• Tuberculosis and Respiratory Diseases
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• v.66 no.3
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• pp.198-204
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• 2009

Background: First-line drugs, if sensitive, are the most potent drugs in the treatment of multidrug-resistant tuberculosis (MDR-TB). This study examined the frequency and risk factors associated with acquired drug resistance to first-line drugs during a standardized treatment using first-line drugs in patients with MDR-TB. Methods: This study included patients who were diagnosed with MDR-TB at the National Masan Tuberculosis Hospital between January 2004 and May 2008, treated with standardized first-line drugs, and for whom the preand post-treatment results of the drug susceptibility test were available. Their medical records were reviewed retrospectively. Results: Of 41 MDR-TB patients, 14 (34.1%) acquired additional resistance to ethambutol (EMB) or pyrazinamide (PZA). Of 11 patients initially resistant to isoniazid (INH) and rifampicin (RFP), 3 (27.3%) acquired additional resistance to both EMB and PZA, and 3 (27.3%) to PZA. Of 18 patients initially resistant to INH, RFP and EMB, 6 (33.3%) acquired additional resistance to PZA. Of 6 patients initially resistant to INH, RFP and PZA, 2 (33.3%) acquired additional resistance to EMB. Ten of the 41 MDR-TB patients (24.4%) changed from resistant to susceptible. No statistically significant risk factors associated with acquired resistance could be found. Conclusion: First-line drugs should be used cautiously in the treatment of MDR-TB in Korea considering the potential acquisition of drug resistance.

• Progress in Medical Physics
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• v.2 no.2
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• pp.141-148
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• 1991

A since authors started IORT for stomach cancer patient on 198, we developed various sized, shaped IORT cones for better clinical application and homogeneous surface and depth dose distribution. Authors concluded as following. 1. The shaping block should be fixed on the tray, not under the tray for homogeneous dose distribution. 2. The straight cone was showed better dose distribution than divergence cone. 3. The acryl cone was superior than the stainless-steel cone. 4. The acryl cover fixed on the end for IORT cone not only improvement of surface dose, but also homogenity of depth dose.

• Korean Journal of Acupuncture
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• v.34 no.3
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• pp.164-171
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• 2017

Objectives : The purpose of this study is to study the effects of acupuncture on Young-gol and Dae-back on night fever and investigate the meridian and collateral aspects of Dong-Si acupuncture through cases of night fever due to Yin deficiency. Methods : Patients have received acupuncture on both sides(Young-gol and Dae-back) at 10 pm. The acupuncture treatment lasted for 15 minutes. Body temperature, pulse, and Numeric Rating Scale(NRS) scores for dryness of mouth were measured for the evaluation. Results : Both patients reported symptomatic reduction including night fever, pulse rate, NRS about dry mouth following the described treatments. The night fever disappeared after acupuncture treatment. The mean of pulse rate changed from 82.6 to 74.8(case 1), from 83.5 to 74.3(case 2). The mean of NRS changed from 4.2 to 1.7(case 1), from 3.3 to 2.4(case 2). Conclusions : In both cases, acupuncture was effective in relieving night fever symptoms. This can be considered from meridian and collateral aspects and the Korean medicine physiological perspective. In the future, systematic and diverse studies related to this will be needed.

• Proceedings of the KSLP Conference
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• 1999.11a
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• pp.177-177
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• 1999

배경 : 성문폐쇄부전을 나타내는 질환 중 성대구증은 음성개선을 위한 치료면에서 가장 어려운 질환중에 하나다. 성대구증의 음성개선을 위해서 현재 다양한 수술적 방법과 보형물의 주입술이 이용되고는 있으나 만족할 만한 음성개선을 얻기는 힘들었다. 목적 : 진행된 성대구증 환자의 성문폐쇄부전을 치료하기 위한 새로운 방법으로 본 교실에서 시도하고 있는 경피적 근전도유도하 교원질주입술의 치료성적 및 음성 및 음향학적 추적결과와 술기의 유용성에 관하여 알아보고자 하였다. (중략)

• Tuberculosis and Respiratory Diseases
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• v.49 no.6
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• pp.715-723
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• 2000

Background : Obstructive sleep apnea syndrome (OSAS) affects systemic blood pressure and cardiac function. The development of cardiovascular dysfunction including the changes of systemic blood pressure and cardiac rhythm, suggests that recurrent hypoxia and arousals from sleep may increase a sympathetic nervous system activity. Continuous positive airway pressure (CPAP) therapy has been found to be an effective treatment of OSAS. However, only a few studies have investigated the cardiovascular and sympathetic effects of CPAP therapy. We evaluated influences of nasal CPAP therapy on the cardiovascular system and the sympathetic activity in patients with OSAS. Methods : Thirteen patients with OSAS underwent CPAP therapy and were monitored using polysomnography, blood pressure, heart rate, presence of arrhythmia and the concentration of plasma catecholamines, before and with CPAP therapy. Results: The apnea-hypopnea index (AHI) was significant1y decreased (p<0.01) and the lowest arterial oxygen saturation level was elevated significantly after applying CPAP (p<0.01). Systolic blood pressure tended to decrease after CPAP but without statistical significance. Heart rates during sleep were not significantly different after CPAP. However, the frequency and number of types of arrhythmia decreased and sinus bradytachyarrhythmia disappeared after CPAP. Although there was no significant difference in the level of plasma epinephrine concentration, plasma norepinephrine concentration significantly decreased after CPAP (p<0.05). Conclusion : CPAP therapy decreased the apnea-hypopnea index, hypoxic episodes and plasma norepinephrine concentration. In addition, it decreased the incidence of arrhythmia and tended to decrease the systemic blood pressure. These results indicate that CPAP may play an important role in the prevention of cardiovascular complications in patients with OSAS.

• The Journal of Korean Society for Radiation Therapy
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• v.13 no.1
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• pp.23-29
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• 2001

• The Journal of Korean Society for Radiation Therapy
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• v.5 no.1
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• pp.88-91
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• 1992

• 대한방사선치료학회:학술대회논문집
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• 1997.03a
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• pp.7-8
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• 1997

• 대한방사선치료학회:학술대회논문집
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• 2002.05a
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• pp.18-19
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• 2002

• Journal of Acupuncture Research
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• v.24 no.5
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• pp.185-195
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• 2007

목적 : 부신피질 스테로이드약을 포함한 약물치료에도 조절되지 않았던 기관지천식 환자 6 증례에 대하여 침구치료를 행하여，연구방법의 하나인 조건반전법(N-of-1)을 이용하여 침치료의 효과를 검토하였다. 방법 : 연구디자인 : 조건반전법으로 침치료 기간(A기간)과 침치료 휴지기간(B기간)을 서로 반복하였다. A기간은 10주간으로 하고 1주간에 1회의 침치료를행하였다. 실시장소 : 메이지 침구대학부속병원 내과와 부속침구센터 대상 : 기관지천식의 표준적인 약물치료를 행하여도 천식발작이 충분히 개선되지 않았던 중등증에서 중증의 천식환자 6 증례를 대상으로 하였다. 평가 기관치천식에 대한 침치료의 효과를 아래의 항목을 이용하여 평가하였다. (1) 발작상태를 천식일지에 의해 평가 (2) 호흡곤란감을 VAS(Visual Analogue Scale)에 의해 평가 (3) 호흡기능검사 (4) 말초혈호산구수 (5) 스테로이드약의 투여량 (6) 중증도 효과 : A기간에 동시적으로 모든 예에서 천식발작과 호흡곤란감의 개선이 인정되었다. 한편 B기간에서는 6례 중 5례에서 천식발작의 재연이 확인되었다. 또한 천식발작의 개선에 수반하여 모든 예에서 중증도의 개선도 인정되었으며，6례 중 4례에서 스테로이드약의 감량이 가능하게 되었다. 결론 : 약물치료로 조절되지 않았던 기관지천식 환자에 대하여 침치료를 행한 결과, 환자의 천식발작, 자각증상, 호흡기능의 개선에 유효하였다고 생각된다.