• Journal of Biomedical Engineering Research
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• v.22 no.1
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• pp.59-68
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• 2001

유체-고체 상호작용을 고려하여 다양한 복부대동맥류 모델에 대해서 맥동유동 및 구조를 동시에 해석하였다. 동맥류의 확장부 크기와 혈관벽 두께에 따라서 총 여덟 개의 축대칭 동맥류 모델을 선정하였다. 유한체적법 및 압력기반의 유한차분법을 이용하여 유동을 해석하였으며, 유한요소법을 이용하여 구조해석을 수행하였다. 동맥류의 확장부위가 클수록 최대응력은 최대확장부위와 변곡점에 해당하는 동맥류의 입구 및 출구 부분에 집중되었으며, Von Mises 응력은 최대확장부위 뿐만 아니라 동맥류의 근위부와 원위부($\pm$1D)에서도 현저하게 증가하였다. 또한 더욱 확장된 모델일수록 혈관벽은 직경방향의 변위보다 축방향의 변위가 지배적이었으며, 동맥류 원위부보다 근위부에서 큰 축방향 변위를 나타냈다. 동맥류 입구부의 미약한 와류는 한 주기동안 그 크기와 강도를 더해가며 동맥류 원외부로 이동하였고, 동맥류의 내부 유동은 압력차이가 감소하는 기간동안 더 큰 영향을 받았다. 확장정도가 심할수록 동맥류 내부에 더 크고 강한 와류가 관찰되었다. 압력차이가 최소가 된 직후 동맥류의 근위부와 원위부동맥 벽 근처에서의 역방향 유동이 관찰되었다. 대체로 혈관벽 두께가 감소한 모델과 더욱 확장된 모델일수록 벽전달률은 감소하였다. 혈관벽의 탄성에 의하여 압력차이와 벽전달률 사이에 위상차가 존재함이 확인되었다. 유체-고체의 상호작용을 고려한 연구는 다른 심혈관계를 이해하는데도 매우 유익할 것으로 생각된다.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.18 no.11
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• pp.1-6
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• 2017

Stents are widely used as the most common method of treating coronary artery disease with implants in the form of a metal mesh. The blood flow is normalized by inserting a stent into the narrowed or clogged areas of the human body. In this study, the mechanical characteristics of a stent are investigated according to the variations of its design parameters by the Taguchi method and finite element analysis. A stent model of the Palmaz-Schatz type was used for the analysis. In the analysis, an elasto-plastic material model was adopted for the stent and a hyper-elastic model was used for the balloon. The main interest of this study is to investigate the effects of the design parameters which reduce the possibility of restenosis by adjusting the recoil amount. A Taguchi orthogonal array was constructed on the model of the stent. The thickness and length and angle of the slot were selected as the design parameters. The amounts of radial recoil and longitudinal recoil were calculated by finite element analysis. The statistical analysis using the Taguchi method showed that optimizing the shape of the stent could reduce the possibility of restenosis. The optimized shape showed improvements of recoil in the radial and longitudinal directions of ~1% and ~0.1%, respectively, compared to the default model.

• Journal of the Korean Society for Precision Engineering
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• v.22 no.3 s.168
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• pp.154-161
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• 2005

In this study, the leaflet motion of a mechanical heart valve and the characteristics of two-dimensional transient blood flow in an elastic blood vessel have been numerically investigated by using fluid-structure interaction method. Here, blood has been assumed as a Newtonian, incompressible fluid. Pressure profiles have been used as boundary conditions at the ventricle and the aorta. As a result, closing motion of the leaflet is faster than opening one. While opening angles of leaflet grow up, vortex is detected at the sinus and backward of the leaflets. When the leaflet is fully closed, vortex is detected at the ventricle and at that moment maximum displacement of the elastic blood vessel is observed in the vicinity of the sinus region. Maximum displacement is caused in association with the blood flow that is oriented toward the elastic blood vessel.

• 한국전산유체공학회:학술대회논문집
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• 2004.10a
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• pp.203-206
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• 2004

In this study, a numerical analysis has been performed for a three-dimensional pulsatile blood flow associated with the elastic blood vessel and curved bileaflet for multiple cycles in terms of fluid-structure interaction. Here, blood has been assumed as a Newtonian, incompressible fluid. Pressure profiles have been used as boundary conditions at the ventricle and the aorta. From this analysis, the motion of the leaflet has been observed with fluttering phenomenon and rebound, and the flow fields of blood have been obtained with recirculation and regurgitation. The results can contribute to the development of design methodology for the curved bileaflet mechanical heart valve.

• Journal of the Korean Society for Precision Engineering
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• v.27 no.6
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• pp.90-97
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• 2010

In order to understand the biomaterial like the blood vessel of artery, there is a need to quantify the biomechanical behavior of the vessel. Using computer-controlled experimental system, the experiment can acquire data such as inner pressure, axial load, diameter and axial gauge length without contacting the specimen. Rubber-liked material which is similar to passive artery was selected as pseudo-biomaterial. Deformations are measured for pressure-diameter curves. The data were collected and stored online to be used in the feedback control of experimental protocols. Finally, the illustrative data obtained from the experimental system were presented and the system shows that strain invariants are controlled to understand the nonlinear elastic behavior of biomaterial which is involved with strain energy function.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.29 no.4 s.235
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• pp.425-434
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• 2005

In order to analyze pulsating flows in elastic blood vessels, a method based on the ALE concept and finite volume method was reformed and modulated to include wall motion of elastic vessels and impedance phase angle(phase difference between wall motion and blood flow). Our study indicated wall shear rates(WSR) were significantly influenced by the wall motion and the impedance phase angle. For larger wall motion more than $5{\%},$ the computed WSR started to deviate from the results of the perturbation theory that assumed smaller wall motion. The study showed that oscillatory shear index increased as the impedance phase angle became more negative like $-70{\circ}\;or\;-80{\circ}$ due to reduced mean WSR and increased amplitude of WSR. This result indicated that hypertensive patients are more vulnerable to atherosclerosis than normal persons because of the role of more negative impedance phase angles usually observed in these patients.

• 한국전산유체공학회:학술대회논문집
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• 2011.05a
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• pp.500-503
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• 2011

Blood flow simulations in an idealized carotid bifurcation model with considering wall compliance were carried out to investigate the effect of wall elasticity on the wall shear stress and wall solid stress. Canonical waveforms of flowrates and pressure in the carotid arteries were imposed for the boundary conditions. Comparing to rigid wall model, generally, we could find an increased recirculation region at the carotid bulb and an overall reduced wall shear stress. Also, there was appreciable change of flowrate and pressure waveform in longitudinal direction. Solid and wall shear stress concentration occurs at the bifurcation apex.

• Journal of Chest Surgery
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• v.30 no.11
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• pp.1092-1096
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• 1997

Thromboelastography(TEG) enables a global assessment of hemostatic function to be made from a single blood sample, documenting the interaction of platelets with protein coagulation cascade from the time of the initial platelet-fibrin interaction, through platelet aggregation, clot strengthening and fibrin cross linking to eventual clot Iysis. Thirty-five patients(mean age 34$\pm$ 12) undergoing open heart surgery from April 1st, 1996 to August 31th, 1996 were investigated at preoperatively and immediate, one hour, and 24 hours after cessation of cardiopulmonary bypass using TEG. Comparisons were made between classic hematological indices and TEG data. There were statistically significant correlation between maximal amplitude(MA) and platelet count before CPB, activating clotting time(ACT) and TEG date(R time, K time and a angle) at 24-hour after CPB. The data on the predictive accuracy for postoperative bleeding at 24-hour after CPB, the TEG was significantly better than ACT(57%) or the coagulation profiles(43%) as a predictor of postoperative bleeding, with an accuracy rate of 100% (P=0.0043). In conclusion, TEG seems to be easy to use, clinically accurate, cost effective and provides data which can effectively manage a patient's hemostasis.

• Journal of the Korean Society for Nondestructive Testing
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• v.32 no.5
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• pp.484-493
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• 2012

Since the 1980s, there have been many research activities devoted to quantitatively characterizing and imaging human tissues based on sound speed, attenuation coefficient, density, nonlinear B/A parameter, etc., but those efforts have not yet reached the stage of commercialization. However, a new imaging technology termed elastography, which was proposed in the early 1980s, has recently been implemented in commercial clinical ultrasound scanners, and is now being used to diagnose prostates, breasts, thyroids, livers, blood vessels, etc., more quantitatively as a complementary adjunct modality to the conventional B-mode imaging. The purpose of this article is to introduce and review various elastographic algorithms for use in quasistatic or static compression type elasticity imaging modes. Most of the algorithms are based on the crosscorrelation or autocorrelation function methods, and the fundamental difference is that the time shift is estimated by changing the lag variable in the former, while it is directly obtained from the phase shift at a fixed lag in the latter.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.4
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• pp.813-820
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• 2009

This paper describes the realization of ubiquitous healthcare monitoring system using wearable pulse oximeter based on a wireless sensor network. In order to obtain information of oxygen saturation from a patient, a small size and low power consumption wearable pulse oximeter was designed. Information of oxygen saturation collected by wireless sensor node was transmitted wirelessly to a base-station for storage and display purposes via wireless sensor network. Wireless sensor nodes were programmed by TinyOS application to perform data acquisition and transmission. Lab VIEW server program was designed to monitor information of oxygen saturation and process the measured PPG (photo plethysmogram) signals to APG(Accelerated plethysmogram) signals by appling second order derivatives. PPG signals are simple and cost effective technique to measure blood volume change.