• Korean Journal of Psychosomatic Medicine
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• v.25 no.2
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• pp.176-184
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• 2017

Objectives : Middle aged women with depression often experience hot flush symptoms. It is still unclear about the association between depression and hot flush symptoms. Therefore, we investigated hormonal profile, functional somatic symptoms, coping styles and attitude for menopause between depressed women with hot flush and those without hot flush. Methods : This study included 33 depressed patients with hot flush symptoms and 33 depressed patients without hot flush symptoms. Hot flush was confirmed through prospective daily symptom ratings for a week. Subjects' coping styles were assessed by the stress coping checklist. Somatic symptoms were assessed by the Patient Health Questionnaire-15(PHQ-15). Sex hormonal levels were assayed by a radioimmunoassay. The Brief World Health Organization Quality of Life Assessment Instrument(WHOQOL-BREF) was used to evaluate quality of life. Results : In coping style, depressed women with hot flush symptoms used less 'problem-centered coping'($13.15{\pm}3.17$) and 'search for social support'($11.83{\pm}2.84$) than those without hot flush symptoms($15.17{\pm}3.1$, p=0.028 ; $14.25{\pm}3.22$, p=0.009 ; respectively). Depressed women with hot flush symptoms showed more negative attitude toward post-menopause, but its statistical significance was marginally insufficient(p=0.059). We did not find any group differences in sex hormonal levels and somatic complaints assessed by the PHQ-15. The score of social relationship domain of WHOQOL-BREF was significantly lower in subjects with hot flush symptoms($8.62{\pm}2.04$) than subjects without hot flush symptoms($9.71{\pm}1.65$ ; p=0.044). Conclusions : Among middle aged women with depression, the manifestation of hot flush symptoms was associated with coping styles and attitude for menopausal transition. Hot flush symptoms in depressed women negatively influence quality of life, so clinicians actively perform therapeutic approach in case of depressed patients with hot flush symptoms. In case of depressed patients who present hot flushes, cognitive behavior therapy or stress management might be an effective treatment option in company with antidepressants or hormonal treatment. Later, longitudinal study will be needed to evaluate risk factor, cause and effect associated with hot flush and depression.

• Women's Health Nursing
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• v.12 no.1
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• pp.29-36
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• 2006

Purpose: The purpose of this study was to investigate postmenopausal women's risk factors and subjective symptoms of coronary artery disease, their knowledge about the risk factors and their performance of health behaviors. Method: The subjects were 285 women aged between 50~60 who had naturally reached menopause. We interviewed them using a questionnaire on the subjects' risk factors of coronary artery disease, their knowledge about the risk factors and their performance of preventive health behaviors. Collected data was analyzed through t-test, ANOVA & Duncan test. Results: Risk factors of coronary artery disease observed in the subjects were diabetes (10.9%), hypertension (22.8%) and hyperlipidemia (14.7%). Symptoms of coronary artery disease were experienced more by those who had diabetes, smoked, had a history of coronary artery disease, and thought that they might have coronary artery disease. With regard to the subjects' knowledge about the risk factors of coronary artery disease, the average score was 13.88 out of 20 points. Conclusion: The results of this study suggest that postmenopausal women have several risk factors of coronary arterial disease but they did not have sufficient knowledge about the risk factors and did not manage the factors appropriately.

• Journal of Nutrition and Health
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• v.22 no.2
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• pp.102-107
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• 1989

The present experiment was performed to study whether or not ovariectomized female rats can be used as an animal model to investigate the effects of estrogen on body compositions. Six-month-old, female rats were ovariectomized and the changes in body compositions were evaluated 6 months after surgery. As summarized in Fig. 2, body fat accretion was double in ovariectomized rats compared to shamoperated rats. Muscle weights were not d!fferent, while bone weights were lower in ovx rats than in sham rats when the values were expressed as a per\ulcornercentage of body weight. Results of the present study suggest that these ovariectomized rats can be utilized as an animal model to study the body compositions of postmenopausal obese women and related health problems.

• KSBB Journal
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• v.19 no.1
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• pp.83-87
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• 2004

This research was designed to investigate the effects of Estromon including FGF271 (Female Growth Factor 271) which was developed as a phytoestrogen for post- and pre-menopausal syndrome (PMS). The oral administration of two capsules of Estromon twice a day for 3 months significantly improved PMS (Post-/Premenopausal Syndrome) about 5 times more than placebo group (OR=5.04, 95% C.1. 1.40-18.14). In the group of 24 patients having taken Estromon, the concentration of alkaline phosphatase asn the bone marker decreased by -9.3${\pm}$9.5 IU/L after 3 months with a statistic significance. Since the concentration of osteocalcin as the other bone marker also decreased in more patients in Estromon group than in placebo group, the bone density might be expected to be improved in long-term treatment. Serum human growth hormone level increased in 17 out of 24 patients. Triglycerides decreased by -8.0${\pm}$40 (mg%) after 1 month and by -4.4${\pm}$36 (mg%) after 3 months in Estomon group while triglycerides increased in both cases in placebo group (p.0.01). Therefore, PMS patients might benefit from Estromon as a phytoestrogen supplement without any serious side effects.

• Proceedings of the Korean Journal of Food and Nutrition Conference
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• 2003.07a
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• pp.79-79
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• 2003

최근 소득수준의 향상과 여성의 사회진출로 인해 우리의 식생활도 많은 부분이 사회화되고 있다. 즉 완전조리식품과 반조리식품이 급격히 증가하고 있다. 기존의 인스탄트식품이 저가격, 반건강 특성으로 생각되어진 반면 최근 고가의 건강 지향적인 반조리식품으로 변화하고 있다. 이러한 경향은 식품가공기술 및 식품포장기술의 향상과 사회적요구에 부합된 결과로 사료된다. 이에 대표적인 경우가 다양한 소스류의 상품화 경향이다. 본 연구개발 사업에서 이루어지는 냉면소스도 가정에서 하기에는 번거롭고, 건강지향적 식생활로 메밀의 수효가 증가하여 냉면의 소비가 증가하리라 생각된다. 현재 시판되고 있는 기존의 몇몇의 제품들이 있기는 하나 제조공정, 보존상태 등에서 많은 문제점이 있다. 따라서 문헌 통하여 기존제품의 배합비를 조사하고, 냉면소스 배합비의 최적화를 위해 10여차례에 걸쳐 20종류의 소스에 대하여 배합비의 변화와 관능검사에 의해 배주스, 양파, 겨자, 마늘, 설탕, 물엿, 소금, 미원, 참기름, 고춧가루, 진간장, 생강즙, 식초, 파인애플로 구성된 소스를 개발하였다. 개발된 소스의 pH, 당도, 염도, 색차를 측정하여 관능검사의 결과와 비교 검토하였고, 식품재료의 차이에 의한 맛의 변화를 보정하기 위한 근거로 사용하였다. 저장성 검사를 위해 일반세균과 대장균을 검사하였다. 그 결과는 다음과 같다. 소비자들의 기호에 맞는 냉면소스를 개발하기 위해 다양한 식품의 배합을 시도하여 상품성이 있을 것으로 판단되는 recipe를 완성하였고, 일반인(주부)들을 상대로 한 호감도 조사에서도 좋은 성적을 나타내었다. 시료를 1주간격으로 한달간 실험한 결과 쇠고기가 들어 있는 제품을 제외하구 대장균은 검출되지 않았으며 일반세균은 위생법의 허용치내에 있었다. 쇠고기가 있는 제품은 가격상승과 저장성에 문제가 있어 이를 제하고 최종적인 레시피를 결정하였다.있었다. 그러나 식이 섭취상태와의 관련성은 나타나지 않았다. 이상에서 생활습관이 신체계측치 및 혈중 지질 농도와 일부 상관을 보이는 것을 알 수 있었으며, 건강위험 요인도 관찰할 수 있었다. 고지혈증은 심혈관계질환의 주요한 위험 인자로 알려져 있으며, 그 유발 요인에는 여러 환경적인 요인과 식이 요인이 있다. 또한 생활습관은 영양소의 섭취량에도 영향을준다. 이처럼 식이 요인과 생활습관은 단독 혹은 상호 영향을 주게 되므로 고지혈증 및 심혈관계질환을 개선하려면 식사요법과 생활습관 교정을 병행하여야 한다. 고지혈증의 원인 중의 하나로 지적되고 있는 음주와 흡연은 상호 유도작용이 있으므로 금연이나 절주를 하고자 할 경우 두가지를 동시에 자제해야 효과적일 것으로 생각된다. 폐경후 여성들에게 발생 빈도가 높은 심혈관질환의 위험요인인 고지혈증을 예방하고자 하는 노력은 폐경후 여성들의 삶의 질적 향상을 위해서도 매우 중요하다. 또한 균형식 섭취와 운동을 통해 혈중 지질 수준을 건강하게 유지하고, 비만으로의 이행을 방지함으로써 심혈관계질환을 예방하도록 하여야겠다.료보다 절반이하 수준이었다. Ferric citrate는 차이가 거의 없었으며 ferrous lactate는 70%수준이었다. 이상의 결과에서 철분강화우유에 사용하기 적합한 철분염은 ferrous lactate, ferric citrate였는데 특히 ferrous lactate는 제품의 이화학적 품질, 생이용성 측면 모두에서 가장 좋은 것으로 나타났다.다 높았으며, 1회당 평균 8.1$\pm$5.1개의 난포란을 회수하였다. investigation can be separated into sampling and analytical uncertainties, it can be used as a criterion where the resources for the inves

• Journal of the Korea Society of Computer and Information
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• v.26 no.8
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• pp.209-220
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• 2021

The effect of body composition such as lean mass and fat mass on bone mineral density (BMD) is complex and still controversial. In this study, we investigated the relationship between body composition and bone mineral density using nation-wide data from 2008 to 2011 Korea National Health and Nutrition Examination Survey (KNHANES) in 2,139 men and 2,193 postmenopausal women aged 50 years or older. Subjects with history of medication for osteoporosis or with diseases or malignancy affecting bone metabolism were excluded. Data of anthropometric measurements and demographic characteristics were collected by trained examiner. Fasting blood sample was obtained for blood chemistry analysis. BMD of the lumbar spine, total femur, and femoral neck, and body composition such as total lean mass (TLM), total fat mass (TFM), truncal fat mass (TrFM) were measured using dual-energy X-ray absorptiometry (DXA). There were significant positive correlations between body composition indices such as lean mass and fat mass with BMD. In multiple regression analysis, TLM was positively associated with BMD after adjusting age, body mass index, monthly house income, education level, physical activity, daily calcium intake and vitamin D concentration in both men and postmenopausal women. BMD at lumbar spine and femur in lowest quartile of TLM was significantly lower than other quartiles after adjusting those confounding factors in both gender. TrFM was negatively associated with total femur BMD in male and femur neck BMD in postmenopausal women after adjusting confounding factors. In conclusion, TLM is very important factor in maintaining BMD in subjects aged 50 years or older in men and postmenopausal women.

• Research in Community and Public Health Nursing
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• v.14 no.2
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• pp.253-262
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• 2003

Purpose: This study was carried out to identify factors influencing osteoporosis in women at pre- and post-menopausal state. Methods: The subjects of this study were 52 pre-menopausal and 125 post-menopausal women who were assessed of bone density in one general hospital. The data were collected through review of clinical records and telephone interviews using a questionnaire. Results: In the pre-menopausal women, the factors influencing osteoporosis were regular exercise (protective factor) and age (risk factor). Regression analysis showed that the factors attributable to osteoporosis included educational level, weight, age and number of pregnancy, accounted for 41.89% of the total variance. In the post-menopausal women. the factors influencing osteoporosis were age (risk factor), low educational level (risk factor), low economical state (risk factor), high parity (risk factor), and intake of coffee (protective factor). Regression analysis also showed that factors attributable to their osteoporosis included age, educational level, number of delivery, intake of the coffee, regular exercise, number of pregnancy and duration of oral pill intake, accounted for 37.41 % of the total variance. Conclusion: In pre-menopausal women, regular exercise was one of the most powerful determinant of their bone mass. Therefore, it is necessary to participate in a regular exercise program to maintain peak bone mass density prior to the onset of menopause. In post-menopausal women, increased age was the most influencing factor of their bone mass. Therefore, it is essential to establish early diagnosis and management of osteoporosis after menopause.

• Journal of Korean Public Health Nursing
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• v.27 no.2
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• pp.313-326
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• 2013

Purpose: The aim of this study was to evaluate the effects of lifestyle modification program on body composition and metabolic syndrome makers, depression in obese postmenopausal women. Method: The research design of this study included a non-equivalent control group pretest-posttest design. The lifestyle modification program was administered twice a week for 12 weeks the experimental group, whereas the control group had no program. The experimental group consisted of 22 obese postmenopausal women while the control group contained 19 subjects. The study also attempted to measure the effects of the program on body composition, metabolic syndrome markers, and depression in obese postmenopausal women. The data were analyzed by descriptive statistics and a t-test using the SPSS/WIN 17.0 program. Results: After participating in the lifestyle modification program, the experimental group showed statistically significant decreases in systolic pressure, diastolic pressure and depression, but no change in body composition. Conclusions: The result of this study show that the lifestyle modification program had a significant impact on obese postmenopausal women. In the future, it is necessary to offer more tailed program for a longer period.

• Research in Community and Public Health Nursing
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• v.17 no.1
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• pp.46-55
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• 2006

Objective: This study is to examine the physical function, psychological well-being, and subjective symptom of postmenopausal osteoporotic women. Methods: Data used for this study was collected from 397 women who had experienced one years or longer menopause and visited a hospital in Seoul, Korea during the period from May to December 2005. Results: The level of physical function of the fracture osteoporosis group was significantly lower than the other three groups. The psychological well-being of the fracture osteoporosis group was significantly lower than the other three groups. Subjective symptom of the fracture osteoporosis group was significantly higher than the other three groups. The level of physical function was positively correlated with psychological well-being and negatively with subjective symptom. Psychological well-being was also negatively correlated with the level of subjective symptom. Based on the results, it is recommended that the prevention of vertebral fracture in osteoporotic woman is important, and nursing intervention is necessary for the physical function, psychological well-being, and subjective symptom care.

• Journal of the Korean Society of Food Science and Nutrition
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• v.31 no.6
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• pp.1043-1047
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• 2002

It is well known that soy isoflavones play beneficial roles in the prevention of chronic diseases such as breast cancer, cardiovascular disease and osteoporosis. However current data are not sufficient for estimating the level of isoflavone intake. To use the urinary isoflavone excretion as a maker of isoflavone intake,26 participants consumed the isoflavone extract capsule (90 mg soy isoplavones/capsule) daily for 3 months. The study compared effects of pre- and post-isoflavone supplement in the following parameters; physical examination, dietary recalls, and urinary isoflavon excretion. The average age, height and weight were 65.7 years, 149.4 cm, and 57.3 kg. Subjects maintained regular diet pattern, and average daily nutrient intakes between pre- and post- supplementation were not significantly different except vitamin A, carotene and vitamin C. There was no significant difference between pre- and post- supplementation in terms of daily isoflavone intake. The basal urinary isoflavone excretion was 8.37 mg/day (daidzein 6.23 mu genistein 2.14 mg), and average daily excretion rate was IS.8%. Urinary isoflavone excretion was significantly increased, after isoflavone supplementation for 3 months as compared the basal level (p<0.01). Our data suggest that urinary isoflavone level, especially daidzein and genistein, may be a useful maker to estimate isoflavone intake.