• Membrane Journal
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• v.33 no.4
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• pp.191-200
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• 2023

Polyethersulfone (PES) is a widely employed membrane material for water and industrial purification applications owing to its hydrophilicity and ease of phase separation. However, PES membranes and filters prepared using the nonsolvent induced phase separation method often encounter significant flux decline due to pore clogging and cake layer formation on the dense membrane surfaces. Our investigation revealed that tight microfiltration or loose ultrafiltration membranes can be subject to physical fouling due to the formation of a dense skin layer on the bottom side caused by water intrusion to the gap between the shrank membrane and the substrate. To investigate the effect of the bottom surface porosity on membrane fouling, two membranes with the same selective layers but different sub-layer structures were prepared using single and double layer casting methods, respectively. The double layered PES membrane with highly porous bottom surface showed high flux and physical fouling tolerance compared to the pristine single layer membrane. This study highlights the importance of physical optimization of the membrane structure to prevent membrane fouling.

• Journal of Life Science
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• v.33 no.9
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• pp.754-765
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• 2023

Exosomes are a type of extracellular vesicle containing proteins and messenger and microRNAs; they are secreted by all cell types. Once released, exosomes are selectively taken up by other cells adjacent or at a distance, releasing their contents and reprogramming the target cells. Since exosomes are natural vesicles produced by cells as small sizes, it is generally accepted that exosomes have a non-toxic nature and non-immunogenic behaviors. Recently, exosomes have elicited scientific attention as drug delivery vehicles to the central nervous system. The central nervous system has a blood-brain barrier that makes it difficult for drugs to penetrate. Thus, the blood-brain barrier has been a major obstacle to the development of drugs for treating neurodegenerative diseases. However, accumulating evidence suggests that exosomes can cross the blood-brain barrier primarily through transcytosis. Consequently, exosomes are expected to become a new delivery vehicle that can cross the blood-brain barrier and deliver drugs into the brain parenchyma. In addition, since different types of exosomes are secreted depending on the cell type and disease state, exosomes can also be utilized as biomarkers for the diagnosis of diseases in the central nervous system. In this review, we summarized recent research trends on exosomes, including clinical trials as biomarkers and treatment options for diseases in the central nervous system.

• Proceedings of the Korea Water Resources Association Conference
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• 2020.06a
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• pp.106-106
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• 2020

물 이용 측면에서 유출해석은 강수, 증발산, 침투, 유출 등 물 순환의 핵심이다. 또 기상자료는 증발산량을 산정하는데 꼭 필요하다. 그러나 해외 수자원 사업에서 기상자료가 없어 곤란을 겪는 경우가 많다. 여기서, NASA POWER에서 전지구 0.5° 격자로 제공하는 위성기반의 일 기상자료를 이용한 증발산량과, 지상의 기상자료를 이용한 증발산량을, 각각 일 유출 모형에 적용한 결과를 비교하였다. 유역면적 4,134 ㎢인 대청댐 유역에 1984년부터 2001년까지 일별 유입량을 모의하고 관측 유입량과 비교하고, R², RMSE, NSE 등으로 평가하였다. 지상의 기상관측소는 위도 36.21°, 경도 127.34°인 대전 관측소를, 위성자료는 대전 지점과 동일한 위치의 경위도의 기상자료를 적용하였고, 일 증발산량은 Penman-Monteith 방법으로, 일 유출량은 ONE 모형에 의해 모의하였다. 강수량을 대청댐 유역 면적강수량을 적용한 경우, 지상 기상자료를 적용하여 유입량을 모의한 결과는 연평균하여 연 유입량 668.1 mm, 일 최대 82.9 mm, 유출률 56.1%(관측은 연 강수량 1,191.3 mm, 연 유입량 668.3 mm, 일 최대 87.0 mm, 유출률 56.1%)로 나타났고, R² 0.805, RMSE 2.425, NSE 0.802였고, 위성 기상자료를 적용하여 유입량을 모의한 결과는 연평균하여 연 유입량 668.4 mm, 일 최대 83.7 mm, 유출률 57.8%로 나타났고, R² 0.803, RMSE 2.431, NSE 0.801였다. 또한, 강수량을 위성 제공의 강수량을 적용한 경우, 지상 기상자료를 적용하여 유입량을 모의한 결과는 연평균하여 연 유입량 718.0 mm, 일 최대 97.7 mm, 유출률 56.7%(관측은 연 강수량 1,265.3 mm, 유출률 52.8%)로 나타났고, R² 0.582, RMSE 3.524, NSE 0.581였고, 위성 기상자료를 적용하여 유입량을 모의한 결과는 연평균하여 연 유입량 741.5 mm, 일 최대 99.0 mm, 유출률 58.6%로 나타났고, R² 0.578, RMSE 3.541, NSE 0.577였다. 결과적으로 위성 기상자료를 이용하여 증발산량을 산정하여 일 유출해석에 적용한 결과는 지상 기상자료를 이용한 경우와 거의 같은 값을 나타내, NASA POWER가 제공한 기상자료의 활용성은 매우 높게 나타났다. 그러나 위성 제공 강수량의 활용은 R², RMSE, NSE 등의 지표가 낮게 나타나, 신중하게 검토되어야 할 것으로 평가하였다.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.43 no.1
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• pp.21-32
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• 2023

Interrill erosion dominates in forest areas, and the erosion rate in surface-disturbed areas is significantly increased by the development and expansion of rill. In this study, soil erosion experiments using simulated rainfall and inflow were performed to understand the development and the micromorphological changes of rill on steep slopes. The characteristic factors of the micromorphology, such as the rill cross section, rill volume, rill density, rill order, and rill sharpness, were analyzed according to steepness and location (upper or lower) of slope. The head-cut of the simultaneous incised rills by rainfall simulation moved rapidly upslope, and the randomly developed rills expanded deeply and widely with their connection. The rill cross section evolved to downslope gradually increased. The rill volume occupied about 78 % of the sediment volume, confirming that the contribution of the sediment from the rill erosion is greater than that of the interrill erosion. Although the rate of increase in rill order slowed as the slope increased, the total length and density of the rill generally increased. As the slope increased from 15° to 20°, the bed incision of rills became larger than the sidewall expansion, and the rill sharpness increased by 1.6 times. The runoff coefficient on the lower slope decreased by 12.3 % than that on the upper slope. It was evaluated that the subsoil exposures and formation changes by the rill expansion increased the infiltration rate. Although the sediment accompanying the rills generally increased with slope increase, it was directly influenced by the hydraulic velocity of enhanced rill with the local convergence and expansion in the process of the rill evolution.

• Proceedings of the Korea Contents Association Conference
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• 2006.11a
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• pp.145-148
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• 2006

This study aimed at preventing women from suffering from health problems and stress due to excessive lookism and encouraging them to participate in sports activities to form desirable body image and eventually to live a healthy and sound life. To achieve this goal, this study formed a population with members of sports centers located in Seoul and Daejeon areas as of 2006 and made a sample of 450 participants in physical exercise at a sports center through stratified cluster random sampling and that of 450 non-participants through a survey with mothers and sisters of those students from elementary and secondary schools within the areas for sampling the participants' group, thereby analyzing the data on a total of 900 persons. A questionnaire was used as a tool to collect data; a reliability test presented weight-, health-, and figure-related factors as a=.807, a=.819, and a=.784, respectively. This study used such statistical analysis methods as t-test, One-way ANOVA, and the Analysis of Covariance to analyze data. This study produced the following conclusions through these research methods and procedure. Pticipation in physical exercise has a positive effect on body image. Pticipation in physical exercise at a sports center show higher satisfaction with body image than non-participats.

• Journal of Nuclear Fuel Cycle and Waste Technology(JNFCWT)
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• v.4 no.2
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• pp.117-131
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• 2006

A coupled T-H-M(Thermo-Hydro-Mechanical) analysis was carried out for KENTEX (KAERI Engineering-scale T-H-M Experiment for Engineered Barrier System), which is a facility for validating the coupled T-H-M behavior in the engineered barrier system of the Korean reference HLW(high-level waste) disposal system. The changes of temperature, water saturation, and stress were estimated based on the coupled T-H-M analysis, and the influence of the types of mechanical constitutive material laws was investigated by using elastic model, poroelastic model, and poroelastic-plastic model. The analysis was done using ABAQUS, which is a commercial finite element code for general purposes. From the analysis, it was observed that the temperature in the bentonite increased sharply for a couple of days after heating the heater and then slowly increased to a constant value. The temperatures at all locations were nearly at a steady state after about 37.5 days. In the steady state, the temperature was maintained at $90^{\circ}C$ at the interface between the heater and the bentonite and at about $70^{\circ}C$ at the interface between the bentonite and the confining cylinder. The variation of the water saturation with time in bentonite was almost same independent of the material laws used in the coupled T-H-M processes. By comparing the saturation change of T-H-M and that of H-M(Hydro-Mechanical) processes using elastic and poroelastic material mod31 respectively, it was found that the degree of saturation near the heater from T-H-M calculation was higher than that from the coupled H-M calculation mainly because of the thermal flux, which seemed to speed up the saturation. The stresses in three cases with different material laws were increased with time. By comparing the stress change in H-M calculation using poroelasetic and poroelasetic-plastic model, it was possible to conclude that the influence of saturation on the stress change is higher than the influence of temperature. It is, therefore, recommended to use a material law, which can model the elastic-plastic behavior of buffer, since the coupled T-H-M processes in buffer is affected by the variation of void ratio, thermal expansion, as well as swelling pressure.

• Restorative Dentistry and Endodontics
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• v.32 no.3
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• pp.208-221
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• 2007

The fracture toughness test is believed as a clinically relevant method for assessing the fracture resistance of the dentinal restoratives. The objectives of this study were to measure the fracture toughness $(K_{1C})$ and microtensile bond strength of dentin-resin composite interface and compare their relationship for their use in evaluation of the integrity of the dentin-resin bond. A minimum of six short-rod specimens for fracture toughness test and fifteen specimens for microtensile bond strength test was fabricated for each group of materials used. After all specimens storing for 24 hours in distilled water at $37^{\circ}C$, they were tensile-loaded with an EZ tester universal testing machin. Statistical analysis was performed using ANOVA and Tukey's test at the 95% confidence level, Pearson's coefficient was used to verify the correlation between the mean of fracture toughness and microtensile bond strength. FE-SEM was employed on fractured surface to describe the crack propagation. Fracture toughness value of Clearfil SE Bond (SE) was the highest, followed by Adper Single Bond 2 (SB), OptiBond Solo (OB), ONE-STEP PLUS (0S), ScotchBond Multi-purpose (SM) and there was significant difference between SE and other 4 groups (p < 0.05). There were, however, no significant difference among SB, OB, OS, SM (p > 0.05). Microtensile bond strength of SE was the highest, followed by SB, OB, SM, OS and OS only showed significant lower value (p < 0.05). There was no correlation between fracture toughness and microtensile bond strength values. FE-SEM examination revealed that dentin bonding agent showed different film thickness and different failure pattern according to the film thickness. From the limited results of this study, it was noted that there was statistically no correlation between K1C and ${\mu}TBS$. We can conclude that for obtaining the reliability of bond strength test of dentin bonding agent, we must pay more attention to the test procedure and its profound scrutiny.

• Journal of agriculture & life science
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• v.46 no.6
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• pp.117-126
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• 2012

This study carried out on the manufacturing of pidan. The production of pidan can be one of solutions for over-produced eggs and stable egg price. For the alkali-pickling solution for manufacturing of Pidan, the tested concentration of NaOH and NaCl were respectively as 3, 5, 7% and 5, 10, 15, 20%, and examined every 2 days for 14days. According to the results, pH value of alkali-pickling solution was increased by the increment of NaOH concentration and the pickling period, and was decreased by the increment of NaCl concentration. The pH value of egg yolk was increased by the increment of NaOH concentration, but it was not significantly different by the NaCl concentration. By the increment of NaOH and NaCl concentrations, the alkali infiltration in egg yolk and egg white was accelerated. Furthermore, the weight change of the eggs in the alkali-solution has no effects on manufacturing of Pidan. Liquefied albumen showed significant differences by NaOH concentration rather than that of NaCl. There was no liquefied albumen for 14days at 3% of NaOH, but it was found between 11-12days at 5% and 8-10days at 7%, respectively. The pH values of egg white when it was liquefied albumen were between 11.8 and 12.0. Pidan was made by heat treatment after 6-7days dipped in the solution at the concentration of 7%, about 10days at 5%, and 12-14days at 3% of NaOH, respectively. Although, the period of manufacturing of Pidan was saved by the increment of NaOH concentration, liquefied albumen was accelerated and the food preference was decreased by ammonia odor. Therefore, the suitable concentration of NaOH is between 3 and 5%, and that of NaCl is between 5 and 10% due to the effect of salinity by the soaking period. Through this study, optimal pickling solution and dipping time for manufacturing of Pidan was figured out, and also find out that it can save a time about 15days for manufacturing of Pidan.

• Korean Journal of Soil Science and Fertilizer
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• v.42 no.6
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• pp.439-446
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• 2009

Nitrogen balance in the regional scale which was calculated the difference between nitrogen input and output was estimated to assess the impact of rice cultivation on water environment. Nitrogen balances in Gyeonggi province, where nitrogen concentration in irrigation water was high and in Chungnam province, where nitrogen absorbtion by rice was high, were -5.4 and -8.3 kg $-8.3kg\;ha^{-1}\;yr^{-1}$, respectively. Nitrogen balances of paddy field in Gangwon province, where nitrogen output was small and irrigation water was clean, and in Gyeongnam province, where organic matter content of soil was high and rice yield was low, were 4.9 and $14.0kg\;ha^{-1}\;yr^{-1}$, respectively. Average nitrogen balance and total nitrogen absorption of paddy field in Korea were estimated to $-0.3kg\;ha^{-1}\;yr^{-1}$ and $-3,315Mg\;yr^{-1}$, respectively. When the nitrogen concentration in irrigation water was increased by $1mg \;L^{-1}$, nitrogen balance of rice paddy changed by $-2.91kg\;ha^{-1}\;yr^{-1}$. Also, when nitrogen fertilizer applied was decreased from 110 to $90kg\;ha^{-1}$ and the same harvest was maintained, the nitrogen absorption by rice paddy from irrigation water was estimated to increase by 10,600 Mg per year in Korea. However, in cases, the harvest was reduced to either 90% or 85%, nitrogen balances were changed from -11.7 to -2.3 and $2.4kg\;ha^{-1}$, respectively. These results suggest that the reduction of nitrogen fertilizer use may not always lead to a negative nitrogen balance and sustainable agriculture can achieve by not cutting down the use of fertilizer only but by reduction of fertilizer application concurrently by maintenance of harvest and by utilization of environmental characteristics such as nutrient contents in irrigation water and soils.

• Magazine of the Korean Society of Agricultural Engineers
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• v.13 no.3
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• pp.2322-2341
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• 1971

The studies were conducted to determine the methods of irrigation control which is not only able to save the irrigation water as a adaptable measures for the insufficient irrigation water and the drought but also increase the yields of rice, in the paddy field which shows over percolating tendency through the couple years of 1968 and 1969 at Suwon. These experiments were carried with late maturing rice variety, Norim No. 6 and the major treatments in this experiments were filling the clay under surface soil, periodic irrigation and lining the Vinyl under the surface soil and three replicated completely randomized design was employed. Results obtained will be summarzed as follows. 1. Through the couple years, the plots tilled the clay under 15cm of the surface soil saved the irrigation water by 364% to 45% and 78% to 88% respectively. Particulary, the plot of filling the clay with 9cm thick under 15cm of the surface soil, saved the amount of irrigation water by 45% to 88% and also increased yields by 12% to 20% through the couple years. 2. The plots in which amount of 40mm of irrigation water is irrigated periodically from 5 to 8 days at the stages of tillering and ripening, saved theamount of irrigation water by 41% to 55% and also increased yields by 10% to 16% respectively through the couple years. 3. The plot lined the Vinyl under 15cm of the surface soil, saved the amount of irrigation water by 75% to 88% in accordance with the size of hole. The plot of lining the Vinyl with $3cm/m^2$ hole yielded almost same as the check plot, but in the case of lesser hole than above yielded less. 4. The plots inserted the Vinyl paper in 57cm depth and with 6cm height from the soil surface around the plot to prevent the ridge percolation reduced the amount of percolation by 25% to 33%. 5. The plot filled the wheat straw with 6cm thick under 15cm of the surface soil increased yields by 30% in former year but opposite results were gained in later year. 6. Generally, yields and yield components such as number of spikes of spikes per hill and number of grains per spike were decreased in 1969. These faots are considered to depend upon the rainy and cold weather in the stages of vigorous tillering and less sunshine in the stages of ripening. 7. The variation of characters among the plots will be summarized as follows. (1) Tallerplant height was found in the plots of clay filling and irrigation control. (2) longer culm length and higher yields were founds in the plots filled the clay with 9cm thick and controled the irrigation periodically froir 7 to 8 days. (3) Length of spike increased generally with yields but opposite tendency was found also. (4) Number of spikes per hill increased with yields in the plots of irrigation control. (5) Number of grains per spike increased with yields in the plots filled the clay with 9cm thick and controled irrigation periodically from 5 to 8 days. (6) Tendency of variation of 1000 grain weight is similar to Number of grains per spike. (7) Percentage of complete grains increased in the plot of clay filling and irrigation control.