• Polymer(Korea)
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• v.35 no.4
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• pp.277-283
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• 2011

Solid dispersion is mainly used for improved dissolution of poorly water-soluble drugs. Solid dispersion of pranlukast was prepared by spray-drying with plasdone S-630. When pH of water was high, pranlukast was highly soluble in the solubility experiment of solid dispersions with varying pH. The particle size of pranlukast particles in solid dispersions was measured to be in nanometers scale based on particle size analysis. Zeta-potential analysis confirmed the negative charge of solid dispersion. SEM was used to observe the surface of solid dispersion, which confirmed spherical morphology, DSC and XRD confirmed the amorphous nature of solid dispersions. The in vitro test was carried out to find improved dissolution rate of pranlukast solid dispersion in simulated juice gastric and a controlled experiment was carried out to compare pranlukast solid dispersions with a conventional drug (Onon$^{(R)}$), These results showed the dissolution properties of pranlukast solid dispersions prepared by spray drying proper for the oral pharmaceutical formulation.

• Cross-Cultural Studies
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• v.41
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• pp.177-197
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• 2015

This study found that La hija del mar (1859) by Rosalía de Castro describes, as the background to the work, the lives of Galicians, along with the movement of the sea, scenes of the coast, storms, and lively plants in Muxía, a small city of Galicia and Cabo de Finisterre. It was shown that the nature of Galicia, as described in the work, is a beautiful site where fishermen and farmers live among the full aroma of plants and flowers, as well as being a subject of fear to the people there. Furthermore, it was also shown through the funeral process, along with a depiction of the natural environment, the unique place of Galicia is part of the traditional heritage that the Galician people have preserved, in which Roman Catholic rituals are mixed with superstitious rites. Moreover, the author shows through a description of the excessive drinking culture of Dionysian rites or Libation rites that Galicia is a land with longstanding and profound folk customs, as well as a special culture. It was proved that the work is a specific representation of the author's perspective. Thus, Rosalía depicts the lives of people and the natural environment, which have not been examined profoundly, although they always existed in Galicia. This provides space where the external reality of Galicia and part of the identity of Galicia can be elucidated.

• The Journal of the Korea Contents Association
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• v.19 no.12
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• pp.615-622
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• 2019

Recently, reports of cruel group sexual assault in India have been frequently reported. The most prominent group sexual assault incident in India was a medical student, Joti Singh case, that six men raped her and damaged her genitals and organs on a bus and caused her death in 2012. This incident led to the launch and passage of a strong punishment bill including death penalty for sexual assault. But since then, sexual assault is still on the rise. As a result of examining the relations with regional characteristics centering on the areas where sexual assaults occurred, it was found that most of the cases of group sexual assault reported in the media occurred in the mid-north of India, and this was consistent with the region of the Hindu stressed region. If so, it can only be concluded that Hindu fundamentalism, in which female neglect is severe, is the cause. Hindu fundamentalists try to revive the traditional values of women with a strong retroism tendency. In Indian society, women are still at risk of collateral damage. The pursuit of Hindu fundamentalism by the ruling party and political leaders will require much more time to improve the women's social status and human rights.

• Polymer(Korea)
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• v.36 no.1
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• pp.41-46
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• 2012

In this study, poly(ethylene glycol) (PEG) was used as a hydrophilic polymer carrier to develop solid dispersion formulations for enhancing solubility and dissolution rate of pranlukast, one of poorly soluble drugs that has been broadly used for the treatment of asthma. PEG based solid dispersions with or without poloxamer were prepared by hot melting and solvent evaporation methods. The resultant solid dispersions were characterized by DSC and powder X-ray measurements, and their morphological properties were observed to be partially changed to amorphous state with reduced crystallinity. Dissolution and solubility tests showed that the solubility and dissolution rate of the solid dispersions were significantly enhanced. The solid dispersion formulation prepared by the hot melting method with a chemical composition of pranlukast:PEG:poloxamer = 1:5:1 demonstrated the most enhanced solubility and dissolution rate. The results suggest that the solid dispersions based on PEG and poloxamer are promising systems for the enhancement of solubility and bioavailability of pranlukast.