• Title/Summary/Keyword: 폴리코사놀

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Policosanol Reduces Blood Cholesterol Levels by Inhibiting Sterol Regulatory Element-binding Proteins-1c and Fatty Acid Synthase (Sterol regulatory element-binding proteins-1c와 지방산 합성효소의 억제를 통한 폴리코사놀의 혈중 콜레스테롤 감소)

  • Min Jung Park;Byeong Min An;Dongjun Lee;Ji Myung Choi;Yung Hyun Choi;Bo Sun Joo
    • Journal of Life Science
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    • v.33 no.4
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    • pp.315-324
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    • 2023
  • The underlying action of policosanol in lowering cholesterol level has not yet been clearly elucidated. Several recent studies have suggested that sterol regulatory element-binding proteins (SREBP)-1c play a role in the regulation of cholesterol synthesis via the fatty acid synthesis pathway. To date, no study has evaluated the effects of policosanol on SREBP-1c-mediated fatty acid synthesis. Therefore, this study aimed to investigate whether the SREBP-1c-mediated fatty acid biosynthetic pathway is associated with the cholesterol-lowering effects of policosanol. Seven-week-old C57BL/6 male mice were randomly divided into 7 groups (n=7 per group) and treated for 8 weeks as follows: 1) normal diet (normal control), 2) high-fat diet (HFD), 3) HFD+ethanol (Pol-0), 4) HFD+policosanol 1 mg/kg (Pol-1), 5) HFD+policosanol 2 mg/kg (Pol-2), 6) HFD+policosanol 4 mg/kg (Pol-4), and 7) HFD+simvastatin 50 ㎍/kg (positive control). Policosanol and simvastatin were administered at the same time every day while maintaining the HFD. Body weight and food intake were measured weekly for 8 weeks. After 8 weeks, serum cholesterol levels were measured, histological analysis was carried out, and the expressions of SREBP-1c and fatty acid synthase (FAS) in the liver tissues were examined. Policosanol reduced body weight and the amount of food intake in a dose-dependent manner. Serum cholesterol levels were significantly lowered in the Pol-1 and Pol-4 groups. The expression of SREBP-1c and FAS was also significantly decreased in the Pol-4 group. These results suggest that the cholesterol-lowering effects of policosanol can occur due to the inhibition of the expression of SREBP-1c and FAS.

The Effect of 12-Weeks Combined Training and Policosanol Supplimentation Inflammatory and Maker and Leptin in Obese Women (12주간 복합운동 및 Policosanol 섭취가 비만 중년여성의 염증표지인자 및 렙틴에 미치는 효과)

  • Jung, Chan-Kyoung;Youm, Jeong-Hown
    • Journal of Digital Convergence
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    • v.13 no.4
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    • pp.387-393
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    • 2015
  • The purpose of this study is investigating the effects of combination of policosanol intake and combined exercise to the defence mechanism and the changes of fat cell control hormones by analyzing the changes of inflammatory markers LDH and CPK, and Leptin when having policosanol intake and combined exercise together against obese women for 12 week. These groups are randomly assigned to the control group, policosanol intake group, combined exercise group and combined treatment group with 12 obese women in esch group and they performed muscular resistance exercise and an aerobic exercise which was walking twice a week. After 12 weeks the LDH showed significant differences(p<.01) at exercise period, and also showed the significant differences(p<.05) in the effect of the interaction between exercise period and group. The changes in Leptin showed significant differences(p<.001) at exercise period. In summary, carrying out together of the aerobic exercise, muscular resistance exercise or policosanol intake can be considered to have the beneficial effects to prevent various disease which caused by inflammatory maker and Leptin and it also increases its effects.

Effects of genotype and environmental factors on content variations of the bioactive constituents in rice seeds (벼의 유전형질과 재배환경 요인이 기능성물질 함량 변이에 미치는 영향 비교)

  • Soo-Yun Park;Hyoun-Min Park;Jung-Won Jung;So Ra Jin;Sang-Gu Lee;Eun-Ha Kim;Seonwoo Oh
    • Journal of Applied Biological Chemistry
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    • v.65 no.4
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    • pp.429-438
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    • 2022
  • The composition of crops reveal natural variation according to genetic characteristics and environmental factors such as the cultivated regions. For comparative investigation of the impact of genetic difference and environmental influence on the levels of bioactive components in rice seeds, 23 cultivars including indica, japonica, and tongil rice were grown in two location in Korea (Jeonju and Cheonan) for two years (2015 and 2016). Sixteen compounds consisting of tocopherols, tocotrienols, phytosterols, and policosanols were identified from 368 rice samples and the compositional data were subjected to data mining processes including principal component analysis and Pearson's correlation analysis. Under 4 different environmental conditions (Jeonju in 2015, Cheonan in 2015, Jeonju in 2016, Cheonan in 2016), the natural variability of rice seeds showed that the genetic background (indica vs japonica vs tongil) had more impact on the compositional changes of bioactive components compared to the environments. Especially, the results of correlation analysis revealed negative correlation between α-, β-tocopherols and γ-, δ-tocopherols as a representative genetic effect that did not changed by the environmental influence.