• The Journal of the Korea Contents Association
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• v.16 no.11
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• pp.154-165
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• 2016

The purpose of this study is to see the effect of the art therapy in group on the work stresses and emotional burnouts of social workers for diabled facility. The subjects are the 8 members of social workers at the facility for disabled located in city A. From Feb 16, 2016 to May 31, 2016, 70 minutes per session, overall 13 therapies were given. To see the therapeutic effects, there were test of stress and burnout before, afterwards and 4 weeks later. To find out the similarities in group, Mann Whitney U test was done, and Wilcoxon's signed ranks test was done to see the difference afterwards. As a result, art therapy in group was effective on the work stress and burnout of social workers in daisabled facility and the positive effect lasted. This results suggests a developed ways to reduce work stress and emotional burnout of social workers for disabled facility.

• Journal of Korean Library and Information Science Society
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• v.39 no.4
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• pp.505-522
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• 2008

This research aimed at the investigation of the effectiveness of bibliotherapy for depressed older adults from 90 to 65 years of age and older. For implementing the research, 12 subjects, aged 65 or over, were recruited from the community on a volunteer basis to participate in a bibliotherapy program. The score of MMSE-K, while there was no statistical significance in the score of SDS. Experiment results were analyzed via t-ananlysis. The analysis of hypothesis was revealed that the Depressed effectiveness of interactive Remark bibliotherapy was superior to that of reading bibliotherapy.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.6 no.2
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• pp.152-160
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• 2003

Purpose: We compared the therapeutic efficacy of low dose with that of standard dose of interferon (IFN) treatment and also compared the first IFN treatment with retreatment. Methods: We have studied 51 children (age, 2~14) treated for chronic hepatitis B from March 1990 to August 1999. Twenty seven children had been treated with $3\;MU/m^2$ ($2.66{\pm}0.66\;MU/m^2$) of IFN-${\alpha}$ three times a week for 6 months (range, 6~12 months), whereas 24 children with $6\;MU/m^2$ ($4.45{\pm}0.94\;MU/m^2$). There was no significant difference in gender, age, initial ALT and HBV DNA levels between each comparative group. Results: Among the 27 children treated with $3\;MU/m^2$ of IFN, ALT level had normalized in 11 children (41%) and anti-HBe seroconversion occurred in 9 children (33%) one year after the initiation of treatment. In comparison, among the 24 children treated with $6\;MU/m^2$ of IFN, ALT normalized in 12 children (50%) and anti-HBe seroconversion occurred in 7 children (29%). In comparing the first treatment group to retreatment group, ALT level had normalized in 23 children (45%) and anti-HBe seroconversion occurred in 16 children (31%) among the 51 children treated with the first course of IFN treatment. In comparison, ALT normalized and anti-HBe seroconversion occurred in 3 children (25%) among the retreated 12 children. Conclusion: There was no significant difference in the therapeutic efficacies between $3\;MU/m^2$ and $6\;MU/m^2$ dose of IFN treated groups in ALT normalization and anti-HBe seroconversion. The retreatment efficacy of IFN-${\alpha}$ was as effective as the first treatment.

• Radiation Oncology Journal
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• v.11 no.1
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• pp.51-58
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• 1993

We tried to establish the theoretical basis of clinical use of combined modality of hyperthermia and radiation therapy. For this purpose, we made an in vitro experiment in order to get the synergistic and/or additive effects on the cell killing of hyperthermia combined with radiation therapy by using the microwave-hyperthermia machine already installed at our department. In our experiment, we use two human cell lines: MKN-45 (adenocarcinoma of stomach) and K-562 (leukemia cell lines). In cases of combined treatments of hyperthermia and gamma-irradiation, the therapeutic effect was the highest in the simultaneous trial. Hyperthermia after gamma irradiation showed slightly higher therapeutic effect than that before irradiation without significant difference, but its effect was the same in the interval of 6 hours between hyperthermia and irradiation. The higher temperature and the longer treatment time were applied, the higher therapeutic effects were observed. We could observe the thermoresistance by time elapse at $43^{\circ}C$. When hyperthermia was done for 30 minutes at the same temperature, thermal enhancement ratio (TER) at DO. 01 (dose required surviving fraction of 0.01) were $2.5{\pm}0.08,\;3.75{\pm}0.18$, and $5.0{\pm}0.15\;at\;436{\circ}C,\;44^{\circ}C,\;and\;45^{\circ}C$ respectively in K-562 leukemia cell lines. Our experimental data showed that more cell killing effect can be obtained in the leukemia cell lines, although they usually are known to be radiosensitive, when treated with combined hyperthermia and radiation therapy. Furthermore, our data show that leukemia cell lines may have various intrinsic radiosensitivity, especially in vitro experiments. The magnitude of cell killing effect, however, will be less than that of MKN-45.

• Physical Therapy Korea
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• v.10 no.4
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• pp.69-76
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• 2003

본 연구는 급성기가 지난 뇌졸중 환자를 위한 치료적 운동 프로그램이 심박동수에 미치는 영향과 부가적으로 뇌졸중 환자의 기능적 상태에 따라 치료적 운동 형태를 알아보기 위해서 시행되었다. 대상자는 뇌졸중이 발생한지 3개월이 지난 23명의 환자이었다. 심박동수의 변화는 대상자가 각자의 치료적 운동을 수행하는 동안 Polar Vantage XL Heart Rate Monitor를 사용하여 측정하였다. 그 결과, 치료적 운동 동안 환자의 기능 수준 및 발병 기간에 따른 심박동수와 치료 형태의 차이는 없었다. 또한 전체 치료 시간 중 목표심박동수에 도달하는 시간은 2.47%에 불과하였다. 이는 치료적 운동이 뇌졸중 환자에게 과도한 심혈관 부담을 주지 않을 뿐만 아니라 유산소 훈련의 효과는 거의 존재하지 않음을 의미한다. 따라서 환자의 상태에 적절하고 유산소 훈련 효과를 고려한 치료적 운동 프로그램의 구성이 필요하다.

• Korean Journal of Clinical Laboratory Science
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• v.49 no.2
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• pp.150-160
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• 2017

Atopic dermatitis (AD) is a chronic inflammatory skin disease. It is characterized by eczematous lesions, skin dryness, and pruritus. The existing treatment drugs for AD have side effects, especially if the drugs are taken for extended periods. Therefore, new alternative therapies are necessary. The aim of this study was to investigate the combined effects of curcumin administration and LED irradiation on AD. AD-like lesions were induced in BALB/c mice by repeated application of 1-chloro-2,4-dinitrobenzene (DNCB) to the shaved skin of the ear and neck. Thirty male BALB/c mice were divided into five groups: vehicle, DNCB, curcumin, LED, and curcumin+LED groups. Curcumin (0.1 g/kg/day) was administrated repeatedly during a period of 14 days (experimental period) and 630 nm LED irradiation ($5J/cm^2/day$) was performed in the acryl box once a day for 10 days, after inducing AD-like lesions via DNCB application. The severity of AD-like lesions was evaluated during the experimental period, using a modified SCORAD index. Both ear and neck skin tissues were examined histologically for epidermal thickness, mast cell, eosinophil counting, and dermal collagen density. Epidermal cell proliferation and apoptosis were detected using immunohistochemistry and TUNEL, respectively. These were all reduced in SCORAD index, epidermal thickness, collagen density, number of mast cell and eosinophil in dermis, and number of proliferating cell and apoptotic cell in epidermis by curcumin administration and 630 nm LED irradiation. Moreover, all parameters were significantly lower in the curcumin+LED group compared with the curcumin group and LED group. These results suggest that the combined therapy of curcumin and LED is more effective than a single treatment. We recommend that this can be a feasible alternative therapy to manage AD.

• Journal of Industrial Convergence
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• v.20 no.10
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• pp.209-218
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• 2022

Individuals often report significant relief from pain and stress even after a single session of massage therapy; however, no previous studies have provided objective evidence supporting the effectiveness of a solitary massage therapy session. In the present study, we aimed to investigate the effectiveness of one-time treatment with a spinal thermal massage device reported to exert the same therapeutic effects as massage therapy in terms of pain reduction and stress relief. A man with chronic low back pain (LBP) underwent two rounds of experiments involving spinal massage treatment and bed rest, respectively. Pain was assessed using a visual analog scale, and heart rate variability (HRV) was measured in real-time to examine autonomic nervous system (ANS) activity. Blood samples were obtained at five points during each round of the experiment to examine changes in cortisol, epinephrine, and norepinephrine. Spinal massage significantly reduced pain and enhanced parasympathetic activity when compared with the bed rest condition. In addition, both epinephrine and norepinephrine levels were lower following spinal massage than following bed rest. These results are consistent with the reported effects of conventional massage therapy and support the effectiveness of one-time treatment using a spinal thermal massage device.

• Journal of Veterinary Clinics
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• v.15 no.2
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• pp.319-324
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• 1998

본 연구의 목적은 개에서 사염화탄소에 의하여 실험적으로 유발된 급성 간장질환에 대 한 침술의 치료효과를 알아보는데 있다. 잡종의 성견 24두를 실험에 사용하였다. 사염화탄소 를 동량의 광유에 회석하고, 24두의 개에 kg당 2 ml을 피하로 주사하였으며, 그리고 6두는 laserpuncture로 치료하였고, 6두는 침으로 치료하였으며, 6두는 전침으로 치료하였고, 6두는 대조군으로서 처치를 안 하였다. 치료는 매일 1회씩 4일동안 실시하였다. 적용된 경혈은 간유 와 영태이었다. 침술의 치료효과는 임상증상, 혈액화학치 및 심전도에 의하여 측정되었다. 치 료후에, laserpuncture군이 다른 군들에 비하여 임상중상, 혈액화학치 및 심전도에 있어서 비 교적 빠른 회복을 나타내었다. 전침 및 침군은 대조군에 비하여 약간 빠른 회복을 나타내었다.

• Prospectives of Industrial Chemistry
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• v.22 no.6
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• pp.2-12
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• 2019

최근 암 면역치료는 임상연구에서 긍정적인 결과를 보이고 있으며 암 질환의 표준치료법으로 자리 잡아가고 있다. 암 면역치료는 암의 재발과 전이를 획기적으로 개선시킬 수 있다는 이점이 있다. 하지만 전체 암 환자의 15~20%에서만 치료 효과를 보이고 심각한 부작용을 유발할 수 있다는 임상적 한계가 있다. 이러한 문제점들을 개선하기 위해서 기존에 약물전달 또는 조직공학 분야에서 활용되었던 생체재료를 도입하여 면역치료의 효과를 개선하고 부작용은 줄이려는 시도가 활발하다. 본 기고문에서는 효율적인 암 면역치료를 위한 생체재료(나노입자, 리포좀, 미립구, 및 하이드로젤)에 관한 최신 연구동향을 다루고자 한다. 고기능성 생체재료 개발과 종양 면역학 분야의 깊은 이해는 효과적인 암 면역치료제를 개발하는데 있어서 매우 중요하다.

• Clinical and Experimental Pediatrics
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• v.48 no.6
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• pp.594-598
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• 2005

Purpose : Phimosis is the inability to retract the foreskin of the penis over the glans of the penis. Even though phimosis is not pathogenic, the presence of phimosis is known to increase the risk of urinary tract infection in infancy. The use of topical steroids has been advocated as a safe and economical alternative to surgical intervention. The purpose of the study was to assess the effectiveness of topical steroids for the treatment of phimosis in young boys. Methods : A total of 53 boys with phimosis were divided into two groups to distinguish between the efficacy of low-potency topical steroid(group 1, 27 cases) and of high-potency topical steroid (group 2, 26 cases). Results : The success rate increased in the process of time. After 6 weeks, the success rate was 21 cases in group 1 and 22 cases in group 2. There was no significant differences in treatment outcomes between the two groups. The age of the boys, the appearance of prepuce prior to treatment, and the presence of previous symptoms, including symptoms of UTI, and ballooning of the prepuce at micturation had no significant difference on treatment outcomes. Conclusion : Topical steroid was effective in treatment of phimosis in boys younger than 4 years old. Although treatment outcomes between low- and high-potency topical steroids were not significantly different, those treated with a high-potency steroid cream showed more fast improvement. Further studies are necessary to assess systemic side effects of steroid treatment, duration of treatment and prevention of genitourinary tract infection in male infants.