• 생약학회지
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• 제38권4호
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• pp.354-357
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• 2007

Three compounds (1-3) were isolated from the roots of Potentilla discolor (Rosaceae). The structure of compounds 1-3 were elucidated as stigmast-5-en-3-ol $({\beta}-sitosterol,\;1),\;2,19{\alpha}-dihydroxy$-2-oxo-urs-1,12-dien-28-oic acid (fupenjic acid, 2), 3-O-${\beta}$-D-glucopyranosylstigmast-5-en-3-ol (${\beta}-sitosterol\;{\beta}-D-glucopyranoside, 3) based on physical and spectroscopic data. $^{13}C-NMR$ assignments were completed by 2D-NMR technique. The three compounds were firstly isolated from Potentilla discolor.

• Journal of Applied Biological Chemistry
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• 제66권
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• pp.467-476
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• 2023

오미자(Schisandra chinensis)는 오미자과에 속하는 낙엽활엽덩굴식물로 한국, 일본, 중국, 대만 등 동아시아에 널리 분포한다. 오미자에 함유된 주요 성분에는 리그난 화합물뿐만 아니라 트리테르페노이드 화합물도 포함되어 있는 것으로 보고되었다. 한국 산지별 오미자의 특성을 구별하기 위해 대사산물 프로파일링과 다변량 통계 분석 기법인 PCA을 수행하여 판별식을 설정하였고, 그 결과 triterpenoids 16종, lignan 9종, flavonoid, phenylpropanoid, fatty acid 각 1종을 동정하였다. 또한 다변량 통계분석을 통해 OPLS-DA의 s-plot 모델을 적용하여 단양, 문경, 거창, 평창의 4개 그룹을 구분하는 것을 확인하였고, lanostane, cycloartane, 그리고 schiartane triterpenoid, dibenzocyclooctadiene lignan 이 각각 화학적마커로 동정하였다.

• 생약학회지
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• 제26권1호
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• pp.40-46
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• 1995

A methanol extract of the herbs of Lactuca indica L. effectively decreased the serum levels of total cholesterol and LDL-cholesterol when orally administered with diet. On fractionation of the extract, a chloroform-soluble fraction showed the similar effects with the methanol extract. Chromatographic separation afforded a mixture of triterpene alcohols and their acyl derivatives. A mixture of triterpene alcohols were identified as ${\beta}-amyrin$, ${\alpha}-amyrin$, lupeol, pseudotaraxasterol, taraxasterol and germanicol on the basis of spectroscopic methods. The acyl moieties in the corresponding acyl mixture were characterized as acetates and palmitates, respectively. And three kinds of sterol such as ${\beta}-sitossterol$, compesterol and stigmasterol were isolated as a mixture state.

• 생약학회지
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• 제51권4호
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• pp.238-243
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• 2020

Perilla frutescens Britton var. acuta Kudo, an annual plant primarily cultivated in China, Japan, and Korea, has been used as a traditional medicine to treat inflammatory diseases, depression, and many anxiety-related disorders. Previously, we reported the inhibitory effects of n-hexane layer of P. frutescens var. acuta extract against beta-amyloid (Aβ) aggregation, and the isolation of asarone derivatives as active constituents from n-hexane layer. In this study, dichloromethane layer of P. frutescens var. acuta was applied to bioassay-guided isolation methods accompanied with Thioflavin T (Th T) fluorescence assay to investigate the inhibitory effect on Aβ aggregation and disaggregation. As the results, three triterpenoids including ursolic acid (1), tormentic acid (2) and corosolic acid (3) were isolated. All compounds reduced Aβ aggregation and increased disaggregation of preformed Aβ aggregates in a dose-dependent manner. However, the inhibitory effect of three compounds on Aβ aggregation was not correlated with antioxidant activity, which was measured by DPPH assay. Taken together, these results suggest that the triterpenoid derivatives from P. frutescens have the potential to be developed as good therapeutics or preventatives for AD.