• Journal of the Korean Chemical Society
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• v.63 no.6
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• pp.427-434
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• 2019

The role of hydrophobic residues on protein folding reaction was studied by folding kinetics measurements in conjunction with protein engineering. The HubWA, which was derived from human ubiquitin by mutating the residues at 45 (Phe to Trp) and 26 (Val to Ala), was used as a mutational background. Fourteen hydrophobic residues were mutated to alanine. Among fourteen variants generated, only four variant proteins (V5A, I13A, V17A, and I36A) were suitable for folding study. The folding kinetics of these variants was measured by stopped-flow fluorescence spectroscopy. The folding kinetics of HubWA and V17A was observed to follow a three-state on-pathway mechanism. On the other hand, folding kinetics of V5A, I13A, and I36A was observed to follow a two-state mechanism. Based on these observations, transition of protein folding reaction from collision-diffusion mechanism to nucleation-condensation mechanism was discussed.

• Proceedings of the Korea Contents Association Conference
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• 2015.05a
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• pp.215-216
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• 2015

연구의 목적은 이러닝 학습환경에서 학습자들의 학습 참여를 촉진할 수 있는 시각적 스캐폴딩을 개발하고 그것이 학습참여, 개별학습, 팀프로젝트학습에 미치는 교육적 효과를 분석하고자 한다. 시각적 스캐폴딩에는 개별 참여도, 팀 참여도, 팀활동에 대한 개인 기여도, 팀간 상호작용 정도가 표상되도록 설계하였다. 시각적 스캐폴딩의 교육적 효과는 실험연구를 통해 분석되었다. 연구결과 이 연구를 통해 개발된 시각적 스캐폴딩은 학습참여도 및 학습성과에 긍정적인 영향을 미치는 것으로 분석되었다.

• Journal of Korean Association for Spatial Structures
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• v.7 no.2 s.24
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• pp.45-52
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• 2007

The purpose of this study is to explore folding as a tool diversifying structures and shapes or forms, and to consider the role and possibilities as structural design sources. First, the morphological characteristics and the elements for transforming pattern of folding are investigated and the way of forming space is also shown. Secondly, the application methods and systems of folding are descrived.

• The Journal of the Korea Contents Association
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• v.7 no.2
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• pp.161-169
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• 2007

This study examines the effects of learner's metacognition and scaffolding types on problem solving processes by examined 49 undergraduates to identify effective scaffolding type in Web-based PBL. This study classifies problem solving processes as defining the problem, developing solutions, making selections and justifications for the Proposed solution(s), and monitoring the solution. Moreover, it classifies scaffolding types as subject-related scaffolding and process-related scaffolding. As a result, the upper metacognition group showed higher performance only in monitoring solutions than the lower metacognioon group. This study also showed that offered scaffolding effects are not statistically significant. However, the lower metacognition group showed higher performance when subject-related scaffolding was offered and the upper metacognition group showed higher performance when process-related scaffolding was offered in making selections and justifications for the proposed solution(s) and monitoring solution. This study, based on the result of research, can partially verify the effects of learner's metacognition on problem solving processes and interaction effects between scaffolding and metacogniton in Web-based PBL.

• 한국정보교육학회:학술대회논문집
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• 2007.01a
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• pp.173-180
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• 2007

최근 모바일 기기의 활성화에 따라 M-learning (Mobile learning)이 활성화되고 있다. M-learning을 기반으로 한 코스웨어나 모듈 설계 시 학습자의 적극적 참여와 의미 있는 상호작용의 기회 제공과 실제적 환경에서의 교육활동을 지원하는 것에 초점을 맞추어야 한다. 근접발달영역이론 (Zone of Proximal Development : ZPD)이란 독자적으로 문제를 해결함으로써 결정되는 실제적 발달수준과 성인의 안내나 보다 능력 있는 또래들과 협동하여 문제를 해결함으로써 결정되는 잠재적 발달수준간의 거리이다. 한편, 스캐폴딩은 학습자의 근접발달영역을 변화시키며, 학습자가 스스로 학습할 수 있도록 도와주는 구체적인 방식이라 할 수 있다. 또한 스캐폴딩 (Scaffolding)은 학습자가 구조를 조직하고 새로운 지식을 구성하도록 교수자 또는 촉진자가 도와주면서 교수자와 학습자간에 상호작용하는 과정이다. 본 연구에서는 근접발달영역이론을 이용하여 모바일로 교사가 학습자에게 스캐폴딩을 제공하는 수업모형을 제안한다. 본 모형의 특징은 다음과 같다. 첫째, 문제해결을 위한 스캐폴딩만이 아니라 문제 해결 후 격려 스캐폴딩을 제공하여 학습력 강화가 이뤄지도록 하였다. 둘째, 교사와 학습자 사이에 다양한 스캐폴딩을 제공하여 상호작용을 강화하였다. 셋째, 자신에게 맞는 개별학습, 반복 학습이 가능하고 자기 주도적 학습이 강화되도록 하였다.

• Journal of The Korean Association For Science Education
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• v.32 no.7
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• pp.1204-1221
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• 2012

The purpose of this research was to identify the components of scaffolding in open inquiry and to explore the functions of teachers' scaffolding, which is necessary to support students' open inquiry. In order to identify scaffolding components, at first, we conducted a survey using a questionnaire on what students think about open inquiry on 110 students who performed open inquiry in two middle schools, and then carried out factor analysis based on the survey results. It was attempted to investigate students' perception through focus group interviews corresponding to scaffolding components that were identified through factor analysis. Also, we examined teachers' empirical view of scaffolding functions in open inquiry through in-depth interviews with four teachers. The results of exploratory factor analysis revealed that there were five scaffolding components of open inquiry: motivation, planning, strategy, environment and participation. The results of focus group interviews showed that students experienced difficulties in planning, strategy, environment and participation components, except for motivation component. In particular, students asked for support to strengthen the participation component, which means recognizing their role, active participation and collaboration with peers. Meanwhile, the results of in-depth interviews with teachers showed that teachers' empirical views of scaffolding function in open inquiry were categorized as cognitive (conceptual, metacognitive), emotional (motivational, arbitrative) and strategic. Interviewed teachers preferred the strategic scaffolding and cognitive scaffolding to the emotional scaffolding. Based on the results, we also discussed the implications for performing open inquiry effectively.

• Journal of the Institute of Electronics Engineers of Korea SD
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• v.41 no.11
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• pp.35-42
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• 2004

A CMOS folding ADC with transistor differential pair folding circuit for low power consumption and high speed operation is presented in this paper. This paper explains the theory of transistor differential pair folding technique and many advantages compared with conventional folding and interpolation circuits. A ADC based on transistor differential pair folding circuit uses 16 fine comparators and 32 interpolation resistors. So it is possible to achieve low power consumption, high speed operation and small chip size. Design technology is based on fully standard 0.25${\mu}{\textrm}{m}$ double poly 2 metal n-well CMOS process. A power consumption is 45mW at 2.5V applied voltage and 250MHz sampling frequency. The INL and DNL are within $\pm$0.15LSB and $\pm$0.15LSB respectively. The SNDR is approximately 50dB at 10MHz input frequency.

• Journal of The Korean Association of Information Education
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• v.10 no.1
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• pp.93-104
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• 2006

The purpose of this study is to examine the effects of GLAS(Guided-Learner Adaptable Scaffolding) strategies in web-based collaborative learning environments. Through the extensive literature reviews, web-based collaborative learning environments considering GLAS types were developed. 93 sixth graders were selected from a elementary school in Seoul, and they learned in the web-based system for 4 weeks. The results revealed that the impact of scaffolding on transfer of learning, cognitive overload by reflective scaffolding, learning motivation affected intrinsic scaffolding.

• Journal of Digital Convergence
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• v.20 no.4
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• pp.63-72
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• 2022

The interest in online education has increased due to the spread of COVID-19. Especially, in the online environment, the importance of scaffolding, which refers to the help and support provided by instructors or peer learners, is being emphasized. This study aimed to review the antecedents of online scaffolding at the university of Korea through the method of systematic review. For this purpose, we collected 578 studies conducted from 2010 to 2021 and selected 7 studies according to the criteria of selection and exclusion. As a result, we found general features, types, and effects of online scaffolding at the university of Korea. Based on these results, we discussed suggestions and implications for a follow-up study. We hope many empirical kinds of research will be conducted about online scaffolding at the university.

• Journal of The Korean Association For Science Education
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• v.39 no.4
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• pp.545-562
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• 2019

The purpose of this study is to develop cognitive scaffolding tools and to explore their effects on integrated science process skills of high school students. For this purpose, we developed cognitive scaffolding tools including one kind of classroom instruction for training integrated process skills and two kinds of individual learning materials that students can selectively study according to their level of inquiry ability. In addition, we developed hypothetico-deductive inquiry tasks as a tool to investigate the level of students on the integrated process skills for pre-test and post-test respectively. In order to verify the effectiveness of the cognitive scaffolding tools, we conducted inferential statistics on the pre-and post-tests of the experimental group and control group to examine statistical significance of students' inquiry level change depending on the usage of the cognitive scaffolding tools. We also produced Wrightmaps based on Rasch model to compare the change of inquiry ability depending on usage of the cognitive scaffolding tools. As a result, the experimental group using the cognitive scaffolding tools showed a significantly higher scores in all the components of integrated process skills namely, designing inquiry, collecting data, analyzing data, and forming conclusion than the control group. In addition, students who used cognitive scaffolding tools improved their inquiry ability and showed a distinct transition to higher level in each component of the integrated process skills. The results of this study suggest that high school students need cognitive scaffolding to alleviate or eliminate the functional barriers they face in conducting scientific inquiries.