• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.1
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• pp.11-18
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• 2020

The emergence of the flow-through cell (FTC) method has made up for the limitations of previous dissolution test methods, but the high cost of the FTC dissolution devices have seriously hindered the progression of research and application of the FTC. This new design uses a peristaltic pump to simulate the sinusoidal flow rate of a piston pump. The flow profile of each peristaltic pump was sinusoidal with a pulsation of 120 ± 1 pulses per minute, and the flow rate ranged from 1.0 - 36.0 mL/min. The flow control of each channel was adjusted independently so the flow errors of the seven channels were close to 2%. The structure of the system was simplified, and the cost was reduced through manual sampling and immersing the FTC in a water bath. The dissolution rate of the theophylline and aminophylline films was determined, and good experimental results were obtained.