• Journal of Life Science
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• v.20 no.5
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• pp.639-643
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• 2010

Sudden deaths have occurred in feedlot cattle with marked necro-hemorrhagic enteritis of the jejunum, ileum and colon. Suckling beef calves are the most frequently affected. Over-consumption of large amounts of milk, inadequate colostrum intake, chilling and stress are conducive to the development of enterotoxemia. Enterotoxemia caused by Clostridium perfringens type D mostly occurs following a sudden change of diet, particularly to feeds made richer in order to grow the cattle to market weight in feedlots. During July 2006, sudden deaths of cattle occurred in the Youngcheon regional area of Gyeongbuk province. There were no significant clinical signs except anorexia, depression, intermittent diarrhea and mild respiratory failure. Histological findings revealed a prominent intranuclear inclusion as well as infiltration of the globular leukocytes in various organs including the heart, kidneys, liver, spleen and lymph nodes. Spleen and lymphatic tissues showed lymphatic necrosis and a starry sky appearance. In the submucosa of the small intestines, basophilic aggregation was detected with massive infiltration of the globular leukocytes and eosinophils. Gram staining for the tissue sections containing inclusions of the small intestines revealed a positive histochemical reaction. Taken together, we suggest that Clostridium perfringens type D-induced enterotoxemia is determined to be the cause of sudden death of feedlot cattle.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.32 no.1
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• pp.55-68
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• 2020

In order to investigate the hydraulic characteristics of a boundary layer streaming over the beach cusps appeared in swells prevailing mild seas, we numerically simulated the shoaling process of Edge waves over the beach cusp. Synchronous Edge waves known to sustain the beach cusps could successfully be duplicated by generating two obliquely colliding Edge waves in front of beach cusps. The amplitude A_B and length L_B of Beach Cusp were elected to be 1.25 m and 18 m, respectively based on the measured data along the Mang-Bang beach. Numerical results show that boundary layer streaming was formed at every phase of shoaling process without exception, and the maximum boundary layer streaming was observed to occur at the crest of sand bar. In RUN 1 where the shortest waves were deployed, the maximum boundary layer streaming was observed to be around 0.32 m/s, which far exceeds the amplitude of free stream by two times. It is also noted that the maximum boundary layer streaming mentioned above greatly differs from the analytical solution by Longuet-Higgins (1957) based on wave Reynolds stress. In doing so, we also identify the recovery procedure of natural beaches in swells prevailing mild seas, which can be summarized such as: as the infra-gravity waves formed in swells by the resonance wave-wave interaction arrives near the breaking line, the sediments ascending near the free surface by the Phase II waves orbital motion were carried toward the pinnacle of foreshore by the shoreward flow commenced at the steep front of breaking waves, and were deposited near the pinnacle of foreshore due to the infiltration.

• Economic and Environmental Geology
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• v.31 no.2
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• pp.127-139
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• 1998

A new technique of simultaneous inversion for 3-D seismic velocity structure by using direct, reflected, and refracted waves is applied to the southeast part of the Korean Peninsula including Pohang Basin, Kyongsang Basin and Ryongnam Massif. Pg, Sg, PmP, SmS, Pn, and Sn arrival times of 44 events with 554 seismic rays are inverted for locations and crustal structure. $6{\times}6$ with $0.5^{\circ}$ and 8 layers (4 km each layer) model was inverted. 3-D seismic crustal velocity tomography including eight sections from surface to Moho, ten profiles along latitude and longitude are analyzed. The results are as follows: 1) the average velocity and thickness of sediment are 5.04 km/s and 3-4 km, and the velocity of basement is 6.11 km/s. The shape of velocity in shallower layer is agreement with Bouguer gravity anomaly (Cho et al., 1997). 2) the velocities fluctuate strongly in the upper crust. The velocity distribution of the lower crust under Conrad appears basically horizontal. 3) the average depth of Moho is 30.4 km, and velocity is 8.01 km/s. 4) from the velocity and depth of the sediment, the thickness, velocity and form of the upper crust, and the depth and form of Moho, we can find the obvious differences among Ryongnam Massif, Kyongsang Basin and Pohang Basin. 5) the deep faults (a Ulsan series faults) near Kyongju and Pohang areas can be found to be normal and/or thrust faults with detachment extended to the bottom of the upper crust.

• Economic and Environmental Geology
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• v.31 no.3
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• pp.235-247
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• 1998

A new technique of simultaneons inversion for 3-D seismic velocity structure by using direct, reflected, and refracted waves is applied to the center of the Korean Peninsula including Pyongnam Basin, Kyonggi Massif, Okchon Fold Zone, Taebaeksan Fold Zone, Ryongnam Massif and Kyongsang Basin. Pg, Sg, PmP, SmS, Pn, and Sn arrival times of 32 events with 404 seismic rays are inverted for locations and crustal structure. 5 ($1^{\circ}$ along the latitude)${\times}6$ ($0.5^{\circ}$ along the longitude) ${\times}8$ block (4 km each layer) model was inverted. 3-D seismic crustal velocity tomography including eight sections from the surface to the Moho, eight profiles along latitude and longitude and the Moho depth distribution was determined. The results are as follows: (1) the average velocity and thickness of sediment are 5.15 km/sec and 3-4 km, and the velocity of basement is 6.12 km/sec. (2) the velocities fluctuate strongly in the upper crust, and the velocity distribution of the lower crust under Conrad appears basically horizontal. (3) the average depth of Moho is 29.8 km and velocity is 7.97 km/sec. (4) from the sedimentary depth and velocity, basement thickness and velocity, form of the upper crust, the Moho depth and form of the remarkable crustal velocity differences among Pyongnam Basin, Kyonggi Massif, Okchon Zone, Ryongnam Massif and Kyongsang Basin can be found. (5) The different crustal features of ocean and continent crust are obvious. (6) Some deep index of the Chugaryong Rift Zone can be located from the cross section profiles. (7) We note that there are big anisotropy bodies near north of Seoul and Hongsung in the upper crust, implying that they may be related to the Chugaryong Rift Zone and deep fault systems.

• Geophysics and Geophysical Exploration
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• v.13 no.2
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• pp.153-158
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• 2010

To investigate the velocity structure in the central and southern parts of the Korean peninsula, a 299-km NW-SE seismic refraction profile KCRT-2008was obtained across major tectonic boundaries. Seismic waves were generated by detonating 250 ~ 1500 kg explosives at depths of 50 ~ 100 m in eight drill holes located at intervals of 21 ~ 113 km. The seismic signals were detected by 4.5 Hz geophones at a nominal interval of 500 m. The first-arrival times were inverted to derive a velocity tomogram. The raypaths indicate several mid-crust interfaces including those at approximate depths of 2 ~ 3, 11 ~ 13, and 20 km. The Moho discontinuity with refraction velocity of 7.7 to 8.1 km/s has a maximum depth of 34.5 km under the central portion of the peninsula. The Moho becomes shallower as the Yellow Sea and the East Sea are approached on the west and east coasts of the peninsula, respectively. The depth of the 7.6 km/s velocity contour varies from 31.3 km to 34.4 km. The velocity tomogram shows the existence of a 129 km wide low-velocity zone centered at 7.2 km depth under the Okchon fold belt and Gyeonggi massif and low-velocity(< 5.4 km/s) rocks in the Gyeongsang sedimentary basin with a maximum thickness of 2.6 km

• Geophysics and Geophysical Exploration
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• v.19 no.4
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• pp.220-227
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• 2016

Marine seismic data have not only primary signals from subsurface but also ghost signals reflected from the sea surface. The ghost decreases temporal resolution of seismic data because it attenuates specific frequency components. For eliminating the ghost signals effectively, the exact ghost delaytimes and reflection coefficients are required. Because of undulation of the sea surface and vertical movements of airguns and streamers, the ghost delaytime varies spatially and randomly while acquiring seismic data. The reflection coefficient is a function of frequency, incidence angle of plane-wave and the sea state. In order to estimate the proper ghost delaytimes considering these characteristics, we compared the ghost delaytimes estimated with L-1 norm, L-2 norm and kurtosis of the deghosted trace and its autocorrelation on synthetic data. L-1 norm of autocorrelation showed a minimal error and the reflection coefficient was calculated using Kirchhoff approximation equation which can handle the effect of wave height. We applied the estimated ghost delaytimes and the calculated reflection coefficients to remove the source and receiver ghost effects. By removing ghost signals, we reconstructed the frequency components attenuated near the notch frequency and produced the migrated stack section with enhanced temporal resolution.

• Journal of the Korea Society for Simulation
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• v.30 no.1
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• pp.11-20
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• 2021

As unmanned underwater systems have recently emerged, a high-speed underwater channel modeling technique, which is one of the most important techniques in the system, has received a lot of attention. In this paper, we proposed a high-speed sound propagation model and verified the applicability through quantitative performance analyses. We used a high-order finite difference method (FDM) for wave propagation modeling in the water, and a domain decomposition method was adopted using multiple general-purpose graphics processing units (GPUs) to increase the calculation efficiency. We compared the results of the model we proposed with the analytic solution in the half-infinite media and results of the Virtual Timeseries Experiment (VirTEX) model, which is based on the ray method. Finally, we analyzed the performance of the model quantitatively using numerical examples. Through quantitative analyses of the improvement in computational performance, we confirmed that the computational speed increases linearly as the number of GPUs increases. The computation times are increased by 2 times and 8 times, respectively, when the domain size of computation and the maximum frequency are doubled. We expect that the proposed high-speed underwater channel modeling technique is able to contribute to the enhancement of national defense as an underwater communication channel model and analysis tool to develop the underwater communication technique for the unmanned underwater system.

• Journal of Chest Surgery
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• v.38 no.12 s.257
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• pp.835-843
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• 2005

Background: Cancer of the esophagus is one of the most malignant tumors with poor prognosis. The p53 gene alteration, over expression of Cyclin D1, and Ki67 index were thought to be the prognostic factors. However, their clinical significances in esophageal squamous cell carcinoma are controversial and p53 accumulation may not correlate with genetic mutation. The current study investigates their prognostic significance in squamous cell carcinoma of the esophagus. Material and Method: The Subjects studied were 124 esophageal squamous cell carcinoma patients who underwent esophagectomy. The mutation of p53, over expression of Cyclin D1, Ki67 labelling index, mitotic index were examined by using an immunohistochemical staining. We compared the results and investigated the correlation with the mutation of p53, overexpression of Cyclin D1, Ki67 labelling index, mitotic index and tumor size, and duration of survival. Result: There was no correlation between the results in immunohistochemical staining according to age, sex, tumor size, Iymph node status, and clinical stage of the disease. Mutant p53 protein was found in 69 cases (55.6$\%$). Median survival time was 21 months in cases with negative for mutant p53 protein and 22 months in positive cases. There was no significant difference in survival (p=0.46). Median survival time was 22 months in cases with negative for Cyclin D1 and 16 months in positive cases (p=0.18). Median and mean survival time was 22 months and 36 months when Ki67 labeling index was 40 or less (102 cases). Median and mean survival was 16 months and 23 months, when Ki67 labeling index was more than 40 (22 cases). There was significant difference in survival rate (p=0.011). Conciusion: Positivity of p53 and cyclin D1 was not useful in predicting the prognosis in our study. There was no significant correlation among mutant p53 protein accumulation, Cyclin D1 over expression, and Ki67 labeling index. However, in several studies, PCR single strand conformational polymorphism analysis of p53 showed a correlation to the prognosis. We thought that there was a significant discordance between p53 gene mutation and mutant p53 protein accumulation. When Ki67 labeling index was more than 40, prognosis was poorer, Ki67 seems to be a prognostic factor in our study. Therefore, we confirmed the possibility of using molecular markers as prognostic factors.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.181-190
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• 2001

Purpose: The aim of this study is to investigate the usefulness of intestinal ultrasonography (US) and upper gastrointestinal endoscopy in the early diagnosis of Henoch-Sch$\"{o}$nlein purpura (HSP) with the gastrointestinal (GI) symptoms preceding the emergence of the skin lesion. Methods: The clinical, intestinal US and upper gastrointestinal endoscopic records of 85 patients (88 cases) with GI symptoms relating to HSP presenting between January 1999 and April 2001 were reviewed. Results: 1) GI symptoms were observed in 52 cases (59%) and skin, joint, renal and scrotal manifestations were observed in 88 (100%), 64 (73%), 15 (17%), 3 cases (3%) respectively. 2) Out of 52 cases with GI symptoms, abdominal pain was observed in all cases (100%). Positive stool occult blood, nausea and vomiting, abdominal tenderness, melena or tarry stool, diarrhea, hematemesis, rebound tenderness and rigidity were observed in 28 (50%), 17 (33%), 17 (33%), 12 (23%), 6 (12%), 4 (8%), 1 (2%) and 1 case (2%) respectively in order of frequency. 3) Intestinal US examination was performed in 27 cases with HSP and GI symptoms (52 cases). Out of 27 sonographic examinations 22 showed abnormal findings. Thickening of the duodeno-jejunal wall was observed in 16 cases (73%). Free peritoneal fluid, enlarged mesenteric lymph node, ileus and abnormal gall bladder were seen in 8 (36%), 8 (36%), 4 (18%) and 1 case (5%) respectively. In three cases of HSP without GI symptoms, those changes were absent. 4) In all of five cases with HSP and GI symptoms, endoscopic study showed mucosal edema and multiple hemorrhagic erosions especially at the second portion of the duodenum. Biopsy specimens from the duodenum of 2 cases out of 5 endoscopic examinations showed acute inflammatory infiltrates in the mucosa with hemorrhage. 5) Both intestinal US and endoscopic studies were performed in 4 cases with HSP and GI symptoms simultaneously. Out of 4 those cases, 3 cases showed the thickened duodeno-jejunal wall on the intestinal US, which suggested erosive hemorrhagic duodenitis by endoscopic findings. Conclusion: The typical but nonpathognomonic intestinal US findings including the thickening of the duodeno-jejunal wall and upper gastrointestinal endoscopic findings including hemorrhagicerosive duodenitis, in children with GI symptoms, should be considered a manifestation of HSP, even in the absence of skin lesion.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.4 no.2
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• pp.167-174
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• 2001

Purpose: Adenovirus infection with swollen Peyer patches in the ileum, known as one of the causes of intussusception, may cause vitamin C depletion in human body because vitamin C is a first line antioxidant. Or low vitamin C status in human body makes the man more susceptible to infection of adenovirus in the ileum with a markedly swollen lymph node. In this study, we tried to find out the relationship between pediatric intussusceptions and vitamin C concentrations of whole blood and plasma. Methods: Whole blood and plasma vitamin C concentrations of fifty-seven patients with intussusceptions from May 1995 to December 1998 at the Gyeongsang National University Hospital were compared with those of 256 normal healthy children. Vitamin C was measured by the 2, 4-dinitrophenylhydrazine methods. Results: The average age of patients (male=39, female=18) with intussusceptions was fifteen months of age. Whole blood vitamin C concentrations of patients and healthy children were $1.49{\pm}0.64$ mg/dL, and $2.18{\pm}0.49$ mg/dL, respectively. Plasma vitamin C concentrations of patients and healthy children were $0.59{\pm}0.36$ mg/dL, $1.47{\pm}0.56$ mg/dL, respectively. But no differences in the vitamin C concentrations of whole blood and plasma according to age, degree of leukocytosis, fever, interval from onset, hematochezia, and need for operation were found. Conclusion: Whole blood and plasma vitamin C concentrations of patients with intussusceptions were lower than those of healthy children (P=0.0001). Prospective studies are needed to elucidate whether these results were consequences or causes of intussusceptions.