• Journal of Life Science
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• v.34 no.7
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• pp.509-519
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• 2024

A previous study showed that krill oil improved recognition and memory through anti-oxidative effects in an amyloid β model, but the authors noted that further investigations are necessary of alterations to neurotransmitters' states and of serum lipid profile improvements related to serum lipid peroxidation. Accordingly, in this study, ICR mice were pre-treated intraperitoneally with scopolamine prior to induced neurotransmission impairment, and the effects of krill oil provision on their capabilities of cognition were tested by performing a passive avoidance test (PAT), water maze test (WMT), and novel object recognition test. Then, parameters including the acetylcholine (ACh) concentration, acetylcholinesterase activity (AChE), lipid peroxidation, serum lipid levels, and nerve cell proliferation were investigated. The results showed that krill oil improved the mice's abilities in recognition and memory as the times taken to complete the PAT and WMT were reduced compared to the mice in a comparison scopolamine-treated group. Krill oil produced an increased concentration of Ach, and this was accompanied by a decrease in AChE. As shown in a scopolamine-treated SH-SY5Y cell line, krill oil reduced the activity of AChE. Moreover, the suppression of lipid peroxidation-reflected in the finding that malondialdehyde was decreased with krill oil provision-is speculated to affect the recorded serum triglyceride and cholesterol decreases and LDL cholesterol increase. The intake of krill oil was also found to produce an improvement in brain-derived neurotrophic factor expression by stimulating the activation of cyclic AMP response element binding protein in the brain tissue. Overall, the current results imply that the provision of krill oil raises the cognition and memory by elevating neurotransmitters and by improving the serum lipid profile and nerve cell proliferation, which occur as lipid peroxidation is suppressed in the brain tissue.

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• pp.307-311
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• pp.43-48
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• 1979

南大洋의 크릴(krill)資源에 關한 本格的인 調査는 1961年 소련이 처음 着手한 以後 日本을 위시한 各國이 參與하고 있다. 1968年 現在 南大洋의 調査에 參與하고 있는 國家는 漁業에는 日本 소련 서독 프랑스 臺灣 칠레 폴란드等 7 個국이, 處理加工 誠驗에는 노르웨이 덴마크 모나코 남아프리카等 4 個國이고, 그외 美國 알젠티나等이 資源硏究所 設立計劃과 資源評價및 技術練修등을 計劃함으로써 모두 13 個國이다. 그 중 日本 1961年에 東京수산대학의 “우미다까마루”로써 南大洋의 綜合的인 海洋觀測과 調査를 實施한 것이 시초이나. 本格的인 調査는 1972年 海洋水産資原開發센터에 의하여 着手되어 現在까지 6年째에 이르렀다. 1972~75年間은 試驗 및 漁場開發段階에 不過했으나, 1976年~1977年은 企業化로써 採算面에서 收支가 맞는 企業漁業으로 成長하였다. 試驗 및 漁場開發段階에 不過했으나, 1976年~1977年은 企業化로써 採算面에서 收支가 맞는 企業漁業으로 成長하였다.