• Korean Journal of Clinical Laboratory Science
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• v.51 no.1
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• pp.26-33
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• 2019

Recently, the rapid growth of the companion animal market has led to the development of animal disease diagnosis kits. Therefore, the utility of the introduction of biomarkers for the development of animal molecular diagnostics is being reevaluated. A good biomarker should be precise and reliable, distinguish between normal and diseased states, and differentiate between different diseases. Recently reported genetic markers, tumor markers (cell free DNA, circulating tumor cells, granzyme, and skin tumors), and others (brucellosis, programmed death recovery-1, symmetric dimethylarginine, periostin, and cysteinyl leukotrien) have been developed. The biomarkers are used for risk prediction or for the screening, diagnosis, and monitoring of disease progression. The most important criteria for related biomarkers are disease specificity. Many potential biomarkers have emerged from laboratory and test studies, but they have not been validated in independent or large-scale clinical studies. Candidate biomarkers evaluate disease associations, verify the effectiveness of biomarkers for early detection and disease progression, and incorporate them into humans and animals. In the future, it will be necessary to reevaluate the utility of well-structured biomarker-based research and study the development of kits that can be used in on-site tests in accordance with the trends introduced in the diagnosis of animal diseases.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.19 no.1
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• pp.1-11
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• 2019

Purpose: Congenital hypothyroidism (CH) is the most common congenital endocrine disorder. The purpose of the present study was to determine the incidence of CH in South Korea during the period from January 1991 to March 2004. Methods: Central data from each city branch of SCL (Seoul Clinical Reference Laboratories) in Yongin, South Korea, was gathered and collectively analyzed. Newborn screening (NBS) for CH was based on measuring the levels of neonatal thyroid stimulating hormone (TSH) and free T4 (a cut-off of 20 mIU/L and less than 0.8 ng/dL, respectively). Results: During the study period, 671,805 live births were screened for CH based on TSH and free T4 ELISA assays. A total of 159 newborns were deemed positive for CH out of 671,805, with a corresponding incidence of 1 in 4,225. When a cut-off of 20 mIU/L was used in TSH assays, the associated sensitivity, specificity, and positive predictive values (PPV) were 100.0%, 99.7%, and 10.8%, respectively. When a cut-off of 0.8 ng/dL in free T4 assays was used, the associated sensitivity, specificity, and PPV were 100.0%, 98.5%, and 3.9%, respectively. Conclusion: CH incidence in South Korea as evidenced by the results of NBS was compared with its incidence and comparable to the other countries prior to 2004.

• Journal of KIISE
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• v.42 no.5
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• pp.573-579
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• 2015

Nationwide supercomputing infrastructures in Korea consist of geographically distributed supercomputing clusters. We developed High-Throughput Computing as a Service(HTCaaS) based on these distributed national supecomputing clusters to facilitate the ease at which scientists can explore large-scale and complex scientific problems. In this paper, we present our mechanism for dynamically managing computing resources and show its effectiveness through a case study of a real scientific application called drug repositioning. Specifically, we show that the resource utilization, accuracy, reliability, and usability can be improved by applying our resource management mechanism. The mechanism is based on the concepts of waiting time and success rate in order to identify valid computing resources. The results show a reduction in the total job completion time and improvement of the overall system throughput.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.4
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• pp.120-130
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• 2019

In this study, based on the correlation between traffic volume data and vertical displacement data developed in previous research using the bridge maintenance big data of 2006, the vertical displacement estimation model using the traffic volume data of Gwangan Bridge for 10 years A comparison of the performance of the developed model with the current applicability is presented. The present applicability of the developed model is analyzed that the estimated displacement is similar to the actual displacement and that the displacement estimation performance of the model based on the structured regression analysis and the principal component analysis is not significantly different from each other. In conclusion, the vertical displacement estimation model using the traffic volume data developed by this study can be effectively used for the analysis of the behavior according to the traffic load of Gwangan Bridge.

• Composites Research
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• v.20 no.5
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• pp.56-63
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• 2007

An approach using complex potentials is presented for analysis of composite plate with an elliptical hole or a rectilinear crack. Composite structure is susceptible to encounter impact damages, which lead to considerable decrease in its residual strength. Such impact damages could be modeled as an equivalent elliptical hole or notch-like crack. Even though finite element method is widely used to analyze stresses or fracture mechanics parameters around such damage, it is tedious to make successive FE-modeling for damage tolerance assessment under fatigue loadings. In this point of view, the solutions based on complex potentials are very simple and easy to use. The computed results are also compared and discussed with those from FEA.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.49 no.6
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• pp.441-446
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• 2004

To reduce water input by water-saving irrigation techniques a field study was carried out with three water managements, very shallow intermittent irrigation (VSII, 2cm), shallow intermittent irrigation (SII, 4cm) and traditional deep water irrigation (DWI, 10cm) for two years. Rice growth and grain yields of three water managements were not significantly different. However, when the water irrigation depth was decreased, the breaking and lodging resistance were increased and the roots were widely distributed into deeper paddy soil. More numbers of both annual and perennial weeds were occurred in VSII than in DWI at maximum heading stage and only the number of perennial weeds was three times in VSII than in DWI at heading stage. The total water inputs were 777, 654 and 527 mm in DWI, SII and VSII, therefore the water-saving rates of VSII and SII were $32.2\%\;and\;15.9\%$ compared to typical deep water irrigation. The water-productivity (Rice yield to water input) was highest in VSII as 0.94 and followed by SII as 0.76 and DWI as 0.63. In the face of water scarcity, it is very important to find or develope water saving irrigation system and find ways to increase the productivity of water used for rice cultivation.

• The Journal of the Korea Contents Association
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• v.20 no.1
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• pp.1-15
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• 2020

This study examined the factors that influence creative performance in corporate collaboration projects. Specifically to facilitate team collaboration, we identified that scaffolding, which is one of the important factors in organizational learning communication, and the Boundary Objects, which are collaboration tools & vehicle, influence performance. The survey was collected for 203 employees who experienced collaborative projects, and three-step mediated regression analysis was conducted after conducting exploratory factor analysis. In other words, we examined the median effect of boundary objects on the impact of scaffolding on creative collaborative performance. Analysis showed that while the effects of the boundary objects in relation to the impact of cognitive scaffolding on creative performance were not significant, emotional scaffolding had a full-scale effect on the creative performance and also had a full-scale effect on the efficacy performance. Given these results, it is necessary to share a vision and form personal relationships among team members in order to activate them, since scaffolding is useful in organizational learning and boundary objects also have some effect as a medium for promoting collaboration in projects.

• Journal of Korean Society of Health-System Pharmacists
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• v.35 no.4
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• pp.453-462
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• 2018

Background : The prevalence of chronic hepatitis C virus (HCV) tends to be higher in the elderly. Pegylated interferon and ribavirin therapy (Peg-IFN/RBV) was recommended as the first-line treatment in the past decades, but this regimen showed unsatisfactory results in terms of safety and efficacy especially in elderly patients. Recently, it was demonstrated that dual therapy with daclatasvir and asunaprevir was well tolerated and led to high sustained virological response (SVR) rates, irrespective of age. We conducted a study to evaluate the efficacy and safety of daclatasvir plus asunaprevir by involving elderly patients aged above 65 years. Methods : We retrospectively analyzed clinical data from chronic hepatitis C virus (HCV) genotype 1b patients treated with daclatasvir plus asunaprevir from September 2015 to December 2016 at Seoul St. Mary's hospital. The patients were divided into two groups as elderly patients (older than 65 years) and non-elderly patients (younger than 65 years) and compared the efficacy and safety. Results : A total of 112 patients were treated with daclatasvir plus asunaprevir for chronic hepatitis C. Among them, 101 patients completed the whole treatment, and in 88 patients the amount of HCV RNA was measured after 12 weeks of treatment. There was no significant difference in SVR at 12 weeks between both the groups (p=0.68). Typically, 91.4%(32/35) of elderly patients and 94.3%(50/53) of non-elderly patients achieved SVR12. Common adverse events included elevation in transaminase level, headache, and gastrointestinal disorders. There was no statistical difference in the symptoms between the two groups. Conclusions : The combination therapy with daclatasvir plus asunaprevir exhibited similar rates of SVR12 in HCV elderly patients without leading to further adverse events compared to non-elderly patients. Therefore, it is proposed that daclatasvir plus asunaprevir therapy could be considered as an effective and safe treatment, even in patients aged over 65 years.

• Journal of Internet Computing and Services
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• v.16 no.4
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• pp.13-23
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• 2015

In order to reduce public medical expenses as well as to provide effective medical services, telemedicine between doctors and patients is considered as an alternative to the conventional hospital visit. But the medical community has been protesting the introduction of telemedicine for the efficacy and safety reasons. Korean government has been conducting a number of pilot projects to demonstrate the efficacy and safety of telemedicine for more than 10 years. However, still the system is not yet legalized. In this study, we have conducted a telemedicine pilot project in Cambodia for one year, where telemedicine can be more freely exercised. After the project, we conducted a survey based on the 'Rogers diffusion' theory. Survey results show that both physicians and patients are positive about the relative advantage of the telemedicine. However, the complexity and high cost of the equipment used in telemedicine has been found to be a possible obstacle. In addition, we found that there is no problem for providing telemedicine services under challenged environment, such as in Cambodia.

• Proceedings of the Korea Water Resources Association Conference
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• 2016.05a
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• pp.80-80
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• 2016

GPS로 대표되는 위성항법시스템(GNSS : Global Navigation Satellite System)은 지구 주위를 돌면서 연속적으로 항법신호를 보내고 있다. 그 중 지구표면으로부터 반사되는 항법신호를 수신하고 해석함으로써 지구표면에 관한 정보를 취득할 수가 있다. GPS로 대표되는 항법신호는 L밴드를 사용하기 때문에 토양수분의 변화 등에 대한 반사강도의 감도가 비교적 높다고 알려져 있으며, 토양수분 측정 등에 사용할 수 있다. 뿐만 아니라 경량화, 소형화하기 쉬운 점, 능동적 마이크로웨이브 리모트센싱시스템(Active Microwave Remote Sensing System)과 달리 스스로 신호를 발사하지 않기 때문에 관측의 스텔스성(Stealth)dl 뛰어난 점 등의 장점을 가지고 있다. 또한 향후 10년 이내에 준천정위성(QZSS), Galileo, COMPAS, IRNSS 등 많은 위성항법시스템이 본격 운용되어 GPS와 함께 120기 정도의 항법위성이 항법신호를 송신할 예정이므로 이용 가능성은 크게 늘어날 것으로 기대된다.한편, 항법위성을 이용한 바이스테이틱 리모트센싱은 반사파의 강도가 상당히 미약하기 때문에 정량적 계측모델의 구축은 미미한 상태이다. 즉, 지상 타워에서의 관측, 항공기에서의 관측, 소형 위성에서의 관측 등이 수행되고 있으나, 타워관측과 같이 지상의 거의 동일한 장소를 계속적으로 관측하는 경우를 제외한 기존의 연구에서는 토지의 피복상황이나 토양수분 등의 상관관계를 제시하는 수준으로써 정량적인 계측방법은 아직 확립되어 있지 않다. 이러한 관점에서 본 연구에서는 GPS위성으로부터의 항법신호를 이용하여 지구표면에 관한 정보를 얻는 바이스테이틱 리모트센싱(Bi-static Remote Sensing) 기술을 바탕으로 육지면과 해면의 판별에 신호특성이 어떻게 유효한가를 실험적으로 밝혔다. 이러한 기술은 토양수분 측정 등 수자 원인자를 추출하는데 유용할 뿐만 아니라 수면의 고도 측정, 해상풍 산출 등에도 응용 가능하다.