증가하는 것으로 나타났다.

• Journal of Chest Surgery
• /
• v.32 no.6
• /
• pp.579-583
• /
• 1999

Background: Thoracic sympathicotomy has been used safely and successfully to manage palmar hyperhidrosis. The preoperative and postoperative recording of Sympathetic Skin Responses(SSR) was performed for objective evaluation and follow-up of thoracic sympathicotomy in hyperhidrosis patients, and also for ascertaining the clinical usefullness of SSR. Material and Method: The recording of SSR was performed on 15 patients suffering from palmar hyperhidrosis with Medelec Sapphire Plus electromyogragh before and after thoracic sympathicotomy. Eletrical stimuli on the right median nerve was made in patients in supine position and results were recorded on right and left palms with soles at the same time by 4 channels. Skin temperatures were also monitored simultaneously. T2,3 sympathicotomy was performed with VATS in every patients. SSR was done in 2 patients one month later. Result: Clinically, all patients had symptomatic improvement with satisfaction. Postoperative complication was small amount of residual pneumothorax in 5 patients but it was absorbed sponteneously. There was no recurrence during follow-up period and ten patients(66%) complained compensatory hyperhidrosis. After operation, SSR change was shown in every 15 patients. Abolition of SSR on both palms was achieved in 12 patients(80%) and on both soles in 6 patients. In the other 3 patients, the latencies were significantly delayed and the amplitudes were significantly reduced at both palms and soles. In two patients who were examined at one month later after operation, similar results with postoperative SSRs were shown. The skin temperature on preoperative both palm and sole were lower than normal temperature, and those on postoperative both palm and sole were increased. Those had statistical significance(p<0.05), and the temperature on the palm was increased higher that than on the sole. Conclusion: After thoracic sympathicotomy was performed on palmar hyperhidrosis patients, an increment of skin temperatures and SSR changes were achieved at both palms and soles of all patients. Palmar SSRs were completely abolished in 12 patients(80%), and similar results of postoperative SSRs were achieved. The recording of SSR may be useful to easily and objectively assess the completeness of sympathicotomy and the follow-up of recurrence in hyperhidrosis patients.

• Tuberculosis and Respiratory Diseases
• /
• v.39 no.4
• /
• pp.334-342
• /
• 1992

Background: The activated T lymphocyte by inhalaed mycobacterial antigen may evoke cell-mediated immunity in patients with active pulmonary tuberculosis. These activated lymphocyte may influence the response of tuberculin-purified protein derivative (PPD) in skin test. But occasionally, anergy to PPD appear in patients with pulmonary tuberculosis in spite of active stage. Thus we evaluated the effect of change of subtypes of lymphocyte in bronchoalveolar lavage fluid (BAL) and peripheral blood on anergy to PPD in patients with active pulmonary tuberculosis. Method: We performed tuberculin skin test and flow-cytometry analysis of lymphocytes obtained from BAL fluid and peripheral blood in 11 healthy normal volunteers and 20 patients with active pulmonary tuberculosis. Results: 1) The composition of lymphocyte significantly increased in patients with active pulmonary tuberculosis when compared with that in healthy control ($25.2{\pm}4.8$ vs $6.5{\pm}1.3%$, p<0.01), but composition of monocyte significantly decreased ($69.6{\pm}5.7$ vs $89.2{\pm}1.4%$, p<0.05) in analysis of BAL fluid. 2) There were no differences in compositions of cells in BAL fluid between responders and no-responders to PPD. 3) The compositions of CD3 (+), CD4 (+), CD3 (+) IL-2R (+), CD3 (+) HLA-DR (+) significantly increased in BAL fluid when compared with those in peripheral blood in patients with active pulmonary tuberculosis. But the composition of CDS (+), CD4/CDS were not different between BAL fluid and peripheral blood. 4) There were no correlations between response to PPD and compositions of cells and lymphocyte subtypes in BAL fluid and peripheral blood in all patients with tuberculosis, responders, and no-responders, respectively. Conclusion: From these results, we suggest no direct relationship between compositions of inflammatory cells in bronchoalveolar lavage fluid and we could not rule out the possibility of compartmentalization of activated lymphocyte involving in anergy to PPD in skin test in patients with active pulmonary tuberculosis.

• Science of Emotion and Sensibility
• /
• v.2 no.1
• /
• pp.61-68
• /
• 1999

본 연구의 목적은 운전 상황과 도로 상황에 따른 자율신경계의 반응을 측정하는 것이다. 지금까지의 생리 신호는 대부분 제한된 실험실에서 측정되었고, 이 결과들은 자연스러운 상황에 측정된 데이터와는 차이가 있을 것이다. 그러므로 보다 동적인 환경에서 인간의 감성을 추출하고자 본 연구를 수행하였다. 건강한 5명의 피험자로부터 심박 변화율, 피부 저항, 피부온도 등의 생리 신호를 측정하였다. 먼저, 정차, 정속 주행, 급출발, 급제동의 운전 상황 변화에 따른 자율신경계의 반응을 측정하였고, 둘째로, 직선 도로와 굴곡이 심한 도로에서 정속 주행을 하면서 생리 신호를 측정하여 도로상황 변화에 따른 자율신경계의 반응을 측정하였다. 정차 및 정속 주행에 비해 급출발, 급제동일 때, 직선도로에 비해 굴곡이 심한 도로에서 주행을 할 때 평균 R-R 간격은 감소하였고, 전력 스펙트럼의 (LF+MF)/HF비는 증가하였고, 피부온도는 감소하였고, 피부저항은 증가하였다. 본 연구로부터, 정차 및 정속 주행에 비해 급출발, 급제동일 때 그리고 직선도로에 비해 굴곡이 심한 도로에서 주행을 할 때 교감신경계의 활성화비가 증가한다는 일치된 경향을 관찰할 수 있었다. 앞으로 피실험자수를 늘려 보다 정확한 통계적 분석을 하고자 한다.